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Find Clinical Drug Pipeline Developments & Deals by Immune-Onc Therapeutics
IO-202 is a first-in-class antagonist antibody with specific, high affinity binding to LILRB4. It is being evaluated for the treatment of relapsed or refractory chronic myelomonocytic leukemia.
Under the collaboration, Roche will conduct clinical trial studies to evaluate the safety, efficacy of IO-108 in combination with atezolizumab and bevacizumab compared to atezolizumab and bevacizumab for the treatment of locally advanced hepatocellular carcinoma.
Proceeds from the financing will be used to accelerate development of Immune-Onc’s lead clinical candidates, IO-108 and IO-202, and advance the selection of additional novel myeloid checkpoint inhibitor programs.
In hematologic malignancies, preclinical studies showed that IO-202 converts a “don’t kill me” to a “kill me” signal by activating T cell killing and converts a “don’t find me” to a “find me” signal by inhibiting infiltration of blood cancer cells.
IO-108 is a novel myeloid checkpoint inhibitor targeting Leukocyte Immunoglobulin-Like Receptor B2 (LILRB2, also known as ILT4) in adult patients with advanced or refractory solid tumors.
Under the terms of the collaboration, Immune-Onc will sponsor and fund the IO-108 and IO-202 clinical trials in China, and BeiGene will provide tislelizumab. Immune-Onc retains global development and commercial rights to IO-108 and IO-202.
IO-106 is third development candidate arising from Immune-Onc’s pioneering pipeline of myeloid checkpoint inhibitors, a new class of immunotherapy that aims to overcome immune resistance in cancer.
IO-108, a novel myeloid checkpoint inhibitor targeting Leukocyte Immunoglobulin-Like Receptor B2, promotes innate and adaptive anti-cancer immunity in preclinical models, and it is well-tolerated to date in the ongoing Phase 1 study for treatment of solid tumors.
IO-108, a novel antagonist antibody binds to LILRB2 with high affinity and specificity and blocks the interaction of LILRB2 with multiple ligands that are involved in cancer-associated immune suppression for treatment of AML, chronic myelomonocytic leukemia, and solid tumors.
IO-202, a first-in-class antibody targeting LILRB4, is in Phase 1 clinical development for the treatment of acute myeloid leukemia and chronic myelomonocytic leukemia.
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