
Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target

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Lead Product(s) : Lenadogene Nolparvovec
Therapeutic Area : Ophthalmology
Study Phase : Phase III
Recipient : Catalent Pharma Solutions
Deal Size : Undisclosed
Deal Type : Partnership
GenSight Biologics Announces Milestone in Manufacturing Partnership with Catalent
Details : The upstream phase of the manufacturing process for Lumevoq, the Company’s gene therapy candidate for the rare mitochondrial disease LHON, has been successfully transferred to Catalent.
Product Name : Lumevoq
Product Type : Cell & Gene Therapy
Upfront Cash : Undisclosed
June 26, 2025
Lead Product(s) : Lenadogene Nolparvovec
Therapeutic Area : Ophthalmology
Highest Development Status : Phase III
Recipient : Catalent Pharma Solutions
Deal Size : Undisclosed
Deal Type : Partnership

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Lead Product(s) : Lenadogene Nolparvovec
Therapeutic Area : Ophthalmology
Study Phase : Phase III
Sponsor : ANSM
Deal Size : Undisclosed
Deal Type : Agreement
GenSight Biologics Opens LUMEVOQ Early Access Program with ANSM in France
Details : Lumevoq (lenadogene nolparvovec) is a gene therapy developed by GenSight Biologics to treat vision loss in Leber Hereditary Optic Neuropathy (LHON) patients.
Product Name : Lumevoq
Product Type : Cell & Gene Therapy
Upfront Cash : Undisclosed
June 12, 2025
Lead Product(s) : Lenadogene Nolparvovec
Therapeutic Area : Ophthalmology
Highest Development Status : Phase III
Sponsor : ANSM
Deal Size : Undisclosed
Deal Type : Agreement

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Lead Product(s) : Lenadogene Nolparvovec
Therapeutic Area : Ophthalmology
Study Phase : Phase III
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
GenSight Reports Five-Year Efficacy Data on LUMEVOQ Gene Therapy
Details : Lumevoq (lenadogene nolparvovec) is a recombinant rAAV2/2 investigational gene therapy containing the wild-type ND4 gene. It is being evaluated for the treatment of leber hereditary optic neuropathy.
Product Name : Lumevoq
Product Type : Cell & Gene Therapy
Upfront Cash : Inapplicable
February 12, 2025
Lead Product(s) : Lenadogene Nolparvovec
Therapeutic Area : Ophthalmology
Highest Development Status : Phase III
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Lenadogene Nolparvovec
Therapeutic Area : Ophthalmology
Study Phase : Phase III
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
GenSight Biologics Submits LUMEVOQ® Dossier to ANSM for Early Access in France
Details : Lumevoq (lenadogene nolparvovec) is a recombinant adeno-associated viral vector serotype 2, investigational gene therapy being evaluated for the treatment of leber hereditary optic neuropathy.
Product Name : Lumevoq
Product Type : Cell & Gene Therapy
Upfront Cash : Inapplicable
November 13, 2024
Lead Product(s) : Lenadogene Nolparvovec
Therapeutic Area : Ophthalmology
Highest Development Status : Phase III
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Lenadogene Nolparvovec
Therapeutic Area : Ophthalmology
Study Phase : Phase III
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
GenSight Confirms Efficacy and Safety Of LUMEVOQ® Four Years Post-Injection
Details : Lumevoq (lenadogene nolparvovec) is an investigational gene therapy using a recombinant adeno-associated viral vector for the treatment of Leber hereditary optic neuropathy.
Product Name : Lumevoq
Product Type : Cell & Gene Therapy
Upfront Cash : Inapplicable
March 20, 2024
Lead Product(s) : Lenadogene Nolparvovec
Therapeutic Area : Ophthalmology
Highest Development Status : Phase III
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Lenadogene Nolparvovec
Therapeutic Area : Ophthalmology
Study Phase : Phase III
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : Lumevoq® (lenadogene nolparvovec) targets LHON by leveraging a mitochondrial targeting sequence proprietary technology platform, allows it to specifically address defects inside the mitochondria using an AAV vector.
Product Name : Lumevoq
Product Type : Cell & Gene Therapy
Upfront Cash : Inapplicable
March 13, 2023
Lead Product(s) : Lenadogene Nolparvovec
Therapeutic Area : Ophthalmology
Highest Development Status : Phase III
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : GS030
Therapeutic Area : Genetic Disease
Study Phase : Phase I/ Phase II
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : GS030 delivered via a single intravitreal injection, introduces a gene encoding for a light-sensitive protein (ChrimsonR-tdT) into retinal ganglion cells, making them responsive to light and bypassing photoreceptors killed off by diseases such as retinit...
Product Name : Undisclosed
Product Type : Cell & Gene Therapy
Upfront Cash : Inapplicable
February 13, 2023
Lead Product(s) : GS030
Therapeutic Area : Genetic Disease
Highest Development Status : Phase I/ Phase II
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Lenadogene Nolparvovec
Therapeutic Area : Ophthalmology
Study Phase : Phase III
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : Safety findings at 5 years post-injection were consistent with previous readouts, which concluded that LUMEVOQ (GS010/lenadogene nolparvovec) is well-tolerated, no SAE were recorded among LUMEVOQ®-treated eyes, and no discontinuations occurred due to oc...
Product Name : Lumevoq
Product Type : Cell & Gene Therapy
Upfront Cash : Inapplicable
July 20, 2022
Lead Product(s) : Lenadogene Nolparvovec
Therapeutic Area : Ophthalmology
Highest Development Status : Phase III
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Lenadogene Nolparvovec
Therapeutic Area : Ophthalmology
Study Phase : Phase III
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : Safety findings at 4 years post-injection were consistent with previous readouts, which concluded that LUMEVOQ (lenadogene Nolparvovec) is well-tolerated with no serious adverse events were recorded among LUMEVOQ treated eyes, and no discontinuations occ...
Product Name : Lumevoq
Product Type : Cell & Gene Therapy
Upfront Cash : Inapplicable
January 24, 2022
Lead Product(s) : Lenadogene Nolparvovec
Therapeutic Area : Ophthalmology
Highest Development Status : Phase III
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Lenadogene Nolparvovec
Therapeutic Area : Ophthalmology
Study Phase : Phase III
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : The REFLECT trial’s demonstration of a sustained, significant and safe improvement in visual acuity for LHON patients treated bilaterally with LUMEVOQ provides additional impetus for our push to gain regulatory approval.
Product Name : Lumevoq
Product Type : Cell & Gene Therapy
Upfront Cash : Inapplicable
December 14, 2021
Lead Product(s) : Lenadogene Nolparvovec
Therapeutic Area : Ophthalmology
Highest Development Status : Phase III
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
