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Find Clinical Drug Pipeline Developments & Deals by GenSight Biologics

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                          01

                          Simposio AFI
                          Not Confirmed
                          Simposio AFI
                          Not Confirmed

                          Details : Lumevoq (lenadogene nolparvovec) is a recombinant rAAV2/2 investigational gene therapy containing the wild-type ND4 gene. It is being evaluated for the treatment of leber hereditary optic neuropathy.

                          Product Name : Lumevoq

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Inapplicable

                          February 12, 2025

                          Lead Product(s) : Lenadogene Nolparvovec

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : Phase III

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          02

                          Simposio AFI
                          Not Confirmed
                          Simposio AFI
                          Not Confirmed

                          Details : Lumevoq (lenadogene nolparvovec) is a recombinant adeno-associated viral vector serotype 2, investigational gene therapy being evaluated for the treatment of leber hereditary optic neuropathy.

                          Product Name : Lumevoq

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Inapplicable

                          November 13, 2024

                          Lead Product(s) : Lenadogene Nolparvovec

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase III

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          03

                          Simposio AFI
                          Not Confirmed
                          Simposio AFI
                          Not Confirmed

                          Details : Lumevoq (lenadogene nolparvovec) is an investigational gene therapy using a recombinant adeno-associated viral vector for the treatment of Leber hereditary optic neuropathy.

                          Product Name : Lumevoq

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Inapplicable

                          March 20, 2024

                          Lead Product(s) : Lenadogene Nolparvovec

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase III

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          04

                          Simposio AFI
                          Not Confirmed
                          Simposio AFI
                          Not Confirmed

                          Details : Lumevoq® (lenadogene nolparvovec) targets LHON by leveraging a mitochondrial targeting sequence proprietary technology platform, allows it to specifically address defects inside the mitochondria using an AAV vector.

                          Product Name : Lumevoq

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Inapplicable

                          March 13, 2023

                          Lead Product(s) : Lenadogene Nolparvovec

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase III

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          05

                          Simposio AFI
                          Not Confirmed
                          Simposio AFI
                          Not Confirmed

                          Details : GS030 delivered via a single intravitreal injection, introduces a gene encoding for a light-sensitive protein (ChrimsonR-tdT) into retinal ganglion cells, making them responsive to light and bypassing photoreceptors killed off by diseases such as retinit...

                          Product Name : GS030

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Inapplicable

                          February 13, 2023

                          Lead Product(s) : GS030

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          06

                          Simposio AFI
                          Not Confirmed
                          Simposio AFI
                          Not Confirmed

                          Details : Safety findings at 5 years post-injection were consistent with previous readouts, which concluded that LUMEVOQ (GS010/lenadogene nolparvovec) is well-tolerated, no SAE were recorded among LUMEVOQ®-treated eyes, and no discontinuations occurred due to oc...

                          Product Name : Lumevoq

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Inapplicable

                          July 20, 2022

                          Lead Product(s) : Lenadogene Nolparvovec

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase III

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          07

                          Simposio AFI
                          Not Confirmed
                          Simposio AFI
                          Not Confirmed

                          Details : Safety findings at 4 years post-injection were consistent with previous readouts, which concluded that LUMEVOQ (lenadogene Nolparvovec) is well-tolerated with no serious adverse events were recorded among LUMEVOQ treated eyes, and no discontinuations occ...

                          Product Name : Lumevoq

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Inapplicable

                          January 24, 2022

                          Lead Product(s) : Lenadogene Nolparvovec

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase III

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          08

                          Simposio AFI
                          Not Confirmed
                          Simposio AFI
                          Not Confirmed

                          Details : The REFLECT trial’s demonstration of a sustained, significant and safe improvement in visual acuity for LHON patients treated bilaterally with LUMEVOQ provides additional impetus for our push to gain regulatory approval.

                          Product Name : Lumevoq

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Inapplicable

                          December 14, 2021

                          Lead Product(s) : Lenadogene Nolparvovec

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase III

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          09

                          Simposio AFI
                          Not Confirmed
                          Simposio AFI
                          Not Confirmed

                          Details : LUMEVOQ® (GS010; lenadogene nolparvovec) targets Leber Hereditary Optic Neuropathy (LHON) by leveraging a mitochondrial targeting sequence (MTS) proprietary technology platform.

                          Product Name : Lumevoq

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Inapplicable

                          June 30, 2021

                          Lead Product(s) : Lenadogene Nolparvovec

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase III

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          10

                          Simposio AFI
                          Not Confirmed
                          Simposio AFI
                          Not Confirmed

                          Details : GenSight submitted the MAA based on the benefit-risk balance established by results from a Phase-I/IIa study, two pivotal Phase-III efficacy studies and the long-term follow up study of RESCUE and REVERSET to demonstrate the efficacy of LUMEVOQ®.

                          Product Name : Lumevoq

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Inapplicable

                          September 15, 2020

                          Lead Product(s) : Lenadogene Nolparvovec

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase III

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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