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    [{"orgOrder":0,"company":"GenSight Biologics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Ophthalmology","country":"FRANCE","productType":"Cell and Gene therapy","year":"2020","type":"Inapplicable","leadProduct":"Lenadogene Nolparvovec","moa":"MTND4","graph1":"Ophthalmology","graph2":"Phase III","graph3":"GenSight Biologics","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"Intravitreal Injection","sponsorNew":"GenSight Biologics \/ Inapplicable","highestDevelopmentStatusID":"10","companyTruncated":"GenSight Biologics \/ Inapplicable"},{"orgOrder":0,"company":"GenSight Biologics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Ophthalmology","country":"FRANCE","productType":"Cell and Gene therapy","year":"2020","type":"Inapplicable","leadProduct":"Lenadogene Nolparvovec","moa":"MTND4","graph1":"Ophthalmology","graph2":"Phase III","graph3":"GenSight 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Capital","pharmaFlowCategory":"D","therapeuticArea":"Ophthalmology","country":"FRANCE","productType":"Cell and Gene therapy","year":"2020","type":"Agreement","leadProduct":"Lenadogene Nolparvovec","moa":"MTND4","graph1":"Ophthalmology","graph2":"Phase III","graph3":"GenSight Biologics","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"Intravitreal Injection","sponsorNew":"GenSight Biologics \/ Kreos Capital","highestDevelopmentStatusID":"10","companyTruncated":"GenSight Biologics \/ Kreos Capital"},{"orgOrder":0,"company":"GenSight Biologics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Genetic Disease","country":"FRANCE","productType":"Cell and Gene therapy","year":"2025","type":"Inapplicable","leadProduct":"Lenadogene Nolparvovec","moa":"MTND4","graph1":"Genetic Disease","graph2":"Phase III","graph3":"GenSight Biologics","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Genetic Disease","amount2New":0,"dosageForm":"Intravitreal Injection","sponsorNew":"GenSight Biologics \/ Inapplicable","highestDevelopmentStatusID":"10","companyTruncated":"GenSight Biologics \/ Inapplicable"},{"orgOrder":0,"company":"GenSight Biologics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Genetic Disease","country":"FRANCE","productType":"Cell and Gene therapy","year":"2023","type":"Inapplicable","leadProduct":"GS030","moa":"Undisclosed","graph1":"Genetic Disease","graph2":"Phase I\/ Phase II","graph3":"GenSight Biologics","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Genetic Disease","amount2New":0,"dosageForm":"Intravitreal Injection","sponsorNew":"GenSight Biologics \/ Inapplicable","highestDevelopmentStatusID":"7","companyTruncated":"GenSight Biologics \/ Inapplicable"},{"orgOrder":0,"company":"GenSight 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III","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"Intravitreal Injection","sponsorNew":"GenSight Biologics \/ ANSM","highestDevelopmentStatusID":"10","companyTruncated":"GenSight Biologics \/ ANSM"}]

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                            01

                            GenSight Biologics

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                            Specialty & Agro Chemical
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                            GenSight Biologics

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                            Lead Product(s) : Lenadogene Nolparvovec

                            Therapeutic Area : Ophthalmology

                            Study Phase : Phase III

                            Sponsor : ANSM

                            Deal Size : Undisclosed

                            Deal Type : Agreement

                            DEALS_DEV arrow-down

                            GenSight Biologics Opens LUMEVOQ Early Access Program with ANSM in France

                            Details : Lumevoq (lenadogene nolparvovec) is a gene therapy developed by GenSight Biologics to treat vision loss in Leber Hereditary Optic Neuropathy (LHON) patients.

                            Product Name : Lumevoq

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Undisclosed

                            June 12, 2025

                            Lead Product(s) : Lenadogene Nolparvovec

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Phase III

                            Sponsor : ANSM

                            Deal Size : Undisclosed

                            Deal Type : Agreement

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                            02

                            GenSight Biologics

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                            Specialty & Agro Chemical
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                            Lead Product(s) : Lenadogene Nolparvovec

                            Therapeutic Area : Genetic Disease

                            Study Phase : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            GenSight Reports Five-Year Efficacy Data on LUMEVOQ Gene Therapy

                            Details : Lumevoq (lenadogene nolparvovec) is a recombinant rAAV2/2 investigational gene therapy containing the wild-type ND4 gene. It is being evaluated for the treatment of leber hereditary optic neuropathy.

                            Product Name : Lumevoq

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Inapplicable

                            February 12, 2025

                            Lead Product(s) : Lenadogene Nolparvovec

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            03

                            GenSight Biologics

                            France arrow
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                            Lead Product(s) : Lenadogene Nolparvovec

                            Therapeutic Area : Ophthalmology

                            Study Phase : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            GenSight Biologics Submits LUMEVOQ® Dossier to ANSM for Early Access in France

                            Details : Lumevoq (lenadogene nolparvovec) is a recombinant adeno-associated viral vector serotype 2, investigational gene therapy being evaluated for the treatment of leber hereditary optic neuropathy.

                            Product Name : Lumevoq

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Inapplicable

                            November 13, 2024

                            Lead Product(s) : Lenadogene Nolparvovec

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            04

                            GenSight Biologics

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                            GenSight Biologics

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                            Lead Product(s) : Lenadogene Nolparvovec

                            Therapeutic Area : Ophthalmology

                            Study Phase : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            GenSight Confirms Efficacy and Safety Of LUMEVOQ® Four Years Post-Injection

                            Details : Lumevoq (lenadogene nolparvovec) is an investigational gene therapy using a recombinant adeno-associated viral vector for the treatment of Leber hereditary optic neuropathy.

                            Product Name : Lumevoq

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Inapplicable

                            March 20, 2024

                            Lead Product(s) : Lenadogene Nolparvovec

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            05

                            GenSight Biologics

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                            Specialty & Agro Chemical
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                            GenSight Biologics

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                            Specialty & Agro Chemical
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                            Lead Product(s) : Lenadogene Nolparvovec

                            Therapeutic Area : Ophthalmology

                            Study Phase : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            GenSight Biologics Confirms Sustained Efficacy and Safety of Bilateral LUMEVOQ® Injections at 3-Year Follow-U...

                            Details : Lumevoq® (lenadogene nolparvovec) targets LHON by leveraging a mitochondrial targeting sequence proprietary technology platform, allows it to specifically address defects inside the mitochondria using an AAV vector.

                            Product Name : Lumevoq

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Inapplicable

                            March 13, 2023

                            Lead Product(s) : Lenadogene Nolparvovec

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            06

                            GenSight Biologics

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                            GenSight Biologics

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                            Lead Product(s) : GS030

                            Therapeutic Area : Genetic Disease

                            Study Phase : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            GenSight Biologics Announces 1 Year Safety Data and Efficacy Signals from Pioneer Phase I/II Clinical Trial of...

                            Details : GS030 delivered via a single intravitreal injection, introduces a gene encoding for a light-sensitive protein (ChrimsonR-tdT) into retinal ganglion cells, making them responsive to light and bypassing photoreceptors killed off by diseases such as retinit...

                            Product Name : GS030

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Inapplicable

                            February 13, 2023

                            Lead Product(s) : GS030

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            07

                            GenSight Biologics

                            France arrow
                            Specialty & Agro Chemical
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                            GenSight Biologics

                            France arrow
                            Specialty & Agro Chemical
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                            Lead Product(s) : Lenadogene Nolparvovec

                            Therapeutic Area : Ophthalmology

                            Study Phase : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            GenSight Biologics Reports 5 Years’ Data Showing Sustained Efficacy and Safety Following One-time Treatment ...

                            Details : Safety findings at 5 years post-injection were consistent with previous readouts, which concluded that LUMEVOQ (GS010/lenadogene nolparvovec) is well-tolerated, no SAE were recorded among LUMEVOQ®-treated eyes, and no discontinuations occurred due to oc...

                            Product Name : Lumevoq

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Inapplicable

                            July 20, 2022

                            Lead Product(s) : Lenadogene Nolparvovec

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            08

                            GenSight Biologics

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                            Lead Product(s) : Lenadogene Nolparvovec

                            Therapeutic Area : Ophthalmology

                            Study Phase : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            GenSight Biologics Reports Clinically Meaningful Vision Improvement is Maintained 4 Years After One-time Treat...

                            Details : Safety findings at 4 years post-injection were consistent with previous readouts, which concluded that LUMEVOQ (lenadogene Nolparvovec) is well-tolerated with no serious adverse events were recorded among LUMEVOQ treated eyes, and no discontinuations occ...

                            Product Name : Lumevoq

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Inapplicable

                            January 24, 2022

                            Lead Product(s) : Lenadogene Nolparvovec

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            09

                            GenSight Biologics

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                            Specialty & Agro Chemical
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                            GenSight Biologics

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                            Lead Product(s) : Lenadogene Nolparvovec

                            Therapeutic Area : Ophthalmology

                            Study Phase : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            GenSight Biologics Confirms Sustained Efficacy and Safety of Bilateral LUMEVOQ® Injections at 2-Year Follow-U...

                            Details : The REFLECT trial’s demonstration of a sustained, significant and safe improvement in visual acuity for LHON patients treated bilaterally with LUMEVOQ provides additional impetus for our push to gain regulatory approval.

                            Product Name : Lumevoq

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Inapplicable

                            December 14, 2021

                            Lead Product(s) : Lenadogene Nolparvovec

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            10

                            GenSight Biologics

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                            Lead Product(s) : Lenadogene Nolparvovec

                            Therapeutic Area : Ophthalmology

                            Study Phase : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            GenSight Biologics Reports Topline Results from REFLECT Phase III Clinical Trial, Confirming LUMEVOQ® Efficac...

                            Details : LUMEVOQ® (GS010; lenadogene nolparvovec) targets Leber Hereditary Optic Neuropathy (LHON) by leveraging a mitochondrial targeting sequence (MTS) proprietary technology platform.

                            Product Name : Lumevoq

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Inapplicable

                            June 30, 2021

                            Lead Product(s) : Lenadogene Nolparvovec

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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