Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target
Lead Product(s) : EBT-101
Therapeutic Area : Infections and Infectious Diseases
Study Phase : Phase I/ Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Excision BioTherapeutics Announces Data from Phase 1/2 Trial Of EBT-101 in HIV
Details : EBT-101 is a CRISPR/Cas9 gene editing system for HIV-1, delivered via adenovirus-associated virus vector serotype 9 (AAV9), for intravenous administration.
Product Name : EBT-101
Product Type : Cell and Gene therapy
Upfront Cash : Inapplicable
May 13, 2024
Lead Product(s) : EBT-101
Therapeutic Area : Infections and Infectious Diseases
Highest Development Status : Phase I/ Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : EBT-107
Therapeutic Area : Infections and Infectious Diseases
Study Phase : Preclinical
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Excision Highlights Positive HBV Program Data, EBT-107, at ASGCT 2024 Meeting
Details : EBT-107, uses dual guide RNAs to effectively deactivate the virus and prevent the emergence of escape variants. It is being investigated for the treatment of HBV infection.
Product Name : EBT-107
Product Type : Cell and Gene therapy
Upfront Cash : Inapplicable
April 22, 2024
Lead Product(s) : EBT-107
Therapeutic Area : Infections and Infectious Diseases
Highest Development Status : Preclinical
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : EBT-104
Therapeutic Area : Infections and Infectious Diseases
Study Phase : Preclinical
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Excision BioTherapeutics Presents Positive Data from HSV-1 Keratitis Program EBT-104
Details : EBT-104 is a CRISPR-based gene therapy that utilizes a CRISPR/Cas gene editing system to inactivate the latent HSV-1 virus. It is being evaluated for the treatment of herpes simplex keratitis.
Product Name : EBT-104
Product Type : Cell and Gene therapy
Upfront Cash : Inapplicable
April 22, 2024
Lead Product(s) : EBT-104
Therapeutic Area : Infections and Infectious Diseases
Highest Development Status : Preclinical
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : EBT-101
Therapeutic Area : Infections and Infectious Diseases
Study Phase : Phase I
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : EBT-101 is a unique, in vivo CRISPR-based therapeutic designed to cure HIV infection after a single intravenous infusion. In vivo editing approach that simultaneously targets three distinct sites within the HIV genome.
Product Name : EBT-101
Product Type : Cell and Gene therapy
Upfront Cash : Inapplicable
July 20, 2023
Lead Product(s) : EBT-101
Therapeutic Area : Infections and Infectious Diseases
Highest Development Status : Phase I
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : EBT-101
Therapeutic Area : Infections and Infectious Diseases
Study Phase : Phase I
Sponsor : California Institute for Regenerative Medicine
Deal Size : $6.9 million
Deal Type : Funding
Details : The CIRM grant provides further validation for the EBT-101 clinical trial, which is the first ever to evaluate an in vivo CRISPR-based therapy in an infectious disease.
Product Name : EBT-101
Product Type : Cell and Gene therapy
Upfront Cash : Undisclosed
September 29, 2022
Lead Product(s) : EBT-101
Therapeutic Area : Infections and Infectious Diseases
Highest Development Status : Phase I
Sponsor : California Institute for Regenerative Medicine
Deal Size : $6.9 million
Deal Type : Funding
Lead Product(s) : EBT-101
Therapeutic Area : Infections and Infectious Diseases
Study Phase : Phase I/ Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : EBT-101 employs an adeno-associated virus (AAV) to deliver CRISPR-Cas9 and dual guide RNAs, enabling a multiplex editing approach that simultaneously targets three distinct sites within the HIV genome.
Product Name : EBT-101
Product Type : Cell and Gene therapy
Upfront Cash : Inapplicable
September 15, 2022
Lead Product(s) : EBT-101
Therapeutic Area : Infections and Infectious Diseases
Highest Development Status : Phase I/ Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : EBT-101
Therapeutic Area : Infections and Infectious Diseases
Study Phase : Phase I
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : EBT-101 is a unique, clinical-stage, in vivo CRISPR-based therapeutic designed to functionally cure HIV infections after a single intravenous infusion, target sites against the human reference genome and show no identical matches.
Product Name : EBT-101
Product Type : Cell and Gene therapy
Upfront Cash : Inapplicable
May 17, 2022
Lead Product(s) : EBT-101
Therapeutic Area : Infections and Infectious Diseases
Highest Development Status : Phase I
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : EBT-101
Therapeutic Area : Infections and Infectious Diseases
Study Phase : IND Enabling
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : EBT-101, a CRISPR-based therapeutic candidate in development as a potential functional cure for chronic HIV. EBT-101 has demonstrated removal of proviral DNA in multiple animal models and offers an opportunity for individuals living with HIV.
Product Name : EBT-101
Product Type : Cell and Gene therapy
Upfront Cash : Inapplicable
September 15, 2021
Lead Product(s) : EBT-101
Therapeutic Area : Infections and Infectious Diseases
Highest Development Status : IND Enabling
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : EBT-101
Therapeutic Area : Infections and Infectious Diseases
Study Phase : IND Enabling
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : The IND clearance enables Excision to initiate a first-in-human Phase 1/2 clinical trial to evaluate the safety, tolerability, and efficacy of EBT-101 in individuals living with human immunodeficiency virus type 1 (HIV).
Product Name : EBT-101
Product Type : Cell and Gene therapy
Upfront Cash : Inapplicable
September 15, 2021
Lead Product(s) : EBT-101
Therapeutic Area : Infections and Infectious Diseases
Highest Development Status : IND Enabling
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable