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Find Clinical Drug Pipeline Developments & Deals by Excision BioTherapeutics

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                          01

                          India Med Expo
                          Not Confirmed
                          India Med Expo
                          Not Confirmed

                          Details : EBT-101 is a CRISPR/Cas9 gene editing system for HIV-1, delivered via adenovirus-associated virus vector serotype 9 (AAV9), for intravenous administration.

                          Product Name : EBT-101

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Inapplicable

                          May 13, 2024

                          Lead Product(s) : EBT-101

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          02

                          India Med Expo
                          Not Confirmed
                          India Med Expo
                          Not Confirmed

                          Details : EBT-107, uses dual guide RNAs to effectively deactivate the virus and prevent the emergence of escape variants. It is being investigated for the treatment of HBV infection.

                          Product Name : EBT-107

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Inapplicable

                          April 22, 2024

                          Lead Product(s) : EBT-107

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Preclinical

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          03

                          India Med Expo
                          Not Confirmed
                          India Med Expo
                          Not Confirmed

                          Details : EBT-104 is a CRISPR-based gene therapy that utilizes a CRISPR/Cas gene editing system to inactivate the latent HSV-1 virus. It is being evaluated for the treatment of herpes simplex keratitis.

                          Product Name : EBT-104

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Inapplicable

                          April 22, 2024

                          Lead Product(s) : EBT-104

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Preclinical

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          04

                          India Med Expo
                          Not Confirmed
                          India Med Expo
                          Not Confirmed

                          Details : EBT-101 is a unique, in vivo CRISPR-based therapeutic designed to cure HIV infection after a single intravenous infusion. In vivo editing approach that simultaneously targets three distinct sites within the HIV genome.

                          Product Name : EBT-101

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Inapplicable

                          July 20, 2023

                          Lead Product(s) : EBT-101

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          05

                          India Med Expo
                          Not Confirmed
                          India Med Expo
                          Not Confirmed

                          Details : The CIRM grant provides further validation for the EBT-101 clinical trial, which is the first ever to evaluate an in vivo CRISPR-based therapy in an infectious disease.

                          Product Name : EBT-101

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Undisclosed

                          September 29, 2022

                          Lead Product(s) : EBT-101

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Phase I

                          Sponsor : California Institute for Regenerative Medicine

                          Deal Size : $6.9 million

                          Deal Type : Funding

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                          06

                          India Med Expo
                          Not Confirmed
                          India Med Expo
                          Not Confirmed

                          Details : EBT-101 employs an adeno-associated virus (AAV) to deliver CRISPR-Cas9 and dual guide RNAs, enabling a multiplex editing approach that simultaneously targets three distinct sites within the HIV genome.

                          Product Name : EBT-101

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Inapplicable

                          September 15, 2022

                          Lead Product(s) : EBT-101

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          07

                          India Med Expo
                          Not Confirmed
                          India Med Expo
                          Not Confirmed

                          Details : EBT-101 is a unique, clinical-stage, in vivo CRISPR-based therapeutic designed to functionally cure HIV infections after a single intravenous infusion, target sites against the human reference genome and show no identical matches.

                          Product Name : EBT-101

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Inapplicable

                          May 17, 2022

                          Lead Product(s) : EBT-101

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          08

                          India Med Expo
                          Not Confirmed
                          India Med Expo
                          Not Confirmed

                          Details : EBT-101, a CRISPR-based therapeutic candidate in development as a potential functional cure for chronic HIV. EBT-101 has demonstrated removal of proviral DNA in multiple animal models and offers an opportunity for individuals living with HIV.

                          Product Name : EBT-101

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Inapplicable

                          September 15, 2021

                          Lead Product(s) : EBT-101

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : IND Enabling

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          09

                          India Med Expo
                          Not Confirmed
                          India Med Expo
                          Not Confirmed

                          Details : The IND clearance enables Excision to initiate a first-in-human Phase 1/2 clinical trial to evaluate the safety, tolerability, and efficacy of EBT-101 in individuals living with human immunodeficiency virus type 1 (HIV).

                          Product Name : EBT-101

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Inapplicable

                          September 15, 2021

                          Lead Product(s) : EBT-101

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : IND Enabling

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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