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Find Clinical Drug Pipeline Developments & Deals by Evaxion Biotech
The net proceeds will be used to advance the Company’s preclinical and clinical pipeline, including EVX-01, a personalized cancer immunotherapy intended for the first-line treatment of metastatic and unresectable cancer patients.
The net proceeds will be used to advance the Company’s preclinical and clinical pipeline, including EVX-01, a personalized cancer immunotherapy intended for the first-line treatment of metastatic and unresectable cancer patients.
Evaxion Biotech is developing tailored cancer vaccines by targeting a novel category of AI-identified tumor antigens, named Endogenous Retroviruses (ERVs) to provide treatment solutions to cancer patients who are usually unresponsive to cancer immunotherapy.
EVX-01 is a peptide-based personalized cancer vaccine which is being evaluated for first-line treatment of metastatic and unresectable cancer. It will engage each patient's immune system to fight off cancer by mounting a targeted response against tumors.
The collaboration aims at developing a novel, prophylactic, mRNA vaccine, EVX-B2, based on Evaxion’s EDEN™ platform, a proprietary AI platform capable of rapidly identifying those antigens that will trigger a highly protective immune response, to discover gonorrhea targets.
EVX-B3, an AI-designed vaccine using both its EDEN™ and RAVEN™ AI platforms to identify protective antigens capable of eliciting both a humoral (antibody) and cellular response to the pathogen.
The net proceeds will enable Evaxion to advance its ongoing clinical phase 2 trial, EVX-01, in patients with metastatic melanoma and its next-generation cancer vaccine, EVX-03, towards a Phase 1 clinical trial in patients with lung cancer and other solid tumors.
EVX-B1, a vaccine against Staphylococcus aureus (S. aureus) containing AI-identified antigens, is highly protective against S. aureus disease in preclinical animal models.
EVX-02 is a DNA-based neoantigen cancer immunotherapy in combination with the checkpoint inhibitor nivolumab is intended for the adjuvant treatment of patients with advanced resectable melanoma.
The preclinical data demonstrate that tumor neoantigens identified by Evaxion’s AI platform, PIONEER, drive a strong immune response and lead to complete inhibition of tumor growth in a preclinical model.