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    [{"orgOrder":0,"company":"Enteris Biopharma Inc","sponsor":"CARA Therapeutics","pharmaFlowCategory":"DU","therapeuticArea":"Dermatology","country":"U.S.A","productType":"Peptide","year":"2022","type":"Inapplicable","leadProduct":"Difelikefalin Acetate","moa":"Kappa opioid receptor","graph1":"Dermatology","graph2":"Approved FDF","graph3":"Enteris Biopharma Inc","amount2":0,"highestDevelopmentShortName":"Approved FDF","therapeuticAreaShortName":"Dermatology","amount2New":0,"dosageForm":"Oral Tablet","sponsorNew":"Enteris Biopharma Inc \/ Enteris Biopharma Inc","highestDevelopmentStatusID":"15","companyTruncated":"Enteris Biopharma Inc \/ Enteris Biopharma Inc"},{"orgOrder":0,"company":"Enteris Biopharma Inc","sponsor":"CARA Therapeutics","pharmaFlowCategory":"DU","therapeuticArea":"Dermatology","country":"U.S.A","productType":"Peptide","year":"2021","type":"Inapplicable","leadProduct":"Difelikefalin Acetate","moa":"Kappa opioid receptor","graph1":"Dermatology","graph2":"Approved 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                            01

                            Enteris Biopharma Inc

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                            Enteris Biopharma Inc

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                            Lead Product(s) : Leuprolide Acetate

                            Therapeutic Area : Obstetrics/Gynecology (Women’s Health)

                            Study Phase : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Enteris BioPharma Presents Study of Ovarest® Demonstrating Oral Delivery Comparable to or Exceeding Injectabl...

                            Details : Ovarest® (leuprolide) is a gonadotropin-releasing hormone analogue that is used to treat endometriosis and uterine fibroids in women, prostate cancer in men, and central precocious puberty in boys and girls.

                            Product Name : Ovarest

                            Product Type : Peptide

                            Upfront Cash : Inapplicable

                            October 26, 2022

                            Lead Product(s) : Leuprolide Acetate

                            Therapeutic Area : Obstetrics/Gynecology (Women’s Health)

                            Highest Development Status : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            02

                            Enteris Biopharma Inc

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                            Enteris Biopharma Inc

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                            Lead Product(s) : Difelikefalin Acetate

                            Therapeutic Area : Dermatology

                            Study Phase : Phase II

                            Sponsor : CARA Therapeutics

                            Deal Size : $46.0 million

                            Deal Type : Licensing Agreement

                            DEALS_DEV arrow-down

                            SWK Holdings' Subsidiary, Enteris BioPharma, Receives $5 Million Milestone Payment from Cara Therapeutics

                            Details : The milestone payment is related to continued clinical progress of Oral KORSUVA (difelikefalin), which is currently the subject of four separate clinical programs for pruritus in patients with hepatic impairment due to primary biliary cholangitis.

                            Product Name : Korsuva

                            Product Type : Peptide

                            Upfront Cash : $8.0 million

                            October 10, 2022

                            Lead Product(s) : Difelikefalin Acetate

                            Therapeutic Area : Dermatology

                            Highest Development Status : Phase II

                            Sponsor : CARA Therapeutics

                            Deal Size : $46.0 million

                            Deal Type : Licensing Agreement

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                            03

                            Enteris Biopharma Inc

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                            Lead Product(s) : Difelikefalin Acetate

                            Therapeutic Area : Dermatology

                            Study Phase : Phase III

                            Recipient : CARA Therapeutics

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Cara Therapeutics Announces Oral KORSUVA™ (difelikefalin) Data Selected for Late-Breaking Presentation at 20...

                            Details : KORSUVA™ (difelikefalin) injection is the first and only FDA-approved treatment for moderate-to-severe pruritus associated with chronic kidney disease in adults undergoing hemodialysis.

                            Product Name : Korsuva

                            Product Type : Peptide

                            Upfront Cash : Inapplicable

                            August 03, 2022

                            Lead Product(s) : Difelikefalin Acetate

                            Therapeutic Area : Dermatology

                            Highest Development Status : Phase III

                            Recipient : CARA Therapeutics

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            04

                            Enteris Biopharma Inc

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                            Enteris Biopharma Inc

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                            Lead Product(s) : Leuprolide Acetate

                            Therapeutic Area : Obstetrics/Gynecology (Women’s Health)

                            Study Phase : Phase II

                            Sponsor : SWK Holdings Corporation

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Enteris BioPharma Announces Acceptance of Abstract for Oral Presentation at ASRM 2022 Scientific Congress & Ex...

                            Details : Oral administration of Ovarest (leuprolide) offers the potential to better address diseases in which gonadotropin-releasing hormone (GnRH) agonists are known to provide benefit and for which an oral format can improve patient compliance.

                            Product Name : Ovarest

                            Product Type : Peptide

                            Upfront Cash : Inapplicable

                            July 14, 2022

                            Lead Product(s) : Leuprolide Acetate

                            Therapeutic Area : Obstetrics/Gynecology (Women’s Health)

                            Highest Development Status : Phase II

                            Sponsor : SWK Holdings Corporation

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            05

                            Enteris Biopharma Inc

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                            Enteris Biopharma Inc

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                            Lead Product(s) : Difelikefalin Acetate

                            Therapeutic Area : Nephrology

                            Study Phase : Phase II

                            Sponsor : CARA Therapeutics

                            Deal Size : Undisclosed

                            Deal Type : Licensing Agreement

                            DEALS_DEV arrow-down

                            SWK Holdings' Subsidiary, Enteris BioPharma, Receives $10 Million Milestone Payment from Cara Therapeutics

                            Details : This milestone payment was triggered by confirmation from Cara of the completion of an End-of-Phase 2 Meeting with the U.S. Food and Drug Administration (FDA) for Oral KORSUVA in patients with non-dialysis dependent (NDD) chronic kidney disease (CKD-aP).

                            Product Name : Korsuva

                            Product Type : Peptide

                            Upfront Cash : $8.0 million

                            November 06, 2021

                            Lead Product(s) : Difelikefalin Acetate

                            Therapeutic Area : Nephrology

                            Highest Development Status : Phase II

                            Sponsor : CARA Therapeutics

                            Deal Size : Undisclosed

                            Deal Type : Licensing Agreement

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                            06

                            Enteris Biopharma Inc

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                            Enteris Biopharma Inc

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                            Lead Product(s) : Difelikefalin Acetate

                            Therapeutic Area : Dermatology

                            Study Phase : Phase II

                            Recipient : CARA Therapeutics

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Cara Initiates Phase 2 Trial of Oral KORSUVA™ for the Treatment of Pruritus in Patients with Notalgia Parest...

                            Details : The Phase 2 multicenter, randomized, double-blind, placebo-controlled 8-week study is designed to evaluate the efficacy and safety of Oral KORSUVA™ for moderate-to-severe pruritus in approximately 120 subjects with NP.

                            Product Name : Korsuva

                            Product Type : Peptide

                            Upfront Cash : Inapplicable

                            November 01, 2021

                            Lead Product(s) : Difelikefalin Acetate

                            Therapeutic Area : Dermatology

                            Highest Development Status : Phase II

                            Recipient : CARA Therapeutics

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            07

                            Enteris Biopharma Inc

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                            ChemOutsourcing
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                            Enteris Biopharma Inc

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                            Lead Product(s) : Leuprolide Acetate

                            Therapeutic Area : Obstetrics/Gynecology (Women’s Health)

                            Study Phase : Phase II

                            Sponsor : Parexel | Syneos Health

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Study to Evaluate the Pharmacodynamics and Efficacy of Leuprolide Tablets (Ovarest®) in Women With Endometr...

                            Details : Undisclosed

                            Product Name : Undisclosed

                            Product Type : Protein

                            Upfront Cash : Inapplicable

                            October 27, 2021

                            Lead Product(s) : Leuprolide Acetate

                            Therapeutic Area : Obstetrics/Gynecology (Women’s Health)

                            Highest Development Status : Phase II

                            Sponsor : Parexel | Syneos Health

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            08

                            Enteris Biopharma Inc

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                            Enteris Biopharma Inc

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                            Lead Product(s) : Difelikefalin Acetate

                            Therapeutic Area : Dermatology

                            Study Phase : Phase II

                            Sponsor : CARA Therapeutics

                            Deal Size : $28.0 million

                            Deal Type : Licensing Agreement

                            DEALS_DEV arrow-down

                            SWK Holdings' Subsidiary, Enteris BioPharma, Receives $5 Million Milestone Payment from Cara Therapeutics

                            Details : Enteris is eligible to receive additional potential milestone payments over the next several quarters, subject to the achievement of certain development milestones for Oral KORSUVA, of which Enteris will retain half.

                            Product Name : Korsuva

                            Product Type : Peptide

                            Upfront Cash : $8.0 million

                            September 12, 2021

                            Lead Product(s) : Difelikefalin Acetate

                            Therapeutic Area : Dermatology

                            Highest Development Status : Phase II

                            Sponsor : CARA Therapeutics

                            Deal Size : $28.0 million

                            Deal Type : Licensing Agreement

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                            09

                            Enteris Biopharma Inc

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                            ChemOutsourcing
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                            Enteris Biopharma Inc

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                            ChemOutsourcing
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                            Lead Product(s) : Difelikefalin Acetate

                            Therapeutic Area : Dermatology

                            Study Phase : Phase II

                            Recipient : CARA Therapeutics

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Cara Announces Topline Results From KARE Phase 2 Dose-Ranging Trial in Atopic Dermatitis Patients with Moderat...

                            Details : Statistically significant improvement in 4-point responder analysis in mild-to-moderate (BSA <10%) AD patients with 32% of KORSUVA-treated patients achieving a > 4-point reduction vs. 19% in placebo group.

                            Product Name : Korsuva

                            Product Type : Peptide

                            Upfront Cash : Inapplicable

                            April 29, 2021

                            Lead Product(s) : Difelikefalin Acetate

                            Therapeutic Area : Dermatology

                            Highest Development Status : Phase II

                            Recipient : CARA Therapeutics

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            10

                            Enteris Biopharma Inc

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                            Enteris Biopharma Inc

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                            Lead Product(s) : Difelikefalin Acetate

                            Therapeutic Area : Dermatology

                            Study Phase : Phase II

                            Recipient : CARA Therapeutics

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Cara Therapeutics Presents Late-Breaking Results of KARE Phase 2 Trial of Oral Difelikefalin (Oral KORSUVA™)...

                            Details : KORSUVA™ (CR845/difelikefalin), a first-in-class KOR agonist used for the treatment of moderate-to-severe pruritus in mild-to-severe atopic dermatitis (AD) patients.

                            Product Name : Korsuva

                            Product Type : Peptide

                            Upfront Cash : Inapplicable

                            April 10, 2021

                            Lead Product(s) : Difelikefalin Acetate

                            Therapeutic Area : Dermatology

                            Highest Development Status : Phase II

                            Recipient : CARA Therapeutics

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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