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AmbioPharm"},{"orgOrder":0,"company":"Alpine Biotech","sponsor":"Lawry Han","pharmaFlowCategory":"DU","therapeuticArea":"Endocrinology","country":"","productType":"Undisclosed","year":"2025","type":"Inapplicable","leadProduct":"Undisclosed","moa":"Undisclosed","graph1":"Endocrinology","graph2":"Undisclosed","graph3":"Alpine Biotech","amount2":0,"highestDevelopmentShortName":"Undisclosed","therapeuticAreaShortName":"Endocrinology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Alpine Biotech \/ Lawry Han","highestDevelopmentStatusID":"1","companyTruncated":"Alpine Biotech \/ Lawry Han"},{"orgOrder":0,"company":"Remedium Bio","sponsor":"Eli Lilly","pharmaFlowCategory":"D","therapeuticArea":"Endocrinology","country":"U.S.A","productType":"Cell & Gene Therapy","year":"2025","type":"Collaboration","leadProduct":"Undisclosed","moa":"Undisclosed","graph1":"Endocrinology","graph2":"Undisclosed","graph3":"Remedium Bio","amount2":0,"highestDevelopmentShortName":"Undisclosed","therapeuticAreaShortName":"Endocrinology","amount2New":0,"dosageForm":"Injection","sponsorNew":"Remedium Bio \/ Eli Lilly","highestDevelopmentStatusID":"1","companyTruncated":"Remedium Bio \/ Eli Lilly"},{"orgOrder":0,"company":"LMC Diabetes & Endocrinology","sponsor":"Abbott Laboratories","pharmaFlowCategory":"DU","therapeuticArea":"Endocrinology","country":"CANADA","productType":"Undisclosed","year":"2025","type":"Inapplicable","leadProduct":"Undisclosed","moa":"Undisclosed","graph1":"Endocrinology","graph2":"Undisclosed","graph3":"LMC Diabetes & Endocrinology","amount2":0,"highestDevelopmentShortName":"Undisclosed","therapeuticAreaShortName":"Endocrinology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"LMC Diabetes & Endocrinology \/ Abbott Laboratories","highestDevelopmentStatusID":"1","companyTruncated":"LMC Diabetes & Endocrinology \/ Abbott Laboratories"},{"orgOrder":0,"company":"INQUIS Clinical Research","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Endocrinology","country":"CANADA","productType":"Peptide, Unconjugated","year":"2025","type":"Inapplicable","leadProduct":"Collagen","moa":"Undisclosed","graph1":"Endocrinology","graph2":"Undisclosed","graph3":"INQUIS Clinical Research","amount2":0,"highestDevelopmentShortName":"Undisclosed","therapeuticAreaShortName":"Endocrinology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"INQUIS Clinical Research \/ Undisclosed","highestDevelopmentStatusID":"1","companyTruncated":"INQUIS Clinical Research \/ Undisclosed"},{"orgOrder":0,"company":"QuickSilver Scientific","sponsor":"KGK Science","pharmaFlowCategory":"DU","therapeuticArea":"Endocrinology","country":"U.S.A","productType":"Dietary Supplement","year":"2025","type":"Inapplicable","leadProduct":"AMPK Charge Plus","moa":"Undisclosed","graph1":"Endocrinology","graph2":"Undisclosed","graph3":"QuickSilver 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Nutriscience","highestDevelopmentStatusID":"1","companyTruncated":"Nanjing Nutrabuilding Bio-tech Co., Ltd. \/ Biofortis M\u00e9rieux Nutriscience"},{"orgOrder":0,"company":"Ajinomoto Company","sponsor":"Daniel Moore","pharmaFlowCategory":"DU","therapeuticArea":"Endocrinology","country":"JAPAN","productType":"Miscellaneous","year":"2017","type":"Inapplicable","leadProduct":"Amino Acids Mixture","moa":"Amino acid metabolism","graph1":"Endocrinology","graph2":"Undisclosed","graph3":"Ajinomoto Company","amount2":0,"highestDevelopmentShortName":"Undisclosed","therapeuticAreaShortName":"Endocrinology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Ajinomoto Company \/ Daniel Moore","highestDevelopmentStatusID":"1","companyTruncated":"Ajinomoto Company \/ Daniel Moore"},{"orgOrder":0,"company":"BioGaia Pharma","sponsor":"Vastra Gotaland 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Knickmeyer Santelli, PhD","pharmaFlowCategory":"DU","therapeuticArea":"Endocrinology","country":"U.S.A","productType":"Hormone","year":"2011","type":"Inapplicable","leadProduct":"Recombinant Human Growth Hormone","moa":"Growth hormone receptor","graph1":"Endocrinology","graph2":"Undisclosed","graph3":"Pfizer Inc","amount2":0,"highestDevelopmentShortName":"Undisclosed","therapeuticAreaShortName":"Endocrinology","amount2New":0,"dosageForm":"Injection","sponsorNew":"Pfizer Inc \/ Rebecca Knickmeyer Santelli, PhD","highestDevelopmentStatusID":"1","companyTruncated":"Pfizer Inc \/ Rebecca Knickmeyer Santelli, PhD"},{"orgOrder":0,"company":"Merck Group","sponsor":"Elaine Chow","pharmaFlowCategory":"DU","therapeuticArea":"Endocrinology","country":"GERMANY","productType":"Miscellaneous","year":"2022","type":"Inapplicable","leadProduct":"Metformin","moa":"Mitochondrial complex I (NADH dehydrogenase)","graph1":"Endocrinology","graph2":"Undisclosed","graph3":"Merck 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                          Top Deals by Deal Size (USD bn)

                          01

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Endocrinology

                          Study Phase : Undisclosed

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Details : This drug candidate is currently being evaluated in clinical studies for the treatment of Diabetes Mellitus, Type 2.

                          Product Name : Undisclosed

                          Product Type : Undisclosed

                          Upfront Cash : Inapplicable

                          January 13, 2023

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Endocrinology

                          Highest Development Status : Undisclosed

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Sanofi Company Banner

                          02

                          Lead Product(s) : Vildagliptin

                          Therapeutic Area : Endocrinology

                          Study Phase : Undisclosed

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Details : Vildagliptin is a Other Small Molecule drug candidate, which is currently being evaluated in clinical studies for the treatment of Diabetes Mellitus.

                          Product Name : Undisclosed

                          Product Type : Miscellaneous

                          Upfront Cash : Inapplicable

                          April 15, 2022

                          Lead Product(s) : Vildagliptin

                          Therapeutic Area : Endocrinology

                          Highest Development Status : Undisclosed

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Tiefenbacher Compnay Banner

                          03

                          Lead Product(s) : Insulin Glargine,Lixisenatide

                          Therapeutic Area : Endocrinology

                          Study Phase : Undisclosed

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Details : Participants were randomized to switch from their prior insulin to either Soliqua once daily or premixed insulin twice daily, with starting doses determined and adjusted weekly. Any metformin or SGLT-2i treatment was maintained through the study period.

                          Product Name : Soliqua

                          Product Type : Peptide, Unconjugated

                          Upfront Cash : Inapplicable

                          June 28, 2021

                          Lead Product(s) : Insulin Glargine,Lixisenatide

                          Therapeutic Area : Endocrinology

                          Highest Development Status : Undisclosed

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Sanofi Company Banner

                          04

                          Nanjing Nutrabuilding Bio-tech Co., Ltd.

                          Country arrow
                          AIChE Annual Meeting
                          Not Confirmed

                          Nanjing Nutrabuilding Bio-tech Co., Ltd.

                          Country arrow
                          AIChE Annual Meeting
                          Not Confirmed

                          Details : Dihydroberberine is a small molecule drug candidate, which is currently being evaluated in Undisclosed clinical studies for the treatment of Prediabetic State.

                          Product Name : Undisclosed

                          Product Type : Miscellaneous

                          Upfront Cash : Inapplicable

                          October 07, 2025

                          Lead Product(s) : Dihydroberberine

                          Therapeutic Area : Endocrinology

                          Highest Development Status : Undisclosed

                          Sponsor : Biofortis Mérieux Nutriscience

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          05

                          AIChE Annual Meeting
                          Not Confirmed
                          AIChE Annual Meeting
                          Not Confirmed

                          Details : The collaboration aims to advance innovative gene therapies for Type 2 diabetes and obesity using Remedium's proprietary Prometheus™ platform.

                          Product Name : Undisclosed

                          Product Type : Cell & Gene Therapy

                          Upfront Cash : Undisclosed

                          September 23, 2025

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Endocrinology

                          Highest Development Status : Undisclosed

                          Sponsor : Eli Lilly

                          Deal Size : Undisclosed

                          Deal Type : Collaboration

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                          06

                          LMC Diabetes & Endocrinology

                          Country arrow
                          AIChE Annual Meeting
                          Not Confirmed

                          LMC Diabetes & Endocrinology

                          Country arrow
                          AIChE Annual Meeting
                          Not Confirmed

                          Details : This drug candidate is currently being evaluated in Undisclosed clinical studies for the treatment of Diabetes Mellitus, Type 2.

                          Product Name : Undisclosed

                          Product Type : Undisclosed

                          Upfront Cash : Inapplicable

                          September 05, 2025

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Endocrinology

                          Highest Development Status : Undisclosed

                          Sponsor : Abbott Laboratories

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          07

                          Alpine Biotech

                          Country arrow
                          AIChE Annual Meeting
                          Not Confirmed

                          Alpine Biotech

                          Country arrow
                          AIChE Annual Meeting
                          Not Confirmed

                          Details : This drug candidate is currently being evaluated in clinical studies for the treatment of Hyperglycemia.

                          Product Name : Undisclosed

                          Product Type : Undisclosed

                          Upfront Cash : Inapplicable

                          August 26, 2025

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Endocrinology

                          Highest Development Status : Undisclosed

                          Sponsor : Lawry Han

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          08

                          AIChE Annual Meeting
                          Not Confirmed
                          AIChE Annual Meeting
                          Not Confirmed

                          Details : Cofrogliptin is a Other Small Molecule drug candidate, which is currently being evaluated in clinical studies for the treatment of Diabetes Mellitus, Type 2.

                          Product Name : Undisclosed

                          Product Type : Miscellaneous

                          Upfront Cash : Inapplicable

                          August 14, 2025

                          Lead Product(s) : Cofrogliptin

                          Therapeutic Area : Endocrinology

                          Highest Development Status : Undisclosed

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          09

                          The People's Hospital of Gaozhou

                          Country arrow
                          AIChE Annual Meeting
                          Not Confirmed

                          The People's Hospital of Gaozhou

                          Country arrow
                          AIChE Annual Meeting
                          Not Confirmed

                          Details : Amino acid is a Other Small Molecule drug candidate, which is currently being evaluated in clinical studies for the treatment of Diabetes Mellitus.

                          Product Name : Undisclosed

                          Product Type : Miscellaneous

                          Upfront Cash : Inapplicable

                          July 22, 2025

                          Lead Product(s) : Amino Acids Mixture

                          Therapeutic Area : Endocrinology

                          Highest Development Status : Undisclosed

                          Sponsor : Chengdu Qingshan Likang Pharmaceutical

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          10

                          Richmond Pharmacology

                          Country arrow
                          AIChE Annual Meeting
                          Not Confirmed

                          Richmond Pharmacology

                          Country arrow
                          AIChE Annual Meeting
                          Not Confirmed

                          Details : Glucose is a Dietary Supplement drug candidate, which is currently being evaluated in clinical studies for the treatment of Diabetes Mellitus, Type 2.

                          Product Name : Undisclosed

                          Product Type : Dietary Supplement

                          Upfront Cash : Inapplicable

                          June 11, 2025

                          Lead Product(s) : Glucose

                          Therapeutic Area : Endocrinology

                          Highest Development Status : Undisclosed

                          Sponsor : Richmond Research Institute

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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