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            Details:

            AZP-3813, a peptide GHR antagonist, is being developed as a potential treatment for acromegaly to be used in combination with somatostatin analogues (SSAs) for patients who do not adequately respond to SSAs alone.

            Lead Product(s): AZP-3813

            Therapeutic Area: Endocrinology Product Name: AZP-3813

            Highest Development Status: Phase I Product Type: Peptide

            Partner/Sponsor/Collaborator: PeptiDream

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable June 05, 2023

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            AZP-3601, a long-acting parathyroid hormone (PTH) analog, normalizes blood calcium in thyroparathyroidectomized (TPTX) rats without causing deleterious changes in bone.

            Lead Product(s): AZP-3601

            Therapeutic Area: Endocrinology Product Name: AZP-3601

            Highest Development Status: Phase I Product Type: Peptide

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable May 16, 2022

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            AZP-3601, investigational therapeutic peptide designed to target specific conformation of PTH receptor safely produce sustained and stable levels of calcium in blood and manage symptoms of hypoparathyroidism, with goal of consequently preventing chronic kidney disease.

            Lead Product(s): AZP-3601

            Therapeutic Area: Endocrinology Product Name: AZP-3601

            Highest Development Status: Phase I Product Type: Peptide

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable March 17, 2022

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            Details:

            AZP-3601 is an investigational therapeutic peptide designed to target a specific conformation of the parathyroid hormone (PTH) receptor to safely produce sustained and stable levels of calcium in the blood and thereby manage the symptoms of hypoparathyroidism.

            Lead Product(s): AZP-3601

            Therapeutic Area: Endocrinology Product Name: AZP-3601

            Highest Development Status: Phase I Product Type: Peptide

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable March 01, 2022

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            Details:

            This acquisition strengthens the protection and the potential of the First in Class drug candidate of T.H.A.C which incorporates the active ingredient ALF-5755 for the treatment of Type 2 Diabetes Mellitus and severe complications.

            Lead Product(s): ALF-5755

            Therapeutic Area: Endocrinology Product Name: ALF-5755

            Highest Development Status: Phase I Product Type: Large molecule

            Partner/Sponsor/Collaborator: T.H.A.C.

            Deal Size: Undisclosed Upfront Cash: Undisclosed

            Deal Type: Acquisition September 27, 2021

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            Details:

            Amolyt will use the proceeds to advance its pipeline for rare endocrine and related diseases, including clinical development of AZP-3601 for hypoparathyroidism, pre-clinical development of AZP-3813 for acromegaly and ongoing research related to AZP-3404.

            Lead Product(s): AZP-3601

            Therapeutic Area: Endocrinology Product Name: AZP-3601

            Highest Development Status: Phase I Product Type: Peptide

            Partner/Sponsor/Collaborator: Sectoral Asset Management

            Deal Size: $80.0 million Upfront Cash: Undisclosed

            Deal Type: Series B Financing September 16, 2021

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            Details:

            Pramlintide, despite being the only drug approved as an adjunct to insulin in type 1 diabetes, is underused as it requires three additional daily injections in addition to the multiple injections of insulin.

            Lead Product(s): Insulin Lispro,Pramlintide

            Therapeutic Area: Endocrinology Product Name: BC LisPram

            Highest Development Status: Phase I Product Type: Peptide

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable June 29, 2021

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            Details:

            Data from all cohorts from its Phase 1 Single Ascending Dose clinical trial evaluating AZP-3601, a parathyroid hormone (PTH) analog specifically designed for the treatment of hypoparathyroidism will be presented.

            Lead Product(s): AZP-3601

            Therapeutic Area: Endocrinology Product Name: AZP-3601

            Highest Development Status: Phase I Product Type: Peptide

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable May 18, 2021

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            Details:

            AZP-3601 is a therapeutic peptide designed to target a specific configuration of the parathyroid hormone (PTH) receptor in order to safely produce sustained levels of calcium in the blood and thereby manage the symptoms of hypoparathyroidism.

            Lead Product(s): AZP-3601

            Therapeutic Area: Endocrinology Product Name: AZP-3601

            Highest Development Status: Phase I Product Type: Peptide

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable January 06, 2021

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