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    [{"orgOrder":0,"company":"Cadila Pharmaceuticals","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Gastroenterology","country":"INDIA","productType":"Other Small Molecule","year":"2025","type":"Inapplicable","leadProduct":"Lactulose","moa":"||Undisclosed","graph1":"Gastroenterology","graph2":"Approved FDF","graph3":"Cadila Pharmaceuticals","amount2":0,"highestDevelopmentShortName":"Approved FDF","therapeuticAreaShortName":"Gastroenterology","amount2New":0,"dosageForm":"Oral Solution","sponsorNew":"Cadila Pharmaceuticals \/ Inapplicable","highestDevelopmentStatusID":"15","companyTruncated":"Cadila Pharmaceuticals \/ Inapplicable"},{"orgOrder":0,"company":"Bausch Health","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Neurology","country":"CANADA","productType":"Antibiotic","year":"2020","type":"Inapplicable","leadProduct":"Rifaximin","moa":"||RNA polymerase","graph1":"Neurology","graph2":"Approved FDF","graph3":"Bausch Health","amount2":0,"highestDevelopmentShortName":"Approved FDF","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Oral Tablet","sponsorNew":"Bausch Health \/ Inapplicable","highestDevelopmentStatusID":"15","companyTruncated":"Bausch Health \/ Inapplicable"},{"orgOrder":0,"company":"Johnson & Johnson Innovative Medicine","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Undisclosed","country":"U.S.A","productType":"Other Small Molecule","year":"2021","type":"Inapplicable","leadProduct":"Indomethacin","moa":"||Cyclooxygenase","graph1":"Undisclosed","graph2":"Phase I","graph3":"Johnson & Johnson Innovative Medicine","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"","amount2New":0,"dosageForm":"Oral Capsule","sponsorNew":"Johnson & Johnson Innovative Medicine \/ Inapplicable","highestDevelopmentStatusID":"6","companyTruncated":"Johnson & Johnson Innovative Medicine \/ Inapplicable"},{"orgOrder":0,"company":"Avva Rus JSC","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Infections and Infectious Diseases","country":"RUSSIA","productType":"Antibiotic","year":"2024","type":"Inapplicable","leadProduct":"Natamycin","moa":"||Ergosterol","graph1":"Infections and Infectious Diseases","graph2":"Phase III","graph3":"Avva Rus JSC","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Infectious Diseases","amount2New":0,"dosageForm":"Vaginal Suppository","sponsorNew":"Avva Rus JSC \/ Inapplicable","highestDevelopmentStatusID":"10","companyTruncated":"Avva Rus JSC \/ Inapplicable"},{"orgOrder":0,"company":"AVVA Pharma","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Infections and Infectious Diseases","country":"CYPRUS","productType":"Other Small Molecule","year":"2025","type":"Inapplicable","leadProduct":"Clotrimazole","moa":"||Cytochrome P450 51","graph1":"Infections and Infectious Diseases","graph2":"Phase II\/ Phase III","graph3":"AVVA Pharma","amount2":0,"highestDevelopmentShortName":"Ph II\/III","therapeuticAreaShortName":"Infectious Diseases","amount2New":0,"dosageForm":"Vaginal Suppository","sponsorNew":"AVVA Pharma \/ Inapplicable","highestDevelopmentStatusID":"9","companyTruncated":"AVVA Pharma \/ Inapplicable"}]

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                            01

                            Cadila Pharmaceuticals

                            India arrow
                            EPSC
                            Not Confirmed

                            Cadila Pharmaceuticals

                            India arrow
                            EPSC
                            Not Confirmed
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                            Lead Product(s) : Lactulose,Inapplicable

                            Therapeutic Area : Gastroenterology

                            Study Phase : Approved FDF

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Cadila Pharma Launches Cadilose for Constipation, Hepatic Encephalopathy

                            Details : Cadilose is an advanced Lactulose formulation designed to effectively manage constipation and hepatic encephalopathy (HE).

                            Product Name : Cadilose

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            March 25, 2025

                            Lead Product(s) : Lactulose,Inapplicable

                            Therapeutic Area : Gastroenterology

                            Highest Development Status : Approved FDF

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            02

                            AVVA Pharma

                            Cyprus arrow
                            EPSC
                            Not Confirmed

                            AVVA Pharma

                            Cyprus arrow
                            EPSC
                            Not Confirmed
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                            Lead Product(s) : Clotrimazole,Lactulose

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : Phase II/ Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Efficacy and Safety of Clotrimazole+Lactulose Vaginal Suppositories Vs. Clotrimazole Monotherapy in Adult Wome...

                            Details : Undisclosed

                            Product Name : Undisclosed

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            February 19, 2025

                            Lead Product(s) : Clotrimazole,Lactulose

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : Phase II/ Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            03

                            Avva Rus JSC

                            Russia arrow
                            EPSC
                            Not Confirmed

                            Avva Rus JSC

                            Russia arrow
                            EPSC
                            Not Confirmed
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                            • EDQM
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                            Lead Product(s) : Natamycin,Lactulose

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Efficacy and Safety of Natamycin and Lactulose Vaginal Suppositories in Treatment of Vulvovaginal Candidiasis

                            Details : Undisclosed

                            Product Name : Undisclosed

                            Product Type : Antibiotic

                            Upfront Cash : Inapplicable

                            May 13, 2024

                            Lead Product(s) : Natamycin,Lactulose

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            04

                            Johnson & Johnson Innovative Medicine

                            U.S.A arrow
                            EPSC
                            Not Confirmed

                            Johnson & Johnson Innovative Medicine

                            U.S.A arrow
                            EPSC
                            Not Confirmed
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                            Lead Product(s) : Indomethacin,Lactulose,Mannitol

                            Therapeutic Area : Undisclosed

                            Study Phase : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            A Study Exploring the Use of Challenge Agents in Healthy Volunteers - Intervention Specific Appendix

                            Details : Undisclosed

                            Product Name : Undisclosed

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            March 29, 2021

                            Lead Product(s) : Indomethacin,Lactulose,Mannitol

                            Therapeutic Area : Undisclosed

                            Highest Development Status : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            05

                            Bausch Health

                            Canada arrow
                            EPSC
                            Not Confirmed

                            Bausch Health

                            Canada arrow
                            EPSC
                            Not Confirmed
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                            • EDQM
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                            Lead Product(s) : Rifaximin,Lactulose

                            Therapeutic Area : Neurology

                            Study Phase : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Bausch Health Announces Favorable Topline Results From Investigative Formulation of Rifaximin SSD IR

                            Details : In the study, the treatment arm evaluating 40 mg BID of rifaximin SSD IR plus standard of care therapy met its primary endpoint of time to resolution of OHE.

                            Product Name : Xifaxan

                            Product Type : Antibiotic

                            Upfront Cash : Inapplicable

                            March 31, 2020

                            Lead Product(s) : Rifaximin,Lactulose

                            Therapeutic Area : Neurology

                            Highest Development Status : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            06

                            Academisch Medisch Centrum - Universiteit van Amsterdam

                            Country arrow
                            EPSC
                            Not Confirmed

                            Academisch Medisch Centrum - Universiteit van Amsterdam

                            Country arrow
                            EPSC
                            Not Confirmed
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                            Lead Product(s) : Rifaximin,Lactulose

                            Therapeutic Area : Neurology

                            Study Phase : Phase IV

                            Sponsor : Gamaleya Research Institute of Epidemiology and Microbiology, Health Ministry of the Russian Federation | Leiden University Medical Center | Maastricht University Medical Center | Radboud University Medical Center | University Medical Center Groningen | U

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Prevention of Post-TIPS Hepatic Encephalopathy by Administration of Rifaximin and Lactulose

                            Details : Undisclosed

                            Product Name : Undisclosed

                            Product Type : Antibiotic

                            Upfront Cash : Inapplicable

                            August 29, 2019

                            Lead Product(s) : Rifaximin,Lactulose

                            Therapeutic Area : Neurology

                            Highest Development Status : Phase IV

                            Sponsor : Gamaleya Research Institute of Epidemiology and Microbiology, Health Ministry of the Russian Federation | Leiden University Medical Center | Maastricht University Medical Center | Radboud University Medical Center | University Medical Center Groningen | U

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            07

                            Fresenius Kabi AB Brunna

                            Sweden arrow
                            EPSC
                            Not Confirmed

                            Fresenius Kabi AB Brunna

                            Sweden arrow
                            EPSC
                            Not Confirmed
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                            Lead Product(s) : Lactulose,Inapplicable

                            Therapeutic Area : Endocrinology

                            Study Phase : Phase IV

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Blood Glucose Response After Oral Intake of Lactulose in Mildly Constipated Patients With Diabetes Mellitus Ty...

                            Details : Undisclosed

                            Product Name : Undisclosed

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            September 12, 2018

                            Lead Product(s) : Lactulose,Inapplicable

                            Therapeutic Area : Endocrinology

                            Highest Development Status : Phase IV

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            08

                            Nova Scotia Health Authority

                            Canada arrow
                            EPSC
                            Not Confirmed

                            Nova Scotia Health Authority

                            Canada arrow
                            EPSC
                            Not Confirmed
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                            Lead Product(s) : Senna,Lactulose,Macrogol

                            Therapeutic Area : Gastroenterology

                            Study Phase : Phase IV

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Peritoneal Dialysis Pilot Study: Evaluating Polyethylene Glycol (PEG) for Constipation

                            Details : Undisclosed

                            Product Name : Undisclosed

                            Product Type : Plant Extract/Herbal

                            Upfront Cash : Inapplicable

                            May 10, 2017

                            Lead Product(s) : Senna,Lactulose,Macrogol

                            Therapeutic Area : Gastroenterology

                            Highest Development Status : Phase IV

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            09

                            Fresenius Kabi AB Brunna

                            Sweden arrow
                            EPSC
                            Not Confirmed

                            Fresenius Kabi AB Brunna

                            Sweden arrow
                            EPSC
                            Not Confirmed
                            • fda
                            • EDQM
                            • WHO-GMP
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                            Lead Product(s) : Lactulose,Glucose,Still Water

                            Therapeutic Area : Undisclosed

                            Study Phase : Undisclosed

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Blood Glucose Response After Oral Intake of Lactulose in Healthy Volunteers

                            Details : Undisclosed

                            Product Name : Undisclosed

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            November 18, 2016

                            Lead Product(s) : Lactulose,Glucose,Still Water

                            Therapeutic Area : Undisclosed

                            Highest Development Status : Undisclosed

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            10

                            Johnson & Johnson Innovative Medicine

                            U.S.A arrow
                            EPSC
                            Not Confirmed

                            Johnson & Johnson Innovative Medicine

                            U.S.A arrow
                            EPSC
                            Not Confirmed
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                            • WHO-GMP
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                            Lead Product(s) : Prucalopride Succinate,Macrogol,Lactulose

                            Therapeutic Area : Gastroenterology

                            Study Phase : Phase IV

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Efficacy and Safety of Prucalopride in Combination With Polyethylene Glycol or Lactulose in Women With Chronic...

                            Details : Undisclosed

                            Product Name : Undisclosed

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            August 29, 2014

                            Lead Product(s) : Prucalopride Succinate,Macrogol,Lactulose

                            Therapeutic Area : Gastroenterology

                            Highest Development Status : Phase IV

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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