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    [{"orgOrder":0,"company":"Destiny Pharma","sponsor":"Not Applicable","pharmaFlowCategory":"DU","amount":"Not Applicable","upfrontCash":"Not Applicable","newsHeadline":"Independent Expert Review of Data Supports the Potential of XF-73 to Address Antimicrobial Resistance","therapeuticArea":"Infections and Infectious Diseases","highestDevelopmentStatus":"Phase II","country":"UNITED KINGDOM","productType":"Small molecule","productStatus":"New Molecular Entity","date":"May 2020","url1":"","url2":"","graph1":"Infections and Infectious Diseases","graph2":"Phase II"},{"orgOrder":0,"company":"Destiny Pharma","sponsor":"Not Applicable","pharmaFlowCategory":"DU","amount":"Not Applicable","upfrontCash":"Not Applicable","newsHeadline":"Destiny Pharma Provides Update on its Phase 2b Clinical Study of XF-73","therapeuticArea":"Infections and Infectious Diseases","highestDevelopmentStatus":"Phase II","country":"UNITED KINGDOM","productType":"Small molecule","productStatus":"New Molecular 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Pharma","sponsor":"SporeGen","pharmaFlowCategory":"DU","amount":"Not Applicable","upfrontCash":"Not Applicable","newsHeadline":"Destiny Pharma and SporeGen\u00ae Announce Update from Research Collaboration Under Innovate UK Grant Award to Develop a Biotherapeutic Treatment (SPOR-COV\u00ae) for COVID-19 and Influenza","therapeuticArea":"Infections and Infectious Diseases","highestDevelopmentStatus":"Preclinical","country":"UNITED KINGDOM","productType":"Vaccine","productStatus":"New Molecular Entity","date":"May 2023","url1":"","url2":"","graph1":"Infections and Infectious Diseases","graph2":"Preclinical"}]

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              Destiny Pharma

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              Destiny Pharma and SporeGen® Announce Update from Research Collaboration Under Innovate UK Grant Award to Develop a Biotherapeutic Treatment (SPOR-COV®) for COVID-19 and ...

              Details:

              SPOR COV product consists of a proprietary formulation of Bacillus bacteria that is administered nasally as a spray. It is being developed for for COVID-19 and Influenza.

              Lead Product(s): Bacillus Bacteria

              Therapeutic Area: Infections and Infectious Diseases Product Name: SPOR-COV

              Highest Development Status: Preclinical Product Type: Vaccine

              Partner/Sponsor/Collaborator: SporeGen

              Deal Size: Not Applicable Upfront Cash: Not Applicable

              Deal Type: Not Applicable May 02, 2023

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              Agreement with Sebela Pharmaceuticals for NTCD-M3

              Details:

              Under the terms of the deal, Sebela will lead the future clinical development and commercialisation activities of NTCD-M3 in North America. NTCD-M3 is a naturally occurring non-toxigenic strain of C. difficile which lacks the genes that can express C. difficile toxins.

              Lead Product(s): NTCD-M3

              Therapeutic Area: Infections and Infectious Diseases Product Name: NTCD-M3

              Highest Development Status: Phase II Product Type: Large molecule

              Partner/Sponsor/Collaborator: Sebela Pharmaceuticals

              Deal Size: $570.0 million Upfront Cash: $1.0 million

              Deal Type: Collaboration February 24, 2023

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              Destiny Pharma

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              Destiny Pharma Announces Fundraising Upto £8 Million

              Details:

              The net proceeds of the Fundraising will allow the Company to complete final Phase 3 clinical trial preparation for NTCD-M3, Destiny pharma’s lead asset for the prevention of Clostridioides difficile infection (CDI) recurrence.

              Lead Product(s): NTCD-M3

              Therapeutic Area: Infections and Infectious Diseases Product Name: NTCD-M3

              Highest Development Status: Phase II Product Type: Large molecule

              Partner/Sponsor/Collaborator: finnCap Limited

              Deal Size: $9.6 million Upfront Cash: Undisclosed

              Deal Type: Financing February 24, 2023

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              Destiny Pharma

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              Destiny Pharma Reports Positive Phase 2b Results for XF-73 Nasal Gel

              Details:

              XF-73 reduced the mean nasal burden of S. aureus in patients undergoing open heart surgery by 2.5 log (CFU/ml) in the 24 hours immediately before surgery in the micro-ITT (Intend to Treat) population, a statistically highly significant result.

              Lead Product(s): Exeporfinium chloride

              Therapeutic Area: Infections and Infectious Diseases Product Name: XF-73

              Highest Development Status: Phase II Product Type: Small molecule

              Partner/Sponsor/Collaborator: Not Applicable

              Deal Size: Not Applicable Upfront Cash: Not Applicable

              Deal Type: Not Applicable March 29, 2021

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              Destiny Pharma Completes Phase 2b Clinical Trial of XF-73 Patient Recruitment

              Details:

              XF-73 is a first-in-class drug candidate from Destiny Pharma’s XF platform, initially being developed for the prevention of postsurgical staphylococcal infections, such as methicillin-resistant Staphylococcus aureus.

              Lead Product(s): Exeporfinium chloride

              Therapeutic Area: Infections and Infectious Diseases Product Name: XF-73

              Highest Development Status: Phase II Product Type: Small molecule

              Partner/Sponsor/Collaborator: Not Applicable

              Deal Size: Not Applicable Upfront Cash: Not Applicable

              Deal Type: Not Applicable January 05, 2021

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              Destiny Pharma

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              Update On the Recently Acquired NTCD-M3 Programme

              Details:

              Destiny Pharma reported that it is making good progress with preparations for the clinical development of NTCD-M3, a Phase 3 ready biotherapeutic for the prevention of C. difficile infection (CDI) recurrence.

              Lead Product(s): NTCD-M3

              Therapeutic Area: Infections and Infectious Diseases Product Name: NTCD-M3

              Highest Development Status: Phase II Product Type: Large molecule

              Partner/Sponsor/Collaborator: Not Applicable

              Deal Size: Not Applicable Upfront Cash: Not Applicable

              Deal Type: Not Applicable December 22, 2020

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              SporeGen® Announces Collaboration with Destiny Pharma Supported by an Innovate UK grant award for a Preventative Treatment for COVID-19

              Details:

              Under the agreement, the parties will share any costs and commercial returns from SPOR-COV and plan to complete a pre-clinical programme with the aim of being ready to enter the first human clinical trials within 18 months.

              Lead Product(s): SPOR-COV

              Therapeutic Area: Infections and Infectious Diseases Product Name: SPOR-COV

              Highest Development Status: Preclinical Product Type: Large molecule

              Partner/Sponsor/Collaborator: SporeGen

              Deal Size: $1.0 million Upfront Cash: Undisclosed

              Deal Type: Collaboration September 08, 2020

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              Destiny Pharma

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              Destiny Pharma’s Novel Antibiotic Asset XF-73 Clears Safety Review

              Details:

              Positive interim safety review has been completed by an Independent Data Monitoring Committee (IDMC) of the Company’s ongoing Phase 2b study of its lead asset XF-73 in the prevention of post-surgical bacterial infections.

              Lead Product(s): Exeporfinium chloride

              Therapeutic Area: Infections and Infectious Diseases Product Name: XF-73

              Highest Development Status: Phase II Product Type: Small molecule

              Partner/Sponsor/Collaborator: Not Applicable

              Deal Size: Not Applicable Upfront Cash: Not Applicable

              Deal Type: Not Applicable August 11, 2020

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              Destiny Pharma Provides Update on its Phase 2b Clinical Study of XF-73

              Details:

              Destiny Pharma agreed with FDA to reduce Phase 2b study size without compromising its statistical power or clinical value. The study is evaluating XF-73 for the prevention of post-surgical hospital infections caused by Staphylococcus aureus bacteria, such as MRSA.

              Lead Product(s): Exeporfinium chloride

              Therapeutic Area: Infections and Infectious Diseases Product Name: XF-73

              Highest Development Status: Phase II Product Type: Small molecule

              Partner/Sponsor/Collaborator: Not Applicable

              Deal Size: Not Applicable Upfront Cash: Not Applicable

              Deal Type: Not Applicable July 27, 2020

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              Independent Expert Review of Data Supports the Potential of XF-73 to Address Antimicrobial Resistance

              Details:

              Data published to date support the unique target profile of XF-73 and its potential to address the threat of AMR.

              Lead Product(s): Exeporfinium chloride

              Therapeutic Area: Infections and Infectious Diseases Product Name: Undisclosed

              Highest Development Status: Phase II Product Type: Small molecule

              Partner/Sponsor/Collaborator: Not Applicable

              Deal Size: Not Applicable Upfront Cash: Not Applicable

              Deal Type: Not Applicable May 04, 2020

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              Minakem offers CDMO services for API & HPAPI, generics, regulatory expertise, track record performance & FDA & GMP certifications.
              ChemWerth works in generic API development & supply, non-infringement patent strategy development and regulatory support.
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