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            Details:

            Jamteki (ustekinumab) is a monoclonal antibody and a biosimilar candidate to Stelara® (ustekinumab). Ustekinumab binds to two cytokines, IL-12 and IL-23, that are involved in inflammatory and immune responses.

            Lead Product(s): Ustekinumab

            Therapeutic Area: Dermatology Product Name: Jamteki

            Highest Development Status: Phase III Product Type: Large molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable November 14, 2023

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            Details:

            AVT04 (ustekinumab) is a monoclonal antibody and a biosimilar candidate to Stelara® (ustekinumab). Ustekinumab binds to two cytokines, IL-12 and IL-23, that are involved in inflammatory and immune responses.

            Lead Product(s): Ustekinumab

            Therapeutic Area: Dermatology Product Name: AVT04

            Highest Development Status: Phase III Product Type: Large molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable October 12, 2023

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            Details:

            The net proceeds will be used for the continued development of its biosimilars pipeline, including AVT04, a monoclonal antibody, a biosimilar candidate to Stelara (ustekinumab).

            Lead Product(s): Ustekinumab

            Therapeutic Area: Dermatology Product Name: AVT04

            Highest Development Status: Phase III Product Type: Large molecule

            Partner/Sponsor/Collaborator: ATP Holdings

            Deal Size: $100.0 million Upfront Cash: Undisclosed

            Deal Type: Private Placement July 31, 2023

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            Details:

            The agreement grants a license entry date for AVT04, Alvotech’s proposed biosimilar to Stelara® (ustekinumab), in the United States. Ustekinumab is a monoclonal antibody and binds to two cytokines, IL-12 and IL-23, that are involved in inflammatory and immune responses.

            Lead Product(s): Ustekinumab

            Therapeutic Area: Dermatology Product Name: AVT04

            Highest Development Status: Phase III Product Type: Large molecule

            Partner/Sponsor/Collaborator: Teva Pharmaceutical Industries

            Deal Size: Undisclosed Upfront Cash: Undisclosed

            Deal Type: Licensing Agreement June 12, 2023

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            Details:

            AVT04 (ustekinumab) is a monoclonal antibody and a biosimilar candidate to Stelara® (ustekinumab). Ustekinumab binds to two cytokines, IL-12 and IL-23, that are involved in inflammatory and immune responses.

            Lead Product(s): Ustekinumab

            Therapeutic Area: Dermatology Product Name: AVT04

            Highest Development Status: Phase III Product Type: Large molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable February 09, 2023

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            Details:

            AVT04 (Ustekinumab) is a monoclonal antibody and a biosimilar candidate to Stelara® (ustekinumab). Ustekinumab binds to two cytokines, IL-12 and IL-23, that are involved in inflammatory and immune responses.

            Lead Product(s): Ustekinumab

            Therapeutic Area: Dermatology Product Name: AVT04

            Highest Development Status: Phase III Product Type: Large molecule

            Partner/Sponsor/Collaborator: Teva Pharmaceutical Industries

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable January 06, 2023

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            Details:

            Results from pharmacokinetic similarity study demonstrate bioequivalence of AVT04 (ustekinumab), a human IgG1k monoclonal antibody that binds with specificity to p40 protein subunit used by both interleukin-12 and interleukin-23 cytokines to reference product Stelara.

            Lead Product(s): Ustekinumab

            Therapeutic Area: Dermatology Product Name: AVT04

            Highest Development Status: Phase III Product Type: Large molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable May 16, 2022

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            Details:

            AVT02-GL0302 is a multicenter, randomized, double-blind, parallel-group study to evaluate PK, efficacy, safety & immunogenicity between patients receiving Humira and patients undergoing repeated switches between Humira and AVT02, followed by an optional safety Extension Phase.

            Lead Product(s): Adalimumab

            Therapeutic Area: Dermatology Product Name: AVT02

            Highest Development Status: Phase III Product Type: Large molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable June 15, 2021

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            Details:

            Proceeds will be used for the development of companies lead drug AVT02. As part of the first round Shinhan from Korea, Baxter Healthcare SA from the US and ATHOS (Strüngmann Family Office) from Germany invested in Alvotech.

            Lead Product(s): Adalimumab

            Therapeutic Area: Dermatology Product Name: AVT02

            Highest Development Status: Phase III Product Type: Large molecule

            Partner/Sponsor/Collaborator: Baxter Healthcare Corporation

            Deal Size: $100.0 million Upfront Cash: Undisclosed

            Deal Type: Private Placement March 17, 2021

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            Details:

            AVT02 is a proposed biosimilar of HUMIRA® (adalimumab) with high concentration (100mg/mL) dosage forms that are expected to be beneficial to patients and to be differentiated from most biosimilar competitors, while matching the newest dosage forms of the reference product.

            Lead Product(s): Adalimumab

            Therapeutic Area: Dermatology Product Name: AVT02

            Highest Development Status: Phase III Product Type: Large molecule

            Partner/Sponsor/Collaborator: Teva Pharmaceutical Industries

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable November 19, 2020

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