Drugs in Dev.
Dermatology
IND Enabling
United States Of America 
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Lead Product(s) : RLS-1496
Therapeutic Area : Dermatology
Study Phase : IND Enabling
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Rubedo Life Sciences Gets FDA IND Clearance for RLS-1496 for Actinic Keratosis
Details : RLS-1496 is a first-in-class disease-modifying selective glutathione peroxidase 4 (GPX4) modulator which is being evaluated for the treatment of actinic keratosis.
Product Name : RLS-1496
Product Type : Miscellaneous
Upfront Cash : Inapplicable
September 17, 2025
Lead Product(s) : RLS-1496
Therapeutic Area : Dermatology
Highest Development Status : IND Enabling
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Fibroblast Spheroids
Therapeutic Area : Dermatology
Study Phase : IND Enabling
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
FibroBiologics Reports IND-Enabling Data Showing Promise of Fibroblast Spheroids
Details : Company announced positive IND-enabling updates from its psoriasis research program demonstrating potential of human dermal fibroblast (HDF) spheroids as a novel therapeutic approach for psoriasis.
Product Name : Undisclosed
Product Type : Undisclosed
Upfront Cash : Inapplicable
September 11, 2025
Lead Product(s) : Fibroblast Spheroids
Therapeutic Area : Dermatology
Highest Development Status : IND Enabling
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : SAR447971
Therapeutic Area : Dermatology
Study Phase : IND Enabling
Sponsor : Sanofi
Deal Size : $2,150.0 million
Deal Type : Collaboration
Kymera Therapeutics Announces Sanofi IRAK4 Collaboration Update
Details : Sanofi has informed Kymera that KT-485/SAR447971, an oral, highly potent and selective development candidate targeting IRAK4 has been selected to advance into clinical studies.
Product Name : Undisclosed
Product Type : Undisclosed
Upfront Cash : $150.0 million
June 25, 2025
Lead Product(s) : SAR447971
Therapeutic Area : Dermatology
Highest Development Status : IND Enabling
Sponsor : Sanofi
Deal Size : $2,150.0 million
Deal Type : Collaboration

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Lead Product(s) : ALY-301
Therapeutic Area : Dermatology
Study Phase : IND Enabling
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Alys Submits CTA for ALY-301, c-Kit Inhibitor for Cold Urticaria
Details : ALY-301 is the first mast cell-selective c-Kit inhibitor to enter the clinic. It is a cis-targeting bispecific antibody binding c-Kit and CD-203c, allowing selective targeting of mast cells.
Product Name : ALY-301
Product Type : Antibody, Unconjugated
Upfront Cash : Inapplicable
June 10, 2025
Lead Product(s) : ALY-301
Therapeutic Area : Dermatology
Highest Development Status : IND Enabling
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : ENV-294
Therapeutic Area : Dermatology
Study Phase : IND Enabling
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Enveda Reports Phase 1 Safety and Starts Phase 1B Trial in Atopic Dermatitis
Details : ENV-294 is a first-in-class, oral small molecule, JAK-inhibitor therapeutic being investigated for atopic dermatitis, asthma.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Inapplicable
May 28, 2025
Lead Product(s) : ENV-294
Therapeutic Area : Dermatology
Highest Development Status : IND Enabling
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : HCW9302
Therapeutic Area : Dermatology
Study Phase : IND Enabling
Sponsor : Maxim Group
Deal Size : $5.0 million
Deal Type : Public Offering
HCW Biologics Prices $5M Follow-On Offering Under NASDAQ Guidelines
Details : The Company intends to use the net proceeds from this offering for funding preclinical and clinical development, including the clinical trials of HCW9302 for Alopecia Areata.
Product Name : Undisclosed
Product Type : Cell & Gene Therapy
Upfront Cash : Undisclosed
May 13, 2025
Lead Product(s) : HCW9302
Therapeutic Area : Dermatology
Highest Development Status : IND Enabling
Sponsor : Maxim Group
Deal Size : $5.0 million
Deal Type : Public Offering

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Lead Product(s) : TVB-3567
Therapeutic Area : Dermatology
Study Phase : IND Enabling
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Sagimet IND Cleared for TVB-3567, a FASN Inhibitor for Acne Treatment
Details : TVB-3567 is a potent and selective small molecule FASN inhibitor is planned to enter clinical development for the treatment of acne.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Inapplicable
March 11, 2025
Lead Product(s) : TVB-3567
Therapeutic Area : Dermatology
Highest Development Status : IND Enabling
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : ORKA-002
Therapeutic Area : Dermatology
Study Phase : IND Enabling
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Oruka Therapeutics Announces Preclinical Data for ORKA-002
Details : ORKA-002 is a novel, subcutaneously administered, half-life extended monoclonal antibody targeting IL-17A/F. It is being evaluated for the treatment of plaque psoriasis.
Product Name : Undisclosed
Product Type : Antibody, Unconjugated
Upfront Cash : Inapplicable
March 07, 2025
Lead Product(s) : ORKA-002
Therapeutic Area : Dermatology
Highest Development Status : IND Enabling
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : HCW9302
Therapeutic Area : Dermatology
Study Phase : IND Enabling
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
HCW Biologics Gets FDA Nod for First-In-Human Phase 1 Trial
Details : HCW9302 is an injectable, first-in-kind interleukin 2 fusion protein complex, which is being evaluated in patients with moderate-to-severe alopecia areata.
Product Name : Undisclosed
Product Type : Cell & Gene Therapy
Upfront Cash : Inapplicable
February 03, 2025
Lead Product(s) : HCW9302
Therapeutic Area : Dermatology
Highest Development Status : IND Enabling
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : ORKA-001
Therapeutic Area : Dermatology
Study Phase : IND Enabling
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Oruka Doses First Participants in Phase 1 Trial of ORKA-001 Anti-IL-23p19 Antibody
Details : ORKA-001 is a IL-23p19 inhibitor, antibody. It is currently being evaluated in early-stage clinical trials for the treatment of psoriasis.
Product Name : Undisclosed
Product Type : Antibody, Unconjugated
Upfront Cash : Inapplicable
December 19, 2024
Lead Product(s) : ORKA-001
Therapeutic Area : Dermatology
Highest Development Status : IND Enabling
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
