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Find Clinical Drug Pipeline Developments & Deals by CytoDyn
PRO 140 (leronlimab) is a CCR5 antagonist with the potential for multiple therapeutic indications. It is being evaluated for the treatment of HIV infection.
PRO 140 (leronlimab) is a CCR5 antagonist with the potential for multiple therapeutic indications. It is being evaluated in phase 2 clinical trials for the treatment of HIV infection.
PRO 140 (leronlimab) is an investigational humanized IgG4 monoclonal antibody (mAb) that is designed to bind to C-C chemokine receptor type 5 (CCR5), a protein on the surface of certain immune system cells that is believed to play a role in numerous disease processes.
The grant will fund the development and preclinical research of a single-injection gene therapy that codes for the leronlimab protein sequence and which will be delivered via an adeno-associated virus (AAV) vector.
Leronlimab treatment reduced SHIV viral loads by 10,000 fold and leronlimab was found within all anatomical compartments analyzed, including mucosal and lymphatic tissues, sites of early viral replication after transmission and latency.
Leronlimab, an investigational humanized IgG4 monoclonal antibody (mAb) that is designed to bind to C-C chemokine receptor type 5 (CCR5), a protein on the surface of certain immune system cells that is believed to play a role in numerous disease processes.
The trial was conducted in two parts for PRO 140 (Leronlimab), Part 1 compared a 700 mg weekly dose and Part 2 evaluated a 350 mg weekly dose, positive result is obtained from the 350 mg weekly dose for Phase 2 NASH clinical trial.
During recent discussions with the FDA, the agency suggested that developing Vyrologix (leronlimab) for critically ill COVID-19 patients in current situation in U.S. appears feasible.
Phase 3 pivotal trial yielded a statistically significant primary endpoint for efficacy (p=0.0032), had an 81% success rate in suppressing viral load (VL<50 cp/mL) in the MDR population after 24 weeks of Vyrologix (leronlimab) treatment.
Company developing Vyrologix (leronlimab), a CCR5 antagonist announced that its CRO in Brazil met with ANVISA to modify the CD16 trial for critically ill COVID-19 patients.
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