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                          01

                          Lead Product(s) : Cemiplimab

                          Therapeutic Area : Oncology

                          Study Phase : Approved FDF

                          Sponsor : Regeneron Pharmaceuticals

                          Deal Size : $1,100.0 million

                          Deal Type : Collaboration

                          Details : Under the terms announced today, Sanofi will transfer the rights to develop, commercialize and manufacture Libtayo (cemiplimab) entirely to Regeneron, on a worldwide basis, over the course of a defined transition period.

                          Product Name : Libtayo

                          Product Type : Antibody

                          Upfront Cash : $900.0 million

                          February 06, 2022

                          Lead Product(s) : Cemiplimab

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved FDF

                          Sponsor : Regeneron Pharmaceuticals

                          Deal Size : $1,100.0 million

                          Deal Type : Collaboration

                          Sanofi Company Banner

                          02

                          Lead Product(s) : Cemiplimab

                          Therapeutic Area : Oncology

                          Study Phase : Phase III

                          Sponsor : Regeneron Pharmaceuticals

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Details : Libtayo is a fully human monoclonal antibody targeting the immune checkpoint receptor PD-1 on T-cells. By binding to PD-1, Libtayo has been shown to block cancer cells from using the PD-1 pathway to suppress T-cell activation.

                          Product Name : Libtayo

                          Product Type : Antibody

                          Upfront Cash : Inapplicable

                          January 28, 2022

                          Lead Product(s) : Cemiplimab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Regeneron Pharmaceuticals

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Sanofi Company Banner

                          03

                          Lead Product(s) : Cemiplimab

                          Therapeutic Area : Oncology

                          Study Phase : Approved FDF

                          Sponsor : Regeneron Pharmaceuticals

                          Deal Size : $1,100.0 million

                          Deal Type : Acquisition

                          Details : Regeneron intends to update its full year 2022 financial guidance to reflect the Libtayo (cemiplimab) purchase during its second quarter 2022 earnings announcement in early August.

                          Product Name : Libtayo

                          Product Type : Antibody

                          Upfront Cash : $900.0 million

                          January 07, 2022

                          Lead Product(s) : Cemiplimab

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved FDF

                          Sponsor : Regeneron Pharmaceuticals

                          Deal Size : $1,100.0 million

                          Deal Type : Acquisition

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                          04

                          Lead Product(s) : Cemiplimab

                          Therapeutic Area : Oncology

                          Study Phase : Phase III

                          Sponsor : Regeneron Pharmaceuticals

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Details : In Phase 3 trial, Libtayo, a fully human monoclonal antibody targeting the immune checkpoint receptor PD-1, significantly improved overall survival in women with advanced cervical cancer after progression on chemotherapy, lowering the risk of death by 31...

                          Product Name : Libtayo

                          Product Type : Antibody

                          Upfront Cash : Inapplicable

                          December 05, 2021

                          Lead Product(s) : Cemiplimab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Regeneron Pharmaceuticals

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Sanofi Company Banner

                          05

                          Lead Product(s) : Cemiplimab

                          Therapeutic Area : Oncology

                          Study Phase : Approved FDF

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Details : In the Phase 3 trial, safety was assessed in 697 patients, with a duration of exposure of 27 weeks (range: 9 days to 115 weeks) for the Libtayo group and 18 weeks (range: 18 days to 87 weeks) for the chemotherapy group.

                          Product Name : Libtayo

                          Product Type : Antibody

                          Upfront Cash : Inapplicable

                          June 25, 2021

                          Lead Product(s) : Cemiplimab

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved FDF

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Sanofi Company Banner

                          06

                          Lead Product(s) : Cemiplimab

                          Therapeutic Area : Oncology

                          Study Phase : Phase III

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Details : Protocol-specified interim analysis conducted by the Independent Data Monitoring Committee demonstrated that patients treated with Libtayo monotherapy had a significant increase in overall survival.

                          Product Name : Libtayo

                          Product Type : Antibody

                          Upfront Cash : Inapplicable

                          April 27, 2020

                          Lead Product(s) : Cemiplimab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Sanofi Company Banner

                          07

                          American Thoracic Society
                          Not Confirmed
                          American Thoracic Society
                          Not Confirmed

                          Details : The net proceeds from the private placement will help the company to advance the clinical development of THIO -101 (ateganosine), which is being evaluated for 3L-NSCLC.

                          Product Name : THIO -101

                          Product Type : Other Small Molecule

                          Upfront Cash : Undisclosed

                          May 01, 2025

                          Lead Product(s) : Ateganosine,Cemiplimab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Regeneron Pharmaceuticals

                          Deal Size : $1.0 million

                          Deal Type : Private Placement

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                          08

                          American Thoracic Society
                          Not Confirmed
                          American Thoracic Society
                          Not Confirmed

                          Details : THIO (ateganosine) is a telomere-targeting agent currently in clinical development in combination with a checkpoint inhibitor for third line non-small cell lung cancer.

                          Product Name : THIO

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          March 19, 2025

                          Lead Product(s) : Ateganosine,Cemiplimab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          09

                          American Thoracic Society
                          Not Confirmed
                          American Thoracic Society
                          Not Confirmed

                          Details : THIO(6-Thio-2-Deoxyguanosine) is a telomere-targeting agent currently in clinical development in combination with a checkpoint inhibitor for third line non-small cell lung cancer.

                          Product Name : THIO

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          February 27, 2025

                          Lead Product(s) : Ateganosine,Cemiplimab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          10

                          American Thoracic Society
                          Not Confirmed
                          American Thoracic Society
                          Not Confirmed

                          Details : THIO-101 (6-Thio-2-Deoxyguanosine) is a telomere-targeting agent currently in clinical development in combination with cemiplimab for non-small cell lung cancer.

                          Product Name : THIO

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          February 26, 2025

                          Lead Product(s) : Ateganosine,Cemiplimab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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