Drugs in Dev.
Cardiology/Vascular Diseases
Phase III
Israel 
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Lead Product(s) : EscharEx
Therapeutic Area : Cardiology/Vascular Diseases
Study Phase : Phase III
Sponsor : H.C. Wainwright & Co
Deal Size : $30.0 million
Deal Type : Public Offering
MediWound Announces $30 Million Registered Direct Offering of Ordinary Shares
Details : The Company intends to use the net proceeds primarily to support EscharEx’s pre-commercial activities, including EscharEx, a next-generation enzymatic therapy candidate for wound care.
Product Name : EscharEx
Product Type : Enzyme
Upfront Cash : Undisclosed
September 29, 2025
Lead Product(s) : EscharEx
Therapeutic Area : Cardiology/Vascular Diseases
Highest Development Status : Phase III
Sponsor : H.C. Wainwright & Co
Deal Size : $30.0 million
Deal Type : Public Offering

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Lead Product(s) : Bromelain Enriched Proteolytic Enzyme,Anacaulase
Therapeutic Area : Cardiology/Vascular Diseases
Study Phase : Phase III
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
MediWound Starts Global Phase III VALUE Trial of EscharEx for Venous Ulcers
Details : EscharEx is a bioactive, multimodal debridement therapy for the treatment of chronic and other hard-to-heal wounds, currently in the advanced stages of clinical development for the venous leg ulcers.
Product Name : EscharEx
Product Type : Enzyme
Upfront Cash : Inapplicable
February 12, 2025
Lead Product(s) : Bromelain Enriched Proteolytic Enzyme,Anacaulase
Therapeutic Area : Cardiology/Vascular Diseases
Highest Development Status : Phase III
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Bromelain Enriched Proteolytic Enzyme,Anacaulase
Therapeutic Area : Cardiology/Vascular Diseases
Study Phase : Phase III
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
MediWound Phase II Trial of EscharEx® in Leg Ulcers Begins
Details : EscharEx is a bioactive, multimodal debridement therapy for the treatment of chronic and other hard-to-heal wounds, currently in the advanced stages of clinical development for the venous leg ulcers.
Product Name : EscharEx
Product Type : Enzyme
Upfront Cash : Inapplicable
October 10, 2024
Lead Product(s) : Bromelain Enriched Proteolytic Enzyme,Anacaulase
Therapeutic Area : Cardiology/Vascular Diseases
Highest Development Status : Phase III
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Escharex
Therapeutic Area : Cardiology/Vascular Diseases
Study Phase : Phase III
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : Escharex is a Enzyme drug candidate, which is currently being evaluated in phase III clinical studies for the treatment of Leg Ulcer.
Product Name : Undisclosed
Product Type : Enzyme
Upfront Cash : Inapplicable
August 23, 2024
Lead Product(s) : Escharex
Therapeutic Area : Cardiology/Vascular Diseases
Highest Development Status : Phase III
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Fremanezumab
Therapeutic Area : Cardiology/Vascular Diseases
Study Phase : Phase III
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
New data Supporting the sAfety and Efficacy Profile of AJOVY
Details : Combined review of Phase 3 studies with fremanezumab indicates positive cardiovascular safety profile in adult patients. Additional data on injection-related adverse reactions provide new guidance to healthcare professionals for the optimal selection of ...
Product Name : Ajovy
Product Type : Antibody, Unconjugated
Upfront Cash : Inapplicable
June 21, 2021
Lead Product(s) : Fremanezumab
Therapeutic Area : Cardiology/Vascular Diseases
Highest Development Status : Phase III
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Emiplacel
Therapeutic Area : Cardiology/Vascular Diseases
Study Phase : Phase III
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Pluristem Announces DMC Recommendation Following Interim Analysis of its Phase III CLI Study
Details : Based on the review, the DMC concluded that the CLI study is unlikely to meet the primary endpoint by the time of the final analysis. Company to terminate the CLI study of PLX-PAD to focus on different therapeutic areas in its pipeline.
Product Name : PLX-PAD
Product Type : Cell & Gene Therapy
Upfront Cash : Inapplicable
December 09, 2020
Lead Product(s) : Emiplacel
Therapeutic Area : Cardiology/Vascular Diseases
Highest Development Status : Phase III
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Mesenchymal-Like Adherent Stromal Cell
Therapeutic Area : Cardiology/Vascular Diseases
Study Phase : Phase III
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : Mesenchymal-Like Adherent Stromal Cell is a Cell and Gene Therapy drug candidate, which is currently being evaluated in phase III clinical studies for the treatment of Chronic Limb-Threatening Ischemia.
Product Name : Undisclosed
Product Type : Cell & Gene Therapy
Upfront Cash : Inapplicable
December 30, 2016
Lead Product(s) : Mesenchymal-Like Adherent Stromal Cell
Therapeutic Area : Cardiology/Vascular Diseases
Highest Development Status : Phase III
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Amlodipine Besylate
Therapeutic Area : Cardiology/Vascular Diseases
Study Phase : Phase III
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : Amlodipine Besylate is a Other Small Molecule drug candidate, which is currently being evaluated in phase III clinical studies for the treatment of Hypertension.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Inapplicable
December 01, 2016
Lead Product(s) : Amlodipine Besylate
Therapeutic Area : Cardiology/Vascular Diseases
Highest Development Status : Phase III
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Amiodarone Hydrochloride
Therapeutic Area : Cardiology/Vascular Diseases
Study Phase : Phase III
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Treatment of Postoperative Atrial Fibrillation - Comparison of Amiodarone and Placebo.
Details : Amiodarone is a Other Small Molecule drug candidate, which is currently being evaluated in phase III clinical studies for the treatment of Atrial Fibrillation.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Inapplicable
March 22, 2016
Lead Product(s) : Amiodarone Hydrochloride
Therapeutic Area : Cardiology/Vascular Diseases
Highest Development Status : Phase III
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Amlodipine Besylate
Therapeutic Area : Cardiology/Vascular Diseases
Study Phase : Phase III
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : Amlodipine Besylate is a Other Small Molecule drug candidate, which is currently being evaluated in phase III clinical studies for the treatment of Hypertension.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Inapplicable
June 24, 2014
Lead Product(s) : Amlodipine Besylate
Therapeutic Area : Cardiology/Vascular Diseases
Highest Development Status : Phase III
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
