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Find Clinical Drug Pipeline Developments & Deals by Atreca
Through the acquisition, Immunome aims to utilize Atreca's APN-497444, a Glycan receptor inhibitor currently in the discovery stage, for the treatment of gastrointestinal cancers.
APN-346958 targets a novel RNA-binding protein which is tumor-reactive in at least 50% of samples for six tumor types evaluated, including colorectal, thyroid, head and neck, urothelial, melanoma and brain cancer.
ATRC-101 is a monoclonal antibody derived from an antibody identified using Atreca’s discovery platform. ATRC-101 is believed to function through Driver Antigen Engagement, a novel mechanism of action in oncology.
Immunohistochemistry studies demonstrated tumor-selective binding of ATRC-101 to multiple non-autologous tumor tissues, and biochemical analyses indicate that it targets an extracellular, tumor-specific ribonucleoprotein (RNP) complex.
As part of the licensing agreement with Zymeworks, Atreca’s novel antibodies ATRC-301, will be conjugated using ZymeLink™, Zymeworks’ suite of proprietary cytotoxins, linkers, and conjugation technologies.
APN-850271 is an IgG antibody, Currently undergoing Preclinical phase target SARS-CoV-2-binding antibodies and had neutralizing activity against replication-competent SARS-CoV-2 in an initial screen.
Under the agreement, Gates MRI will lead the development of MAM01/ATRC-501 and receive commercial rights in GAVI-eligible countries located in malaria-endemic regions of the world, to advance its charitable purposes.
ATRC-101, which targets a novel tumor antigen and acts via a novel MOA in oncology, was well-tolerated at all doses evaluated in the study with no dose-limiting toxicities observed.
ATRC-101 has demonstrated robust anti-tumor activity as a single agent in multiple preclinical syngeneic tumor models, including one model in which PD-1 checkpoint inhibitors typically display limited activity.
Under the terms of the agreement, the companies will engage in a three-year discovery program. Atreca will provide antibodies against novel tumor targets from which Xencor will engineer XmAb bispecific antibodies that also bind to the CD3 receptor on T cells.
Lead Product(s):
T Cell Engaging Bispecific Antibodies
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