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    [{"orgOrder":0,"company":"Infinity Pharmaceuticals","sponsor":"BVF Partners L.P","pharmaFlowCategory":"D","amount":"$71.5 million","upfrontCash":"Undisclosed","newsHeadline":"Infinity Pharmaceuticals Raises $20 Million Through an Innovative Non-Dilutive Asset-Backed Financing from BVF","therapeuticArea":"Genetic Disease","highestDevelopmentStatus":"Phase II","country":"U.S.A","productType":"Undisclosed","productStatus":"New Molecular Entity","date":"January 2020","url1":"","url2":"","graph1":"Genetic Disease","graph2":"Phase II"},{"orgOrder":0,"company":"Exelixis","sponsor":"Not Applicable","pharmaFlowCategory":"DU","amount":"Not Applicable","upfrontCash":"Not Applicable","newsHeadline":"Exelixis Further Expands Prostate Cancer Cohort in Phase 1b COSMIC-021 Trial of Cabozantinib in Combination with Atezolizumab in Patients with Advanced Solid Tumors","therapeuticArea":"Oncology","highestDevelopmentStatus":"Phase I","country":"U.S.A","productType":"Small molecule","productStatus":"Approved","date":"January 2020","url1":"","url2":"","graph1":"Oncology","graph2":"Phase I"},{"orgOrder":0,"company":"PharmaMar","sponsor":"Not Applicable","pharmaFlowCategory":"DU","amount":"Not Applicable","upfrontCash":"Not Applicable","newsHeadline":"PharmaMar announces the initiation of a study of lurbinectedin in combination with immunotherapy ","therapeuticArea":"Oncology","highestDevelopmentStatus":"Phase II","country":"SPAIN","productType":"Small molecule","productStatus":"New Molecular Entity","date":"January 2020","url1":"","url2":"","graph1":"Oncology","graph2":"Phase II"},{"orgOrder":0,"company":"Kintai Therapeutics","sponsor":"Not Applicable","pharmaFlowCategory":"DU","amount":"Not Applicable","upfrontCash":"Not Applicable","newsHeadline":"AI Therapeutics announces that a common LAM-002 mechanism in cancer and neurodegenerative diseases shows antitumor activity in the clinic and hope for ALS","therapeuticArea":"Neurology","highestDevelopmentStatus":"Preclinical","country":"U.S.A","productType":"Small molecule","productStatus":"Approved","date":"January 2020","url1":"","url2":"","graph1":"Neurology","graph2":"Preclinical"},{"orgOrder":0,"company":"Basilea Pharmaceutica","sponsor":"Not Applicable","pharmaFlowCategory":"DU","amount":"Not Applicable","upfrontCash":"Not Applicable","newsHeadline":"Basilea announces clinical supply agreement for its planned study FIDES-03 with derazantinib in gastric cancer","therapeuticArea":"Oncology","highestDevelopmentStatus":"Phase I\/ Phase II","country":"SWITZERLAND","productType":"Small molecule","productStatus":"Approved","date":"January 2020","url1":"","url2":"","graph1":"Oncology","graph2":"Phase I\/ Phase II"},{"orgOrder":0,"company":"F. 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Hoffmann-La Roche","sponsor":"Not Applicable","pharmaFlowCategory":"DU","amount":"Not Applicable","upfrontCash":"Not Applicable","newsHeadline":"European Commission approves Roche\u2019s Tecentriq SC, the EU's first PD-(L)1 Cancer Immunotherapy Subcutaneous Injection for Multiple Cancer Types","therapeuticArea":"Oncology","highestDevelopmentStatus":"Approved","country":"SWITZERLAND","productType":"Large molecule","productStatus":"Approved","date":"January 2024","url1":"","url2":"","graph1":"Oncology","graph2":"Approved"},{"orgOrder":0,"company":"Oncolytics Biotech","sponsor":"Not Applicable","pharmaFlowCategory":"DU","amount":"Not Applicable","upfrontCash":"Not Applicable","newsHeadline":"Oncolytics Biotech\u00ae Initiates Enrollment Expansion of GOBLET Anal Cancer Cohort","therapeuticArea":"Oncology","highestDevelopmentStatus":"Phase I\/ Phase II","country":"U.S.A","productType":"Large molecule","productStatus":"New Molecular Entity","date":"February 2024","url1":"","url2":"","graph1":"Oncology","graph2":"Phase I\/ Phase II"},{"orgOrder":0,"company":"Chugai Pharmaceutical","sponsor":"Not Applicable","pharmaFlowCategory":"DU","amount":"Not Applicable","upfrontCash":"Not Applicable","newsHeadline":"Chugai Files for Additional Indication of Tecentriq for the Treatment of Alveolar Soft Part Sarcoma, an Ultra-rare Disease","therapeuticArea":"Oncology","highestDevelopmentStatus":"Phase II","country":"JAPAN","productType":"Large molecule","productStatus":"Approved","date":"March 2024","url1":"","url2":"","graph1":"Oncology","graph2":"Phase II"},{"orgOrder":0,"company":"BioNTech","sponsor":"Not Applicable","pharmaFlowCategory":"DU","amount":"Not Applicable","upfrontCash":"Not Applicable","newsHeadline":"Three-year Phase 1 Follow-up Data for mRNA-based Individualized Immunotherapy Candidate Show Persistence of Immune Response and Delayed Tumor Recurrence in Some Patients with Resected Pancreatic Cancer","therapeuticArea":"Oncology","highestDevelopmentStatus":"Phase II","country":"GERMANY","productType":"Vaccine","productStatus":"New Molecular Entity","date":"April 2024","url1":"","url2":"","graph1":"Oncology","graph2":"Phase II"}]

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              BioNTech

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              Three-year Phase 1 Follow-up Data for mRNA-based Individualized Immunotherapy Candidate Show Persistence of Immune Response and Delayed Tumor Recurrence in Some Patients wi...

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              Autogene cevumeran (RO7198457) is a messenger RNA (mRNA)-based personalized cancer vaccine, which is being evaluated in combination with atezolizumab for the treatment of resected pancreatic ductal adenocarcinoma.

              Lead Product(s): Autogene Cevumeran,Atezolizumab,Oxaliplatin

              Therapeutic Area: Oncology Product Name: RO7198457

              Highest Development Status: Phase II Product Type: Vaccine

              Partner/Sponsor/Collaborator: Not Applicable

              Deal Size: Not Applicable Upfront Cash: Not Applicable

              Deal Type: Not Applicable April 07, 2024

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              Chugai Pharmaceutical

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              Chugai Files for Additional Indication of Tecentriq for the Treatment of Alveolar Soft Part Sarcoma, an Ultra-rare Disease

              Details:

              Tecentriq (atezolizumab) is a USFDA approved programmed death-ligand 1 (PD-L1) blocking antibody. It is being evaluated for the treatment of alveolar soft part sarcoma, an ultra-rare disease.

              Lead Product(s): Atezolizumab

              Therapeutic Area: Oncology Product Name: Tecentriq

              Highest Development Status: Phase II Product Type: Large molecule

              Partner/Sponsor/Collaborator: Not Applicable

              Deal Size: Not Applicable Upfront Cash: Not Applicable

              Deal Type: Not Applicable March 14, 2024

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              Harpoon Therapeutics

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              Merck Completes Acquisition of Harpoon Therapeutics, Inc.

              Details:

              Through the acquisition, Merck leverages Harpoon lead candidate HPN328 (MK-6070), which is being evaluated in Phase I/II clinical trial studies in combination with Atezolizumab for the treatment of Small-cell Lung Cancer.

              Lead Product(s): MK-6070,Atezolizumab

              Therapeutic Area: Oncology Product Name: HPN328

              Highest Development Status: Phase I/ Phase II Product Type: Cell and Gene therapy

              Partner/Sponsor/Collaborator: Merck & Co

              Deal Size: $650.0 million Upfront Cash: Undisclosed

              Deal Type: Acquisition March 11, 2024

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              Immune-Onc Therapeutics

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              Immune-Onc Therapeutics Announces Clinical Trial Collaboration to Evaluate IO-108 in a Randomized Global Phase 1b/2 Study for First-Line Treatment of Advanced Liver Cancer

              Details:

              Under the collaboration, Roche will conduct clinical trial studies to evaluate the safety, efficacy of IO-108 in combination with atezolizumab and bevacizumab compared to atezolizumab and bevacizumab for the treatment of locally advanced hepatocellular carcinoma.

              Lead Product(s): IO-108,Atezolizumab,Bevacizumab

              Therapeutic Area: Oncology Product Name: IO-108

              Highest Development Status: IND Enabling Product Type: Large molecule

              Partner/Sponsor/Collaborator: F. Hoffmann-La Roche

              Deal Size: Undisclosed Upfront Cash: Undisclosed

              Deal Type: Collaboration February 20, 2024

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              Oncolytics Biotech

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              Oncolytics Biotech® Initiates Enrollment Expansion of GOBLET Anal Cancer Cohort

              Details:

              Reolysin (pelareorep) is an oncolytic reovirus, which can induce a T cells-inflamed phenotype in PDAC. It is being evaluated in combination with atezolizumab in patients with second-line or later unresectable squamous cell carcinoma of the anal canal.

              Lead Product(s): Pelareorep,Atezolizumab

              Therapeutic Area: Oncology Product Name: Reolysin

              Highest Development Status: Phase I/ Phase II Product Type: Large molecule

              Partner/Sponsor/Collaborator: Not Applicable

              Deal Size: Not Applicable Upfront Cash: Not Applicable

              Deal Type: Not Applicable February 14, 2024

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              F. Hoffmann-La Roche

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              European Commission approves Roche’s Tecentriq SC, the EU's first PD-(L)1 Cancer Immunotherapy Subcutaneous Injection for Multiple Cancer Types

              Details:

              Tecentriq® SC (atezolizumab) is a programmed death-ligand 1 (PD-L1) blocking antibody indicated for urothelial carcinoma, non-small cell lung cancer, small cell lung cancer, hepatocellular carcinoma & melanoma.

              Lead Product(s): Atezolizumab

              Therapeutic Area: Oncology Product Name: Tecentriq SC

              Highest Development Status: Approved Product Type: Large molecule

              Partner/Sponsor/Collaborator: Not Applicable

              Deal Size: Not Applicable Upfront Cash: Not Applicable

              Deal Type: Not Applicable January 16, 2024

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              Affimed

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              Affimed Provides Clinical Response Update on AFM24-102 Trial in EGFR-wildtype Non-Small Cell Lung Cancer

              Details:

              AFM24 is a tetravalent, bispecific innate cell engager that binds to CD16A on innate immune cells and EGFR. It is under phase 1/2 clinical development in combination with atezolizumab for the treatment of EGFR-Wildtype Non-Small Cell Lung Cancer.

              Lead Product(s): AFM24,Atezolizumab

              Therapeutic Area: Oncology Product Name: AFM24

              Highest Development Status: Phase I/ Phase II Product Type: Large molecule

              Partner/Sponsor/Collaborator: Not Applicable

              Deal Size: Not Applicable Upfront Cash: Not Applicable

              Deal Type: Not Applicable January 08, 2024

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              Harpoon Therapeutics

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              Merck to Acquire Harpoon Therapeutics, Further Diversifying Oncology Pipeline

              Details:

              The acquisition will expand Merck's oncology portfolio by including HPN328, an investigational delta-like ligand 3 (DLL3) targeting T-cell engager being evaluated in certain patients with small cell lung cancer and neuroendocrine tumors.

              Lead Product(s): HPN328,Atezolizumab

              Therapeutic Area: Oncology Product Name: HPN328

              Highest Development Status: Phase I/ Phase II Product Type: Large molecule

              Partner/Sponsor/Collaborator: Merck & Co

              Deal Size: $680.0 million Upfront Cash: $680.0 million

              Deal Type: Acquisition January 08, 2024

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              Affimed

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              Affimed Announces Positive Data for AFM24 in Combination with the PD-L1 Checkpoint Inhibitor Atezolizumab in Heavily Pre-treated EGFR-Wildtype Non-Small Cell Lung Cancer Pa...

              Details:

              AFM24 is a tetravalent, bispecific innate cell engager that activates innate immune system by binding to CD16A on innate immune cells and EGFR. AFM24 in combination with atezolizumab is being evaluated in heavily pre-treated EGFR-wildtype non-small cell lung cancer patients.

              Lead Product(s): AFM24,Atezolizumab

              Therapeutic Area: Oncology Product Name: AFM24

              Highest Development Status: Phase I/ Phase II Product Type: Large molecule

              Partner/Sponsor/Collaborator: Not Applicable

              Deal Size: Not Applicable Upfront Cash: Not Applicable

              Deal Type: Not Applicable December 11, 2023

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              NiKang Therapeutics

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              NiKang Therapeutics Enters into Clinical Trial Collaboration and Supply Agreement to Evaluate NKT2152 in Combination with Standard-of-Care in First-Line Advanced Hepatocell...

              Details:

              The collaboration aims to evaluate NKT2152, a small molecule that inhibits hypoxia inducible factor 2α (HIF2α), in combination with standard-of-care Tecentriq (atezolizumab) and Avastin (bevacizumab) in first-line treatment of unresectable/advanced hepatocellular carcinoma.

              Lead Product(s): NKT2152,Atezolizumab,Bevacizumab

              Therapeutic Area: Oncology Product Name: NKT2152

              Highest Development Status: Preclinical Product Type: Small molecule

              Partner/Sponsor/Collaborator: F. Hoffmann-La Roche

              Deal Size: Undisclosed Upfront Cash: Undisclosed

              Deal Type: Collaboration December 08, 2023

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