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    [{"orgOrder":0,"company":"Alto Neuroscience","sponsor":"Wellcome Trust","pharmaFlowCategory":"D","therapeuticArea":"Psychiatry\/Psychology","country":"U.S.A","productType":"Other Small Molecule","year":"2024","type":"Funding","leadProduct":"ALTO-100","moa":"BDNF","graph1":"Psychiatry\/Psychology","graph2":"Phase II","graph3":"Alto Neuroscience","amount2":0.01,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Psychiatry","amount2New":0.01,"dosageForm":"Undisclosed","sponsorNew":"Alto Neuroscience \/ Wellcome Trust","highestDevelopmentStatusID":"8","companyTruncated":"Alto Neuroscience \/ Wellcome Trust"},{"orgOrder":0,"company":"Alto Neuroscience","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Psychiatry\/Psychology","country":"U.S.A","productType":"Other Small Molecule","year":"2024","type":"Inapplicable","leadProduct":"ALTO-203","moa":"H3 receptor","graph1":"Psychiatry\/Psychology","graph2":"Phase II","graph3":"Alto Neuroscience","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Psychiatry","amount2New":0,"dosageForm":"Oral","sponsorNew":"Alto Neuroscience \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"Alto Neuroscience \/ Inapplicable"},{"orgOrder":0,"company":"Alto Neuroscience","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Psychiatry\/Psychology","country":"U.S.A","productType":"Other Small Molecule","year":"2023","type":"Inapplicable","leadProduct":"ALTO-300","moa":"Melatonin receptor","graph1":"Psychiatry\/Psychology","graph2":"Phase II","graph3":"Alto Neuroscience","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Psychiatry","amount2New":0,"dosageForm":"Oral Capsule","sponsorNew":"Alto Neuroscience \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"Alto Neuroscience \/ Inapplicable"},{"orgOrder":0,"company":"Alto Neuroscience","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Psychiatry\/Psychology","country":"U.S.A","productType":"Other Small Molecule","year":"2025","type":"Inapplicable","leadProduct":"ALTO-300","moa":"Melatonin receptor","graph1":"Psychiatry\/Psychology","graph2":"Phase II","graph3":"Alto Neuroscience","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Psychiatry","amount2New":0,"dosageForm":"Oral Capsule","sponsorNew":"Alto Neuroscience \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"Alto Neuroscience \/ Inapplicable"},{"orgOrder":0,"company":"Alto Neuroscience","sponsor":"Alpha Wave Ventures","pharmaFlowCategory":"D","therapeuticArea":"Psychiatry\/Psychology","country":"U.S.A","productType":"Other Small Molecule","year":"2023","type":"Series B Financing","leadProduct":"ALTO-100","moa":"BDNF","graph1":"Psychiatry\/Psychology","graph2":"Phase II","graph3":"Alto Neuroscience","amount2":0.059999999999999998,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Psychiatry","amount2New":0.059999999999999998,"dosageForm":"Oral Tablet","sponsorNew":"Alto Neuroscience \/ Alpha Wave Ventures","highestDevelopmentStatusID":"8","companyTruncated":"Alto Neuroscience \/ Alpha Wave Ventures"},{"orgOrder":0,"company":"Alto Neuroscience","sponsor":"Apeiron Investment Group","pharmaFlowCategory":"D","therapeuticArea":"Psychiatry\/Psychology","country":"U.S.A","productType":"Other Small Molecule","year":"2021","type":"Series A Financing","leadProduct":"ALTO-100","moa":"BDNF","graph1":"Psychiatry\/Psychology","graph2":"Phase II","graph3":"Alto Neuroscience","amount2":0.040000000000000001,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Psychiatry","amount2New":0.040000000000000001,"dosageForm":"Oral Tablet","sponsorNew":"Alto Neuroscience \/ Apeiron Investment Group","highestDevelopmentStatusID":"8","companyTruncated":"Alto Neuroscience \/ Apeiron Investment Group"},{"orgOrder":0,"company":"Alto Neuroscience","sponsor":"Cerebral Therapeutics","pharmaFlowCategory":"D","therapeuticArea":"Psychiatry\/Psychology","country":"U.S.A","productType":"Other Small Molecule","year":"2021","type":"Collaboration","leadProduct":"ALTO-100","moa":"BDNF","graph1":"Psychiatry\/Psychology","graph2":"Phase II","graph3":"Alto Neuroscience","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Psychiatry","amount2New":0,"dosageForm":"Oral Tablet","sponsorNew":"Alto Neuroscience \/ Cerebral Therapeutics","highestDevelopmentStatusID":"8","companyTruncated":"Alto Neuroscience \/ Cerebral Therapeutics"},{"orgOrder":0,"company":"Alto Neuroscience","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Psychiatry\/Psychology","country":"U.S.A","productType":"Other Small 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Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"Alto Neuroscience \/ Inapplicable"},{"orgOrder":0,"company":"Alto Neuroscience","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Psychiatry\/Psychology","country":"U.S.A","productType":"Other Small Molecule","year":"2023","type":"Inapplicable","leadProduct":"ALTO-100","moa":"BDNF","graph1":"Psychiatry\/Psychology","graph2":"Phase II","graph3":"Alto Neuroscience","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Psychiatry","amount2New":0,"dosageForm":"Oral Tablet","sponsorNew":"Alto Neuroscience \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"Alto Neuroscience \/ Inapplicable"},{"orgOrder":0,"company":"Alto Neuroscience","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Psychiatry\/Psychology","country":"U.S.A","productType":"Other Small 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Jefferies","highestDevelopmentStatusID":"8","companyTruncated":"Alto Neuroscience \/ Jefferies"},{"orgOrder":0,"company":"Alto Neuroscience","sponsor":"Jefferies","pharmaFlowCategory":"D","therapeuticArea":"Psychiatry\/Psychology","country":"U.S.A","productType":"Other Small Molecule","year":"2024","type":"Public Offering","leadProduct":"ALTO-100","moa":"BDNF","graph1":"Psychiatry\/Psychology","graph2":"Phase II","graph3":"Alto Neuroscience","amount2":0.14999999999999999,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Psychiatry","amount2New":0.14999999999999999,"dosageForm":"Oral Tablet","sponsorNew":"Alto Neuroscience \/ Jefferies","highestDevelopmentStatusID":"8","companyTruncated":"Alto Neuroscience \/ Jefferies"},{"orgOrder":0,"company":"Alto Neuroscience","sponsor":"Jefferies","pharmaFlowCategory":"D","therapeuticArea":"Psychiatry\/Psychology","country":"U.S.A","productType":"Other Small Molecule","year":"2024","type":"Public Offering","leadProduct":"ALTO-100","moa":"BDNF","graph1":"Psychiatry\/Psychology","graph2":"Phase II","graph3":"Alto Neuroscience","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Psychiatry","amount2New":0.14999999999999999,"dosageForm":"Oral Tablet","sponsorNew":"Alto Neuroscience \/ Jefferies","highestDevelopmentStatusID":"8","companyTruncated":"Alto Neuroscience \/ Jefferies"},{"orgOrder":0,"company":"Alto Neuroscience","sponsor":"Lightswitch Capital","pharmaFlowCategory":"D","therapeuticArea":"Psychiatry\/Psychology","country":"U.S.A","productType":"Other Small Molecule","year":"2022","type":"Series B Financing","leadProduct":"ALTO-100","moa":"BDNF","graph1":"Psychiatry\/Psychology","graph2":"Phase II","graph3":"Alto Neuroscience","amount2":0.080000000000000002,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Psychiatry","amount2New":0.080000000000000002,"dosageForm":"Oral Tablet","sponsorNew":"Alto Neuroscience \/ Lightswitch Capital","highestDevelopmentStatusID":"8","companyTruncated":"Alto Neuroscience \/ Lightswitch Capital"},{"orgOrder":0,"company":"Alto Neuroscience","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Psychiatry\/Psychology","country":"U.S.A","productType":"Other Small Molecule","year":"2022","type":"Inapplicable","leadProduct":"ALTO-102","moa":"||cyclic-AMP pathway","graph1":"Psychiatry\/Psychology","graph2":"Phase I","graph3":"Alto Neuroscience","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Psychiatry","amount2New":0,"dosageForm":"Oral Tablet","sponsorNew":"Alto Neuroscience \/ Inapplicable","highestDevelopmentStatusID":"6","companyTruncated":"Alto Neuroscience \/ Inapplicable"},{"orgOrder":0,"company":"Alto Neuroscience","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Psychiatry\/Psychology","country":"U.S.A","productType":"Other Small Molecule","year":"2024","type":"Inapplicable","leadProduct":"ALTO-101","moa":"PDE4","graph1":"Psychiatry\/Psychology","graph2":"Phase I","graph3":"Alto Neuroscience","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Psychiatry","amount2New":0,"dosageForm":"Transdermal Patch","sponsorNew":"Alto Neuroscience \/ Inapplicable","highestDevelopmentStatusID":"6","companyTruncated":"Alto Neuroscience \/ Inapplicable"},{"orgOrder":0,"company":"Alto Neuroscience","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Psychiatry\/Psychology","country":"U.S.A","productType":"Other Small Molecule","year":"2023","type":"Inapplicable","leadProduct":"ALTO-100","moa":"BDNF","graph1":"Psychiatry\/Psychology","graph2":"Phase II","graph3":"Alto Neuroscience","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Psychiatry","amount2New":0,"dosageForm":"Oral Tablet","sponsorNew":"Alto Neuroscience \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"Alto Neuroscience \/ Inapplicable"},{"orgOrder":0,"company":"Alto Neuroscience","sponsor":"InVivium Capital","pharmaFlowCategory":"D","therapeuticArea":"Psychiatry\/Psychology","country":"U.S.A","productType":"Other Small Molecule","year":"2023","type":"Series C Financing","leadProduct":"ALTO-100","moa":"BDNF","graph1":"Psychiatry\/Psychology","graph2":"Phase II","graph3":"Alto Neuroscience","amount2":0.050000000000000003,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Psychiatry","amount2New":0.050000000000000003,"dosageForm":"Oral Tablet","sponsorNew":"Alto Neuroscience \/ InVivium Capital","highestDevelopmentStatusID":"8","companyTruncated":"Alto Neuroscience \/ InVivium Capital"},{"orgOrder":0,"company":"Alto Neuroscience","sponsor":"Chase Therapeutics","pharmaFlowCategory":"D","therapeuticArea":"Psychiatry\/Psychology","country":"U.S.A","productType":"Other Small Molecule","year":"2025","type":"Acquisition","leadProduct":"Pramipexole Dihydrochloride","moa":"||D2 receptor","graph1":"Psychiatry\/Psychology","graph2":"Phase II","graph3":"Alto Neuroscience","amount2":0.070000000000000007,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Psychiatry","amount2New":0.070000000000000007,"dosageForm":"Oral Tablet","sponsorNew":"Alto Neuroscience \/ Alto Neuroscience","highestDevelopmentStatusID":"8","companyTruncated":"Alto Neuroscience \/ Alto Neuroscience"}]

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                            01

                            Alto Neuroscience

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                            Lead Product(s) : Pramipexole Dihydrochloride,Ondansetron

                            Therapeutic Area : Psychiatry/Psychology

                            Study Phase : Phase II

                            Recipient : Chase Therapeutics

                            Deal Size : $73.2 million

                            Deal Type : Acquisition

                            DEALS_DEV arrow-down

                            Alto Neuroscience Announces Acquisition of Novel Dopamine Agonist Combination Product

                            Details : Alto gains a portfolio of potentially best-in-class dopamine agonist, including ALTO-207, a fixed-dose combination of pramipexole and ondansetron, for treatment resistant depression.

                            Product Name : ALTO-207

                            Product Type : Other Small Molecule

                            Upfront Cash : $1.7 million

                            June 03, 2025

                            Lead Product(s) : Pramipexole Dihydrochloride,Ondansetron

                            Therapeutic Area : Psychiatry/Psychology

                            Highest Development Status : Phase II

                            Recipient : Chase Therapeutics

                            Deal Size : $73.2 million

                            Deal Type : Acquisition

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                            02

                            Alto Neuroscience

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                            Lead Product(s) : ALTO-300

                            Therapeutic Area : Psychiatry/Psychology

                            Study Phase : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Alto Neuroscience Reports Positive Interim Data in ALTO-300 MDD Trial

                            Details : ALTO-300 is an investigational small molecule drug candidate, which is a melatonin receptor agonist. It is being evaluated in patients suffering with major depressive disorder.

                            Product Name : ALTO-300

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            February 12, 2025

                            Lead Product(s) : ALTO-300

                            Therapeutic Area : Psychiatry/Psychology

                            Highest Development Status : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            03

                            Alto Neuroscience

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                            Lead Product(s) : ALTO-100

                            Therapeutic Area : Psychiatry/Psychology

                            Study Phase : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Alto Reports Positive Phase 2b ALTO-100 Results for Major Depressive Disorder

                            Details : ALTO-100 is a first-in-class, oral small molecule believed to work through enhancing neural plasticity in the hippocampus, a brain region important for both cognition and mood.

                            Product Name : ALTO-100

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            October 22, 2024

                            Lead Product(s) : ALTO-100

                            Therapeutic Area : Psychiatry/Psychology

                            Highest Development Status : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            04

                            Alto Neuroscience

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                            AGGSpend
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                            Lead Product(s) : ALTO-100

                            Therapeutic Area : Psychiatry/Psychology

                            Study Phase : Phase II

                            Sponsor : Wellcome Trust

                            Deal Size : $11.7 million

                            Deal Type : Funding

                            DEALS_DEV arrow-down

                            Alto Neuroscience Gets Trust Funding for ALTO-100 in Bipolar Depression

                            Details : The fund will used to advance the clinical development of lead candidate ALTO-100 through a Phase 2b study in patients with bipolar depression characterized by a cognitive biomarker.

                            Product Name : ALTO-100

                            Product Type : Other Small Molecule

                            Upfront Cash : Undisclosed

                            July 25, 2024

                            Lead Product(s) : ALTO-100

                            Therapeutic Area : Psychiatry/Psychology

                            Highest Development Status : Phase II

                            Sponsor : Wellcome Trust

                            Deal Size : $11.7 million

                            Deal Type : Funding

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                            05

                            Alto Neuroscience

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                            AGGSpend
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                            Lead Product(s) : ALTO-100

                            Therapeutic Area : Psychiatry/Psychology

                            Study Phase : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Alto Neuroscience Completes Enrollment in Phase 2b Study of ALTO-100 for Depression

                            Details : ALTO-100, targeting brain-derived-neurotrophic-factor (BDNF), which is being developed by Alto Neuroscience for the treatment of major depressive disorder and Post-traumatic stress disorder.

                            Product Name : ALTO-100

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            July 16, 2024

                            Lead Product(s) : ALTO-100

                            Therapeutic Area : Psychiatry/Psychology

                            Highest Development Status : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            06

                            Alto Neuroscience

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                            Lead Product(s) : ALTO-100

                            Therapeutic Area : Psychiatry/Psychology

                            Study Phase : Phase II

                            Sponsor : Jefferies

                            Deal Size : $147.9 million

                            Deal Type : Public Offering

                            DEALS_DEV arrow-down

                            Alto Neuroscience Closes Upsized IPO with Underwriters’ Option Exercise

                            Details : Net proceeds will advance ALTO-100, targeting brain-derived neurotrophic factor (BDNF) for treating major depressive disorder and PTSD, developed by Alto Neuroscience.

                            Product Name : ALTO-100

                            Product Type : Other Small Molecule

                            Upfront Cash : Undisclosed

                            June 02, 2024

                            Lead Product(s) : ALTO-100

                            Therapeutic Area : Psychiatry/Psychology

                            Highest Development Status : Phase II

                            Sponsor : Jefferies

                            Deal Size : $147.9 million

                            Deal Type : Public Offering

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                            07

                            Alto Neuroscience

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                            AGGSpend
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                            Lead Product(s) : ALTO-101

                            Therapeutic Area : Psychiatry/Psychology

                            Study Phase : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Alto Neuroscience Reports Positive Phase 1 Results for ALTO-101, a Novel PDE4 Inhibitor

                            Details : ALTO-101 is a novel PDE4 inhibitor, small molecule drug candidate, which is being evaluated for the treatment of cognitive impairment associated with schizophrenia.

                            Product Name : ALTO-101

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            April 23, 2024

                            Lead Product(s) : ALTO-101

                            Therapeutic Area : Psychiatry/Psychology

                            Highest Development Status : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            08

                            Alto Neuroscience

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                            AGGSpend
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                            Lead Product(s) : ALTO-203

                            Therapeutic Area : Psychiatry/Psychology

                            Study Phase : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Alto Neuroscience Begins Phase 2 Study of ALTO-203 for Major Depressive Disorder

                            Details : ALTO-203 is a novel small molecule histamine H3 receptor inverse agonist, which is being developed for the treatment of patients with MDD and elevated anhedonia.

                            Product Name : ALTO-203

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            March 04, 2024

                            Lead Product(s) : ALTO-203

                            Therapeutic Area : Psychiatry/Psychology

                            Highest Development Status : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            09

                            Alto Neuroscience

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                            AGGSpend
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                            Lead Product(s) : ALTO-100

                            Therapeutic Area : Psychiatry/Psychology

                            Study Phase : Phase II

                            Sponsor : Jefferies

                            Deal Size : Undisclosed

                            Deal Type : Public Offering

                            DEALS_DEV arrow-down

                            Alto Neuroscience preps IPO to Push CNS Therapies Through Clinic

                            Details : The net proceeds will advance clinical development of ALTO-100, targeting BDNF for treating major depressive disorder and post-traumatic stress disorder by Alto Neuroscience.

                            Product Name : ALTO-100

                            Product Type : Other Small Molecule

                            Upfront Cash : Undisclosed

                            January 16, 2024

                            Lead Product(s) : ALTO-100

                            Therapeutic Area : Psychiatry/Psychology

                            Highest Development Status : Phase II

                            Sponsor : Jefferies

                            Deal Size : Undisclosed

                            Deal Type : Public Offering

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                            10

                            Alto Neuroscience

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                            Lead Product(s) : ALTO-100

                            Therapeutic Area : Psychiatry/Psychology

                            Study Phase : Phase II

                            Sponsor : Jefferies

                            Deal Size : $128.6 million

                            Deal Type : Public Offering

                            DEALS_DEV arrow-down

                            Alto Neuroscience Announces Pricing of Upsized Initial Public Offering

                            Details : Net proceeds will advance ALTO-100, targeting brain-derived neurotrophic factor (BDNF) for treating major depressive disorder and PTSD, developed by Alto Neuroscience.

                            Product Name : ALTO-100

                            Product Type : Other Small Molecule

                            Upfront Cash : Undisclosed

                            January 02, 2024

                            Lead Product(s) : ALTO-100

                            Therapeutic Area : Psychiatry/Psychology

                            Highest Development Status : Phase II

                            Sponsor : Jefferies

                            Deal Size : $128.6 million

                            Deal Type : Public Offering

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