
Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target

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Lead Product(s) : Pramipexole Dihydrochloride
Therapeutic Area : Psychiatry/Psychology
Study Phase : Phase II
Sponsor : Perceptive Advisors | Commodore Capital | Vivo Capital
Deal Size : $50.0 million
Deal Type : Private Placement
Alto Neuroscience Announces $50M Private Placement Financing
Details : In a private placement, Pramipexole will be funded to target 5-HT3 and D3/D2 for treatment resistant depression (TRD).
Product Name : ALTO-207
Product Type : Miscellaneous
Upfront Cash : Undisclosed
October 20, 2025
Lead Product(s) : Pramipexole Dihydrochloride
Therapeutic Area : Psychiatry/Psychology
Highest Development Status : Phase II
Sponsor : Perceptive Advisors | Commodore Capital | Vivo Capital
Deal Size : $50.0 million
Deal Type : Private Placement

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Lead Product(s) : ALTO-300
Therapeutic Area : Psychiatry/Psychology
Study Phase : Phase II
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Alto Neuroscience Reports Positive Interim Data in ALTO-300 MDD Trial
Details : ALTO-300 is an investigational small molecule drug candidate, which is a melatonin receptor agonist. It is being evaluated in patients suffering with major depressive disorder.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Inapplicable
February 12, 2025
Lead Product(s) : ALTO-300
Therapeutic Area : Psychiatry/Psychology
Highest Development Status : Phase II
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : ALTO-100
Therapeutic Area : Psychiatry/Psychology
Study Phase : Phase II
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
ALTO-100 in Bipolar Disorder With Depression (BD-D)
Details : ALTO-100 is a Other Small Molecule drug candidate, which is currently being evaluated in phase II clinical studies for the treatment of Depressive Disorder, Major-associated with Bipolar Disorder.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Inapplicable
October 24, 2024
Lead Product(s) : ALTO-100
Therapeutic Area : Psychiatry/Psychology
Highest Development Status : Phase II
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : ALTO-100
Therapeutic Area : Psychiatry/Psychology
Study Phase : Phase II
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Alto Reports Positive Phase 2b ALTO-100 Results for Major Depressive Disorder
Details : ALTO-100 is a first-in-class, oral small molecule believed to work through enhancing neural plasticity in the hippocampus, a brain region important for both cognition and mood.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Inapplicable
October 22, 2024
Lead Product(s) : ALTO-100
Therapeutic Area : Psychiatry/Psychology
Highest Development Status : Phase II
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : ALTO-100
Therapeutic Area : Psychiatry/Psychology
Study Phase : Phase II
Sponsor : Wellcome Trust
Deal Size : $11.7 million
Deal Type : Funding
Alto Neuroscience Gets Trust Funding for ALTO-100 in Bipolar Depression
Details : The fund will used to advance the clinical development of lead candidate ALTO-100 through a Phase 2b study in patients with bipolar depression characterized by a cognitive biomarker.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Undisclosed
July 25, 2024
Lead Product(s) : ALTO-100
Therapeutic Area : Psychiatry/Psychology
Highest Development Status : Phase II
Sponsor : Wellcome Trust
Deal Size : $11.7 million
Deal Type : Funding

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Lead Product(s) : ALTO-100
Therapeutic Area : Psychiatry/Psychology
Study Phase : Phase II
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Alto Neuroscience Completes Enrollment in Phase 2b Study of ALTO-100 for Depression
Details : ALTO-100, targeting brain-derived-neurotrophic-factor (BDNF), which is being developed by Alto Neuroscience for the treatment of major depressive disorder and Post-traumatic stress disorder.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Inapplicable
July 16, 2024
Lead Product(s) : ALTO-100
Therapeutic Area : Psychiatry/Psychology
Highest Development Status : Phase II
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : ALTO-101
Therapeutic Area : Psychiatry/Psychology
Study Phase : Phase II
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Study of ALTO-101 in Patients With Schizophrenia
Details : ALTO-101 is a Other Small Molecule drug candidate, which is currently being evaluated in phase II clinical studies for the treatment of Schizophrenia.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Inapplicable
July 16, 2024
Lead Product(s) : ALTO-101
Therapeutic Area : Psychiatry/Psychology
Highest Development Status : Phase II
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : ALTO-203
Therapeutic Area : Psychiatry/Psychology
Study Phase : Phase II
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
PD, PK, and Safety of ALTO-203 in Patients With MDD
Details : ALTO-203 is a Other Small Molecule drug candidate, which is currently being evaluated in phase II clinical studies for the treatment of Depressive Disorder, Major.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Inapplicable
April 30, 2024
Lead Product(s) : ALTO-203
Therapeutic Area : Psychiatry/Psychology
Highest Development Status : Phase II
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : ALTO-101
Therapeutic Area : Psychiatry/Psychology
Study Phase : Phase I
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Alto Neuroscience Reports Positive Phase 1 Results for ALTO-101, a Novel PDE4 Inhibitor
Details : ALTO-101 is a novel PDE4 inhibitor, small molecule drug candidate, which is being evaluated for the treatment of cognitive impairment associated with schizophrenia.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Inapplicable
April 23, 2024
Lead Product(s) : ALTO-101
Therapeutic Area : Psychiatry/Psychology
Highest Development Status : Phase I
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : ALTO-203
Therapeutic Area : Psychiatry/Psychology
Study Phase : Phase II
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Alto Neuroscience Begins Phase 2 Study of ALTO-203 for Major Depressive Disorder
Details : ALTO-203 is a novel small molecule histamine H3 receptor inverse agonist, which is being developed for the treatment of patients with MDD and elevated anhedonia.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Inapplicable
April 03, 2024
Lead Product(s) : ALTO-203
Therapeutic Area : Psychiatry/Psychology
Highest Development Status : Phase II
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
