
Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target

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Lead Product(s) : Tadekinig Alpha
Therapeutic Area : Rare Diseases and Disorders
Study Phase : Phase III
Sponsor : Nippon Shinyaku
Deal Size : $686.0 million
Deal Type : Licensing Agreement
AB2 Bio Signs U.S. Option and Licensing Agreement with Nippon Shinyaku for Tadekinig Alfa
Details : Under the licensing agreement, Nippon received an option to acquire exclusive U.S. rights to commercialize r-hIL-18BP (tadekinig alfa) to treat NLRC4-MAS.
Product Name : Undisclosed
Product Type : Protein
Upfront Cash : $6.0 million
January 27, 2025
Lead Product(s) : Tadekinig Alpha
Therapeutic Area : Rare Diseases and Disorders
Highest Development Status : Phase III
Sponsor : Nippon Shinyaku
Deal Size : $686.0 million
Deal Type : Licensing Agreement

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Lead Product(s) : Tadekinig Alpha
Therapeutic Area : Genetic Disease
Study Phase : Phase III
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : r-hIL-18BP (tadekinig alfa) is a recombinant human interleukin-18 binding protein inhibiting IL18. It captures excess free IL-18 mimicking the normal physiological situation, and therefore represents a well differentiated approach for the treatment of IL...
Product Name : Undisclosed
Product Type : Protein
Upfront Cash : Inapplicable
March 07, 2023
Lead Product(s) : Tadekinig Alpha
Therapeutic Area : Genetic Disease
Highest Development Status : Phase III
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Tadekinig Alpha
Therapeutic Area : Immunology
Study Phase : Phase III
Recipient : WuXi Biologics
Deal Size : Undisclosed
Deal Type : Collaboration
Details : Tadekinig alfa is a novel IL-18 binding protein in pivotal Phase 3 testing for orphan disease IL-18 driven monogenic Hemophagocytic Lymphohistiocytosis (HLH). WuXi Biologics to undertake commercial scale manufacturing to support U.S. market launch.
Product Name : Undisclosed
Product Type : Protein
Upfront Cash : Undisclosed
October 29, 2020
Lead Product(s) : Tadekinig Alpha
Therapeutic Area : Immunology
Highest Development Status : Phase III
Recipient : WuXi Biologics
Deal Size : Undisclosed
Deal Type : Collaboration

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Lead Product(s) : Tadekinig Alfa
Therapeutic Area : Rare Diseases and Disorders
Study Phase : Phase III
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Therapeutic Use of Tadekinig Alfa in NLRC4 Mutation and XIAP Deficiency As Open Label Extension
Details : Tadekinig Alfa is a Protein drug candidate, which is currently being evaluated in phase III clinical studies for the treatment of XIAP Deficiency.
Product Name : Undisclosed
Product Type : Protein
Upfront Cash : Inapplicable
April 30, 2018
Lead Product(s) : Tadekinig Alfa
Therapeutic Area : Rare Diseases and Disorders
Highest Development Status : Phase III
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Tadekinig Alfa
Therapeutic Area : Immunology
Study Phase : Phase III
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Therapeutic Use of Tadekinig Alfa in NLRC4 Mutation and XIAP Deficiency
Details : Tadekinig Alfa is a Protein drug candidate, which is currently being evaluated in phase III clinical studies for the treatment of NLRC4-associated Macrophage Activation Syndrome.
Product Name : Undisclosed
Product Type : Protein
Upfront Cash : Inapplicable
April 14, 2017
Lead Product(s) : Tadekinig Alfa
Therapeutic Area : Immunology
Highest Development Status : Phase III
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Tadekinig Alfa
Therapeutic Area : Immunology
Study Phase : Phase II
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Therapeutic Use of Tadekinig Alfa in Adult-onset Still's Disease
Details : Tadekinig Alfa is a Protein drug candidate, which is currently being evaluated in phase II clinical studies for the treatment of Still's Disease, Adult-Onset.
Product Name : Undisclosed
Product Type : Protein
Upfront Cash : Inapplicable
March 25, 2015
Lead Product(s) : Tadekinig Alfa
Therapeutic Area : Immunology
Highest Development Status : Phase II
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
