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Therapy","year":"2025","type":"Inapplicable","leadProduct":"4D-150","moa":"VEGF-A|VEGF-B|VEGF-C|PlGF","graph1":"Ophthalmology","graph2":"Phase III","graph3":"4D Molecular Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"4D Molecular Therapeutics \/ Undisclosed","highestDevelopmentStatusID":"10","companyTruncated":"4D Molecular Therapeutics \/ Undisclosed"},{"orgOrder":0,"company":"4D Molecular Therapeutics","sponsor":"Arbor Biotechnologies","pharmaFlowCategory":"D","therapeuticArea":"Neurology","country":"U.S.A","productType":"Undisclosed","year":"2024","type":"Partnership","leadProduct":"Undisclosed","moa":"Undisclosed","graph1":"Neurology","graph2":"Preclinical","graph3":"4D Molecular Therapeutics","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"4D Molecular Therapeutics \/ Arbor Biotechnologies, Inc","highestDevelopmentStatusID":"4","companyTruncated":"4D Molecular Therapeutics \/ Arbor Biotechnologies, Inc"},{"orgOrder":0,"company":"4D Molecular Therapeutics","sponsor":"Cystic Fibrosis Foundation","pharmaFlowCategory":"D","therapeuticArea":"Genetic Disease","country":"U.S.A","productType":"Cell & Gene Therapy","year":"2025","type":"Funding","leadProduct":"4D-710","moa":"CFTR","graph1":"Genetic Disease","graph2":"Phase I\/ Phase II","graph3":"4D Molecular Therapeutics","amount2":0.029999999999999999,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Genetic Disease","amount2New":0.029999999999999999,"dosageForm":"Inhalation","sponsorNew":"4D Molecular Therapeutics \/ Cystic Fibrosis Foundation","highestDevelopmentStatusID":"7","companyTruncated":"4D Molecular Therapeutics \/ Cystic Fibrosis Foundation"},{"orgOrder":0,"company":"4D Molecular Therapeutics","sponsor":"Otsuka Pharmaceutical","pharmaFlowCategory":"D","therapeuticArea":"Ophthalmology","country":"U.S.A","productType":"Protein","year":"2025","type":"Licensing Agreement","leadProduct":"Aflibercept","moa":"Vascular endothelial growth factor A | Placenta growth factor","graph1":"Ophthalmology","graph2":"Phase III","graph3":"4D Molecular Therapeutics","amount2":0.46999999999999997,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Ophthalmology","amount2New":0.46999999999999997,"dosageForm":"Injection","sponsorNew":"4D Molecular Therapeutics \/ Otsuka Pharmaceutical","highestDevelopmentStatusID":"10","companyTruncated":"4D Molecular Therapeutics \/ Otsuka Pharmaceutical"}]

Find Clinical Drug Pipeline Developments & Deals by 4D Molecular Therapeutics

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                          Therapeutic Area by Lead Product

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                          Top Deals by Deal Size (USD bn)

                          01

                          AAPS
                          Not Confirmed
                          AAPS
                          Not Confirmed

                          Details : Through the licensing for Aflibercept, a protein targeting Vascular endothelial growth factor A and Placenta growth factor, the agreement aims to advance treatment for wet AMD.

                          Product Name : 4D-150

                          Product Type : Protein

                          Upfront Cash : $85.0 million

                          October 30, 2025

                          Lead Product(s) : Aflibercept

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase III

                          Sponsor : Otsuka Pharmaceutical

                          Deal Size : $471.0 million

                          Deal Type : Licensing Agreement

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                          02

                          AAPS
                          Not Confirmed
                          AAPS
                          Not Confirmed

                          Details : The funding will support the development of 4D-710, a cell & gene therapy targeting CFTR, to address Cystic Fibrosis.

                          Product Name : 4D-710

                          Product Type : Cell & Gene Therapy

                          Upfront Cash : Undisclosed

                          October 13, 2025

                          Lead Product(s) : 4D-710

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Cystic Fibrosis Foundation

                          Deal Size : $32.0 million

                          Deal Type : Funding

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                          03

                          AAPS
                          Not Confirmed
                          AAPS
                          Not Confirmed

                          Details : 4D-150 is a Cell and Gene Therapy drug candidate, which is currently being evaluated in Phase III clinical studies for the treatment of Wet Macular Degeneration.

                          Product Name : Undisclosed

                          Product Type : Cell & Gene Therapy

                          Upfront Cash : Inapplicable

                          July 15, 2025

                          Lead Product(s) : 4D-150

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase III

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          04

                          AAPS
                          Not Confirmed
                          AAPS
                          Not Confirmed

                          Details : 4D-150 is designed to provide multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) for the treatment of diabetic macular edema.

                          Product Name : Undisclosed

                          Product Type : Cell & Gene Therapy

                          Upfront Cash : Inapplicable

                          May 01, 2025

                          Lead Product(s) : 4D-150

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase II

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          05

                          AAPS
                          Not Confirmed
                          AAPS
                          Not Confirmed

                          Details : 4D-150 is an AAV-based gene therapy comprised of miRNA targeting VEGF-C & codon-optimized sequence encoding aflibercept. It is under development for neovascular (wet) age-related macular degeneration.

                          Product Name : Undisclosed

                          Product Type : Protein

                          Upfront Cash : Inapplicable

                          March 10, 2025

                          Lead Product(s) : Aflibercept,Undisclosed

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase III

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          06

                          AAPS
                          Not Confirmed
                          AAPS
                          Not Confirmed

                          Details : 4D-150 is a Cell and Gene Therapy drug candidate, which is currently being evaluated in phase III clinical studies for the treatment of Wet Macular Degeneration.

                          Product Name : Undisclosed

                          Product Type : Cell & Gene Therapy

                          Upfront Cash : Inapplicable

                          March 07, 2025

                          Lead Product(s) : 4D-150

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase III

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          07

                          AAPS
                          Not Confirmed
                          AAPS
                          Not Confirmed

                          Details : 4D-150 is an AAV-based gene therapy comprised of miRNA targeting VEGF-C & codon-optimized sequence encoding aflibercept. It is under development for neovascular (wet) age-related macular degeneration.

                          Product Name : Undisclosed

                          Product Type : Protein

                          Upfront Cash : Inapplicable

                          February 08, 2025

                          Lead Product(s) : Aflibercept

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          08

                          AAPS
                          Not Confirmed
                          AAPS
                          Not Confirmed

                          Details : 4D-150 is an AAV-based gene therapy comprised of miRNA targeting VEGF-C and codon-optimized sequence encoding aflibercept. It is under development for diabetic macular edema.

                          Product Name : Undisclosed

                          Product Type : Protein

                          Upfront Cash : Inapplicable

                          January 10, 2025

                          Lead Product(s) : Aflibercept

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase II

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          09

                          AAPS
                          Not Confirmed
                          AAPS
                          Not Confirmed

                          Details : 4D-150 is an AAV-based gene therapy comprised of miRNA targeting VEGF-C & codon-optimized sequence encoding aflibercept. It is being evaluated for treatment of wet age-related macular degeneration.

                          Product Name : Undisclosed

                          Product Type : Protein

                          Upfront Cash : Inapplicable

                          July 17, 2024

                          Lead Product(s) : Aflibercept

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          10

                          AAPS
                          Not Confirmed
                          AAPS
                          Not Confirmed

                          Details : 4D-710 utilizes an evolved vector and microCFTR transgene to aerosol-deliver treatment for cystic fibrosis, independent of specific CFTR mutations, targeting lung epithelial cells.

                          Product Name : Undisclosed

                          Product Type : Cell & Gene Therapy

                          Upfront Cash : Inapplicable

                          March 28, 2024

                          Lead Product(s) : 4D-710

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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