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1. Acignost
2. Gastrin Pentapeptide
3. Pentapeptide, Gastrin
4. Peptavlon
1. Peptavlon
2. 5534-95-2
3. Ici-50123
4. Ay-6608
5. Ici 50,123
6. Chembl1328
7. Ef0nx91490
8. Nsc-367746
9. Dsstox_cid_28918
10. Dsstox_rid_83185
11. Dsstox_gsid_48992
12. Gastrodiagnost
13. Pentagastrina
14. Pentagastrine
15. Pentagastrinum
16. Petogasrin
17. Cas-5534-95-2
18. Ici 50123
19. Pentagastrine [inn-french]
20. Pentagastrinum [inn-latin]
21. Pentagastrina [inn-spanish]
22. Unii-ef0nx91490
23. Hsdb 3247
24. Peptavlon (tn)
25. Boc-beta-ala-try-met-asp-phe(nh2)
26. Einecs 226-889-7
27. Pentagastrin [usan:inn:ban:jan]
28. Mfcd00076515
29. Nsc 367746
30. Ay 6608
31. Brn 5472892
32. Pentagastrin [mi]
33. Pentagastrin [inn]
34. Pentagastrin [jan]
35. Pentagastrin [hsdb]
36. Pentagastrin [usan]
37. Pentagastrin [vandf]
38. Schembl26045
39. Pentagastrin [mart.]
40. L-phenylalaninamide, N-((1,1-dimethylethoxy)carbonyl)-beta-alanyl-l-tryptophyl-l-methionyl-l-alpha-aspartyl-
41. Mls006009992
42. Pentagastrin [who-dd]
43. Pentagastrin (jan/usan/inn)
44. Dtxsid3048992
45. Chebi:31974
46. Pentagastrin [orange Book]
47. (3s)-4-[[(2s)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-3-[[(2s)-2-[[(2s)-3-(1h-indol-3-yl)-2-[3-[(2-methylpropan-2-yl)oxycarbonylamino]propanoylamino]propanoyl]amino]-4-methylsulfanylbutanoyl]amino]-4-oxobutanoic Acid
48. Hy-a0261
49. Zinc8214644
50. Boc-
51. A-ala-trp-met-asp-phe-nh2
52. Boc-beta-ala-trp-met-asp-phe-nh2
53. Tox21_113479
54. Bdbm50024321
55. Akos030213248
56. Tox21_113479_1
57. Cs-5667
58. Db00183
59. N-t-butyloxycarbonyl-beta-alanyl-l-tryptophyl-l-methion Yl-l-aspartyl-l-phenylalanine Amide
60. Ncgc00167300-01
61. Ncgc00183362-01
62. Ncgc00183362-02
63. Alaninamide, N-carboxy-beta-alanyl-l-tryptophyl-l-methionyl-l-aspartylphenyl-, N-tert-butyl Ester, L-
64. As-56396
65. N-(alpha-carbamoylphenethyl)-3-(2-(2-(3-(carboxyamino)propionamido)-3-indol-3-ylpropionamido)-4-(methylthio)butyramido)succinamic Acid N-tert-butyl Ester
66. N-(n-(n-(n-(n-tert-butoxycarbonyl-beta-alanyl)-l-tryptophanyl)-l-methionyl)-l-aspartyl)-l-phenylalaninamide
67. N-carboxy-beta-alanyl-l-tryptophyl-l-methionyl-l-aspartylphenyl-l-alaninamide N-tert-butyl Ester
68. Smr004701067
69. D01631
70. 534p952
71. Q423586
72. (10s,13s,16s)-10-((1h-indol-3-yl)methyl)-16-((s)-1-amino-1-oxo-3-phenylpropan-2-ylcarbamoyl)-2,2-dimethyl-13-(2-(methylthio)ethyl)-4,8,11,14-tetraoxo-3-oxa-5,9,12,15-tetraazaoctadecan-18-oic Acid
73. 3-{2-[2-(3-tert-butoxycarbonylamino-propionylamino)-3-(1h-indol-3-yl)-propionylamino]-4-methylsulfanyl-butyrylamino}-n-(1-carbamoyl-2-phenyl-ethyl)-succinamic Acid
74. Alaninamide, N-carboxy-beta-alanyl-l-tryptophyl-l-methionyl-l-aspartylphenyl-, N-tert-butylester, L-
75. L-phenylalaninamide, N-((1,1-dimethylethoxy)carbonyl)-.beta.-alanyl-l-tryptophyl-l-methionyl-l-.alpha.-aspartyl-
76. N-carboxy-.beta.-alanyl-l-tryptophyl-l-methionyl-l-aspartylphenyl-l-alaninamide N-tert-butyl Ester
| Molecular Weight | 767.9 g/mol |
|---|---|
| Molecular Formula | C37H49N7O9S |
| XLogP3 | 1.5 |
| Hydrogen Bond Donor Count | 8 |
| Hydrogen Bond Acceptor Count | 10 |
| Rotatable Bond Count | 22 |
| Exact Mass | 767.33124734 g/mol |
| Monoisotopic Mass | 767.33124734 g/mol |
| Topological Polar Surface Area | 276 Ų |
| Heavy Atom Count | 54 |
| Formal Charge | 0 |
| Complexity | 1310 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 4 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
PENTAGASTRIN...USED WIDELY IN EUROPE SINCE 1966 TO MEASURE MAXIMAL ACID SECRETORY CAPACITY OF STOMACH. IT ELICITS REPRODUCIBLE SECRETORY RESPONSES COMPARABLE TO THOSE INDUCED BY HISTAMINE OR BETAZOLE...
Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 601
.../IT/ OFFERS SEVERAL ADVANTAGES /TO HISTAMINE & BETAZOLE/. ...REQUIRES ONLY SINGLE SC OR IM INJECTION; IT IS RELATIVELY SHORT IN DURATION...
Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 601
PENTAGASTRIN HAS DISTINCT EFFECT ON RATIOS OF NA+, K+, H+/AMINO ACID IN GASTRIC JUICE IN DIFFERENT STATES OF ACIDITY, VALUES OF ALL QUOTIENTS IN PT WITH HYPER, HYPO & ANACIDITY ARE SIGNIFICANTLY REDUCED.
DUNZENDORF R U; ARZNEIM FORSCH 26 (7) 1364-1365 (1976)
Used as a diagnostic aid for evaluation of gastric acid secretory function
Pentagastrin is indicated as a diagnostic aid for evaluation of gastric acid secretory function. It is effective in testing for anacidity (achlorhydria) in patients with suspected pernicious anemia, atrophic gastritis, or gastric carcinoma. It is also effective in determining the reduction in acid output after operations for peptic ulcer, such as vagotomy or gastric resection.
V - Various
V04 - Diagnostic agents
V04C - Other diagnostic agents
V04CG - Tests for gastric secretion
V04CG04 - Pentagastrin
Absorption
Rapidly absorbed after parenteral administration.
ACTIVITY OF ORAL PENTAGASTRIN WAS DETERMINED BY ITS ACTION AS GASTRIC ACID STIMULANT IN 4 HEALTHY SUBJECTS, 2 PT WITH DUODENAL ULCERS, & 1 PT WITH ANNULAR PANCREAS IN ASSOC WITH DUODENAL ULCER.
MORRELL MT, KEYNES WM; ABSORPTION OF PENTAGASTRIN FROM GASTROINTESTINAL TRACT IN MAN; LANCET 2 (OCT 11) 712 (1975)
Primarily hepatic
10 minutes or less
HALF-LIFE OF PENTAGASTRIN IN CIRCULATION APPEARS TO BE ABOUT 10 MIN...
Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 601
The exact mechanism by which pentagastrin stimulates gastric acid, pepsin, and intrinsic factor secretion is unknown; however, since pentagastrin is an analogue of natural gastrin, it is believed that it excites the oxyntic cells of the stomach to secrete to their maximum capacity. Pentagastrin stimulates pancreatic secretion, especially when administered in large intramuscular doses. Pentagastrin also increases gastrointestinal motility by a direct effect on the intestinal smooth muscle. However, it delays gastric emptying time probably by stimulation of terminal antral contractions, which enhance retropulsion.
MOST PROMINENT ACTION OF PENTAGASTRIN IS TO STIMULATE SECRETION OF GASTRIC ACID, PEPSIN, & INTRINSIC FACTOR OF CASTLE...STIMULATES PANCREATIC SECRETION, INHIBITS ABSORPTION OF WATER & ELECTROLYTES FROM ILEUM, CONTRACTS SMOOTH MUSCLE OF LOWER ESOPHAGEAL SPHINCTER & STOMACH (BUT DELAYS GASTRIC EMPTYING TIME)...
Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 601
.../IT/ RELAXES SPHINCTER OF ODDI, INCR BLOOD FLOW IN GASTRIC MUCOSE, STIMULATES L-HISTIDINE DECARBOXYLASE ACTIVITY IN RAT GASTRIC MUCOSA, &, IN HIGH DOSES, STIMULATES VARIETY OF SMOOTH MUSCLES IN DIFFERENT SPECIES.
Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 601
IT ALSO MIMICS OR BLOCKS EFFECTS OF POLYPEPTIDES PANCREOZYMIN-CHOLECYSTOKININ, SECRETIN, CAERULIN, NATURALLY OCCURRING DECAPEPTIDE THAT, ALONG WITH PANCREOZYMIN-CHOLECYSTOKININ, SHARES COMMON C-TERMINAL HEPTAPEPTIDE RESIDUE WITH GASTRIN.
Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 601
PENTAGASTRIN ACTIVATES ADENYLATE CYCLASE IN GASTRIC MUCOSA...
Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 601
PENTAGASTRIN INITIALLY PRODUCED MARKED ANTRAL ACTIVITY IN PHYSIOLOGICAL STRICTURE & SUBSEQUENT DELAY IN OVERALL RATE OF GASTRIC EMPTYING. FUNDAL MOTILITY WAS UNAFFECTED THOUGH REFLUX FROM ANTRUM OCCURRED.
HAMILTON SG ET AL; GUT 17 (4) 273-279 (1976)
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