Find Taselisib manufacturers, exporters & distributors on PharmaCompass

PharmaCompass

Synopsis

Synopsis

ACTIVE PHARMA INGREDIENTS

0

API Suppliers

API Suppliers

0

USDMF

US DMFs Filed

0

CEP/COS

CEP/COS Certifications

0

JDMF

JDMFs Filed

0

EU WC

EU WC

0

KDMF

KDMF

0

NDC API

NDC API

0

VMF

NDC API

0

Listed Suppliers

Other Suppliers

0INTERMEDIATES

REF. STANDARDS OR IMPURITIES

0

EDQM

0

USP

0

JP

0

Others

FINISHED DOSAGE FORMULATIONS

0

FDF Dossiers

FDF Dossiers

0

FDA Orange Book

FDA (Orange Book)

0

Europe

Europe

0

Canada

Canada

0

Australia

Australia

0

South Africa

South Africa

0

Listed Dossiers

Listed Dossiers

0 DRUGS IN DEVELOPMENT

FDF Dossiers

DRUG PRODUCT COMPOSITIONS

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

PATENTS & EXCLUSIVITIES

0

US Patents

0

US Exclusivities

0

Health Canada Patents

API REF. PRICE (USD/KG)

$
$ 0

GLOBAL SALES INFORMATION

US Medicaid

NA

Annual Reports

NA

Regulatory FDF Prices

NA

API/FDF Prices: Book a Demo to
explore the features and consider
upgrading later

MARKET PLACE

0

API

0

FDF

DIGITAL CONTENT

0

Data Compilation #PharmaFlow

0

Stock Recap #PipelineProspector

0

Weekly News Recap #Phispers

Chemistry

Click the arrow to open the dropdown
read-moreClick the button for full data set
Also known as: Gdc-0032, 1282512-48-4, 2-(4-(2-(1-isopropyl-3-methyl-1h-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)-1h-pyrazol-1-yl)-2-methylpropanamide, Gdc 0032, Taselisib [inn], Gdc0032
Molecular Formula
C24H28N8O2
Molecular Weight
460.5  g/mol
InChI Key
BEUQXVWXFDOSAQ-UHFFFAOYSA-N
FDA UNII
L08J2O299M

Taselisib
Taselisib is an orally bioavailable inhibitor of the class I phosphatidylinositol 3-kinase (PI3K) alpha isoform (PIK3CA), with potential antineoplastic activity. Taselisib selectively inhibits PIK3CA and its mutant forms in the PI3K/Akt/mTOR pathway, which may result in tumor cell apoptosis and growth inhibition in PIK3CA-expressing tumor cells. By specifically targeting class I PI3K alpha, this agent may be more efficacious and less toxic than pan PI3K inhibitors. Dysregulation of the PI3K/Akt/mTOR pathway is frequently found in solid tumors and causes increased tumor cell growth, survival, and resistance to both chemotherapy and radiotherapy. PIK3CA, which encodes the p110-alpha catalytic subunit of the class I PI3K, is mutated in a variety of cancer cell types and plays a key role in cancer cell growth and invasion.
1 2D Structure

Taselisib

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
2-methyl-2-[4-[2-(5-methyl-2-propan-2-yl-1,2,4-triazol-3-yl)-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl]pyrazol-1-yl]propanamide
2.1.2 InChI
InChI=1S/C24H28N8O2/c1-14(2)32-22(27-15(3)29-32)19-13-30-8-9-34-20-10-16(6-7-18(20)21(30)28-19)17-11-26-31(12-17)24(4,5)23(25)33/h6-7,10-14H,8-9H2,1-5H3,(H2,25,33)
2.1.3 InChI Key
BEUQXVWXFDOSAQ-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC1=NN(C(=N1)C2=CN3CCOC4=C(C3=N2)C=CC(=C4)C5=CN(N=C5)C(C)(C)C(=O)N)C(C)C
2.2 Other Identifiers
2.2.1 UNII
L08J2O299M
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 2-(3-(2-(1-isopropyl-3-methyl-1h-1,2-4-triazol-5-yl)-5,6-dihydrobenzo(f)imidazo(1,2-d)(1,4)oxazepin-9-yl)-1h-pyrazol-1-yl)-2-methylpropanamide

2. Gdc-0032

3. Gdc0032

4. Ro5537381

2.3.2 Depositor-Supplied Synonyms

1. Gdc-0032

2. 1282512-48-4

3. 2-(4-(2-(1-isopropyl-3-methyl-1h-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)-1h-pyrazol-1-yl)-2-methylpropanamide

4. Gdc 0032

5. Taselisib [inn]

6. Gdc0032

7. Taselisib (gdc0032)

8. Rg-7604

9. Rg7604

10. Chembl2387080

11. L08j2o299m

12. Rg 7604

13. 2-methyl-2-(4-{2-[3-methyl-1-(propan-2-yl)-1h-1,2,4-triazol-5-yl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl}-1h-pyrazol-1-yl)propanamide

14. Taselisib [usan:inn]

15. Unii-l08j2o299m

16. 2-(4-(2-(1-isopropyl-3-methyl-1h-1,2,4-triazol-5-yl)-5,6-dihydrobenzo(f)imidazo(1,2-d)(1,4)oxazepin-9-yl)-1h-pyrazol-1-yl)-2-methylpropanamide

17. Taselisibgdc-0032

18. Taselisib (usan/inn)

19. Taselisib [usan]

20. Taselisib [who-dd]

21. Taselisib (gdc-0032)

22. Gtpl7794

23. Schembl1485247

24. Dtxsid00155842

25. Hms3674g19

26. Amy39941

27. Bcp09253

28. Ex-a1581

29. Bdbm50434806

30. Mfcd26142641

31. Nsc777425

32. Nsc800985

33. S7103

34. Zinc68267049

35. Akos026750303

36. Ccg-269338

37. Cs-1817

38. Db12108

39. Gdc-0032, Taselisib; Rg-7604

40. Nsc-777425

41. Nsc-800985

42. Sb16576

43. Ncgc00387039-02

44. 2-methyl-2-[4-[2-(5-methyl-2-propan-2-yl-1,2,4-triazol-3-yl)-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl]pyrazol-1-yl]propanamide

45. Ac-32794

46. As-10662

47. Bg166285

48. Hy-13898

49. D11774

50. J-690119

51. Q27088940

52. 1395408-87-3

53. 1h-pyrazole-1-acetamide, 4-(5,6-dihydro-2-(3-methyl-1-(1-methylethyl)-1h-1,2,4-triazol-5-yl)imidazo(1,2-d)(1,4)benzoxazepin-9-yl)-.alpha.,.alpha.-dimethyl-

54. 1h-pyrazole-1-acetamide, 4-[5,6-dihydro-2-[3-methyl-1-(1-methylethyl)-1h-1,2,4-triazol-5-yl]imidazo[1,2-d][1,4]benzoxazepin-9-yl]-alpha,alpha-dimethyl-

55. 3-({[(3r,5r)-3-butyl-3-ethyl-7-methoxy-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}amino)pentanedioic Aci D

56. 4-[5,6-dihydro-2-[3-methyl-1-(1-methylethyl)-1h-1,2,4-triazol-5-yl]imidazo[1,2-d][1,4]benzoxazepin-9-yl]-

57. A,

58. A-dimethyl-1h-pyrazole-1-acetamide

2.4 Create Date
2011-04-12
3 Chemical and Physical Properties
Molecular Weight 460.5 g/mol
Molecular Formula C24H28N8O2
XLogP31.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count5
Exact Mass460.23352217 g/mol
Monoisotopic Mass460.23352217 g/mol
Topological Polar Surface Area119 Ų
Heavy Atom Count34
Formal Charge0
Complexity751
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

Digital Content read-more

Create Content with PharmaCompass, ask us

NEWS #PharmaBuzz

read-more
read-more

ABOUT THIS PAGE

Looking for 1395408-87-3 / Taselisib API manufacturers, exporters & distributors?

Taselisib manufacturers, exporters & distributors 1

65

PharmaCompass offers a list of Taselisib API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Taselisib manufacturer or Taselisib supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Taselisib manufacturer or Taselisib supplier.

PharmaCompass also assists you with knowing the Taselisib API Price utilized in the formulation of products. Taselisib API Price is not always fixed or binding as the Taselisib Price is obtained through a variety of data sources. The Taselisib Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Taselisib

Synonyms

Gdc-0032, 1282512-48-4, 2-(4-(2-(1-isopropyl-3-methyl-1h-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)-1h-pyrazol-1-yl)-2-methylpropanamide, Gdc 0032, Taselisib [inn], Gdc0032

Cas Number

1395408-87-3

Unique Ingredient Identifier (UNII)

L08J2O299M

About Taselisib

Taselisib is an orally bioavailable inhibitor of the class I phosphatidylinositol 3-kinase (PI3K) alpha isoform (PIK3CA), with potential antineoplastic activity. Taselisib selectively inhibits PIK3CA and its mutant forms in the PI3K/Akt/mTOR pathway, which may result in tumor cell apoptosis and growth inhibition in PIK3CA-expressing tumor cells. By specifically targeting class I PI3K alpha, this agent may be more efficacious and less toxic than pan PI3K inhibitors. Dysregulation of the PI3K/Akt/mTOR pathway is frequently found in solid tumors and causes increased tumor cell growth, survival, and resistance to both chemotherapy and radiotherapy. PIK3CA, which encodes the p110-alpha catalytic subunit of the class I PI3K, is mutated in a variety of cancer cell types and plays a key role in cancer cell growth and invasion.

Taselisib Manufacturers

A Taselisib manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Taselisib, including repackagers and relabelers. The FDA regulates Taselisib manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Taselisib API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Taselisib Suppliers

A Taselisib supplier is an individual or a company that provides Taselisib active pharmaceutical ingredient (API) or Taselisib finished formulations upon request. The Taselisib suppliers may include Taselisib API manufacturers, exporters, distributors and traders.

Taselisib GMP

Taselisib Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Taselisib GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Taselisib GMP manufacturer or Taselisib GMP API supplier for your needs.

Taselisib CoA

A Taselisib CoA (Certificate of Analysis) is a formal document that attests to Taselisib's compliance with Taselisib specifications and serves as a tool for batch-level quality control.

Taselisib CoA mostly includes findings from lab analyses of a specific batch. For each Taselisib CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Taselisib may be tested according to a variety of international standards, such as European Pharmacopoeia (Taselisib EP), Taselisib JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Taselisib USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
Ask Us for Pharmaceutical Supplier and Partner
Ask Us, Find A Supplier / Partner
No Commissions, No Strings Attached, Get Connected for FREE

What are you looking for?

How can we help you?

The request can't be empty

Please read our Privacy Policy carefully

You must agree to the privacy policy

The name can't be empty
The company can't be empty.
The email can't be empty Please enter a valid email.
The mobile can't be empty