During the big ASCO conference at the beginning of last June, prominent Memorial Sloan Kettering scientist José Baselga had this to say about the data he had collected for an experimental PI3K drug at Roche called taselisib:
Novartis has positive phase III results in hand for its PI3K inhibitor alpelisib in advanced breast cancer patients, which it hopes will be enough to file for regulatory approvals.
Novartis published trial results showing its drug succeeded in tackling difficult to treat breast cancer with PIK3CA mutation, after other pharma giants including Roche failed and abandoned similar research.
Just a few weeks after Novartis $NVS punted a potentially dangerous PI3K drug out of its pipeline to a drug developer in China, the pharma giant has come back with a positive set of Phase III progression-free survival data on another contender in this dicey cancer drug field. And now Novartis says it will start knocking on regulatory doors as it begins the approval process.
ZURICH (Reuters) - Novartis’s efforts to tackle an elusive gene mutation behind tough-to-treat breast cancer were rewarded on Thursday, as the Swiss drugmaker said one of its investigational medicines slowed disease progression.
Adlai Noryte grabbed worldwide rights to Novartis' buparlisib, an oral PI3K inhibitor being developed for blood cancers and solid tumors that has run into toxicity issues.
Just months after a group of researchers warned against the further development of a worrying PI3K inhibitor project Novartis had been working on, the pharma giant licensed out the global rights to a newly active Chinese biotech.
Bad news for Roche Holding AG. Two of its cancer drugs, Tecentriq and taselisib, have been shown to provide only modest protection from disease progression. The findings were released at the American Society of Clinical Oncology annual meeting in Chicago on Saturday.
Roche’s experimental PI3K hopeful taselisib is to be ditched after coming up short at this year’s ASCO cancer conference.
In a disappointment for Roche Holding AG, two of its oncology drugs provided only modest protection from disease progression in lung cancer and breast cancer, according to data from separate clinical trials presented on Saturday.