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Chemistry

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Also known as: (2s,3s,4r,5r,6r)-6-{[(2s,3s,4s,5r,6s)-6-{[(2r,3s,4s,5r)-2-carboxy-4,6-dihydroxy-5-(sulfooxy)oxan-3-yl]oxy}-2-hydroxy-4-(sulfomethyl)-5-(sulfooxy)oxan-3-yl]oxy}-3-{[(2r,3r,4r,5s,6r)-3-acetamido-4,5-dihydroxy-6-[(sulfooxy)methyl]oxan-2-yl]oxy}-4,5-dihydroxyoxane-2-carboxylic acid, Hepflush, Chembl526514, Gtpl4214, S01xa14, Bdbm50480251
Molecular Formula
C26H41NO34S4
Molecular Weight
1039.9  g/mol
InChI Key
ZFGMDIBRIDKWMY-PASTXAENSA-N

Heparin Sodium
A highly acidic mucopolysaccharide formed of equal parts of sulfated D-glucosamine and D-glucuronic acid with sulfaminic bridges. The molecular weight ranges from six to twenty thousand. Heparin occurs in and is obtained from liver, lung, mast cells, etc., of vertebrates. Its function is unknown, but it is used to prevent blood clotting in vivo and vitro, in the form of many different salts.
1 2D Structure

Heparin Sodium

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(2S,3S,4R,5R,6R)-3-[(2R,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(sulfooxymethyl)oxan-2-yl]oxy-6-[(2S,3S,4S,5R,6S)-6-[(2R,3S,4S,5R)-2-carboxy-4,6-dihydroxy-5-sulfooxyoxan-3-yl]oxy-2-hydroxy-4-(sulfomethyl)-5-sulfooxyoxan-3-yl]oxy-4,5-dihydroxyoxane-2-carboxylic acid
2.1.2 InChI
InChI=1S/C26H41NO34S4/c1-4(28)27-7-9(30)8(29)6(2-52-63(43,44)45)53-24(7)56-15-10(31)11(32)25(58-19(15)21(36)37)55-13-5(3-62(40,41)42)14(60-64(46,47)48)26(59-22(13)38)57-16-12(33)17(61-65(49,50)51)23(39)54-18(16)20(34)35/h5-19,22-26,29-33,38-39H,2-3H2,1H3,(H,27,28)(H,34,35)(H,36,37)(H,40,41,42)(H,43,44,45)(H,46,47,48)(H,49,50,51)/t5-,6+,7+,8+,9+,10+,11+,12-,13-,14+,15-,16-,17+,18+,19-,22-,23?,24+,25+,26-/m0/s1
2.1.3 InChI Key
ZFGMDIBRIDKWMY-PASTXAENSA-N
2.1.4 Canonical SMILES
CC(=O)NC1C(C(C(OC1OC2C(C(C(OC2C(=O)O)OC3C(C(C(OC3O)OC4C(C(C(OC4C(=O)O)O)OS(=O)(=O)O)O)OS(=O)(=O)O)CS(=O)(=O)O)O)O)COS(=O)(=O)O)O)O
2.1.5 Isomeric SMILES
CC(=O)N[C@@H]1[C@H]([C@@H]([C@H](O[C@@H]1O[C@H]2[C@@H]([C@H]([C@@H](O[C@@H]2C(=O)O)O[C@H]3[C@@H]([C@H]([C@H](O[C@@H]3O)O[C@H]4[C@@H]([C@H](C(O[C@H]4C(=O)O)O)OS(=O)(=O)O)O)OS(=O)(=O)O)CS(=O)(=O)O)O)O)COS(=O)(=O)O)O)O
2.2 Synonyms
2.2.1 MeSH Synonyms

1. Alpha Heparin

2. Alpha-heparin

3. Heparin

4. Heparin Sodium

5. Heparin, Sodium

6. Heparin, Unfractionated

7. Heparinic Acid

8. Liquaemin

9. Unfractionated Heparin

2.2.2 Depositor-Supplied Synonyms

1. (2s,3s,4r,5r,6r)-6-{[(2s,3s,4s,5r,6s)-6-{[(2r,3s,4s,5r)-2-carboxy-4,6-dihydroxy-5-(sulfooxy)oxan-3-yl]oxy}-2-hydroxy-4-(sulfomethyl)-5-(sulfooxy)oxan-3-yl]oxy}-3-{[(2r,3r,4r,5s,6r)-3-acetamido-4,5-dihydroxy-6-[(sulfooxy)methyl]oxan-2-yl]oxy}-4,5-dihydroxyoxane-2-carboxylic Acid

2. Hepflush

3. Chembl526514

4. Gtpl4214

5. S01xa14

6. Bdbm50480251

7. (2s,3s,4r,5r,6r)-3-[(2r,3r,4r,5s,6r)-3-acetamido-4,5-dihydroxy-6-(sulfooxymethyl)oxan-2-yl]oxy-6-[(2s,3s,4s,5r,6s)-6-[(2r,3s,4s,5r)-2-carboxy-4,6-dihydroxy-5-sulfooxyoxan-3-yl]oxy-2-hydroxy-4-(sulfomethyl)-5-sulfooxyoxan-3-yl]oxy-4,5-dihydroxyoxane-2-carboxylic Acid

2.2.3 Other Synonyms

1. 9005-49-6

2.3 Create Date
2007-12-05
3 Chemical and Physical Properties
Molecular Weight 1039.9 g/mol
Molecular Formula C26H41NO34S4
XLogP3-10.4
Hydrogen Bond Donor Count14
Hydrogen Bond Acceptor Count34
Rotatable Bond Count18
Exact Mass1039.0392821 g/mol
Monoisotopic Mass1039.0392821 g/mol
Topological Polar Surface Area589 Ų
Heavy Atom Count65
Formal Charge0
Complexity2140
Isotope Atom Count0
Defined Atom Stereocenter Count19
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Information
1 of 2  
Drug NameHeparin sodium
Drug LabelIntravenous solutions with heparin sodium (derived from porcine intestinal mucosa) are sterile, nonpyrogenic fluids for intravenous administration. They contain no bacteriostat or antimicrobial agent or added buffer. Edetate disodium, anhydrous is ad...
Active IngredientHeparin sodium
Dosage FormInjectable
RouteInjection
Strength5,000 units/ml; 10,000 units/ml; 20,000 units/ml; 1,000 units/ml
Market StatusPrescription
CompanyHospira; Shenzhen Techdow; Sandoz; Pfizer; Fresenius Kabi Usa; Hikma Maple; Sagent Pharms

2 of 2  
Drug NameHeparin sodium
Drug LabelIntravenous solutions with heparin sodium (derived from porcine intestinal mucosa) are sterile, nonpyrogenic fluids for intravenous administration. They contain no bacteriostat or antimicrobial agent or added buffer. Edetate disodium, anhydrous is ad...
Active IngredientHeparin sodium
Dosage FormInjectable
RouteInjection
Strength5,000 units/ml; 10,000 units/ml; 20,000 units/ml; 1,000 units/ml
Market StatusPrescription
CompanyHospira; Shenzhen Techdow; Sandoz; Pfizer; Fresenius Kabi Usa; Hikma Maple; Sagent Pharms

5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Anticoagulants

Agents that prevent BLOOD CLOTTING. (See all compounds classified as Anticoagulants.)


Fibrinolytic Agents

Fibrinolysin or agents that convert plasminogen to FIBRINOLYSIN. (See all compounds classified as Fibrinolytic Agents.)


API SUPPLIERS

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01

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Virtual BoothSmithfield BioScience transforms bioproducts into trusted, life-saving therapies through safe, reliable U.S.-based manufacturing.

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Heparin Sodium

About the Company : Smithfield BioScience specializes in harvesting and repurposing porcine‑derived biological materials for pharmaceuticals, medical devices, regenerative medicine, and nutraceutica...

Smithfield BioScience specializes in harvesting and repurposing porcine‑derived biological materials for pharmaceuticals, medical devices, regenerative medicine, and nutraceuticals, operating a fully US‑based supply chain for Heparin Sodium USP/EP at its USDA‑approved, FDA‑registered Cincinnati facility. Committed to advancing human health, it invests in R&D to develop new applications for bioproducts-from gelatin agents to tissue fabrication-delivering innovative solutions worldwide. Note: Product(s) under patent(s) are offered only for R&D purposes as per the Patent Act & not for commercial sale.
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Bioiberica

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Virtual BoothBioiberica is a global life science company committed to improving the health & wellbeing of people, animals & plants.

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Heparin Sodium

About the Company : Bioiberica is a global Life Science company with over 45 years of experience developing & producing high‑value biological molecules for the pharmaceutical and nutraceutical indus...

Bioiberica is a global Life Science company with over 45 years of experience developing & producing high‑value biological molecules for the pharmaceutical and nutraceutical industries. It is one of the leading Heparin API manufacturers and a key reference for other biologically derived APIs, as well as clinically backed nutraceutical ingredients targeting mobility, digestive health, and skin and beauty. With a vertically integrated European supply chain, Bioiberica guarantees high quality, safety, & full product traceability. Note: Product(s) under patent(s) are offered only for R&D purposes as per the Patent Act & not for commercial sale.
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Virtual BoothChemWerth works in generic API development & supply, non-infringement patent strategy development and regulatory support.

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Heparin Sodium

About the Company : ChemWerth, established in 1982, is a US-headquartered full-service generic API company. It supplies cGMP-quality APIs to regulated markets worldwide, with exclusive partnerships fo...

ChemWerth, established in 1982, is a US-headquartered full-service generic API company. It supplies cGMP-quality APIs to regulated markets worldwide, with exclusive partnerships for product development, compliance, and secure logistics. ChemWerth accesses over 500 APIs and 30 manufacturing facilities across the US, Europe, India, and China, acts as a regulatory agent for 25+ FDA-approved facilities, sells 100+ products, and operates in 38 countries. In 2020, it filed its 500th DMF with the FDA . Note: Product(s) under patent(s) are offered only for R&D purposes as per the Patent Act & not for commercial sale.
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LGM Pharma

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Virtual BoothLGM Pharma accelerates & optimizes the new product pathway from early development through commercialization.

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Heparin Sodium

About the Company : LGM Pharma is a global leader in sourcing hard-to-find APIs and intermediates for pharmaceutical and biotech industries. LGM also operates as a full-service CDMO, offering formulat...

LGM Pharma is a global leader in sourcing hard-to-find APIs and intermediates for pharmaceutical and biotech industries. LGM also operates as a full-service CDMO, offering formulation, analytical method development and testing, custom API synthesis, regulatory support, and commercial manufacturing. Supported by a network of over 300 accredited cGMP manufacturing partners and more than 100,000 sq. ft. of FDA-inspected cGMP manufacturing and warehouse space, LGM delivers secure, end-to-end solutions across multiple dosage forms. Note: Product(s) under patent(s) are offered only for R&D purposes as per the Patent Act & not for commercial sale.
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05

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Virtual BoothPfizer CentreOne is a global CDMO and a leading supplier of Specialty APIs.

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Heparin Sodium

About the Company : Pfizer CentreOne® is an altogether different global contract development and manufacturing organization (CDMO), and a leading supplier of specialty APIs and intermediates.
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Pfizer CentreOne® is an altogether different global contract development and manufacturing organization (CDMO), and a leading supplier of specialty APIs and intermediates. Backed by Pfizer resources, we’ve been delivering technical expertise, regulatory support and long-term supply for over 40 years. With 35+ sites across six continents, our expansive network allows us to securely and efficiently guide complex compounds from development through commercial manufacture. For more information, visit http://www.pfizercentreone.com
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06

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Virtual BoothTogether we can improve the quality of life

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Heparin Sodium

About the Company : Shamrock Pharmachemi Pvt Ltd. is a globally recognized API leader with 26+ years in human and veterinary pharmaceuticals. Operating in 40+ countries, it owns two Gujarat facilities...

Shamrock Pharmachemi Pvt Ltd. is a globally recognized API leader with 26+ years in human and veterinary pharmaceuticals. Operating in 40+ countries, it owns two Gujarat facilities and partners with 16+ plants. Holding USFDA, EU-GMP, WHO-GMP, and other certifications, it is the largest exporter for 12 molecules worldwide. With robust regulatory compliance (DMF, CEP, ICH Q7), Shamrock is the preferred API partner in India. Note: Product(s) under patent(s) are offered only for R&D purposes as per the Patent Act & not for commercial sale.
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07

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Virtual BoothWillow Birch Pharma delivers trusted, high-quality APIs nationwide with unmatched service, compliance, and competitive value.

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Heparin Sodium

About the Company : Willow Birch Pharma, Inc. is a premier supplier of bulk APIs to North American Compounding Pharmacies, sourcing from FDA registered and GMP manufacturers. With licenses in all 50 s...

Willow Birch Pharma, Inc. is a premier supplier of bulk APIs to North American Compounding Pharmacies, sourcing from FDA registered and GMP manufacturers. With licenses in all 50 states as a drug wholesaler and NABP accreditation since 2007, Willow Birch Pharma delivers top-quality products at competitive prices with unparalleled service and regulatory support nationwide. Note: Product(s) under patent(s) are offered only for R&D purposes as per the Patent Act & not for commercial sale.
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08

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Heparin Sodium

About the Company : Hanways Chempharm Co., Limited, the former one is Hubei Hanways Pharchem CO.,Limited, set up in 2009 in Wuhan, China. We are engaged in supplying APIs, pharmaceutical intermediate...

Hanways Chempharm Co., Limited, the former one is Hubei Hanways Pharchem CO.,Limited, set up in 2009 in Wuhan, China. We are engaged in supplying APIs, pharmaceutical intermediates, and fine chemicals for worldwide markets. With decades of development, now we grow to a leading and outstanding company. We are not just a trading company, but a comprehensive solutions supplier. With our sound knowledge of pharmaceutical business, our advantage is to integrate resources and adapt to all different demands of markets. We are a young but dynamic and energetic company with high efficient and high flexible decision making system.
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09

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Sodium Heparin

About the Company : Syntex is an Argentine company that elaborates active ingredients from biological and semi-synthetic origins for Human and Veterinary Pharmaceutical Industry since 1935. We work wi...

Syntex is an Argentine company that elaborates active ingredients from biological and semi-synthetic origins for Human and Veterinary Pharmaceutical Industry since 1935. We work with the implementation of technological development that allows the obtaining of derivatives and more ecient evolutions for new uses and applications in Diagnose, Human and Veterinary Medicine.
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Heparin Sodium

About the Company : QINGDAO QINGMEI BIOTECH(hereinafter referred to as Qingmei) is a specialized pharmaceutical company founded by DAYON INTERNATIONAL HOLDING LIMITED, which is to expand international...

QINGDAO QINGMEI BIOTECH(hereinafter referred to as Qingmei) is a specialized pharmaceutical company founded by DAYON INTERNATIONAL HOLDING LIMITED, which is to expand international business and strategic cooperation with suppliers. The company is located in the beautiful coastal city of Qingdao, near City Hall and the May Fourth Square, and also close to the port, so that it has convenient traffic conditions for trade. The company's business focuses on the development and promotion of the pharmaceutical chemicals, animal health, food additives, plant extracts, cosmetic raw materials, intermediates and other fine chemicals.
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15-Jan-2022
28-Feb-2026
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Drugs in Development

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Details:

Insulin Glulisine is a Protein drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of Diabetes Mellitus, Type 1.


Lead Product(s): Insulin Glulisine,Insulin aspart,Neutral Protamine Hagedorn Insulin,Glucagon,Glucose,Heparin Sodium

Therapeutic Area: Endocrinology Brand Name: Undisclosed

Study Phase: Phase IProduct Type: Protein

Sponsor: Undisclosed

Deal Size: Inapplicable Upfront Cash: Inapplicable

Deal Type: Inapplicable September 22, 2016

Sanofi Company Banner

01

Sanofi

France
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Lead Product(s) : Insulin Glulisine,Insulin aspart,Neutral Protamine Hagedorn Insulin,Glucagon,Glucose,Heparin Sodium

Therapeutic Area : Endocrinology

Highest Development Status : Phase I

Partner/Sponsor/Collaborator : Undisclosed

Deal Size : Inapplicable

Deal Type : Inapplicable

Details : Insulin Glulisine is a Protein drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of Diabetes Mellitus, Type 1.

Product Name : Undisclosed

Product Type : Protein

Upfront Cash : Inapplicable

September 22, 2016

Sanofi Company Banner
  • Development Update

Details:

Heparin is a small molecule drug candidate, which is currently being evaluated in Phase IV clinical studies for the treatment of Pulmonary Embolism.


Lead Product(s): Heparin Sodium,Inapplicable

Therapeutic Area: Cardiology/Vascular Diseases Brand Name: Undisclosed

Study Phase: Phase IVProduct Type: Miscellaneous

Sponsor: Undisclosed

Deal Size: Inapplicable Upfront Cash: Inapplicable

Deal Type: Inapplicable November 26, 2025

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02

Inova Health Care Services

Country
arrow
IPhEB Russia
Not Confirmed

Inova Health Care Services

Country
arrow
IPhEB Russia
Not Confirmed

Details : Heparin is a small molecule drug candidate, which is currently being evaluated in Phase IV clinical studies for the treatment of Pulmonary Embolism.

Product Name : Undisclosed

Product Type : Miscellaneous

Upfront Cash : Inapplicable

November 26, 2025

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Details:

Heparin sodium is an anticoagulant, or "blood thinner," used to prevent and treat blood clots by inhibiting thrombin and other clotting factors via the antithrombin III complex.


Lead Product(s): Heparin Sodium,Inapplicable

Therapeutic Area: Hematology Brand Name: Undisclosed

Study Phase: Approved FDFProduct Type: Miscellaneous

Sponsor: Undisclosed

Deal Size: Inapplicable Upfront Cash: Inapplicable

Deal Type: Inapplicable July 18, 2025

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03

IPhEB Russia
Not Confirmed
IPhEB Russia
Not Confirmed

Details : Heparin sodium is an anticoagulant, or "blood thinner," used to prevent and treat blood clots by inhibiting thrombin and other clotting factors via the antithrombin III complex.

Product Name : Undisclosed

Product Type : Miscellaneous

Upfront Cash : Inapplicable

July 18, 2025

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Details:

Taurolidine is a Antibiotic drug candidate, which is currently being evaluated in phase III clinical studies for the treatment of Catheter-Related Infections.


Lead Product(s): Taurolidine,Heparin Sodium

Therapeutic Area: Infections and Infectious Diseases Brand Name: Undisclosed

Study Phase: Phase IIIProduct Type: Antibiotic

Sponsor: Undisclosed

Deal Size: Inapplicable Upfront Cash: Inapplicable

Deal Type: Inapplicable February 12, 2025

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04

CorMedix

U.S.A
arrow
IPhEB Russia
Not Confirmed

CorMedix

U.S.A
arrow
IPhEB Russia
Not Confirmed

Details : Taurolidine is a Antibiotic drug candidate, which is currently being evaluated in phase III clinical studies for the treatment of Catheter-Related Infections.

Product Name : Undisclosed

Product Type : Antibiotic

Upfront Cash : Inapplicable

February 12, 2025

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Details:

Taurolidine is a Antibiotic drug candidate, which is currently being evaluated in phase IV clinical studies for the treatment of Catheter-Related Infections.


Lead Product(s): Taurolidine,Heparin Sodium

Therapeutic Area: Infections and Infectious Diseases Brand Name: Undisclosed

Study Phase: Phase IVProduct Type: Antibiotic

Sponsor: Undisclosed

Deal Size: Inapplicable Upfront Cash: Inapplicable

Deal Type: Inapplicable December 04, 2024

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05

CorMedix

U.S.A
arrow
IPhEB Russia
Not Confirmed

CorMedix

U.S.A
arrow
IPhEB Russia
Not Confirmed

Details : Taurolidine is a Antibiotic drug candidate, which is currently being evaluated in phase IV clinical studies for the treatment of Catheter-Related Infections.

Product Name : Undisclosed

Product Type : Antibiotic

Upfront Cash : Inapplicable

December 04, 2024

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Details:

Taurolidine is a Antibiotic drug candidate, which is currently being evaluated in clinical studies for the treatment of Catheter-Related Infections.


Lead Product(s): Taurolidine,Heparin Sodium

Therapeutic Area: Infections and Infectious Diseases Brand Name: Undisclosed

Study Phase: UndisclosedProduct Type: Antibiotic

Sponsor: Undisclosed

Deal Size: Inapplicable Upfront Cash: Inapplicable

Deal Type: Inapplicable November 27, 2024

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06

CorMedix

U.S.A
arrow
IPhEB Russia
Not Confirmed

CorMedix

U.S.A
arrow
IPhEB Russia
Not Confirmed

Details : Taurolidine is a Antibiotic drug candidate, which is currently being evaluated in clinical studies for the treatment of Catheter-Related Infections.

Product Name : Undisclosed

Product Type : Antibiotic

Upfront Cash : Inapplicable

November 27, 2024

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Details:

Through the agreement, Cordemix will supply DefenCath (taurolidine and heparin) to dialysis clinics for CRBSI in adult patients with kidney failure receiving chronic hemodialysis.


Lead Product(s): Taurolidine,Heparin Sodium

Therapeutic Area: Immunology Brand Name: Defencath

Study Phase: Approved FDFProduct Type: Antibiotic

Sponsor: Undisclosed

Deal Size: Undisclosed Upfront Cash: Undisclosed

Deal Type: Agreement September 19, 2024

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07

CorMedix

U.S.A
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IPhEB Russia
Not Confirmed

CorMedix

U.S.A
arrow
IPhEB Russia
Not Confirmed

Details : Through the agreement, Cordemix will supply DefenCath (taurolidine and heparin) to dialysis clinics for CRBSI in adult patients with kidney failure receiving chronic hemodialysis.

Product Name : Defencath

Product Type : Antibiotic

Upfront Cash : Undisclosed

September 19, 2024

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Details:

VMX-C001 is a Enzyme drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of Blood Coagulation Disorders.


Lead Product(s): VMX-C001,Rivaroxaban,Heparin Sodium

Therapeutic Area: Hematology Brand Name: Undisclosed

Study Phase: Phase IProduct Type: Enzyme

Sponsor: Undisclosed

Deal Size: Inapplicable Upfront Cash: Inapplicable

Deal Type: Inapplicable July 24, 2024

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08

VarmX

Netherlands
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IPhEB Russia
Not Confirmed

VarmX

Netherlands
arrow
IPhEB Russia
Not Confirmed

Details : VMX-C001 is a Enzyme drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of Blood Coagulation Disorders.

Product Name : Undisclosed

Product Type : Enzyme

Upfront Cash : Inapplicable

July 24, 2024

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  • Deals

Details:

The agreement aims for the supply of DefenCath, a combination of taurolidine, a thiadiazinane antimicrobial and heparin, an anti-coagulant, indicated to reduce catheter-related bloodstream infections.


Lead Product(s): Taurolidine,Heparin Sodium

Therapeutic Area: Infections and Infectious Diseases Brand Name: DefenCath

Study Phase: Approved FDFProduct Type: Antibiotic

Sponsor: CorMedix

Deal Size: Undisclosed Upfront Cash: Undisclosed

Deal Type: Agreement May 28, 2024

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09

Undisclosed

Country
arrow
IPhEB Russia
Not Confirmed

Undisclosed

Country
arrow
IPhEB Russia
Not Confirmed

Details : The agreement aims for the supply of DefenCath, a combination of taurolidine, a thiadiazinane antimicrobial and heparin, an anti-coagulant, indicated to reduce catheter-related bloodstream infections.

Product Name : DefenCath

Product Type : Antibiotic

Upfront Cash : Undisclosed

May 28, 2024

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Details:

Through the agreement, the company will focus on the supply and commercialization of DefenCath (taurolidine and heparin) for the treatment of catheter-related bloodstream infections.


Lead Product(s): Taurolidine,Heparin Sodium

Therapeutic Area: Immunology Brand Name: Defencath

Study Phase: Approved FDFProduct Type: Antibiotic

Sponsor: ARC Dialysis, LLC

Deal Size: Undisclosed Upfront Cash: Undisclosed

Deal Type: Agreement April 08, 2024

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10

CorMedix

U.S.A
arrow
IPhEB Russia
Not Confirmed

CorMedix

U.S.A
arrow
IPhEB Russia
Not Confirmed

Details : Through the agreement, the company will focus on the supply and commercialization of DefenCath (taurolidine and heparin) for the treatment of catheter-related bloodstream infections.

Product Name : Defencath

Product Type : Antibiotic

Upfront Cash : Undisclosed

April 08, 2024

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Europe

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01

IPhEB Russia
Not Confirmed
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IPhEB Russia
Not Confirmed

Sodium heparin

Brand Name : Heparin?

Dosage Form : Injectable Solution

Dosage Strength :

Packaging :

Approval Date : 19-07-2023

Application Number :

Regulatory Info :

Registration Country : Moldova

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02

Drossapharm Ag

Switzerland
IPhEB Russia
Not Confirmed
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Drossapharm Ag

Switzerland
arrow
IPhEB Russia
Not Confirmed

Heparin Sodium; Dexpanthenol; Allantoin

Brand Name : Lyman

Dosage Form : Gel

Dosage Strength :

Packaging :

Approval Date : 26/06/1996

Application Number : 52854

Regulatory Info : Allowed

Registration Country : Switzerland

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03

FARMIGEA SpA

Italy
IPhEB Russia
Not Confirmed
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FARMIGEA SpA

Italy
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IPhEB Russia
Not Confirmed

Heparin

Brand Name : Heparin

Dosage Form :

Dosage Strength : Coll 25,000 Iu 5 Ml  

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Italy

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04

IPhEB Russia
Not Confirmed
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IPhEB Russia
Not Confirmed

Heparin

Brand Name : Epsoclar

Dosage Form : Heparin Sodium 25,000Iu 10 Units Parenteral Use

Dosage Strength : 10 VIALS EV 25,000 IU 5 ml

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Italy

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05

IPhEB Russia
Not Confirmed
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IPhEB Russia
Not Confirmed

Heparin

Brand Name : Calciparina

Dosage Form : Calcium Heparin 12.500Iu 10 Units Parenteral Use

Dosage Strength : 10 VIALS SC 12,500 IU 0.5 ml

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Italy

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06

IPhEB Russia
Not Confirmed
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IPhEB Russia
Not Confirmed

Bemiparin

Brand Name : Zibor® 2500

Dosage Form : Solution For Injection

Dosage Strength : 2500IU

Packaging :

Approval Date : 01-08-2019

Application Number :

Regulatory Info :

Registration Country : Moldova

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07

Orifarm AS

Denmark
IPhEB Russia
Not Confirmed
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Orifarm AS

Denmark
arrow
IPhEB Russia
Not Confirmed

Heparin sodium

Brand Name : Heparin Leo

Dosage Form : Solution For Injection

Dosage Strength : 5000IU/ml

Packaging :

Approval Date :

Application Number :

Regulatory Info : Not Marketed

Registration Country : Norway

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08

Orifarm Ab

Denmark
IPhEB Russia
Not Confirmed
arrow

Orifarm Ab

Denmark
arrow
IPhEB Russia
Not Confirmed

Heparin Sodium

Brand Name : Heparin Leo

Dosage Form : Injectable Solution

Dosage Strength : 5000IU/ml

Packaging :

Approval Date : 17-05-2010

Application Number : 2.01E+13

Regulatory Info : Approved

Registration Country : Sweden

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09

Orifarm Ab

Denmark
IPhEB Russia
Not Confirmed
arrow

Orifarm Ab

Denmark
arrow
IPhEB Russia
Not Confirmed

Heparin Sodium

Brand Name : Heparin Leo

Dosage Form : Injectable Solution

Dosage Strength : 5000IU/ml

Packaging :

Approval Date : 28-06-2022

Application Number : 2.02E+13

Regulatory Info : Approved

Registration Country : Sweden

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10

Spirig Healthcare Ag

Switzerland
IPhEB Russia
Not Confirmed
arrow

Spirig Healthcare Ag

Switzerland
arrow
IPhEB Russia
Not Confirmed

Sodium Heparin

Brand Name : HepaGel

Dosage Form : Gel

Dosage Strength : 400IU

Packaging :

Approval Date : 07/10/1974

Application Number : 38459

Regulatory Info : Allowed

Registration Country : Switzerland

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DRUG PRODUCT COMPOSITIONS

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DOSAGE - INJECTABLE;INJECTION - 1,000 UNITS/M...DOSAGE - INJECTABLE;INJECTION - 1,000 UNITS/ML

USFDA APPLICATION NUMBER - 17029

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DOSAGE - INJECTABLE;INJECTION - 10,000 UNITS/...DOSAGE - INJECTABLE;INJECTION - 10,000 UNITS/ML

USFDA APPLICATION NUMBER - 17029

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DOSAGE - INJECTABLE;INJECTION - 100 UNITS/ML

USFDA APPLICATION NUMBER - 17029

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DOSAGE - INJECTABLE;INJECTION - 20,000 UNITS/...DOSAGE - INJECTABLE;INJECTION - 20,000 UNITS/ML

USFDA APPLICATION NUMBER - 17029

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DOSAGE - INJECTABLE;INJECTION - 40 UNITS/ML

USFDA APPLICATION NUMBER - 17029

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DOSAGE - INJECTABLE;INJECTION - 5,000 UNITS/M...DOSAGE - INJECTABLE;INJECTION - 5,000 UNITS/ML

USFDA APPLICATION NUMBER - 17029

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DOSAGE - INJECTABLE;INJECTION - 50 UNITS/ML

USFDA APPLICATION NUMBER - 17029

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DOSAGE - INJECTABLE;INJECTION - 1,000 UNITS/M...DOSAGE - INJECTABLE;INJECTION - 1,000 UNITS/ML

USFDA APPLICATION NUMBER - 201370

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DOSAGE - INJECTABLE;INJECTION - 10,000 UNITS/...DOSAGE - INJECTABLE;INJECTION - 10,000 UNITS/ML

USFDA APPLICATION NUMBER - 201370

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DOSAGE - INJECTABLE;INJECTION - 5,000 UNITS/M...DOSAGE - INJECTABLE;INJECTION - 5,000 UNITS/ML

USFDA APPLICATION NUMBER - 201370

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ABOUT THIS PAGE

Looking for / Heparin Sodium API manufacturers, exporters & distributors?

Heparin Sodium manufacturers, exporters & distributors 1

29

PharmaCompass offers a list of Heparin Sodium API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Heparin Sodium manufacturer or Heparin Sodium supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Heparin Sodium manufacturer or Heparin Sodium supplier.

PharmaCompass also assists you with knowing the Heparin Sodium API Price utilized in the formulation of products. Heparin Sodium API Price is not always fixed or binding as the Heparin Sodium Price is obtained through a variety of data sources. The Heparin Sodium Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Heparin Sodium

Synonyms

(2s,3s,4r,5r,6r)-6-{[(2s,3s,4s,5r,6s)-6-{[(2r,3s,4s,5r)-2-carboxy-4,6-dihydroxy-5-(sulfooxy)oxan-3-yl]oxy}-2-hydroxy-4-(sulfomethyl)-5-(sulfooxy)oxan-3-yl]oxy}-3-{[(2r,3r,4r,5s,6r)-3-acetamido-4,5-dihydroxy-6-[(sulfooxy)methyl]oxan-2-yl]oxy}-4,5-dihydroxyoxane-2-carboxylic acid, Hepflush, Chembl526514, Gtpl4214, S01xa14, Bdbm50480251

About Heparin Sodium

A highly acidic mucopolysaccharide formed of equal parts of sulfated D-glucosamine and D-glucuronic acid with sulfaminic bridges. The molecular weight ranges from six to twenty thousand. Heparin occurs in and is obtained from liver, lung, mast cells, etc., of vertebrates. Its function is unknown, but it is used to prevent blood clotting in vivo and vitro, in the form of many different salts.

Sodium Heparin Manufacturers

A Sodium Heparin manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Sodium Heparin, including repackagers and relabelers. The FDA regulates Sodium Heparin manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Sodium Heparin API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Sodium Heparin manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Sodium Heparin Suppliers

A Sodium Heparin supplier is an individual or a company that provides Sodium Heparin active pharmaceutical ingredient (API) or Sodium Heparin finished formulations upon request. The Sodium Heparin suppliers may include Sodium Heparin API manufacturers, exporters, distributors and traders.

click here to find a list of Sodium Heparin suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Sodium Heparin USDMF

A Sodium Heparin DMF (Drug Master File) is a document detailing the whole manufacturing process of Sodium Heparin active pharmaceutical ingredient (API) in detail. Different forms of Sodium Heparin DMFs exist exist since differing nations have different regulations, such as Sodium Heparin USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Sodium Heparin DMF submitted to regulatory agencies in the US is known as a USDMF. Sodium Heparin USDMF includes data on Sodium Heparin's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Sodium Heparin USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Sodium Heparin suppliers with USDMF on PharmaCompass.

Sodium Heparin JDMF

The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

The Sodium Heparin Drug Master File in Japan (Sodium Heparin JDMF) empowers Sodium Heparin API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

PMDA reviews the Sodium Heparin JDMF during the approval evaluation for pharmaceutical products. At the time of Sodium Heparin JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

click here to find a list of Sodium Heparin suppliers with JDMF on PharmaCompass.

Sodium Heparin KDMF

In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.

Pharmaceutical companies submit a Sodium Heparin Drug Master File in Korea (Sodium Heparin KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of Sodium Heparin. The MFDS reviews the Sodium Heparin KDMF as part of the drug registration process and uses the information provided in the Sodium Heparin KDMF to evaluate the safety and efficacy of the drug.

After submitting a Sodium Heparin KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their Sodium Heparin API can apply through the Korea Drug Master File (KDMF).

click here to find a list of Sodium Heparin suppliers with KDMF on PharmaCompass.

Sodium Heparin CEP

A Sodium Heparin CEP of the European Pharmacopoeia monograph is often referred to as a Sodium Heparin Certificate of Suitability (COS). The purpose of a Sodium Heparin CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Sodium Heparin EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Sodium Heparin to their clients by showing that a Sodium Heparin CEP has been issued for it. The manufacturer submits a Sodium Heparin CEP (COS) as part of the market authorization procedure, and it takes on the role of a Sodium Heparin CEP holder for the record. Additionally, the data presented in the Sodium Heparin CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Sodium Heparin DMF.

A Sodium Heparin CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Sodium Heparin CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

click here to find a list of Sodium Heparin suppliers with CEP (COS) on PharmaCompass.

Sodium Heparin NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Sodium Heparin as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for Sodium Heparin API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture Sodium Heparin as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain Sodium Heparin and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Sodium Heparin NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of Sodium Heparin suppliers with NDC on PharmaCompass.

Sodium Heparin GMP

Sodium Heparin Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Sodium Heparin GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Sodium Heparin GMP manufacturer or Sodium Heparin GMP API supplier for your needs.

Sodium Heparin CoA

A Sodium Heparin CoA (Certificate of Analysis) is a formal document that attests to Sodium Heparin's compliance with Sodium Heparin specifications and serves as a tool for batch-level quality control.

Sodium Heparin CoA mostly includes findings from lab analyses of a specific batch. For each Sodium Heparin CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Sodium Heparin may be tested according to a variety of international standards, such as European Pharmacopoeia (Sodium Heparin EP), Sodium Heparin JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Sodium Heparin USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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