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Silicon Dioxide API
Also known as: Silica, Quartz, Dioxosilane, 7631-86-9, Diatomaceous earth, Silica gel
Molecular Formula
O2Si
Molecular Weight
60.084  g/mol
InChI Key
VYPSYNLAJGMNEJ-UHFFFAOYSA-N
FDA UNII
ETJ7Z6XBU4

Silicon Dioxide is a natural compound of silicon and oxygen found mostly in sand, Silica has three main crystalline varieties: quartz, tridymite, and cristobalite. Fine particulate silica dust from quartz rock causes over a long-term progressive lung injury, silicosis. (NCI04)
1 2D Structure

Silicon Dioxide API

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
dioxosilane
2.1.2 InChI
InChI=1S/O2Si/c1-3-2
2.1.3 InChI Key
VYPSYNLAJGMNEJ-UHFFFAOYSA-N
2.1.4 Canonical SMILES
O=[Si]=O
2.2 Other Identifiers
2.2.1 UNII
ETJ7Z6XBU4
2.3 Synonyms
2.3.1 Depositor-Supplied Synonyms

1. Silica

2. Quartz

3. Dioxosilane

4. 7631-86-9

5. Diatomaceous Earth

6. Silica Gel

7. Cristobalite

8. Tridymite

9. Sand

10. Silicic Anhydride

11. 14808-60-7

12. Kieselguhr

13. 112945-52-5

14. Infusorial Earth

15. Aerosil

16. Diatomaceous Silica

17. 61790-53-2

18. 112926-00-8

19. Crystalline Silica

20. Dicalite

21. Wessalon

22. Glass

23. Ludox

24. Nyacol

25. Silicon(iv) Oxide

26. Zorbax Sil

27. Silica, Amorphous

28. 60676-86-0

29. Cab-o-sil

30. Christensenite

31. Crystoballite

32. 14464-46-1

33. Siliceous Earth

34. Synthetic Amorphous Silica

35. Amorphous Silica

36. Silica, Colloidal

37. Quartz (sio2)

38. Chalcedony

39. Diatomite

40. Agate

41. Silica Vitreous

42. Cab-o-sil M-5

43. Colloidal Silica

44. Fused Silica

45. Quartz Glass

46. Quartz Sand

47. Silica Slurry

48. Silicone Dioxide

49. 91053-39-3

50. Colloidal Silicon Dioxide

51. Siliceous Earth, Purified

52. Min-u-sil

53. Silicon Dioxide (amorphous)

54. 15468-32-3

55. Silicon Dioxide, Fumed

56. Siliziumdioxid

57. Silica, Vitreous

58. 68855-54-9

59. Silica, Fumed

60. Kieselsaeureanhydrid

61. Silica Gel, 40-63 Micron Particles

62. Chebi:30563

63. Sio2

64. (sio2)n

65. 43-63c

66. Etj7z6xbu4

67. Silicon Dioxide, Colloidal

68. 15723-40-7

69. Silicon Dioxide, Amorphous

70. Ent 25,550

71. [sio2]

72. Silica, Crystalline - Fused

73. Silicagel

74. Silicon Dioxide, Amorphous Gel

75. 13778-37-5

76. 13778-38-6

77. 17679-64-0

78. Silicondioxide

79. Silica Gel Desiccant, Indicating

80. Celite

81. Sand, Ottawa

82. Sand, Sea

83. Silica Gel Desiccant

84. Calcined Diatomite

85. Mfcd00011232

86. Mfcd00217788

87. Silica, Mesostructured

88. Sillikolloid

89. Acticel

90. Aerosil 380

91. Amethyst

92. Aquafil

93. Carplex

94. Cataloid

95. Crysvarl

96. Extrusil

97. Flintshot

98. Nalcoag

99. Novaculite

100. Porasil

101. Santocel

102. Silikil

103. Silikill

104. Siloxid

105. Sipernat

106. Superfloss

107. Vulkasil

108. Cherts

109. Neosil

110. Neosyl

111. Snowit

112. Aerosil-degussa

113. Imsil

114. Metacristobalite

115. Zipax

116. Quartz Silica

117. Alpha-quartz

118. Fossil Flour

119. Fumed Silica

120. Quartz Dust

121. Rock Crystal

122. Rose Quartz

123. Silica Dust

124. Silica Glass

125. White Carbon

126. Chromosorb P

127. Silica Particles

128. Tiger-eye

129. Vulkasil S

130. Celite Superfloss

131. Cristobalite Dust

132. Snowtex O

133. Corasil Ii

134. Silver Bond B

135. Cab-o-sperse

136. Alpha-cristobalite

137. Alpha-crystobalite

138. Tokusil Tplm

139. Dri-die

140. Gold Bond R

141. Cabosil St-1

142. Manosil Vn 3

143. Sil-co-sil

144. Ultrasil Vh 3

145. Ultrasil Vn 3

146. Aerosil Bs-50

147. Aerosil K 7

148. Cabosil N 5

149. Carplex 30

150. Carplex 80

151. Pigment White 27

152. Siderite (sio2)

153. Snowtex 30

154. Syton 2x

155. Tridymite 118

156. Zeofree 80

157. Cab-o-grip Ii

158. Silicon(iv) Oxide, Amorphous

159. Tridimite [french]

160. Amorphous Silica Gel

161. Hi-sil

162. Glass Wool, For Laboratory Use

163. Positive Sol 232

164. Aerogel 200

165. Aerosil 300

166. Amorphous Silica Dust

167. Ludox Hs 40

168. Silanox 101

169. Silica (sio2)

170. Vitasil 220

171. Positive Sol 130m

172. Siliceous Earth, Purified (nf)

173. Siliceous Earth, Purified [nf]

174. Silicon Oxide Hollow Nanospheres

175. Aerosil A 300

176. Aerosil E 300

177. Aerosil M-300

178. Cristobalite (sio2)

179. Nyacol 830

180. Sibelite M 3000

181. Sibelite M 4000

182. Sibelite M 6000

183. Quazo Puro [italian]

184. Caswell No. 734a

185. Nalfloc N 1050

186. Quso 51

187. Sicron F 300

188. Sikron F 100

189. Spectrosil

190. Accusand

191. Coesite

192. Fuselex

193. Nalcast

194. Nyacol 1430

195. Optocil

196. Quartzine

197. Quarzsand

198. Rancosil

199. Suprasil

200. Tridimite

201. Silica, Amorphous Fused

202. Siltex

203. Vitreous Quartz

204. Vitreous Silica

205. Tridymite Dust

206. W 12 (filler)

207. Beta-quartz

208. Fused Quartz

209. Min-u-sil Alpha Quartz

210. Quartz-beta

211. Quso G 30

212. Amorphous Quartz

213. Dri-die Insecticide 67

214. Nalco 1050

215. Quazo Puro

216. Silica, Amorphous, Fumed

217. Vitrified Silica

218. Mfcd00163736

219. Pyrogenic Colloidal Silica

220. Silica Gel, Spherical, 60 Angstroms

221. Hydrophobic Silica 2482

222. Silica, Fused

223. Suprasil W

224. Vitreosil Ir

225. Borsil P

226. Calcined Diatomaceous Earth

227. Silica Gel, Spherical, 100 Angstroms

228. Silica Gel, Spherical, 300 Angstroms

229. Silane, Dioxo-

230. Crystallized Silicon Dioxide

231. Optocil (quartz)

232. Cp-silicaplot

233. Diatomaceous Earth, Calcined

234. Silicon Oxide, Di- (sand)

235. Quarzsand [german]

236. S-col

237. Admafine So 25h

238. Admafine So 25r

239. Admafine So 32h

240. Admafine So-c 2

241. Admafine So-c 3

242. Cristobalite Asbestos

243. Keatite (sio2)

244. Sg-67

245. Tridymite (sio2)

246. Fumed Silica, Crystalline-free

247. Stishovite (sio2)

248. Ed-c (silica)

249. Fuselex Za 30

250. As 1 (silica)

251. Ccris 2475

252. Ccris 3699

253. Dq12

254. Agate (sio2)

255. Celite 545

256. Dimethyl Siloxanes And Silicones

257. Fumed Synthetic Amorphous Silica

258. Silica, Crystalline - Tridymite

259. Fb 5 (silica)

260. Fuselex Rd 120

261. Corning 7940

262. Microcrystalline Quartz

263. Synthetic Amorphous Silica, Fumed

264. Denka F 90

265. Denka Fb 30

266. Denka Fb 44

267. Denka Fb 74

268. Denka Fs 30

269. Dri-die 67

270. Silica Gel Spherical, 40-75 Mum Particle Size

271. Wgl 300

272. Cryptocrystalline Quartz

273. Fb 20 (silica)

274. Elsil 100

275. F 44 (filler)

276. D & D

277. Sf 35

278. Elsil Bf 100

279. F 125 (silica)

280. F 160 (silica)

281. Fuselex Rd 40-60

282. Silica, Amorphous, Fused

283. Silicon Dioxide, Chemically Prepared

284. Einecs 231-545-4

285. Einecs 238-455-4

286. Einecs 238-878-4

287. Einecs 239-487-1

288. Unii-etj7z6xbu4

289. Hk 400

290. Tgl 16319

291. Silica Gel 60, 0.060-0.2mm (70-230 Mesh)

292. Silica, Crystalline Quartz

293. Silicon Dioxide (vitreous)

294. Epa Pesticide Chemical Code 072605

295. Silica, Amorphous, Fumed, Cryst.-free

296. Silica 2482, Hydrophobic

297. Ci 7811

298. Silica, Crystalline, Quartz

299. Silica, Crystalline: Quartz

300. Gp 7i

301. Cab-o-sil N-70ts

302. Silica, Crystalline Tridymite

303. Kieselgel

304. Seesand

305. Silica, Crystalline - Quartz

306. Af-so 25r

307. Quartz [silica, Crystalline]

308. Siilca

309. Zorbax

310. Quartz-glass

311. Silicom Dioxide

312. Silica Aerogel

313. Silica Flour (powdered Crystalline Silica)

314. Silica, Crystalline: Tridymite

315. Silica-gel

316. Fused-silica

317. Silica,fumed

318. Ai3-25549

319. Gp 11i

320. Rd 8

321. Silica-

322. Fine Grain Sand

323. Quarz

324. U 333

325. W 006

326. Silicon Di-oxide

327. Tridymite [silica, Crystalline]

328. Crs 1102rd8

329. Silica Dispersion

330. Sio2 Nanopowder

331. Silica Gel G

332. Silica, Crystalline: Cristobalite

333. Silica, Tridymite

334. Sio2 Nanospheres

335. Diatomaceous Earth, Flux-calcined, Filter Aid, Treated With Sodium Carbonate, Flux Calcined

336. Silica Gel 60 Adamant(tm) On Tlc Plates, With Fluorescent Indicator 254 Nm

337. Ef 10

338. Fs 74

339. Mr 84

340. Silica, Crystalline - Cristobalite

341. Silica Microspheres

342. Cristobalite [silica, Crystalline]

343. Amorphous Silica: Pyrogenic (fumed)

344. Einecs 262-373-8

345. Silica Gel, Astm

346. Silica Nanoparticles

347. Silicon (iv) Oxide

348. Methyl3-oxohexanoate

349. Siliceous Sand, Cp

350. Bf 100

351. Eq 912

352. Qg 100

353. Rd 120

354. Aerosil 200

355. 99439-28-8

356. Celite 503

357. Nettles P.e. Extract

358. Silicon Dioxide Powder

359. Sea Sand, Acid Washed

360. Silica, Fumed, Powder

361. Silicon Dioxide (nf)

362. Activated Silica Powder

363. Activated Silicon Oxide

364. Sand 50-70 Mesh

365. F 44

366. Silica Gel, Large Pore

367. Y 40

368. Hollow Silica Nanosphere

369. Silicon Oxide Dispersion

370. Silicon Oxide Nanopowder

371. Silica [inci]

372. Silicate [vandf]

373. Activated Silicon Dioxide

374. Celite (r) 545

375. Crystalline Silica Quartz

376. Silica Gel, Acs Reagent

377. Celite(r) 512 Medium

378. Kieselguhr, -325 Mesh

379. Sand [inci]

380. Silica, 99.8%

381. Sba-15 Molecular Sieve

382. Silicon Dioxide Nanopowder

383. Diatomaceous Earth, Powder

384. Dsstox_cid_9677

385. Silicon Dioxide Dispersion

386. Epitope Id:158537

387. Silicon Dioxide Nanospheres

388. Silicon Oxide Nanoparticles

389. Ec 231-545-4

390. Celite(r) 503, Cp

391. Celite(r) 535, Cp

392. Celite(r) 545, Cp

393. Silica Gel [vandf]

394. Nano Silicon Dioxide Powder

395. Dsstox_rid_78805

396. Celatom(r) Fw-60

397. Dsstox_gsid_29677

398. Silicon Dioxide, Acid Washed

399. Silicon Dioxide, Acid-washed

400. Diatomaceous Earth Non-washed

401. Silica Gel [who-dd]

402. Silica, Hydrate(8ci,9ci)

403. Silicon Dioxide [ii]

404. Silicon(iv) Oxide (sio2)

405. Silicon Dioxide, Precipitated

406. Silica Fibers, 1/4'' Long

407. Silicon Dioxide [fcc]

408. Kieselguhr, Calcined, Purified

409. Silica Gel, Cp, Blue, Beads

410. Silica Gel 60-100 Mesh

411. Silica Nanoparticles Dispersion

412. Silica, Fused, Respirable Dust

413. 25wt% Silicon Oxide In Water

414. Aw Standard Super-cel(r) Nf

415. Ins No.551

416. Mcm-41

417. Silica Gel, Cp, Mixed, Beads

418. Silica Gel, Cp, White, Beads

419. Silicates (<1% Crystalline Silica):graphite, Natural

420. Syloid 244 [vandf]

421. Hyflo(r) Super-cel(r), Cp

422. Silicon Dioxide [vandf]

423. Chembl3188292

424. Dtxsid1029677

425. Filter Agent, Celite(r) 545

426. Sand, White Quartz, Cp, Beads

427. Silicone Dioxide [vandf]

428. Quarz Cryst., 0.6-1.3 Mm

429. Silicon Dioxide, Colloidal (nf)

430. Diatomaceous Earth, Flux-calcined

431. Ins-551

432. Silica, Amorphous [iarc]

433. Silicon Dioxide [who-dd]

434. Silicon Dioxide, Saj First Grade

435. Syloid Silica Gel [vandf]

436. Diatomaceous Earth Non-washed, Cp

437. Silica Gel Dessicant (grade 03)

438. Silica Gel, Cp, Blue, Bead Size

439. Filter Agent, Celatom(r) Fw-14

440. Filter Agent, Celatom(r) Fw-50

441. Filter Agent, Celatom(r) Fw-60

442. Filter Agent, Celatom(r) Fw-80

443. Silica, Fused [silica, Amorphous]

444. Silicon Dioxide, Jis Special Grade

445. Silicon Oxide Mesoporous Nanopowder

446. Amy37125

447. Chromosorb(r) G, 80-100 Mesh

448. 2-mercaptoethyl Ethyl Sulfide Silica

449. Celite(r) 545 Aw, Reagent Grade

450. Silica Gel 60, 230-400 Mesh

451. Silica Hollow Nanospheres Dispersion

452. Silicon(iv) Oxide, Electronic Grade

453. Tox21_301288

454. Mfcd00148266

455. Mfcd00603035

456. Mfcd02100519

457. Mfcd06202255

458. Mfcd07370733

459. Sand, White Quartz, Cp, Crystalline

460. Silica Gel, Indicating, 6-16 Mesh

461. Chromosorb(r) W/aw, 45-60 Mesh

462. Light Anhydrous Silicic Acid (jp17)

463. Quarz Fine, Cryst., 0.4-0.8 Mm

464. Silica Gel, 70-200 Mesh (tlc)

465. Silica, Fumed, Powder, 0.008 Mum

466. Akos009085429

467. Colloidal Silica, 30% Susp. In H2o

468. Silicon Dioxide Nanospheres Properties

469. Db11132

470. Iron Sulfide (fes) Sputtering Targets

471. Silicon Dioxide Nanoparticle Dispersion

472. Glass Spheres, 9-13 Mum Particle Size

473. Quartz (silicon Dioxide), Silver, Pure

474. S25266

475. Silica Gel, Cp, White, Medium Granules

476. Silica Gel, Technical Grade, 3-9 Mesh

477. Silica, Mesostructured, Hms (wormhole)

478. Ncgc00257531-01

479. Sand, White Quartz, Purum P.a., Powder

480. Silica Gel Orange, Granular, 0.2-1 Mm

481. Silicon Dioxide Amorphous Fumed Silica

482. Silicon Oxide Nanoparticles / Nanopowder

483. Silicon(iv) Oxide, Powder, 0.5 Micron

484. Silicon(iv) Oxide, Powder, 1.0 Micron

485. Silicon(iv) Oxide, Powder, 1.5 Micron

486. 14639-89-5

487. 92283-58-4

488. E551

489. Silica Gel, Cp, Blue, Bead Size, Medium

490. Silica Gel, Technical Grade, 6-16 Mesh

491. Silicon Oxide Powder, 99% Nano, 20 Nm

492. Cas-7631-86-9

493. Silica Gel Desiccant, -3+8 Mesh Granules

494. Silica Gel, 12-24 Mesh (liquid Drying)

495. Silica Gel, Cp, Mixed, Bead Size, Medium

496. Silica Gel, For Column Chromatography, 60

497. Silicon Dioxide Nanoparticles / Nanopowder

498. Celite(r) 281, Filter Aid, Flux Calcined

499. Celite(r) S, Filter Aid, Dried, Untreated

500. Chromosorb(r) W/aw-dmcs, 80-100 Mesh

501. Silica Gel Desiccant, -6+12 Mesh Granules

502. Silicon Dioxide, Purum P.a., Acid Purified

503. Simethicone Component Silicon Dioxide

504. White Silica Gel Beads, 3 Mm (2-5 Mm)

505. E-551

506. Ft-0624621

507. Ft-0645127

508. Ft-0689145

509. Ft-0689270

510. Ft-0696592

511. Ft-0696603

512. Ft-0697331

513. Ft-0697389

514. Ft-0700917

515. Quartz Rod, Fused, 2.0mm (0.079in) Dia

516. Quartz Rod, Fused, 5.0mm (0.197in) Dia

517. S0822

518. Silica Gel, With 1-4 Mm Moisture Indicator

519. Silica, Amorphous, Fumed (crystalline Free)

520. Silicon Dioxide Nanopowder Kh550 Processing

521. Silicon Dioxide Nanopowder Kh570 Processing

522. Silicon(iv) Oxide, 99.0% (metals Basis)

523. Celite(r) 110, Filter Aid, Flux Calcinated

524. Celite(r) 512 Medium, Filter Aid, Calcined

525. Chromosorb(r) G/aw-dmcs, 100-120 Mesh

526. Chromosorb(r) W/aw-dmcs, 120-140 Mesh

527. K-411 Glass Microspheres, Nist Srm 2066

528. Quartz Rod, Fused, 10.0mm (0.394in) Dia

529. Silica Gel, Technical Grade 40, 6-12 Mesh

530. C18 Silica Gel, Endcapped, 60a, 40-63um

531. D05839

532. D06521

533. D06522

534. D78143

535. Sand, White Quartz, 50-70 Mesh Particle Size

536. Silica, Mesostructured, Msu-f (cellular Foam)

537. Silicon Dioxide Component Of Simethicone

538. Silicon Dioxide, Amorphous Gel, 15% In Water

539. Silicon Dioxide, Amorphous Gel, 40% In Water

540. Silicon(iv) Oxide, 99.999% (metals Basis)

541. Celite(r) 209, Filter Aid, Natural, Untreated

542. Celite(r) Analytical Filter Aid Ii (cafa Ii)

543. Glass Sand, Nist(r) Srm(r) 165a, Low Iron

544. Silica Gel Spherical, 75-200 Mum Particle Size

545. Silica Gel, Davisil(r) Grade 922, -200 Mesh

546. Silica Gel, Large Pore, P.vol. Ca. 1.65cc/g

547. Silicon Oxide (silica, Silicon Dioxide, Quartz)

548. Silicon Oxide Powder, 99.5% Nano, 15-20 Nm

549. Diatomaceous Earth, Calcined, Filter Aid, Calcined

550. Q116269

551. Sand For Sand Sieve Analysis, Nist(r) Rm 8010

552. Silica Gel, Gf254, For Thin Layer Chromatography

553. Silica Gel, Hf254, For Thin Layer Chromatography

554. Silica Gel, Type Iii, Indicating, For Desiccation

555. Silica Standard: Sio2 @ 100 Microg/ml In H2o

556. Silica Standard: Sio2 @ 1000 Microg/ml In H2o

557. Silica, Mesostructured, Mcm-41 Type (hexagonal)

558. Silicon Dioxide, Purum P.a., Acid Purified, Sand

559. Standard Super Cel(r) Fine, Filter Aid, Calcined

560. Celite(r) 500 Fine, Filter Aid, Dried, Untreated

561. Collodial Silica In Aqueous Solution (nanoparticles)

562. Glass Sand, Nist(r) Srm(r) 1413, High Alumina

563. J-002874

564. Sand, White Quartz, >=99.995% Trace Metals Basis

565. Silica Gel, Large Pore, P.v. Ca. 1cc/g, 8 Mesh

566. Silica Gel, Technical Grade, 1-3 Mm Particle Size

567. Silica Gel, Technical Grade, 3-6 Mm Particle Size

568. Silica Gel, With Moisture Indicator (blue), Coarse

569. Celpure(r) P65, Meets Usp/nf Testing Specifications

570. Metal Scavenging Agent, Mercaptopropyl Modified Silica

571. Micro Particles Based On Silicon Dioxide, Size: 2 Mum

572. Micro Particles Based On Silicon Dioxide, Size: 3 Mum

573. Micro Particles Based On Silicon Dioxide, Size: 4 Mum

574. Micro Particles Based On Silicon Dioxide, Size: 5 Mum

575. Quartz Lid For 30ml Quartz Crucible, Fused, Id 48mm

576. Silica Gel Desiccant, Indicating, <1% Cobalt Chloride

577. Silica Gel, -60-120 Mesh, For Column Chromatography

578. Silicon(iv) Oxide, 15% In H2o, Colloidal Dispersion

579. Silicon(iv) Oxide, 30% In H2o, Colloidal Dispersion

580. Silicon(iv) Oxide, 50% In H2o, Colloidal Dispersion

581. Celpure(r) P100, Meets Usp/nf Testing Specifications

582. Celpure(r) P1000, Meets Usp/nf Testing Specifications

583. Celpure(r) P300, Meets Usp/nf Testing Specifications

584. Micro Particles Based On Silicon Dioxide, Size: 0.5 Mum

585. Micro Particles Based On Silicon Dioxide, Size: 1.0 Mum

586. Silica Dispersion (sio2, Aqueous Dispersion, Amorphous)

587. Silica Gel 60, 0.032-0.063mm (230-450 Mesh)

588. Silica Gel 60, 0.036-0.071mm (215-400 Mesh)

589. Silica Gel 60, 0.040-0.063mm (230-400 Mesh)

590. Silica Gel Desiccant, Indicating, -6+16 Mesh Granules

591. Silica Gel, With Moisture Indicator (blue), -6-20 Mesh

592. Silica, Mesostructured, Msu-h (large Pore 2d Hexagonal)

593. Silica, Mesostructured, Sba-15, 99% Trace Metals Basis

594. Silica, Standard Solution, Specpure?, Sio2 1000?g/ml

595. Silicon Dioxide (silica) Nanodispersion Type A (20nm)

596. Silicon Dioxide (silica) Nanodispersion Type B (20nm)

597. Silicon Dioxide, -325 Mesh, 99.5% Trace Metals Basis

598. Silicon Dioxide, Amorphous, Hexamethyldisilazane Treated

599. Silicon Dioxide, Washed And Calcined, Analytical Reagent

600. Silicon(iv) Oxide, Amorphous Fumed, S.a. 85-115m2/g

601. Zeolite - Mesoporous Silica Nanopowder (sba-15 Type)

602. Chromosorb(r) W, Aw-dmcs, 100-120 Mesh Particle Size

603. Diatomaceous Earth, Calcined, Filter Aid, Slightly Calcined

604. Micro Particles Based On Silicon Dioxide, Size: 0.15 Mum

605. Silica Gel, High-purity Grade (15111), Pore Size 60 ??

606. Silica Slurry (sio2, Purity: 99%, Diameter: 15-20nm)

607. Silica, Mesoporous, 1 Mum Particle Size, Pore Size ~2 Nm

608. Silica, Mesoporous, 1 Mum Particle Size, Pore Size ~4 Nm

609. Silica, Mesoporous, 2 Mum Particle Size, Pore Size ~2 Nm

610. Silica, Mesoporous, 2 Mum Particle Size, Pore Size ~4 Nm

611. Silica, Mesoporous, 3 Mum Particle Size, Pore Size ~2 Nm

612. Silica, Mesoporous, 3 Mum Particle Size, Pore Size ~4 Nm

613. Silica,fumed, Hydrophilic, Specific Surface Area 200 M2/g

614. Silica,fumed, Hydrophilic, Specific Surface Area 400 M2/g

615. Silicon(iv) Oxide, Amorphous Fumed, S.a. 175-225m?/g

616. Silicon(iv) Oxide, Amorphous Fumed, S.a. 300-350m?/g

617. Silicon(iv) Oxide, Amorphous Fumed, S.a. 350-420m2/g

618. Amorphous Silica: Vitreous Silica, Quartz Glass, Fused Silica

619. Diatomaceous Earth, Flux-calcined, Filter Aid, Flux Calcined

620. Ludox(r) Am Colloidal Silica, 30 Wt. % Suspension In H2o

621. Ludox(r) Cl Colloidal Silica, 30 Wt. % Suspension In H2o

622. Ludox(r) Cl-x Colloidal Silica, 45 Wt. % Suspension In H2o

623. Ludox(r) Ls Colloidal Silica, 30 Wt. % Suspension In H2o

624. Ludox(r) Sm Colloidal Silica, 30 Wt. % Suspension In H2o

625. Ludox(r) Tma Colloidal Silica, 34 Wt. % Suspension In H2o

626. Silica Gel Orange, With Moisture Indicator Free Of Heavy Metals

627. Silica Gel, High-purity Grade, Fia According To Din 51791

628. Silica, Mesoporous, 0.5 Mum Particle Size, Pore Size ~2 Nm

629. Silica, Mesoporous, 0.5 Mum Particle Size, Pore Size ~4 Nm

630. Silicon Dioxide, Acid Washed And Calcined, Analytical Reagent

631. Silicon Dioxide, Crystalline (fine), Coating Quality, >=99.9%

632. Chromosorb(r) P, Naw, 60-80 Mesh Particle Size, Bottle Of 100 G

633. Chromosorb(r) W, Aw, 80-100 Mesh Particle Size, Bottle Of 100 G

634. Chromosorb(r) W, Hp, 60-80 Mesh Particle Size, Bottle Of 100 G

635. Diatomaceous Earth, Calcined, Powder, Suitable For Most Filtrations

636. Ludox(r) As-30 Colloidal Silica, 30 Wt. % Suspension In H2o

637. Ludox(r) As-40 Colloidal Silica, 40 Wt. % Suspension In H2o

638. Ludox(r) Hs-30 Colloidal Silica, 30 Wt. % Suspension In H2o

639. Ludox(r) Hs-40 Colloidal Silica, 40 Wt. % Suspension In H2o

640. Ludox(r) Tm-40 Colloidal Silica, 40 Wt. % Suspension In H2o

641. Ludox(r) Tm-50 Colloidal Silica, 50 Wt. % Suspension In H2o

642. Quartz Optical Window, 25.4mm (1.0in) Dia X 1mm (0.04in) Thick

643. Quartz Optical Window, 25.4mm (1.0in) Dia X 2mm (0.08in) Thick

644. Silica Gel, Davisil(r) Grade 22, Pore Size 60 ??, 60-200 Mesh

645. Silica Gel, High-purity Grade, 60??, 35-60 Mesh Particle Size

646. Silica Gel, High-purity Grade, Pore Size 60 ??, 70-230 Mesh

647. Silica Gel, Hplc Grade, Spherical, 3 Micron Aps, 120 Angstroms

648. Silica Gel, Hplc Grade, Spherical, 3 Micron Aps, 70 Angstroms

649. Silica Gel, Technical Grade (w/ Fluorescent Indicator), 60 F254

650. Silica Gel, Type H, Without Binder, For Thin Layer Chromatography

651. Silica Gel, Type Ii, 3.5 Mm Bead Size, Suitable For Desiccation

652. Silica, Fumed, Powder, 0.2-0.3 Mum Avg. Part. Size (aggregate)

653. Silicon Dioxide Dispersion (sio2, Aqueous Dispersion, Amorphous)

654. Silicon Dioxide, For Cleaning Of Platinum Crucibles, Calcined, Crude

655. Silicon Dioxide, Fused (pieces), 4 Mm, 99.99% Trace Metals Basis

656. Silicon Oxide, Catalyst Support, High Surface Area, S.a.250m2/g

657. Silicon(iv) Oxide, 99+%, 0.012 Micron (fumed Colloidal Silica)

658. Silicon(iv) Oxide, 99.5% (metals Basis) , -325 Mesh Powder

659. Zeolite - Mesoporous Silica Nanopowder (1d-hexagonal Sba-41 Type)

660. Zeolite - Mesoporous Silica Nanopowder (3d-cubic Mcm-48 Type)

661. Celatom(r), Acid-washed, For Use In Total Dietary Fiber Assay, Tdf-100a

662. Chromosorb(r) G, Hp, 100-120 Mesh Particle Size, Bottle Of 100 G

663. Chromosorb(r) P, Aw-dmcs, 80-100 Mesh Particle Size, Bottle Of 100 G

664. Chromosorb(r) W, Aw, 100-120 Mesh Particle Size, Bottle Of 100 G

665. Chromosorb(r) W, Hp, 100-120 Mesh Particle Size, Bottle Of 100 G

666. Nbs 28 (silicon And Oxygen Isotopes In Silica Sand), Nist(r) Rm 8546

667. Quartz Disc, Fused, 50.8mm (2.0in) Dia X 1.59mm (0.06in) Thick

668. Quartz Disc, Fused, 50.8mm (2.0in) Dia X 3.18mm (0.13in) Thick

669. Quartz Disc, Fused, 76.2 (3.0 In) Dia X 3.18mm (0.13in) Thick

670. Quartz Disc, Fused, 76.2mm (3.0in) Dia X 1.59mm (0.06in) Thick

671. Quartz Microscope Slide, Fused, 25.4x25.4x1.0mm (1.0x1.0x0.0394in)

672. Quartz Microscope Slide, Fused, 50.8x25.4x1.0mm (2.0x1.0x0.0394in)

673. Quartz Microscope Slide, Fused, 76.2x25.4x1.0mm (3.0x1.0x0.0394in)

674. Silica Gel 60, 0.105-0.2mm (70-150 Mesh), S.a. 500-600m2/g

675. Silica Gel, High Purity, 90??, 35-70 Mesh, For Column Chromatography

676. Silica Gel, High-purity Grade (7734), Pore Size 60 ??, 70-230 Mesh

677. Silica Gel, High-purity Grade (7754), Pore Size 60 ??, 70-230 Mesh

678. Silica Gel, High-purity Grade, 40, >=400 Mesh, For Column Chromatography

679. Silica Gel, High-purity Grade, 40, 35-70 Mesh, For Column Chromatography

680. Silica Gel, High-purity Grade, 40, 70-230 Mesh, For Column Chromatography

681. Silica Gel, High-purity Grade, 90??, 15-25 Mum, For Column Chromatography

682. Silica Gel, High-purity Grade, Pore Size 40 ??, 35-70 Mesh Particle Size

683. Silica Gel, High-purity Grade, Pore Size 60 ??, >=400 Mesh Particle Size

684. Silica Gel, Technical Grade, Pore Size 60 ??, 200-425 Mesh Particle Size

685. Silica Gel, Technical Grade, Pore Size 60 ??, 70-230 Mesh, 63-200 Mum

686. Silica Nanoparticles Dispersion (sio2, Purity: 99.9%, Diameter: 50-80nm)

687. Silica, Nanoparticles, Mesoporous, 200 Nm Particle Size, Pore Size 4 Nm

688. Silicon Dioxide, ~99%, 0.5 - 10 Um (approx. 80% Between 1-5 Um)

689. Silicon Dioxide, ~99%, 0.5-10 Mum (approx. 80% Between 1-5 Mum)

690. Silicon Dioxide, Amorphous, Cyclic Azasilane/hexamethyldisilazane Treated

691. Silicon Dioxide, Fused (granular), 4-20 Mesh, 99.9% Trace Metals Basis

692. Silicon Oxide Hollow Nanospheressilicon Dioxide Nanospheres Properties

693. Silicone Sol(sio2, Purity: >99.9%, Diameter: 12nm, Solvent: Methanol)

694. Silicone Sol(sio2, Purity: >99.9%, Diameter: 12nm, Solvent: Toluene)

695. Silicone Sol(sio2, Purity: >99.9%, Diameter: 22nm, Solvent: Methanol)

696. Silicone Sol(sio2, Purity: >99.9%, Diameter: 45nm, Solvent: Methanol)

697. Diatomaceous Earth, Flux-calcined, Filter Aid, Flux Calcined, Treated With Sodium Carbonate

698. Diatomaceous Earth, Flux-calcined, Filter Aid, Treated With Sodium Carbonate, Calcined

699. Hollow Silica Nanospheres Dispersion (sio2, Purity: >99.9%, Diameter: 80-100nm)

700. Nano Silica Water Dispersion (sio2, Purity: >99.9%, Diameter: 10nm, 20 Wt.%)

701. Nano Silica Water Dispersion (sio2, Purity: >99.9%, Diameter: 10nm, 25 Wt.%)

702. Nano Silica Water Dispersion (sio2, Purity: >99.9%, Diameter: 10nm, 30 Wt.%)

703. Nano Silica Water Dispersion (sio2, Purity: >99.9%, Diameter: 15nm, 20 Wt.%)

704. Nano Silica Water Dispersion (sio2, Purity: >99.9%, Diameter: 15nm, 25 Wt.%)

705. Nano Silica Water Dispersion (sio2, Purity: >99.9%, Diameter: 15nm, 30 Wt.%)

706. Silica Gel 60 Adamant(tm) On Tlc Plates, With Fluorescence Indicator 254 Nm

707. Silica Gel 60, 0.019-0.037mm (400-600 Mesh), S.a. 500-600m2/g

708. Silica Gel 60, 0.062-0.105mm (150-230 Mesh), S.a. 500-600m2/g

709. Silica Gel, Davisil(r) Grade 710, Pore Size 50-76 ??, For Thin Layer Chromatography

710. Silica Gel, High-purity Grade (10180), Pore Size 40 ??, 70-230 Mesh Particle Size

711. Silica Gel, High-purity Grade (9385), Pore Size 60 ??, 230-400 Mesh Particle Size

712. Silica Gel, High-purity Grade (davisil Grade 12), Pore Size 22 ??, 28-200 Mesh

713. Silica Gel, High-purity Grade (davisil Grade 62), Pore Size 150 ??, 60-200 Mesh

714. Silica Gel, High-purity Grade (davisil Grade 635), Pore Size 60 ??, 60-100 Mesh

715. Silica Gel, High-purity Grade (davisil Grade 643), Pore Size 150 ??, 200-425 Mesh

716. Silica Gel, High-purity Grade (davisil Grade 646), 35-60 Mesh, Pore Size 150 ??

717. Silica Gel, High-purity Grade (davisil Grade 923), Pore Size 30 ??, 100-200 Mesh

718. Silica Gel, High-purity Grade, 100??, 200-400 Mesh, For Preparative Liquid Chromatography

719. Silica Gel, High-purity Grade, 40??, 230-400 Mesh, For Preparative Liquid Chromatography

720. Silica Gel, High-purity Grade, 60??, Gypsum ~13 %, For Preparative Liquid Chromatography

721. Silica Gel, High-purity Grade, 90??, 70-230 Mesh, For Column Chromatography

722. Silica Gel, High-purity Grade, For Thin Layer Chromatography, H, Without Calcium Sulfate

723. Silica Gel, High-purity Grade, Pore Size 60 ??, 130-270 Mesh, For Column Chromatography

724. Silica Gel, High-purity Grade, Pore Size 60 ??, 200-400 Mesh Particle Size

725. Silica Gel, High-purity Grade, Type G, 5-15 Mum, For Thin Layer Chromatography

726. Silica Gel, Preparative Chromatography Grade, Spherical, 10 Micron Aps, 60 Angstroms

727. Silica Gel, Preparative Chromatography Grade, Spherical, 15 Micron Aps, 120 Angstroms

728. Silica Gel, Preparative Chromatography Grade, Spherical, 15 Micron Aps, 60 Angstroms

729. Silica Gel, Preparative Chromatography Grade, Spherical, 50 Micron Aps, 60 Angstroms

730. Silica Gel, Preparative Chromatography Grade, Spherical, 7.5 Micron Aps, 120 Angstroms

731. Silica Gel, Wide Pore, 150 Angstroms, -100+200 Mesh, S.a. 350-400m2/g

732. Silica Nanosprings Tm Coated With Zinc Oxide And Grown On Fiber Glass Substrate (3.5 X 8cm)

733. Silica, Mesoporous Mcm-48, 15 Mum Particle Size, Pore Size 3 Nm, Cubic Pore Morphology

734. Silica, Mesoporous Sba-16, <150 Mum Particle Size, Pore Size 5 Nm, Cubic Pore Morphology

735. Silica, Nanopowder, Spec. Surface Area 175-225 M2/g (bet), 99.8% Trace Metals Basis

736. Silicon Dioxide, Nanopowder, 10-20 Nm Particle Size (bet), 99.5% Trace Metals Basis

737. Silicon(iv) Oxide Sputtering Target, 50.8mm (2.0in) Dia X 3.18mm (0.125in) Thick

738. Silicon(iv) Oxide Sputtering Target, 50.8mm (2.0in) Dia X 6.35mm (0.250in) Thick

739. Silicon(iv) Oxide Sputtering Target, 76.2mm (3.0in) Dia X 3.18mm (0.125in) Thick

740. Silicon(iv) Oxide Sputtering Target, 76.2mm (3.0in) Dia X 6.35mm (0.250in) Thick

741. Silicon(iv) Oxide, 40% In H20, Colloidal Dispersion, 0.02 Micron Particles

742. Silicon(iv) Oxide, Amorphous Fumed, Surface Treated, S.a. 105-130m2/g, -325 Mesh

743. Silicon(iv) Oxide, Amorphous Fumed, Surface Treated, S.a. 105-145m2/g, -325 Mesh

744. Silicon(iv) Oxide, Amorphous Fumed, Surface Treated, S.a. 205-245m2/g, -325 Mesh

745. Silicone Sol(sio2, Purity: >99.9%, Diameter: 12nm(lock), Solvent: Isopropyl Alcohol)

746. Silicone Sol(sio2, Purity: >99.9%, Diameter: 12nm(lock), Solvent: Methyl Ethyl Ketone)

747. Silicone Sol(sio2, Purity: >99.9%, Diameter: 12nm, Solvent: Dimethylacetamide)

748. Silicone Sol(sio2, Purity: >99.9%, Diameter: 12nm, Solvent: Ethyl Acetate)

749. Silicone Sol(sio2, Purity: >99.9%, Diameter: 12nm, Solvent: Isopropyl Alcohol)

750. Silicone Sol(sio2, Purity: >99.9%, Diameter: 12nm, Solvent: Methyl Ethyl Ketone,30 Wt.%)

751. Silicone Sol(sio2, Purity: >99.9%, Diameter: 12nm, Solvent: Methyl Ethyl Ketone,35 Wt.%)

752. Silicone Sol(sio2, Purity: >99.9%, Diameter: 12nm, Solvent: Methyl Ethyl Ketone,40 Wt.%)

753. Silicone Sol(sio2, Purity: >99.9%, Diameter: 12nm, Solvent: Methyl Ethyl Ketone,45 Wt.%)

754. Silicone Sol(sio2, Purity: >99.9%, Diameter: 12nm, Solvent: N-methylpyrrolidone)

755. Silicone Sol(sio2, Purity: >99.9%, Diameter: 22nm, Solvent: Cyclohexanone)

756. Silicone Sol(sio2, Purity: >99.9%, Diameter: 45nm, Solvent: Ethylene Glycol)

757. Silicone Sol(sio2, Purity: >99.9%, Diameter: 45nm, Solvent: Isopropyl Alcohol)

758. Silicone Sol(sio2, Purity: >99.9%, Diameter: 80nm, Solvent: Dimethylacetamide)

759. Silicone Sol(sio2, Purity: >99.9%, Diameter: 80nm, Solvent: Ethyl Acetate)

760. Silicone Sol(sio2, Purity: >99.9%, Diameter: 80nm, Solvent: Isopropyl Alcohol)

761. Diatomaceous Earth, Flux-calcined, Filter Aid, Acid Washed, Treated With Sodium Carbonate, Flux Calcined

762. Respirable Alpha-quartz, Nist(r) Srm(r) 1878b, Quantitative X-ray Powder Diffraction Standard

763. Silica Gel - Technical Grade, 230-400 Mesh Particle Size, 40-63

764. M Particle Size, Pore Size 60+

765. Silica Gel 60, With Fluorescent Indicator, 0.060-0.2mm (70-230 Mesh), -70+230 Mesh Powder, S.a. 500-600m2/g

766. Silica Gel High-purity Grade, Pore Size 60 ?, 230-400 Mesh Particle Size, 40-63 ?m Particle Size

767. Silica Gel, 30 Mum Particle Size (average), Average Pore Diameter 60 ??, Suitable For Normal-phase Adsorption-partition Chromatography

768. Silica Gel, Emd Millipore, Tlc Grade (11695), 15 Mum, Pore Size 60 ??, With Silica/alumina Binder

769. Silica Gel, High-purity Grade (7749), With Gypsum Binder And Fluorescent Indicator, For Thin Layer Chromatography

770. Silica Gel, High-purity Grade (davisil Grade 633), Pore Size 60 ??, 200-425 Mesh Particle Size

771. Silica Gel, High-purity Grade (davisil Grade 636), Pore Size 60 ??, 35-60 Mesh Particle Size

772. Silica Gel, High-purity Grade (puriss), Pore Size 60 ??, 70-230 Mesh, For Column Chromatography

773. Silica Gel, High-purity Grade (w/ Ca, ~0.1%), Pore Size 60 ??, 230-400 Mesh Particle Size

774. Silica Gel, High-purity Grade, Hf254, Without Calcium Sulfate, With Fluorescent Indicator, For Thin Layer Chromatography

775. Silica Gel, High-purity Grade, Pore Size 60 ??, 2-25 Mum Particle Size, Without Binder, Pore Volume 0.75 Cm3/g, For Thin Layer Chromatography

776. Silica Gel, High-purity Grade, Pore Size 60 ??, 2-25 Mum Particle Size, Without Binder, With Fluorescent Indicator, Pore Volume 0.75 Cm3/g, For Thin Layer Chromatography

777. Silica Gel, High-purity Grade, Pore Size 60 ??, 220-440 Mesh Particle Size, 35-75 Mum Particle Size, For Flash Chromatography

778. Silica Gel, High-purity Grade, Pore Size 60 ??, 230-400 Mesh Particle Size, 40-63 Mum Particle Size, For Flash Chromatography

779. Silica Gel, High-purity Grade, Pore Size 60 ??, 5-25 Mum Particle Size, Without Binder, For Thin Layer Chromatography

780. Silica Gel, High-purity Grade, Pore Size 60 ??, 70-230 Mesh, 63-200 Mum, For Column Chromatography

781. Silica Gel, High-purity Grade, Type G, With ~13% Calcium Sulfate, For Thin Layer Chromatography

782. Silica Gel, High-purity Grade, With ~15% Calcium Sulfate And Fluorescent Indicator, Gf254, For Thin Layer Chromatography

783. Silica Gel, Hplc Grade, Spherical, 2.2 Micron Aps, 120 Angstroms, 99.99+% , S.a. 340m2/g, P.v. 1.00cc/g

784. Silica Gel, Hplc Grade, Spherical, 2.2 Micron Aps, 80 Angstroms, 99.99+% , S.a. 470m2/g, P.v. 0.95cc/g

785. Silica Gel, Hplc Grade, Spherical, 3 Micron Aps, 260 Angstroms, 99.99+%, S.a. 130m2/g, P.v. 0.90cc/g

786. Silica Gel, Hplc Grade, Spherical, 5 Micron Aps, 120 Angstroms, 99.99+% , S.a. 340m2/g, P.v. 1.00cc/g

787. Silica Gel, Hplc Grade, Spherical, 5 Micron Aps, 260 Angstroms, 99.99+% , S.a. 150m2/g, P.v. 0.90cc/g

788. Silica Gel, Hplc Grade, Spherical, 5 Micron Aps, 70 Angstroms, 99.99+% , S.a. 500m2/g, P.v. 0.95cc/g

789. Silica Gel, Hplc/uhplc Grade, Spherical, 1.6 Micron Aps, 110 Angstroms, 99.99+%, S.a. 340m2/g, P.v. 0.95cc/g

790. Silica Gel, Preparative Chromatography Grade, Spherical, 20 Micron Aps, 100 Angstroms, 99.99+% , S.a. 335m2/g, P.v. 1.00cc/g

791. Silica Gel, Preparative Chromatography Grade, Spherical, 20 Micron Aps, 150 Angstroms, 99.99+%, S.a. 270m2/g, P.v. 1.00cc/g

792. Silica Gel, Preparative Chromatography Grade, Spherical, 20 Micron Aps, 80 Angstroms, 99.99+% , S.a. 515m2/g, P.v. 1.00cc/g

793. Silica Gel, Technical Grade (w/ Ca, ~0.1%), 60??, 230-400 Mesh Particle Size, Ca 0.1-0.3 %

794. Silica Gel, Technical Grade, Pore Size 60 ??, 230-400 Mesh Particle Size, 40-63 Mum Particle Size

795. Silica Gel, Tlc High Purity Grade, With Gypsum Binder & Fluorescent Indicator,12 Micron Aps,s.a. 500-600m2/g,60a,ph 6.5-7.5

796. Silica Gel, Tlc High Purity Grade, With Gypsum Binder, 12 Micron Aps, S.a. 500-600m2/g, 60a, Ph 6-7

797. Silica Gel, Tlc High Purity Grade, Without Binder, 12 Micron Aps, S.a. 500-600m2/g, 60, Ph 6.5-7.5

798. Silica Gel, Tlc High Purity Grade, Without Binder, With Fluorescent Indic., 12 Micron Aps, S.a. 500-600m2/g, 60a, Ph 6.5-7.5

799. Silica Gel, Tlc High-purity Grade, 5-25 Mum, Pore Size 60 ??, With Gypsum Binder And Fluorescent Indicator, Pore Volume 0.75 Cm3/g

800. Silica, Mesoporous Sba-15, <150 Mum Particle Size, Pore Size 4 Nm, Hexagonal Pore Morphology

801. Silica, Mesoporous Sba-15, <150 Mum Particle Size, Pore Size 6 Nm, Hexagonal Pore Morphology

802. Silica, Mesoporous Sba-15, <150 Mum Particle Size, Pore Size 8 Nm, Hexagonal Pore Morphology

803. Silicon Dioxide, Nanopowder (spherical, Porous), 5-15 Nm Particle Size (tem), 99.5% Trace Metals Basis

804. Silicon Dioxide, Single Crystal Substrate, Optical Grade, 99.99% Trace Metals Basis, <0001>, L X W X Thickness 10 Mm X 10 Mm X 0.5 Mm

805. Silicon Oxide, Catalyst Support, High Surface Area, S.a.160m2/g, Total Pore Volume 0.5cc/g, Pore Size 100 And 1000 Angstrom

806. Silicon(iv) Oxide, 40% In Water, Colloidal Dispersion, 0.02 Micron Particles, S.a. 200m 2/g

807. Silicone Sol(sio2, Purity: >99.9%, Diameter: 12nm(lock), Solvent: Propylene Glycol Monopropyl Ether)

808. Silicone Sol(sio2, Purity: >99.9%, Diameter: 12nm, Solvent: Bisphenol F Epoxy Resin,30 Wt.%)

809. Silicone Sol(sio2, Purity: >99.9%, Diameter: 12nm, Solvent: Bisphenol F Epoxy Resin,40 Wt.%)

810. Silicone Sol(sio2, Purity: >99.9%, Diameter: 12nm, Solvent: Ethylene Glycol Monopropyl Ether)

811. Silicone Sol(sio2, Purity: >99.9%, Diameter: 12nm, Solvent: Methyl Isobutyl Ketone,30 Wt.%)

812. Silicone Sol(sio2, Purity: >99.9%, Diameter: 12nm, Solvent: Methyl Isobutyl Ketone,40 Wt.%)

813. Silicone Sol(sio2, Purity: >99.9%, Diameter: 12nm, Solvent: Propylene Glycol Monomethyl Ether,30 Wt.%)

814. Silicone Sol(sio2, Purity: >99.9%, Diameter: 12nm, Solvent: Propylene Glycol Monomethyl Ether,42 Wt.%)

815. Silicone Sol(sio2, Purity: >99.9%, Diameter: 12nm, Solvent: Propylene Glycol Monopropyl Ether)

816. Silicone Sol(sio2, Purity: >99.9%, Diameter: 22nm, Solvent: Propylene Glycol Monomethyl Ether)

817. Silicone Sol(sio2, Purity: >99.9%, Diameter: 45nm, Solvent: Methyl Ethyl Ketone, 30 Wt.%)

818. Silicone Sol(sio2, Purity: >99.9%, Diameter: 45nm, Solvent: Methyl Ethyl Ketone, 40 Wt.%)

819. Silicone Sol(sio2, Purity: >99.9%, Diameter: 45nm, Solvent: Methyl Isobutyl Ketone, 30 Wt.%)

820. Silicone Sol(sio2, Purity: >99.9%, Diameter: 45nm, Solvent: Methyl Isobutyl Ketone, 40 Wt.%)

821. Silicone Sol(sio2, Purity: >99.9%, Diameter: 45nm, Solvent: Propylene Glycol Monomethyl Ether)

822. Silicone Sol(sio2, Purity: >99.9%, Diameter: 80nm, Solvent: Methyl Ethyl Ketone, 30 Wt.%)

823. Silicone Sol(sio2, Purity: >99.9%, Diameter: 80nm, Solvent: Methyl Ethyl Ketone, 40 Wt.%)

824. Silicone Sol(sio2, Purity: >99.9%, Diameter: 80nm, Solvent: Methyl Ethyl Ketone, 45 Wt.%)

825. Silicone Sol(sio2, Purity: >99.9%, Diameter: 80nm, Solvent: Propylene Glycol Monopropyl Ether)

2.4 Create Date
2005-03-27
3 Chemical and Physical Properties
Molecular Weight 60.084 g/mol
Molecular Formula O2Si
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count2
Rotatable Bond Count0
Exact Mass59.966755773 g/mol
Monoisotopic Mass59.966755773 g/mol
Topological Polar Surface Area34.1 Ų
Heavy Atom Count3
Formal Charge0
Complexity18.3
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Therapeutic Uses

/Exptl Ther/ Previous in vitro studies showing that bioactive glasses support the growth and maturation of rat osteoblast-like cells and promote the expression and maintenance of the osteoblastic phenotype have suggested that there is both a solution-mediated and a surface-controlled effect on cell activity. This study investigated the behavior of human primary osteoblast-like cells cultured in contact with three different bioactive glasses and compared them with amorphous silica (SiO2) used in the form of granules. Osteoblasts synthesize collagen type I, which is subsequently mineralized. Immunoblot and biochemical studies showed increased collagen release from osteoblast-like cells cultured in contact with bioactive glasses over that of controls. Among the three bioactive glasses, 45S5 is the highest inducer of osteoblast-like cell collagen release; moreover, mRNA for type I collagen was stimulated approximately three- to fivefold after 45S5 treatment. 77S bioactive glass similarly increased type I collagen synthesis even though alkaline phosphatase was not higher. These results suggest that 45S5 Bioglass not only induces osteogenic differentiation of human primary osteoblast-like cells, but can also increase collagen synthesis and release. The newly formulated bioactive gel-glass 77S seems to have potential applications for tissue engineering, inducing increased collagen synthesis.

Bosetti M et al; J Biomed Mater Res 64 A(1): 189-95 (2003)


5 Pharmacology and Biochemistry
5.1 Absorption, Distribution and Excretion

...Rats /were exposed/ by inhalation to... silica (particle size 0.5 to 5 m) in the form of Belgian glass sand for periods ranging from 0.5 to 40 hr. The initial deposition of silica was highest in the tracheobronchial ciliated air passages; it also was seen throughout the acini, where the extent of deposition decreased as the respiratory airways proceeded distally. The distribution of particles was not uniform between the different acini, and, 2 to 3 months following cessation of exposure, aggregates were formed, primarily in the proximal alveolar ducts but also in the distal portion of the acini.

USEPA; Ambient Levels and Noncancer Health Effects of Inhaled Crystalline and Amorphous Silica: Health Issue Assessment p. 4-5 (1996) EPA/600/R-95/115


Inhalation studies with rats... indicate that the long-term clearance of quartz after inhalation is slow and biphasic, whereas amorphous silica dusts are cleared more rapidly. The absolute amount of silica dust eliminated increased with lung burden, but the efficiency of the elimination was either constant or decreased with time. ...The half-life lung clearance of rats exposed via inhalation to an amorphous silica suspension (Ludox ) at concentrations up to 150 mg/cu m was about 50 days.

USEPA; Ambient Levels and Noncancer Health Effects of Inhaled Crystalline and Amorphous Silica: Health Issue Assessment p. 4-5 (1996) EPA/600/R-95/115


A study /in (1983)/, showed that the total silica content in the lungs of guinea pigs exposed by inhalation for up to 2 years to a cristobalite sample or to amorphous silica (at dust concentrations of 150 mg/cu m or 100 mg/cu m , respectively) increased linearly over 21 months, without evidence that lung retention rates changed with time. ...The maximum lung content of cristobalite was only 68 mg/lung, whereas that of amorphous silica was 120 mg/lung. The total amount of accumulated silica varied inversely with the degree of pulmonary damage. /It was/ suggested that silica dust producing cell damage may be more efficiently cleared from the lung than are the less toxic amorphous forms. However, this difference also could be due to different rates of deposition for the two dust forms. The cristobalite sample, which was 45% cristobalite and 55% diatomaceous earth, was significantly coarser (and less likely to deposit in the lungs) than the amorphous silica, which contained 100% diatomaceous earth. Also, tissue changes induced by cristobalite could have altered particle deposition.

USEPA; Ambient Levels and Noncancer Health Effects of Inhaled Crystalline and Amorphous Silica: Health Issue Assessment p. 4-5 (1996) EPA/600/R-95/115


In a long-term inhalation study with guinea pigs, ...the amount of silica retained as a result of 8-hr/day exposures to amorphous silica (Hi-Sil 233) /was compared/ with that retained during inhalation of quartz dust for a comparable 12-month period. Guinea pigs that inhaled quartz dust at a concentration of 106 mg/cu m retained between 500 and 600 mg of silica, whereas <10 mg of dust was retained in those that inhaled 126 mg/cu m of amorphous silica. After 12 months of exposure, the relative silica content (silica mass/lung mass) decreased in guinea pigs exposed to quartz dust, but continued to increase slowly in the animals exposed to the amorphous silica. This difference was explained by an increasing nonsiliceous materials content (e.g., collagen, minerals) in the lungs of the quartz-exposed animals associated with the progressive deposition of fibrous tissue in the lungs. Six months after cessation of exposure, the silica content of the lungs of Hi-Sil 233-exposed animals was similar to that of untreated controls. This lack of accumulation may be due, in large part, to the higher solubility of amorphous silica compared to quartz... . By comparison, the elimination of silica from the quartz-exposed guinea pigs was negligible, and the silicotic lesions continued to progress during this elimination phase.

USEPA; Ambient Levels and Noncancer Health Effects of Inhaled Crystalline and Amorphous Silica: Health Issue Assessment p. 4-6 (1996) EPA/600/R-95/115


For more Absorption, Distribution and Excretion (Complete) data for AMORPHOUS SILICA (6 total), please visit the HSDB record page.


Rats were exposed for 6 hr/day, on 5 days/week, for up to 13 weeks to 3 mg/cu m crystalline... Lung burdens were 819... ug for crystalline...

PMID:10911000 Johnston CJ et al; Toxicol Sci 56 (2): 405-13 (2000)


Deposition of particles in the respiratory bronchioles and proximal alveoli results in slow clearance, interaction with macrophages and a greater likelihood of lung injury. This contrasts with deposition on the conducting airways where the majority of the particles are cleared by the mucociliary escalator. Therefore, quartz particles with an aerodynamic diameter below 10 um are likely to be the most harmful to humans.

IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work). Available at: https://monographs.iarc.fr/ENG/Classification/index.php, p. V68 (1997) 176


There are few data on human lung quartz-dust burdens that allow conclusions to be drawn about deposition or clearance. However, quartz is found in the bronchoalveolar macrophages and sputum of silicotic patients. Also, at autopsy, there is wide variation in the masses and proportions of quartz retained in the lung. For example... 25-264 mg /were reported/ per single lung at autopsy in hard-rock miners with 14-36 years of exposure; these miners had variable amounts of pathological response but there was not a good correlation between lung crystalline quartz content and pathological score. The well-documented effect of smoking on clearance is a further confounding factor in drawing conclusions about clearance kinetics in humans.

IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work). Available at: https://monographs.iarc.fr/ENG/Classification/index.php, p. V68 (1997) 176


The physico-chemical changes in quartz that result from residence in the lung could be an important factor in determining the continuing toxicity of quartz to the lung following deposition. As a response to the rejection of the 'mechanical model' of silicosis, which had propounded that any particle with 'sharp or jagged edges' might injure tissue, a solubility theory of silicosis was proposed. The solubility theory was based on the release from silica of silicic acid, which was considered to be a 'protoplasmic poison.' In fact very little dissolution occurs; for example, 9 mg SiO2 (0.45%) was released from 2 g crystalline silica placed in ascitic fluid for two weeks. Current theories no longer consider that the dissolution of quartz contributes substantially to its clearance or to changes in its biological activity. Indeed there is evidence of enrichment of crystalline silica in lungs of individuals exposed to hard rock compared to the dust in the air they breathed, suggesting that crystalline silica is less-efficiently cleared, either by dissolution or mechanical clearance, than the non-silica mineral components of the dust... biopersistence was assessed in occupationally exposed subjects by counting silica particles in bronchoalveolar lavage (BAL) fluid after varying periods of time since their last occupational exposure. Crystalline silica was found to be among the most biopersistent of non-fibrous mineral particles.

IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work). Available at: https://monographs.iarc.fr/ENG/Classification/index.php, p. V68 (1997) 176


For more Absorption, Distribution and Excretion (Complete) data for CRYSTALLINE SILICA (17 total), please visit the HSDB record page.


5.2 Mechanism of Action

...Some quartz and cristobalite dusts (crystalline) as well as the diatomaceous earths (amorphous), but not the pyrogenic amorphous silica, were cytotoxic and induced morphological transformation of SHE cells in a concentration-dependent manner. The ranking in cytotoxicity was different from that in transforming potency, suggesting two separate molecular mechanisms for the two effects. The cytotoxic and transforming potencies were different from one dust to another, even among the same structural silicas. The type of crystalline structure (quartz vs cristobalite) and the crystalline vs biogenic amorphous form did not correlate with cytotoxic or transforming potency of silica dusts. Comparison of cellular effects induced by original and surface modified samples revealed that several surface functionalities modulate cytotoxic and transforming potencies. The cytotoxic effects appeared to be related to the distribution and abundance of silanol groups and to the presence of trace amounts of iron on the silica surface. Silica particles with fractured surfaces and/or iron-active sites, able to generate reactive oxygen species, induced SHE cell transformation. The results show that the activity of silica at the cellular level is sensitive to the composition and structure of surface functionalities and confirm that the biological response to silica is a surface originated phenomenon.

PMID:11876495 Merget R et al; Arch Toxicol 75: 625-34 (2002)


In vivo exposure of rat lungs to crystalline silica either by intratracheal instillation or by inhalation results in an increase in mRNA levels for inducible nitric oxide synthase (iNOS) in bronchoalveolar lavage cells (BALC), elevated nitric oxide (.NO) production by BALC, and an increase in .NO-dependent chemiluminescence (CL) from alveolar macrophages (AM). Induction of iNOS message occurs in both AM and polymorphonuclear leukocytes (PMN) harvested from silica-exposed lungs but is not significantly elevated in lavaged lung tissue.

PMID:9788892 Full text: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1533358 Castranova V et al; Environ Health Perspect 106 (Suppl 5): 1165-9 (1998)


This review presents characteristics of simple and complicated coal workers' pneumoconiosis (CWP) as well as pathologic indices of acute and chronic silicosis by summarizing results of in vitro, animal, and human investigations. These results support four basic mechanisms in the etiology of CWP and silicosis: a) direct cytotoxicity of coal dust or silica, resulting in lung cell damage, release of lipases and proteases, and eventual lung scarring; b) activation of oxidant production by pulmonary phagocytes, which overwhelms the antioxidant defenses and leads to lipid peroxidation, protein nitrosation, cell injury, and lung scarring; c) activation of mediator release from alveolar macrophages and epithelial cells, which leads to recruitment of polymorphonuclear leukocytes and macrophages, resulting in the production of proinflammatory cytokines and reactive species and in further lung injury and scarring; d) secretion of growth factors from alveolar macrophages and epithelial cells, stimulating fibroblast proliferation and eventual scarring. Results of in vitro and animal studies provide a basis for proposing these mechanisms for the initiation and progression of pneumoconiosis. Data obtained from exposed workers lend support to these mechanisms.

Castranova V and Vallyathan V Environ Health Perspect 108 (Suppl 4): 675-84 (2000)


/The authors/ reported previously that freshly fractured silica (FFSi) induces activator protein-1 (AP-1) activation through extracellular signal-regulated protein kinases (ERKs) and p38 kinase pathways. In the present study, the biologic activities of FFSi and aged silica (ASi) were compared by measuring their effects on the AP-1 activation and phosphorylation of ERKs and p38 kinase. The roles of reactive oxygen species (ROS) in this silica-induced AP-1 activation were also investigated. FFSi-induced AP-1 activation was four times higher than that of ASi in JB6 cells. FFSi also caused greater phosphorylation of ERKs and p38 kinase than ASi. FFSi generated more ROS than ASi when incubated with the cells as measured by electron spin resonance (ESR). Studies using ROS-sensitive dyes and oxygen consumption support the conclusion that ROS are generated by silica-treated cells. N-Acetylcysteine (an antioxidant) and polyvinyl pyridine-N-oxide (an agent that binds to Si-OH groups on silica surfaces) decreased AP-1 activation and phosphorylation of ERKs and p38 kinase. Catalase inhibited phosphorylation of ERKs and p38 kinase, as well as AP-1 activation induced by FFSi, suggesting the involvement of H2O2 in the mechanism of silica-induced AP-1 activation. Sodium formate (an OH /radical/ scavenger) had no influence on silica-induced MAPKs or AP-1 activation. Superoxide dismutase enhanced both AP-1 and MAPKs activation, indicating that H2O2, but not O2, may play a critical role in silica-induced AP-1 activation. These studies indicate that freshly ground silica is more biologically active than aged silica and that ROS, in particular H2O2, play a significant role in silica-induced AP-1 activation.

PMID:11096084 Ding M et al; J Biol Chem 276 (12): 9108-14 (2001)


/The authors/ examined the involvement of oxidative stress and reactive oxygen species formation in silica-induced cytotoxicity and genotoxicity in cultured rat /alveolar macrophages/ AMs. A lucigenin-dependent chemiluminescence test was used to determine superoxide anion... and a 2',7'-dichlorofluorescin diacetate fluorescence test was employed to measure the hydrogen peroxide (H2O2) level. The cytotoxic and genotoxic effects caused by silica in AMs were examined by lactate dehydrogenase (LDH) leakage and single-cell gel electrophoresis (comet assay), respectively. The results showed that silica enhanced superoxide and H2O2 formation in AMs. There were clear dose- and time-dependent relationships in silica-induced cytotoxicity and genotoxicity. Furthermore, superoxide dismutase and catalase were able to reduce silica-induced LDH leakage and DNA damage, with concurrent significant inhibition on silica-induced oxidative stress in AMs. These findings provide convincing evidence that oxidative stress mediates the silica-induced cytotoxicity and genotoxicity.

PMID:10702332 Zhang S et al; Environ Res 82 (3): 245-52 (2000)


For more Mechanism of Action (Complete) data for CRYSTALLINE SILICA (32 total), please visit the HSDB record page.


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