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Omeprazole Magnesium

Synopsis, Chemistry

APIs // Active Pharmaceutical Ingredients

31 API Suppliers, 15 USDMF, 9 CEP/COS, 13 EU WC, 9 NDC API, 15 Listed Suppliers

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12 Drug(s) in Development

12 Drug(s) in Development

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DOSSIERs // Finished Dosage Formulations

33 Dossiers, 12 FDA Orange Book, 7 Europe, 13 Canada, 1 Listed Dossiers

DRUG PRODUCT COMPOSITION

TABLET, DELAYED RELEASE;ORAL - EQ 20MG BASE, FOR SUSPENSION, DELAYED RELEASE;ORAL - EQ 10MG BASE/PACKET, FOR SUSPENSION, DELAYED RELEASE;ORAL - EQ 2.5MG BASE/PACKET

TABLET, DELAYED RELEASE;ORAL - EQ 20MG BASE
FOR SUSPENSION, DELAYED RELEASE;ORAL - EQ 10MG BASE/PACKET
FOR SUSPENSION, DELAYED RELEASE;ORAL - EQ 2.5MG BASE/PACKET

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GLOBAL SALES INFORMATION

7 US Medicaid Prescriptions, 1 Finished Drug Prices

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2 APIs, 1 DOSSIERS // FDF

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Also known as: Omeprazole magnesium, 95382-33-5, Magnesium;6-methoxy-2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl]-1h-benzimidazole

Molecular Formula

C₃₄H₃₈MgN₆O₆S₂+₂

Molecular Weight

715.1 g/mol

InChI Key

ZAUIQBMEUIXDRJ-UHFFFAOYSA-N

A 4-methoxy-3,5-dimethylpyridyl, 5-methoxybenzimidazole derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits an H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS.

1 2D Structure

Omeprazole Magnesium

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

magnesium;6-methoxy-2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl]-1H-benzimidazole

2.1.2 InChI

InChI=1S/2C17H19N3O3S.Mg/c2*1-10-8-18-15(11(2)16(10)23-4)9-24(21)17-19-13-6-5-12(22-3)7-14(13)20-17;/h2*5-8H,9H2,1-4H3,(H,19,20);/q;;+2

2.1.3 InChI Key

ZAUIQBMEUIXDRJ-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CC1=CN=C(C(=C1OC)C)CS(=O)C2=NC3=C(N2)C=C(C=C3)OC.CC1=CN=C(C(=C1OC)C)CS(=O)C2=NC3=C(N2)C=C(C=C3)OC.[Mg+2]

2.2 Synonyms

2.2.1 MeSH Synonyms

1. H 168 68

2. H 168-68

3. H 16868

4. Magnesium, Omeprazole

5. Omeprazole

6. Omeprazole Magnesium

7. Omeprazole Sodium

8. Prilosec

9. Sodium, Omeprazole

2.2.2 Depositor-Supplied Synonyms

1. Omeprazole Magnesium

2. 95382-33-5

3. Magnesium;6-methoxy-2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl]-1h-benzimidazole

2.3 Create Date

2005-08-09

3 Chemical and Physical Properties

Molecular Formula	C₃₄H₃₈MgN₆O₆S₂+₂
Molecular Weight	715.1 g/mol
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	12
Rotatable Bond Count	10
Exact Mass	714.2144670 g/mol
Monoisotopic Mass	714.2144670 g/mol
Topological Polar Surface Area	193 Å²
Heavy Atom Count	49
Formal Charge	2
Complexity	453
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	2
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	3

4 Drug and Medication Information

4.1 Drug Information

1 of 2
Drug Name	Omeprazole magnesium
Drug Label	11 DESCRIPTIONThe active ingredient in PRILOSEC (omeprazole) Delayed-Release Capsules is a substituted benzimidazole, 5-methoxy-2-[[(4-methoxy-3, 5-dimethyl-2-pyridinyl) methyl] sulfinyl]-1H-benzimidazole, a compound that inhibits gastric acid secret...
Active Ingredient	Omeprazole magnesium
Dosage Form	Capsule, delayed release
Route	Oral
Strength	eq 20mg base
Market Status	Over the Counter
Company	Dr Reddys Labs

2 of 2
Drug Name	Omeprazole magnesium
Drug Label	11 DESCRIPTIONThe active ingredient in PRILOSEC (omeprazole) Delayed-Release Capsules is a substituted benzimidazole, 5-methoxy-2-[[(4-methoxy-3, 5-dimethyl-2-pyridinyl) methyl] sulfinyl]-1H-benzimidazole, a compound that inhibits gastric acid secret...
Active Ingredient	Omeprazole magnesium
Dosage Form	Capsule, delayed release
Route	Oral
Strength	eq 20mg base
Market Status	Over the Counter
Company	Dr Reddys Labs

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Proton Pump Inhibitors

Compounds that inhibit H(+)-K(+)-EXCHANGING ATPASE. They are used as ANTI-ULCER AGENTS and sometimes in place of HISTAMINE H2 ANTAGONISTS for GASTROESOPHAGEAL REFLUX. (See all compounds classified as Proton Pump Inhibitors.)

Anti-Ulcer Agents

Various agents with different action mechanisms used to treat or ameliorate PEPTIC ULCER or irritation of the gastrointestinal tract. This has included ANTIBIOTICS to treat HELICOBACTER INFECTIONS; HISTAMINE H2 ANTAGONISTS to reduce GASTRIC ACID secretion; and ANTACIDS for symptomatic relief. (See all compounds classified as Anti-Ulcer Agents.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

Proton Pump Inhibitor [EPC]; Proton Pump Inhibitors [MoA]; Cytochrome P450 2C19 Inhibitors [MoA]