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Chemistry

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Also known as: 144689-63-4, Benicar, Olmetec, Cs-866, Cs 866, Nsc-758924
Molecular Formula
C29H30N6O6
Molecular Weight
558.6  g/mol
InChI Key
UQGKUQLKSCSZGY-UHFFFAOYSA-N
FDA UNII
6M97XTV3HD

Olmesartan Medoxomil
An ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKER that is used to manage HYPERTENSION.
1 2D Structure

Olmesartan Medoxomil

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 5-(2-hydroxypropan-2-yl)-2-propyl-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazole-4-carboxylate
2.1.2 InChI
InChI=1S/C29H30N6O6/c1-5-8-23-30-25(29(3,4)38)24(27(36)39-16-22-17(2)40-28(37)41-22)35(23)15-18-11-13-19(14-12-18)20-9-6-7-10-21(20)26-31-33-34-32-26/h6-7,9-14,38H,5,8,15-16H2,1-4H3,(H,31,32,33,34)
2.1.3 InChI Key
UQGKUQLKSCSZGY-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CCCC1=NC(=C(N1CC2=CC=C(C=C2)C3=CC=CC=C3C4=NNN=N4)C(=O)OCC5=C(OC(=O)O5)C)C(C)(C)O
2.2 Other Identifiers
2.2.1 UNII
6M97XTV3HD
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 5-methyl-2-oxo-1,3-dioxolen-4-yl)methoxy-4-(1-hydroxy-1-methylethyl)-2-propyl-1-(4-(2-(tetrazol-5-yl)phenyl)phenyl)methylimidazol-5-carboxylate - T287346

2. Benicar

3. Cs 866

4. Cs-866

5. Cs866

6. Medoxomil, Olmesartan

7. Olmetec

8. Votum

2.3.2 Depositor-Supplied Synonyms

1. 144689-63-4

2. Benicar

3. Olmetec

4. Cs-866

5. Cs 866

6. Nsc-758924

7. 6m97xtv3hd

8. (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 5-(2-hydroxypropan-2-yl)-2-propyl-3-[[4-[2-(2h-tetrazol-5-yl)phenyl]phenyl]methyl]imidazole-4-carboxylate

9. 1h-imidazole-5-carboxylic Acid, 4-(1-hydroxy-1-methylethyl)-2-propyl-1-((2'-(1h-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl)-, (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl Ester

10. Ncgc00095136-01

11. Benevas

12. Olsertain

13. Olvance

14. (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 1-((2'-(1h-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-4-(2-hydroxypropan-2-yl)-2-propyl-1h-imidazole-5-carboxylate

15. (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 1-((2'-(1h-tetrazol-5-yl)-[1,1'-biphenyl]4-yl)methyl)-4-(2-hydroxypropan-2-yl)-2-propyl-1h-imidazole-5-carboxylate

16. (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 1-((2'-(2h-tetrazol-5-yl)biphenyl-4-yl)methyl)-4-(2-hydroxypropan-2-yl)-2-propyl-1h-imidazole-5-carboxylate

17. Benicar (tn)

18. Olmetec (tn)

19. Cs866

20. Sr-05000001987

21. Unii-6m97xtv3hd

22. Votume

23. Openvas

24. Cs-866dm

25. Cs-866rn

26. Olmesartanmedoxomil

27. Olmesartan-medoxomil

28. (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 5-(2-hydroxypropan-2-yl)-2-propyl-3-[[4-[2-(1h-tetrazol-5-yl)phenyl]phenyl]methyl]imidazole-4-carboxylate

29. Olmesartan Medoxomil [usan:inn:ban]

30. Ks-1182

31. Olmesartan (medoxomil)

32. Spectrum_001944

33. Spectrum2_000506

34. Spectrum3_001676

35. Spectrum4_000740

36. Spectrum5_001556

37. Dsstox_cid_25924

38. Dsstox_rid_81226

39. Dsstox_gsid_45924

40. Schembl16403

41. Bspbio_003491

42. Gtpl591

43. Kbiogr_001040

44. Kbioss_002498

45. 1h-imidazole-5-carboxylic Acid, 4-(1-hydroxy-1-methylethyl)-2-propyl-1-((2'-(1h-tetrazol-5-yl) (1,1'-biphenyl)-4-yl)methyl)-, (5-methyl-2-oxo-1,3-dioxol-4-yl) Methyl Ester

46. Mls006010109

47. Spectrum1505205

48. Spbio_000431

49. Olmesartan Medoxomil (benicar)

50. Chembl1200692

51. Dtxsid9045924

52. Chebi:31932

53. Kbio2_002490

54. Kbio2_005058

55. Kbio2_007626

56. Kbio3_002711

57. Hms1922l15

58. Hms2089k18

59. Hms2093k16

60. Hms3651e13

61. Hms3715n09

62. Hms3743o09

63. Olmesartan Medoxomil (jp17/usp)

64. Olmesartan Medoxomil [inn]

65. Olmesartan Medoxomil [jan]

66. Pharmakon1600-01505205

67. Olmesartan Medoxomil [usan]

68. Amy22222

69. Bcp05214

70. Zinc4149248

71. Olmesartan Medoxomil [vandf]

72. Tox21_111445

73. Bdbm50442892

74. Ccg-39596

75. Mfcd00944911

76. Nsc758924

77. Olmesartan Medoxomil [mart.]

78. S1604

79. Stl451024

80. Olmesartan Medoxomil [usp-rs]

81. Olmesartan Medoxomil [who-dd]

82. Akos015894907

83. Akos015914772

84. Ac-1601

85. Bcp9000555

86. Ccg-221184

87. Cs-0577

88. Nsc 758924

89. Olmesartan Medoxomil, >=98% (hplc)

90. Sb19327

91. Ncgc00095136-02

92. Ncgc00095136-03

93. Ncgc00095136-09

94. (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 1-((2'-(2h-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-4-(2-hydroxypropan-2-yl)-2-propyl-1h-imidazole-5-carboxylate

95. Azor Component Olmesartan Medoxomil

96. Hy-17005

97. Olmesartan Medoxomil [orange Book]

98. Smr002203616

99. Olmesartan Medoxomil [ep Monograph]

100. Sbi-0206741.p001

101. Olmesartan Medoxomil [usp Monograph]

102. Cas-144689-63-4

103. Ft-0601603

104. O0510

105. Olmesartan Medoxomil Component Of Azor

106. Sw199650-2

107. D01204

108. Tribenzor Component Olmesartan Medoxomil

109. Ab01275443-01

110. Ab01275443_02

111. Ab01275443_03

112. Benicar Hct Component Olmesartan Medoxomil

113. 689o634

114. A808260

115. L001061

116. Olmesartan Medoxomil Component Of Tribenzor

117. J-501595

118. Olmesartan Medoxomil Component Of Benicar Hct

119. Sr-05000001987-1

120. Sr-05000001987-2

121. Brd-k78485176-001-02-9

122. Brd-k78485176-001-03-7

123. Q27888058

124. Z1550675457

125. Olmesartan Medoxomil, European Pharmacopoeia (ep) Reference Standard

126. Olmesartan Medoxomil, United States Pharmacopeia (usp) Reference Standard

127. Olmesartan Medoxomil For System Suitability, European Pharmacopoeia (ep) Reference Standard

128. Olmesartan Medoxomil, Pharmaceutical Secondary Standard; Certified Reference Material

129. (5-methyl-2-oxidanylidene-1,3-dioxol-4-yl)methyl 5-(2-oxidanylpropan-2-yl)-2-propyl-3-[[4-[2-(2h-1,2,3,4-tetrazol-5-yl)phenyl]phenyl]methyl]imidazole-4-carboxylate

130. (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 1-((2'-(1h-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-4-(2-hydroxypropan-2-yl)-2-propyl-1h-i Midazole-5-carboxylate

131. (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 1-((2'-(1h-tetrazol-5-yl)biphenyl-4-yl)methyl)-4-(2-hydroxypropan-2-yl)-2-propyl-1h-imidazole-5-carboxylate

132. (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 1-[[2'-(1h-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]methyl]-4-(2-hydroxypr

133. (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 4-(2-hydroxy-2-propanyl)-2-propyl-1-[[2'-(1h-tetrazol-5-yl)-4-biphenylyl]methyl]-1h-imidazole-5-carboxylate

134. (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-{[2'-(1h-tetrazol-5-yl)biphenyl-4-yl]methyl}-1h-imidazole-5-carboxylate

135. (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl1-((2'-(2h-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-4-(2-hydroxypropan-2-yl)-2-propyl-1h-imidazole-5-carboxylate

136. (5-methyl-2-oxo-1,3-dioxolen-4-yl)methyl 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[[2'-(1h-tetrazol-5-yl)biphenyl-4-yl]methyl]imidazole-5-carboxylate

137. (5-methyl-2-oxo-1,3-dioxolen-4-yl)methyl 4-(1-hydroxy-1-methylethyl)-2-propyl-1-{4-[2-(tetrazol-5-yl)phenyl]phenyl}methylimidazole-5-carboxylate

138. (5-methyl-2-oxo-1,3-dioxolen-4yl)methyl 4-(1-hydroxy-1-methylethyl)-2-propyl-1-{4-[2-(tetrazol-5-yl)phenyl]phenyl}methylimidazole-5-carboxylate

139. (5-methyl-2-oxo-2h-1,3-dioxol-4-yl)methyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-{[2'-(1h-1,2,3,4-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]methyl}-1h-imidazole-5-carboxylate

140. 1h-imidazole-5-carboxylic Acid, 4-(1-hydroxy-1-methylethyl)-2-propyl-1-((2'-(1h-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl)-, (5-methyl-2-oxo-1,3- Dioxol-4-yl)methyl Ester

141. 1h-imidazole-5-carboxylic Acid, 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[[2'-(2h-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-, (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl Ester

142. 5-(1-hydroxy-1-methylethyl)-2-propyl-3-[2'-(1h-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3h-imidazole-4-carboxylic Acid 5-methyl-2-oxo-[1,3]dioxol-4-ylmethyl Ester

143. 5-(2-hydroxypropan-2-yl)-2-propyl-3-[[4-[2-(2h-tetrazol-5-yl)phenyl]phenyl]methyl]-4-imidazolecarboxylic Acid (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl Ester

144. Olmesartan Medoxomil

145. 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[[2'-(2h-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1h-imidazole-5-carboxylic Acid-(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl Ester

2.4 Create Date
2005-06-24
3 Chemical and Physical Properties
Molecular Weight 558.6 g/mol
Molecular Formula C29H30N6O6
XLogP33.8
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count10
Rotatable Bond Count11
Exact Mass558.22268270 g/mol
Monoisotopic Mass558.22268270 g/mol
Topological Polar Surface Area154 Ų
Heavy Atom Count41
Formal Charge0
Complexity969
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Information
1 of 6  
Drug NameBenicar
Drug LabelBENICAR (olmesartan medoxomil), a prodrug, is hydrolyzed to olmesartan during absorption from the gastrointestinal tract. Olmesartan is a selective AT1 subtype angiotensin II receptor antagonist.Olmesartan medoxomil is described chemically as 2,3-d...
Active IngredientOlmesartan medoxomil
Dosage FormTablet
RouteOral
Strength5mg; 40mg; 20mg
Market StatusPrescription
CompanyDaiichi Sankyo

2 of 6  
Drug NameBenicar hct
PubMed HealthOlmesartan (By mouth)
Drug ClassesCardiovascular Agent, Renal Protective Agent
Active Ingredientolmesartan medoxomil; Hydrochlorothiazide
Dosage FormTablet
RouteOral
Strength25mg; 12.5mg; 40mg; 20mg
Market StatusPrescription
CompanyDaiichi Sankyo

3 of 6  
Drug NameOlmesartan medoxomil
PubMed HealthOlmesartan/Hydrochlorothiazide (By mouth)
Drug ClassesAngiotensin II Receptor Antagonist/Thiazide Combination
Drug LabelBENICAR (olmesartan medoxomil), a prodrug, is hydrolyzed to olmesartan during absorption from the gastrointestinal tract. Olmesartan is a selective AT1 subtype angiotensin II receptor antagonist.Olmesartan medoxomil is described chemically as 2,3-d...
Active IngredientOlmesartan medoxomil
Dosage FormTablet
Routeoral
Strength5mg; 40mg; 20mg
Market StatusTentative Approval
CompanyMylan Pharma; Sandoz

4 of 6  
Drug NameBenicar
Drug LabelBENICAR (olmesartan medoxomil), a prodrug, is hydrolyzed to olmesartan during absorption from the gastrointestinal tract. Olmesartan is a selective AT1 subtype angiotensin II receptor antagonist.Olmesartan medoxomil is described chemically as 2,3-d...
Active IngredientOlmesartan medoxomil
Dosage FormTablet
RouteOral
Strength5mg; 40mg; 20mg
Market StatusPrescription
CompanyDaiichi Sankyo

5 of 6  
Drug NameBenicar hct
PubMed HealthOlmesartan (By mouth)
Drug ClassesCardiovascular Agent, Renal Protective Agent
Active Ingredientolmesartan medoxomil; Hydrochlorothiazide
Dosage FormTablet
RouteOral
Strength25mg; 12.5mg; 40mg; 20mg
Market StatusPrescription
CompanyDaiichi Sankyo

6 of 6  
Drug NameOlmesartan medoxomil
PubMed HealthOlmesartan/Hydrochlorothiazide (By mouth)
Drug ClassesAngiotensin II Receptor Antagonist/Thiazide Combination
Drug LabelBENICAR (olmesartan medoxomil), a prodrug, is hydrolyzed to olmesartan during absorption from the gastrointestinal tract. Olmesartan is a selective AT1 subtype angiotensin II receptor antagonist.Olmesartan medoxomil is described chemically as 2,3-d...
Active IngredientOlmesartan medoxomil
Dosage FormTablet
Routeoral
Strength5mg; 40mg; 20mg
Market StatusTentative Approval
CompanyMylan Pharma; Sandoz

5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Antihypertensive Agents

Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)


Angiotensin II Type 1 Receptor Blockers

Agents that antagonize ANGIOTENSIN II TYPE 1 RECEPTOR. Included are ANGIOTENSIN II analogs such as SARALASIN and biphenylimidazoles such as LOSARTAN. Some are used as ANTIHYPERTENSIVE AGENTS. (See all compounds classified as Angiotensin II Type 1 Receptor Blockers.)


5.2 FDA Pharmacological Classification
5.2.1 Pharmacological Classes
Angiotensin 2 Receptor Blocker [EPC]; Angiotensin 2 Receptor Antagonists [MoA]
5.3 ATC Code

C09CA08

S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355


C - Cardiovascular system

C09 - Agents acting on the renin-angiotensin system

C09C - Angiotensin ii receptor blockers (arbs), plain

C09CA - Angiotensin ii receptor blockers (arbs), plain

C09CA08 - Olmesartan medoxomil


API Reference Price

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D6 D8, SY.NO. 234\/2,234\/3,"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q4","strtotime":1697394600,"product":"REIMPORT OF OLMESARTAN MEDOXOMIL EP (BATCH NO. 83220885)","address":"PLOT 170-172, CHANDRAMOULI,INDUSTR","city":"SOLAPUR,MAHARASHTRA","supplier":"GLOBAL ADVANCED PHARMACEUTICAL","supplierCountry":"INDIA","foreign_port":"CAIRO","customer":"GLENMARK PHARMACEUTICALS","customerCountry":"INDIA","quantity":"108.29","actualQuantity":"108.29","unit":"KGS","unitRateFc":"250","totalValueFC":"28111.8","currency":"USD","unitRateINR":"21613.3","date":"16-Oct-2023","totalValueINR":"2340507.34","totalValueInUsd":"28111.8","indian_port":"Bombay Air","hs_no":"29339990","bill_no":"8325139","productDescription":"Re-Import","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"CAIRO","supplierAddress":"24, NEW EXTENSION AREA,INDUSTRIAL ZONE, 6TH OF OCTOBERCITY, GIZA, EGYPT,CONTACT PERSON: M EGYPT","customerAddress":"PLOT 170-172, CHANDRAMOULI,INDUSTR"}]
04-Jan-2021
27-Aug-2024
KGS
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Average Price (USD/KGS)

Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country Total Quantity
(KGS)
Average Price
(USD/KGS)
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DRUG PRODUCT COMPOSITIONS

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DOSAGE - TABLET;ORAL - 20MG

USFDA APPLICATION NUMBER - 21286

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DOSAGE - TABLET;ORAL - 40MG

USFDA APPLICATION NUMBER - 21286

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DOSAGE - TABLET;ORAL - 5MG

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DOSAGE - TABLET;ORAL - 12.5MG;20MG

USFDA APPLICATION NUMBER - 21532

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USFDA APPLICATION NUMBER - 21532

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DOSAGE - TABLET;ORAL - 25MG;40MG

USFDA APPLICATION NUMBER - 21532

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DOSAGE - TABLET;ORAL - EQ 10MG BASE;20MG

USFDA APPLICATION NUMBER - 22100

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DOSAGE - TABLET;ORAL - EQ 10MG BASE;40MG

USFDA APPLICATION NUMBER - 22100

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DOSAGE - TABLET;ORAL - EQ 5MG BASE;20MG

USFDA APPLICATION NUMBER - 22100

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DOSAGE - TABLET;ORAL - EQ 5MG BASE;40MG

USFDA APPLICATION NUMBER - 22100

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