menu
    • menu

    Find Marizomib manufacturers, exporters & distributors on PharmaCompass

    Alchem offers Phytochemical APIs for Pharmaceuticals, Cosmetics and Nutraceuticals// FDA-inspected and EU-GMP certified.

    Virtual Booth

    Contact Supplier

    Sharp is a global leader in pharmaceutical packaging and clinical trial supply services.

    Virtual Booth

    Contact Supplier

    dmfs-not-supported-m-2025-06-30

    Virtual Booth

    Contact Supplier

    Interquim comes from an international group of 50 companies active in the pharma, hospital, diagnostics, fine chemicals & feed sectors.

    Virtual Booth

    Contact Supplier

    Phyton is a World Leader in Plant Cell Fermentation Technology and Commercial Manufacturing.

    Virtual Booth

    Contact Supplier

    jdmfs-not-supported-m-2025-06-30

    Virtual Booth

    Contact Supplier

    ACTIVE PHARMA INGREDIENTS

    PharmaCompass

    Synopsis

    Product SearchProduct Search

    Synopsis

    ACTIVE PHARMA INGREDIENTS

    2

    API Suppliers

    API Suppliers

    1

    USDMF

    US DMFs Filed

    0

    CEP/COS

    CEP/COS Certifications

    0

    JDMF

    JDMFs Filed

    0

    EU WC

    EU WC

    0

    KDMF

    KDMF

    0

    NDC API

    NDC API

    0

    VMF

    NDC API

    1

    Listed Suppliers

    Other Suppliers

    0INTERMEDIATES

    REF. STANDARDS OR IMPURITIES

    0

    EDQM

    0

    USP

    0

    JP

    0

    Others

    FINISHED DOSAGE FORMULATIONS

    0

    FDF Dossiers

    FDF Dossiers

    0

    FDA Orange Book

    FDA (Orange Book)

    0

    Europe

    Europe

    0

    Canada

    Canada

    0

    Australia

    Australia

    0

    South Africa

    South Africa

    0

    Listed Dossiers

    Listed Dossiers

    0 DRUGS IN DEVELOPMENT

    FDF Dossiers

    DRUG PRODUCT COMPOSITIONS

    0RELATED EXCIPIENT COMPANIES

    0EXCIPIENTS BY APPLICATIONS

    PATENTS & EXCLUSIVITIES

    0

    US Patents

    0

    US Exclusivities

    0

    Health Canada Patents

    API REF. PRICE (USD/KG)

    $
    $ 0

    GLOBAL SALES INFORMATION

    US Medicaid

    NA

    Annual Reports

    NA

    Regulatory FDF Prices

    NA

    API/FDF Prices: Book a Demo to
    explore the features and consider
    upgrading later

    MARKET PLACE

    0

    API

    0

    FDF

    DIGITAL CONTENT

    0

    Data Compilation #PharmaFlow

    0

    Stock Recap #PipelineProspector

    0

    Weekly News Recap #Phispers

    0

    News #PharmaBuzz

    Chemistry

    Click the arrow to open the dropdown
    read-moreClick the button for full data set
    read-moreClick the button for full data set
    Also known as: Salinosporamide a, 437742-34-2, Npi-0052, (-)-salinosporamide a, Npi 0052, Ml 858
    Molecular Formula
    C15H20ClNO4
    Molecular Weight
    313.77  g/mol
    InChI Key
    NGWSFRIPKNWYAO-SHTIJGAHSA-N
    FDA UNII
    703P9YDP7F
    Marizomib
    Marizomib is a naturally-occurring salinosporamide, isolated from the marine actinomycete Salinospora tropica, with potential antineoplastic activity. Marizomib irreversibly binds to and inhibits the 20S catalytic core subunit of the proteasome by covalently modifying its active site threonine residues; inhibition of ubiquitin-proteasome mediated proteolysis results in an accumulation of poly-ubiquitinated proteins, which may result in the disruption of cellular processes, cell cycle arrest, the induction of apoptosis, and the inhibition of tumor growth and angiogenesis. This agent more may more potent and selective than the proteasome inhibitor bortezomib.
    1 2D Structure

    Marizomib

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    (1R,4R,5S)-4-(2-chloroethyl)-1-[(S)-[(1S)-cyclohex-2-en-1-yl]-hydroxymethyl]-5-methyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione
    2.1.2 InChI
    InChI=1S/C15H20ClNO4/c1-14-10(7-8-16)12(19)17-15(14,13(20)21-14)11(18)9-5-3-2-4-6-9/h3,5,9-11,18H,2,4,6-8H2,1H3,(H,17,19)/t9-,10+,11+,14+,15+/m1/s1
    2.1.3 InChI Key
    NGWSFRIPKNWYAO-SHTIJGAHSA-N
    2.1.4 Canonical SMILES
    CC12C(C(=O)NC1(C(=O)O2)C(C3CCCC=C3)O)CCCl
    2.1.5 Isomeric SMILES
    C[C@]12[C@H](C(=O)N[C@]1(C(=O)O2)[C@H]([C@H]3CCCC=C3)O)CCCl
    2.2 Other Identifiers
    2.2.1 UNII
    703P9YDP7F
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Homosalinosporamide A

    2. Npi 0052

    3. Npi-0052

    4. Salinosporamide A

    2.3.2 Depositor-Supplied Synonyms

    1. Salinosporamide A

    2. 437742-34-2

    3. Npi-0052

    4. (-)-salinosporamide A

    5. Npi 0052

    6. Ml 858

    7. Salinosporamide A (npi-0052, Marizomib)

    8. 703p9ydp7f

    9. Chebi:48045

    10. (1r,4r,5s)-4-(2-chloroethyl)-1-((s)-((s)-cyclohex-2-en-1-yl)(hydroxy)methyl)-5-methyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione

    11. (1r,4r,5s)-4-(2-chloroethyl)-1-[(s)-(1s)-cyclohex-2-en-1-yl(hydroxy)methyl]-5-methyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione

    12. Marizomib [usan:inn]

    13. Marizomibum

    14. Unii-703p9ydp7f

    15. Homosalinosporamide A

    16. Marizomib [inn]

    17. Marizomib (usan/inn)

    18. Marizomib [usan]

    19. Marizomib [who-dd]

    20. Schembl151667

    21. Salinosporamide A [mi]

    22. Chembl371405

    23. Dtxsid00904019

    24. (1s,2r,5r)-2-(2-chloroethyl)-5-[(s)-[(1s)-cyclohex-2-en-1-yl]-hydroxymethyl]-1-methyl-7-oxa-4-azabicyclo[3.2.0]heptane-3,6-dione

    25. Ex-a3259

    26. Zinc3990364

    27. Bdbm50398608

    28. Akos027323566

    29. Db11762

    30. Hy-10985

    31. Cs-0002986

    32. D09640

    33. A872651

    34. Q7404722

    35. (1r,4r,5s)-4-(2-chloroethyl)-1-((s)-((1s)-cyclohex-2-en-1-yl)hydroxymethyl)-5-methyl- 6-oxa-2-azabicyclo(3.2.0)heptane-3,7-dione

    36. (1r,4r,5s)-4-(2-chloroethyl)-1-((s)-((s)-cyclohex-2-enyl)(hydroxy)methyl)-5-methyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione

    37. (1r,4r,5s)-4-(2-chloroethyl)-1-[(s)-[(1s)-cyclohex-2-en-1-yl]-hydroxymethyl]-5-methyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione

    38. 6-oxa-2-azabicyclo(3.2.0)heptane-3,7-dione, 4-(2-chloroethyl)-1-((s)-(1s)-2-cyclohexen-1-ylhydroxymethyl)-5-methyl-, (1r,4r,5s)-

    39. 6-oxa-2-azabicyclo(3.2.0)heptane-3,7-dione, 4-(2-chloroethyl)-1-((s)-(1s)-2-cyclohexen-1-ylhydroxymethyl)-5-methyl-, (1r,4r,5s)-

    2.4 Create Date
    2006-10-26
    3 Chemical and Physical Properties
    Molecular Weight 313.77 g/mol
    Molecular Formula C15H20ClNO4
    XLogP31.8
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count4
    Rotatable Bond Count4
    Exact Mass313.1080858 g/mol
    Monoisotopic Mass313.1080858 g/mol
    Topological Polar Surface Area75.6 Ų
    Heavy Atom Count21
    Formal Charge0
    Complexity508
    Isotope Atom Count0
    Defined Atom Stereocenter Count5
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Indication

    Treatment of malignant glial tumours

    ABOUT THIS PAGE

    Looking for 437742-34-2 / Marizomib API manufacturers, exporters & distributors?

    Marizomib manufacturers, exporters & distributors 1

    74

    PharmaCompass offers a list of Marizomib API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Marizomib manufacturer or Marizomib supplier for your needs.

    Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Marizomib manufacturer or Marizomib supplier.

    PharmaCompass also assists you with knowing the Marizomib API Price utilized in the formulation of products. Marizomib API Price is not always fixed or binding as the Marizomib Price is obtained through a variety of data sources. The Marizomib Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

    API | Excipient name

    Marizomib

    Synonyms

    Salinosporamide a, 437742-34-2, Npi-0052, (-)-salinosporamide a, Npi 0052, Ml 858

    Cas Number

    437742-34-2

    Unique Ingredient Identifier (UNII)

    703P9YDP7F

    About Marizomib

    Marizomib is a naturally-occurring salinosporamide, isolated from the marine actinomycete Salinospora tropica, with potential antineoplastic activity. Marizomib irreversibly binds to and inhibits the 20S catalytic core subunit of the proteasome by covalently modifying its active site threonine residues; inhibition of ubiquitin-proteasome mediated proteolysis results in an accumulation of poly-ubiquitinated proteins, which may result in the disruption of cellular processes, cell cycle arrest, the induction of apoptosis, and the inhibition of tumor growth and angiogenesis. This agent more may more potent and selective than the proteasome inhibitor bortezomib.

    NPI 0052 Manufacturers

    A NPI 0052 manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of NPI 0052, including repackagers and relabelers. The FDA regulates NPI 0052 manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. NPI 0052 API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of NPI 0052 manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    NPI 0052 Suppliers

    A NPI 0052 supplier is an individual or a company that provides NPI 0052 active pharmaceutical ingredient (API) or NPI 0052 finished formulations upon request. The NPI 0052 suppliers may include NPI 0052 API manufacturers, exporters, distributors and traders.

    click here to find a list of NPI 0052 suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    NPI 0052 USDMF

    A NPI 0052 DMF (Drug Master File) is a document detailing the whole manufacturing process of NPI 0052 active pharmaceutical ingredient (API) in detail. Different forms of NPI 0052 DMFs exist exist since differing nations have different regulations, such as NPI 0052 USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A NPI 0052 DMF submitted to regulatory agencies in the US is known as a USDMF. NPI 0052 USDMF includes data on NPI 0052's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The NPI 0052 USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of NPI 0052 suppliers with USDMF on PharmaCompass.

    NPI 0052 GMP

    NPI 0052 Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of NPI 0052 GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right NPI 0052 GMP manufacturer or NPI 0052 GMP API supplier for your needs.

    NPI 0052 CoA

    A NPI 0052 CoA (Certificate of Analysis) is a formal document that attests to NPI 0052's compliance with NPI 0052 specifications and serves as a tool for batch-level quality control.

    NPI 0052 CoA mostly includes findings from lab analyses of a specific batch. For each NPI 0052 CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    NPI 0052 may be tested according to a variety of international standards, such as European Pharmacopoeia (NPI 0052 EP), NPI 0052 JP (Japanese Pharmacopeia) and the US Pharmacopoeia (NPI 0052 USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
    Ask Us for Pharmaceutical Supplier and Partner
    Ask Us, Find A Supplier / Partner
    No Commissions, No Strings Attached, Get Connected for FREE

    What are you looking for?

    How can we help you?

    The request can't be empty

    Please read our Privacy Policy carefully

    You must agree to the privacy policy

    The name can't be empty
    The company can't be empty.
    The email can't be empty Please enter a valid email.
    The mobile can't be empty

    Market Place

    Market Place

    PharmaCompass

    Home

    Market Place

    Menu

    Post Enquiry

    Post Enquiry

    Market Place

    Market Place

    Search