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    Chemistry

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    Also known as: Poloxamer 188, 9003-11-6, Poloxamer 407, Pluronic f-68, 106392-12-5, 2-methyloxirane;oxirane
    Molecular Formula
    C5H10O2
    Molecular Weight
    102.13  g/mol
    InChI Key
    RVGRUAULSDPKGF-UHFFFAOYSA-N
    Detalan
    A copolymer of polyethylene and polypropylene ether glycol. It is a non-ionic polyol surface-active agent used medically as a fecal softener and in cattle for prevention of bloat.
    1 2D Structure

    Detalan

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    2-methyloxirane;oxirane
    2.1.2 InChI
    InChI=1S/C3H6O.C2H4O/c1-3-2-4-3;1-2-3-1/h3H,2H2,1H3;1-2H2
    2.1.3 InChI Key
    RVGRUAULSDPKGF-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CC1CO1.C1CO1
    2.2 Synonyms
    2.2.1 MeSH Synonyms

    1. Bloat Guard

    2. Oxyethylene Oxypropylene Polymer

    3. Oxypropylene Polymer, Oxyethylene

    4. Poloxalene 2930

    5. Polymer, Oxyethylene Oxypropylene

    6. Polyoxyethylene Polyoxypropylene Polyoxyethylene Polymer

    7. Proxanol

    8. Sk And F 18667

    9. Sk And F-18667

    10. Sk And F18667

    11. Tergitol

    12. Therabloat

    2.2.2 Depositor-Supplied Synonyms

    1. Poloxamer 188

    2. 9003-11-6

    3. Poloxamer 407

    4. Pluronic F-68

    5. 106392-12-5

    6. 2-methyloxirane;oxirane

    7. Tergitol(tm)xh(nonionic)

    8. Pluronic L

    9. Pluronic L 122

    10. Polyethylene-polypropylene Glycol

    11. Pluronic

    12. Polyethylene Oxide-polypropylene Oxide

    13. 691397-13-4

    14. Poloxalkol

    15. F-108

    16. Poloxamer 331

    17. Pluronic L 61

    18. Pluronic L-81

    19. Therabloat

    20. Proxanol

    21. Epan 485

    22. Epan 710

    23. Epan 785

    24. Bloat Guard

    25. Tergitol Xh

    26. Oxirane, Methyl-, Polymer With Oxirane, Ether With 1,2-propanediol (2:1)

    27. Pluronic L44

    28. Pluronic F 38

    29. Pluronic F 68

    30. Pluronic F 108

    31. Pluronic F 127

    32. Pluronic L 101

    33. Pluronic L 121

    34. Pluronic L-101

    35. 2-methyloxirane; Oxirane

    36. Hydrowet

    37. Polykol

    38. Proksanol

    39. Regulaid

    40. Slovanik

    41. Magcyl

    42. Ethylene Oxide-propylene Oxide Block Polymer

    43. Pluracol V

    44. Pluronic F

    45. Pluronic P

    46. Monolan Pb

    47. Pluriol Pe

    48. Polyethylene Glycol, Propoxylated

    49. Poloxalene L64

    50. Glycols, Polyethylene-polypropylene

    51. Poloxamer (nf)

    52. Pluronic-68

    53. Pluronic F86

    54. Bsp 5000

    55. Poloxamer 108

    56. Poloxamer 182lf

    57. Rokopol 16p

    58. Rokopol 30p

    59. Component Of Casakol

    60. Pluronic 10r8

    61. Pluronic 31r2

    62. Pluronic F 68lf

    63. Pluronic F 87

    64. Pluronic F 88

    65. Pluronic F 98

    66. Pluronic L 24

    67. Pluronic L 31

    68. Pluronic L 35

    69. Pluronic L 44

    70. Pluronic L 62

    71. Pluronic L 64

    72. Pluronic L 68

    73. Pluronic L 92

    74. Pluronic L122

    75. Pluronic P 75

    76. Pluronic P 85

    77. Pluronic P-65

    78. Pluronic P-75

    79. Propylen M 12

    80. Proxanol 158

    81. Proxanol 228

    82. Slovanik 630

    83. Slovanik 660

    84. Supronic B 75

    85. Rc 102

    86. Wyandotte 7135

    87. Emkalyx Ep 64

    88. Emkalyx L101

    89. Genapol Pf 10

    90. Nixolen Sl 19

    91. Rokopol 30p9

    92. Tergitol Monionic Xh

    93. Vepoloxamer (usan)

    94. Pluronic C 121

    95. Pluronic F 125

    96. Pluronic P 104

    97. Supronic E 400

    98. Teric Pe40

    99. Teric Pe60

    100. Teric Pe70

    101. Velvetol Oe 2nt1

    102. Lutrol F (tn)

    103. Newpol Pe-88

    104. Nissan Pronon 201

    105. Emkalyx L 101

    106. Oxirane, Methyl-, Polymer With Oxirane

    107. Plonon 201

    108. Plonon 204

    109. Pronon 102

    110. Pronon 104

    111. Pronon 201

    112. Pronon 204

    113. Pronon 208

    114. Unilube 50mb26x

    115. Polylon 13-5

    116. Oxirane-propylene Oxide

    117. Sk&f 18,667

    118. Teric Pe 61

    119. Teric Pe 62

    120. Laprol 1502

    121. Pluriol Pe 6810

    122. Voranol P 2001

    123. Berol Tvm 370

    124. Peg-ppg-peg

    125. Unilube 50mb168x

    126. Monolan 8000e80

    127. Niax Lg 56

    128. Tergitol Xh (nonionic)

    129. Thanol E 4003

    130. Eban 710

    131. Epan 750

    132. Epon 420

    133. Ppg Diol 3000eo

    134. Synperonic Pe 30/40

    135. Pluronic F87-a7850

    136. Methyloxirane-oxirane Polymer

    137. Niax 16-46

    138. Oxirane-methyloxirane Polymer

    139. Schembl11737

    140. Pluronic L62(mw 2500)

    141. Pluronic L64(mw 2900)

    142. Ethylene Oxide Propylene Oxide

    143. Oxirane, Polymer With Oxirane

    144. Methyloxirane-oxirane Copolymer

    145. Polyethylene-pluronic L-62lf

    146. Propylene Oxide Ethylene Oxide

    147. Tsl 431

    148. Adeka Pluronic F-108

    149. Polyoxyethylene Polyoxypropylene

    150. Polyoxyethylene-polyoxypropylene

    151. Oligoether L-1502-2-30

    152. Chebi:32026

    153. Polypropylene Glycol, Ethoxylated

    154. Glycols, Polyethylenepolypropylene

    155. Tvm 370

    156. Lg 56

    157. Oxirane, Polymer With Methyloxirane

    158. Peg/ppg-24/34 Triblock Copolymer

    159. Nsc63908

    160. Poly(propylene Oxide-ethylene Oxide)

    161. Polyoxyethylenated Poly(oxypropylene)

    162. Nsc-63908

    163. Ws 661

    164. Poly(mixed Ethylene, Propylene)glycol

    165. Propylene Oxide-ethylene Oxide Polymer

    166. Akos015912614

    167. Db11451

    168. Polyoxyethylene-polyoxypropylene Polymer

    169. Ethylene Glycol-propylene Glycol Polymer

    170. Ethylene Oxide-propylene Oxide Copolymer

    171. Propylene Oxide-ethylene Oxide Copolymer

    172. Sk & F 18,667

    173. Poly(oxyethylene)-poly(oxypropylene) Glycol

    174. N 480

    175. Poly(oxyethylene)-poly(oxypropylene) Polymer

    176. Polypropylene Glycol-ethylene Oxide Copolymer

    177. Propane-1,2-diol, Ethoxylated, Propoxylated

    178. D01941

    179. D10680

    180. Polyethylene Oxide-polypropylene Oxide Copolymer

    181. Polypropoxylated, Polyethoxylated Propylene Glycol

    182. 1,2-propyleneglycol, Ethoxylated And Propoxylated

    183. M 90/20

    184. 75h90000

    185. Propylene Glycol, Propylene Oxide, Ethylene Oxide Polymer

    186. Oxirane, 2-methyl-, Polymer With Oxirane, Ether With 1,2-propanediol (2:1)

    187. .alpha.-hydro-.omega.-hydroxypoly(oxyethylene)poly(oxypropylene)poly(oxyethylene) Block Copolymer

    2.3 Create Date
    2005-03-26
    3 Chemical and Physical Properties
    Molecular Weight 102.13 g/mol
    Molecular Formula C5H10O2
    Hydrogen Bond Donor Count0
    Hydrogen Bond Acceptor Count2
    Rotatable Bond Count0
    Exact Mass102.068079557 g/mol
    Monoisotopic Mass102.068079557 g/mol
    Topological Polar Surface Area25.1 Ų
    Heavy Atom Count7
    Formal Charge0
    Complexity36.7
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count1
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Therapeutic Uses

    Mechanical cleansing of a wound with a sponge soaked in a surfactant has prevented the development of experimental wound infection. The surfactant utilized for wound cleansing is Pluronic F-68 (poloxalene; I), a member of a family of block copolymers called Pluronic polyls. Long term toxicity studies and clinical trials suggest that this surfactant is safe for human use. I is a nonionic detergent that does not have any intrinsic antibacterial activity. Although mechanical cleansing with saline-soaked sponges effectively removes bacteria, it damages the wound and impairs its resistance to infection. The severity of the damage to the skin exerted by the sponge can be correlated with its porosity. Sponges with a low porosity are abrasive and exert more damage to skin than do sponges with a higher porosity. The addition of I to even the most abrasive sponges ensures that the bacterial removal efficiency of the sponge scrub is maintained, while tissue trauma is minimized. This dual effect of the surfactant results in a dramatic reduction in the infection rate of contaminated wounds.

    PMID:1119685 Rodeheaver GT et al; Am J Surg 129 (3): 241-5 (1975)

    (VET): Prevention of bloat in cattle.

    O'Neil, M.J. (ed.). The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. 13th Edition, Whitehouse Station, NJ: Merck and Co., Inc., 2001., p. 1357

    4.2 Drug Warning

    A randomized, double blind, placebo controlled, dose escalation study of the toxicity and pharmacokinetics of poloxamer 188 (RheothRx) was conducted in 36 healthy male subjects (ages 19-35 yr) who received iv injections of 10-90 mg/kg/hr poloxamer or placebo. ... The most common adverse effects were pain, injection site abnormality, and nausea. Eight subjects discontinued treatment with poloxamer due to adverse events.

    PMID:9232521 Jewell RC et al; J Pharm Sci 86 (7): 808-812 (1997)

    4.3 Drug Indication

    Indicated to reduce viscosity in the blood before transfusions.

    5 Pharmacology and Biochemistry
    5.1 Pharmacology

    Poloxamer 188 (P188) exerts a protective action against oxidative stress and inflammation in tissue injury in various experimental models. In the rat model of excitotoxic injury, immediate intrathecal administration of P188 reduced neuronal loss, indicated by smaller spherical excitotoxic lesions. In a murine hind-limb model, P188 mediated a protective action against ischemia-reperfusion injury as indicated by decreased myocyte injury, preserved tissue adenosine 5'-triphosphate levels, and improved survival rates, suggesting that P188 can seal defects in cell membranes and attenuate damage induced by reactive oxygen species. P188 was shown to elicit protective effects against excitotoxic injury, and trauma-induced necrotic and apoptotic cell death in cultured neurons. In the mouse stroke models, P188 exerted a neuroprotective effect in brain ischemia-reperfusion induced acute injury by significantly reducing infarct volume and water content in brain edema and ameliorating the neurological symptoms 24 h after ischemia or reperfusion injury. P188 also significantly inhibited inflammatory, coagulation, and apoptotic responses resulting from superior mesenteric artery occlusion. In the experimental model of striatum injury in rats, P188 was shown to reduce excitotoxicity-induced tissue loss and macrophage infiltrate.

    5.2 MeSH Pharmacological Classification

    Disinfectants

    Substances used on inanimate objects that destroy harmful microorganisms or inhibit their activity. Disinfectants are classed as complete, destroying SPORES as well as vegetative forms of microorganisms, or incomplete, destroying only vegetative forms of the organisms. They are distinguished from ANTISEPTICS, which are local anti-infective agents used on humans and other animals. (From Hawley's Condensed Chemical Dictionary, 11th ed) (See all compounds classified as Disinfectants.)

    Surface-Active Agents

    Agents that modify interfacial tension of water; usually substances that have one lipophilic and one hydrophilic group in the molecule; includes soaps, detergents, emulsifiers, dispersing and wetting agents, and several groups of antiseptics. (See all compounds classified as Surface-Active Agents.)

    Cathartics

    Agents that are used to stimulate evacuation of the bowels. (See all compounds classified as Cathartics.)

    5.3 Absorption, Distribution and Excretion

    Absorption

    Following a 48-hour continuous intravenous infusion of purified P188 in healthy volunteers, the mean concentration of P188 at steady state concentration (Css) was 522 118 mg/L and the maximum concentration occurring at the end of the loading dose was approximately 909 165 mg/L. The plasma concentrations were dose-proportional.

    Route of Elimination

    Renal clearance accounted for 90% of total plasma clearance in healthy male subjects.

    Volume of Distribution

    The volume of distribution at steady state (Vss) after a continuous intravenous infusion of 500 mg/kg of P188 on day 7 was approximately 2.13 mL/kg in pregnant female rats. Vss was 876 mL/kg in dogs receiving a dose of 720 mg/kg/day.

    Clearance

    Following a 48-hour continuous intravenous infusion of purified P188 in healthy volunteers, the mean total body clearance was estimated to be 4.40 0.77 L/h when using the plasma concentration data only. Estimated mean renal clearance from the amount of P-188 excreted in urine was 5.21 1.28 L/h. The clearance of a single metabolite HW1 was slower than the parent compound.

    Absorption and excretion of 14C-Poloxalene 2930 (PX), a nonionic hydrophobic surfactant of large molecular weight, were studied using bile fistula rats. Approximately half of the dose infused intraduodenally was absorbed and some of the absorbed surfactant was excreted in bile. The remainder was excreted in urine. Only trace quantities of the 14C-PX were recovered in liver and carcass at termination of the study. Two studies were also performed with 14C-PX incorporated into the diet. In the first feeding study of 7 days duration, most of the agent was excreted via the gastrointestinal tract within 72 hr of discontinuing treatment. In the second study, rats were fed dietary 14C-PX for 7, 14, or 23 days to determine whether the surfactant continued to accumulate in the body as the test period was extended. Further accumulation did occur between the 7th and 14th days but not when feeding was continued for a total of 23 days. Of the amount of 14C-PX ingested after 23 days of feeding, essentially all was excreted by the end of 7 days after discontinuing treatment. These studies indicate that despite its large molecular weight of about 3,000 some 14C-PX is absorbed. Furthermore, absorbed material is promptly excreted in bile and urine with little retained in body tissues.

    PMID:6149916 Rodgers JB et al; Drug Metab Dispos 12 (5): 631-4 (1984)

    To investigate the distribution of poloxamer 407 (Pluronic F-127), rats received 300 mg of intraperitoneal poloxamer 407 solution; blood and urine samples were taken frequently and liver and kidney homogenates were prepared and analyzed using a colorimetry assay. Clearance was 0.014 mL/min. The mean amount excreted in the urine was 76.3 mg in 24 hr. Amounts of poloxamer 407 in supernatants of liver and kidney homogenates were 15.9 and 3.1 mg, respectively.

    PMID:8738197 Li C et al; J Pharm Biomed Anal 14 (5): 659-65 (1996)

    ...The disposition and pharmacokinetics of Poloxamer 108 was studied in rats as an initial step towards understanding its behavior in man. After iv administration in rats, about 94% of 7 or 100 mg/kg doses of ethylene-14-C-labeled polymer was excreted in the urine in 3 days. About 6% of the label appeared in feces. Erythrocyte membranes were not permeable to the polymer, and only the parent compound was demonstrable in urine. Twenty hours after dosing, small residues were detectable only in the kidney, liver, small intestine and carcass. The 3rd phase of the plasma disappearance pattern was evident only at the larger dose, but plasma disappearance kinetics were independent of the dose in the used range. Most of Poloxamer 108 was eliminated rapidly in rats by renal excretion; a smaller portion probably was removed by biliary excretion.

    PMID:1231 Jo Wang Z-Y et al; Drug Metab Dispos 3 (6): 536-42 (1975)

    A randomized, double blind, placebo controlled, dose escalation study of the toxicity and pharmacokinetics of poloxamer 188 (RheothRx) was conducted in 36 healthy male subjects (ages 19-35 yr) who received iv injections of 10-90 mg/kg/hr poloxamer or placebo. Poloxamer was eliminated primarily by renal excretion. Estimates of clearance, elimination rate constant, and apparent volume of distribution at steady state were independent of infusion rate. Steady state plasma levels increased linearly with increasing infusion rate values up to 90 mg/kg/hr. Mean plasma clearance was 1.06 mL/min/kg. ...

    PMID:9232521 Jewell RC et al; J Pharm Sci 86 (7): 808-812 (1997)

    5.4 Metabolism/Metabolites

    A single metabolite, HW1, with a molecular weight of approximately 16000 Daltons was detected in a pharmacokinetic study in dogs and man. HW1 was present in 10-20 and 40% of the parent compound at steady state in dogs and humans, respectively. However, it is suggested that block polymers are not metabolized and are excreted unchanged in the urine and feces, and HW1 may be a component of the higher molecular weight distribution of P188 that concentrates in the plasma due to its lower clearance rate.

    5.5 Biological Half-Life

    In humans, P188 has half-life of 18 hours. The terminal plasma elimination half-life was approximately 7.65 1.10 hours in healthy volunteers receiving a 48-hour continuous intravenous infusion of purified P188.

    5.6 Mechanism of Action

    P188 seals stable defects in cell membranes induced by skeletal muscle cell membranes rupture induced by ischemia-reperfusion injury, electroporation, irradiation, and heat damage. The full mechanism of action of P188 in inducing cytoprotective effects is not clear; however, based on _in vitro_ experiments and the structural similarity to plasmalemma, P188 may be directly incorporated into the phospholipid bilayer to attenuate the extent of tissue injury. Its high surface activity facilitates P188 to be inserted into lipid monolayers. P188 is proposed to exert localized actions by only interacting with damaged and compromised bilayers where the local lipid packing density is reduced. In addition to the direct interaction with the membrane, P188 was shown to inhibit MMP-9 protein levels and activity, as well as the NF-B signal pathway, in the model of acute cerebral ischemia, which is associated with increased BBB permeability leading to cerebral edema and increased penetration. MMP-9 is a key factor in extracellular matrix (ECM) degradation and BBB disruption.

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    Submission : 2005-05-27

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    Dosage Form : Suspension, Tablet

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    Brand Name : Metolose 90SH-100000SR

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    Brand Name : HPMC 60HD4000

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    DKSH

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    Dosage Form : Suspension, Tablet

    Grade : Oral

    Category : Rheology Modifiers, Thickeners and Stabilizers

    Brand Name : Metolose 90SH-100000SR

    Application : Rheology Modifiers, Thickeners and Stabilizers

    Excipient Details : Metolose 90SH-100000SR is used as a thickener and a viscosity modifier in tablets, film strips and a disperant in liquid formulations.

    Pharmacopoeia Ref : NA

    Technical Specs : NA

    Ingredient(s) : Hydroxypropyl Methyl Cellulose

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    Brand Name : HPMC 60HD4000

    Application : Rheology Modifiers, Thickeners and Stabilizers

    Excipient Details : HPMC 60HD4000 is used as thickener and viscosity modifier in oral solid, liquid and topical dosage forms.

    Pharmacopoeia Ref : NA

    Technical Specs : NA

    Ingredient(s) : Hydroxypropyl Methyl Cellulose

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    Actylis

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    ABOUT THIS PAGE

    Looking for 106392-12-5 / Detalan API manufacturers, exporters & distributors?

    Detalan manufacturers, exporters & distributors 1

    33

    PharmaCompass offers a list of Detalan API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Detalan manufacturer or Detalan supplier for your needs.

    Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Detalan manufacturer or Detalan supplier.

    PharmaCompass also assists you with knowing the Detalan API Price utilized in the formulation of products. Detalan API Price is not always fixed or binding as the Detalan Price is obtained through a variety of data sources. The Detalan Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

    API | Excipient name

    Detalan

    Synonyms

    Poloxamer 188, 9003-11-6, Poloxamer 407, Pluronic f-68, 106392-12-5, 2-methyloxirane;oxirane

    Cas Number

    106392-12-5

    About Detalan

    A copolymer of polyethylene and polypropylene ether glycol. It is a non-ionic polyol surface-active agent used medically as a fecal softener and in cattle for prevention of bloat.

    Monolan 8000E80 Manufacturers

    A Monolan 8000E80 manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Monolan 8000E80, including repackagers and relabelers. The FDA regulates Monolan 8000E80 manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Monolan 8000E80 API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    Monolan 8000E80 Suppliers

    A Monolan 8000E80 supplier is an individual or a company that provides Monolan 8000E80 active pharmaceutical ingredient (API) or Monolan 8000E80 finished formulations upon request. The Monolan 8000E80 suppliers may include Monolan 8000E80 API manufacturers, exporters, distributors and traders.

    click here to find a list of Monolan 8000E80 suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    Monolan 8000E80 USDMF

    A Monolan 8000E80 DMF (Drug Master File) is a document detailing the whole manufacturing process of Monolan 8000E80 active pharmaceutical ingredient (API) in detail. Different forms of Monolan 8000E80 DMFs exist exist since differing nations have different regulations, such as Monolan 8000E80 USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A Monolan 8000E80 DMF submitted to regulatory agencies in the US is known as a USDMF. Monolan 8000E80 USDMF includes data on Monolan 8000E80's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Monolan 8000E80 USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of Monolan 8000E80 suppliers with USDMF on PharmaCompass.

    Monolan 8000E80 GMP

    Monolan 8000E80 Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Monolan 8000E80 GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Monolan 8000E80 GMP manufacturer or Monolan 8000E80 GMP API supplier for your needs.

    Monolan 8000E80 CoA

    A Monolan 8000E80 CoA (Certificate of Analysis) is a formal document that attests to Monolan 8000E80's compliance with Monolan 8000E80 specifications and serves as a tool for batch-level quality control.

    Monolan 8000E80 CoA mostly includes findings from lab analyses of a specific batch. For each Monolan 8000E80 CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Monolan 8000E80 may be tested according to a variety of international standards, such as European Pharmacopoeia (Monolan 8000E80 EP), Monolan 8000E80 JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Monolan 8000E80 USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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