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    Also known as: 83919-23-7, Asmanex, Nasonex, Elocon, Monovo, Sch 32088
    Molecular Formula
    C27H30Cl2O6
    Molecular Weight
    521.4  g/mol
    InChI Key
    WOFMFGQZHJDGCX-ZULDAHANSA-N
    FDA UNII
    04201GDN4R
    Mometasone Furoate
    A pregnadienediol derivative ANTI-ALLERGIC AGENT and ANTI-INFLAMMATORY AGENT that is used in the management of ASTHMA and ALLERGIC RHINITIS. It is also used as a topical treatment for skin disorders.
    1 2D Structure

    Mometasone Furoate

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    [(8S,9R,10S,11S,13S,14S,16R,17R)-9-chloro-17-(2-chloroacetyl)-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] furan-2-carboxylate
    2.1.2 InChI
    InChI=1S/C27H30Cl2O6/c1-15-11-19-18-7-6-16-12-17(30)8-9-24(16,2)26(18,29)21(31)13-25(19,3)27(15,22(32)14-28)35-23(33)20-5-4-10-34-20/h4-5,8-10,12,15,18-19,21,31H,6-7,11,13-14H2,1-3H3/t15-,18+,19+,21+,24+,25+,26+,27+/m1/s1
    2.1.3 InChI Key
    WOFMFGQZHJDGCX-ZULDAHANSA-N
    2.1.4 Canonical SMILES
    CC1CC2C3CCC4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)CCl)OC(=O)C5=CC=CO5)C)O)Cl)C
    2.1.5 Isomeric SMILES
    C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)CCl)OC(=O)C5=CC=CO5)C)O)Cl)C
    2.2 Other Identifiers
    2.2.1 UNII
    04201GDN4R
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Asmanex

    2. Asmanex Twisthaler

    3. Elocon

    4. Furoate Monohydrate, Mometasone

    5. Furoate, Mometasone

    6. Mometasone

    7. Mometasone Furoate Monohydrate

    8. Monohydrate, Mometasone Furoate

    9. Nasonex

    10. Rinelon

    11. Sch 32088

    12. Sch-32088

    13. Sch32088

    14. Twisthaler, Asmanex

    2.3.2 Depositor-Supplied Synonyms

    1. 83919-23-7

    2. Asmanex

    3. Nasonex

    4. Elocon

    5. Monovo

    6. Sch 32088

    7. Mometasone 17-furoate

    8. Sinuva

    9. Mometasone Furoate Anhydrous

    10. Sch32088

    11. Sch-32088

    12. Nsc-746171

    13. Chembl1161

    14. Lyr210

    15. (8s,9r,10s,11s,13s,14s,16r,17r)-9-chloro-17-(2-chloroacetyl)-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3h-cyclopenta[a]phenanthren-17-yl Furan-2-carboxylate

    16. [(8s,9r,10s,11s,13s,14s,16r,17r)-9-chloro-17-(2-chloroacetyl)-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] Furan-2-carboxylate

    17. Chebi:47564

    18. Lyr-210

    19. 04201gdn4r

    20. Nsc-760077

    21. (11beta,16alpha)-9,21-dichloro-17-[(2-furanylcarbonyl)oxy]-11-hydroxy-16-methylpregna-1,4-diene-3,20-dione

    22. Danitin

    23. Ecural

    24. Elomet

    25. Dsstox_cid_3333

    26. Asmanex Twisthaler

    27. Dsstox_rid_76981

    28. Dsstox_gsid_23333

    29. (9beta,10alpha,11alpha,14beta,16alpha,17alpha)-9,21-dichloro-11-hydroxy-16-methyl-3,20-dioxopregna-1,4-dien-17-yl Furan-2-carboxylate

    30. 9,21-dichloro-11beta-hydroxy-16alpha-methyl-3,20-dioxopregna-1,4-dien-17-yl Furan-2-carboxylate

    31. Elocone

    32. Flumeta

    33. Nosorex

    34. Rimelon

    35. Ovixan

    36. Asmanex Hfa

    37. Mometasone Fuorate

    38. Mof

    39. Unii-04201gdn4r

    40. Mometasone-furoate

    41. Ncgc00016950-01

    42. Prestwick_924

    43. Asmanex (tn)

    44. Mometasone Furoate [usan:usp:jan]

    45. Cas-83919-23-7

    46. Elocon (tn)

    47. Las 41002

    48. Brn 4340538

    49. Prestwick0_000572

    50. Prestwick1_000572

    51. Prestwick2_000572

    52. Prestwick3_000572

    53. Mometasone Furancarboxylate

    54. Schembl4568

    55. Bspbio_000384

    56. Mometasone 17-(2-furoate)

    57. Mls002153879

    58. Spbio_002603

    59. Mometasone Furoate (jan/usp)

    60. Bpbio1_000424

    61. Mometasone Furoate [mi]

    62. Dtxsid4023333

    63. Mometasone Furoate [jan]

    64. Mometasone Furoate [usan]

    65. Hms1569d06

    66. Hms2096d06

    67. Hms2235i14

    68. Hms3713d06

    69. Mometasone Furoate [vandf]

    70. Mometasone Furoate [mart.]

    71. Mometasone Furoate [usp-rs]

    72. Mometasone Furoate [who-dd]

    73. Zinc3938677

    74. Tox21_110705

    75. Ac-941

    76. Bdbm50148733

    77. Mfcd00866003

    78. Nsc746171

    79. S1987

    80. Mometasone Furoate, >=98% (hplc)

    81. Akos015994732

    82. Tox21_110705_1

    83. Ccg-220572

    84. Db14512

    85. Ks-1275

    86. Mometasone Furoate [green Book]

    87. Nsc 746171

    88. Nsc 760077

    89. 9,21-dichloro-11beta,17-dihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione 17-(2-furoate)

    90. Mometasone Furoate [orange Book]

    91. Mometasone Furoate [ep Monograph]

    92. Ncgc00179578-01

    93. Ncgc00179578-03

    94. Ncgc00179578-04

    95. (11beta,16alpha)-9,21-dichloro-11-hydroxy-16-methyl-3,20-dioxopregna-1,4-dien-17-yl Furan-2-carboxylate

    96. Dulera Component Mometasone Furoate

    97. Hy-13693

    98. Mometasone Furoate [usp Monograph]

    99. Smr001233233

    100. M2354

    101. Mometasone Furoate Component Of Dulera

    102. C07817

    103. D00690

    104. Mometasone Furoate 1000 Microg/ml In Methanol

    105. 919m237

    106. A840685

    107. Mometasone Furoate 100 Microg/ml In Acetonitrile

    108. Sr-01000841209

    109. Lyr-220 Active Component Mometasone Furoate

    110. Q-101380

    111. Q1044248

    112. Sr-01000841209-2

    113. Brd-k60640630-001-03-7

    114. Brd-k60640630-001-11-0

    115. Mometasone Furoate, European Pharmacopoeia (ep) Reference Standard

    116. Mometasone Furoate, United States Pharmacopeia (usp) Reference Standard

    117. 11?,16?)-9,21-dichloro-11-hydroxy-16-methyl-3,20-dioxopregna-1,4-dien-17-yl 2-furoate

    118. Mometasone Furoate, Pharmaceutical Secondary Standard; Certified Reference Material

    119. (11.beta.,16.alpha.)-9,21-dichloro-17-((2-furanylcarbonyl)oxy)-11-hydroxy-16-methylpregna-1,4-diene-3,20-dione

    120. [(8s,9r,10s,11s,13s,14s,16r,17r)-9-chloro-17-(2-chloroacetyl)-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] Furan-2-carboxylate;mometasone Furoate

    121. [(9r,10s,11s,13s,16r,17r)-9-chloro-17-(2-chloroacetyl)-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] Furan-2-carboxylate

    122. 9,21-dichloro-11.beta.,17-dihydroxy-16.alpha.-methylpregna-1,4-diene-3,20-dione 17-(2-furoate)

    123. Pregna-1,20-dione, 9,21-dichloro-17-[(2-furanylcarbonyl)oxy]-11-hydroxy-16-methyl-, (11.beta.,16.alpha.)-

    124. Pregna-1,4-diene-3,20-dione, 9,21-dichloro-17-((2-furanylcarbonyl)oxy)-11-hydroxy-16-methyl-, (11.beta.,16.alpha.)

    125. Pregna-1,4-diene-3,20-dione, 9,21-dichloro-17-((2-furanylcarbonyl)oxy)-11-hydroxy-16-methyl-, (11beta,16alpha)-

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 521.4 g/mol
    Molecular Formula C27H30Cl2O6
    XLogP33.9
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count6
    Rotatable Bond Count5
    Exact Mass520.1419441 g/mol
    Monoisotopic Mass520.1419441 g/mol
    Topological Polar Surface Area93.8 Ų
    Heavy Atom Count35
    Formal Charge0
    Complexity1020
    Isotope Atom Count0
    Defined Atom Stereocenter Count8
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 6  
    Drug NameElocon
    Drug LabelELOCON (mometasone furoate) Ointment, 0.1% contains mometasone furoate for topical use. Mometasone furoate is a synthetic corticosteroid with anti-inflammatory activity.Chemically, mometasone furoate is 9,21-dichloro-11,17-dihydroxy-16-methylpr...
    Active IngredientMometasone furoate
    Dosage FormLotion; Ointment; Cream
    RouteTopical
    Strength0.1%
    Market StatusPrescription
    CompanyMerck Sharp Dohme

    2 of 6  
    Drug NameMometasone furoate
    PubMed HealthMometasone
    Drug ClassesAnti-Inflammatory, Corticosteroid, Strong
    Drug LabelMometasone furoate, the active component of the ASMANEX TWISTHALER product, is a corticosteroid with the chemical name 9,21-dichloro-11(Beta),17-dihydroxy-16(alpha)-methylpregna-1,4-diene-3,20-dione 17-(2-furoate) and the following chemical structure...
    Active IngredientMometasone furoate
    Dosage FormOintment; Cream; Lotion
    RouteTopical
    Strength0.1%
    Market StatusPrescription
    CompanyTaro; Glenmark Generics; Fougera Pharms; Perrigo; Perrigo New York; Tolmar; G And W Labs

    3 of 6  
    Drug NameNasonex
    Drug LabelMometasone furoate monohydrate, the active component of NASONEX Nasal Spray, 50 mcg, is an anti-inflammatory corticosteroid having the chemical name, 9,21-Dichloro-11,17-dihydroxy-16-methylpregna-1,4-diene-3,20-dione17-(2 furoate) monohydrate, an...
    Active IngredientMometasone furoate monohydrate
    Dosage FormSpray, metered
    RouteNasal
    Strengtheq 0.05mg base/spray
    Market StatusPrescription
    CompanyMerck Sharp Dohme

    4 of 6  
    Drug NameElocon
    Drug LabelELOCON (mometasone furoate) Ointment, 0.1% contains mometasone furoate for topical use. Mometasone furoate is a synthetic corticosteroid with anti-inflammatory activity.Chemically, mometasone furoate is 9,21-dichloro-11,17-dihydroxy-16-methylpr...
    Active IngredientMometasone furoate
    Dosage FormLotion; Ointment; Cream
    RouteTopical
    Strength0.1%
    Market StatusPrescription
    CompanyMerck Sharp Dohme

    5 of 6  
    Drug NameMometasone furoate
    PubMed HealthMometasone
    Drug ClassesAnti-Inflammatory, Corticosteroid, Strong
    Drug LabelMometasone furoate, the active component of the ASMANEX TWISTHALER product, is a corticosteroid with the chemical name 9,21-dichloro-11(Beta),17-dihydroxy-16(alpha)-methylpregna-1,4-diene-3,20-dione 17-(2-furoate) and the following chemical structure...
    Active IngredientMometasone furoate
    Dosage FormOintment; Cream; Lotion
    RouteTopical
    Strength0.1%
    Market StatusPrescription
    CompanyTaro; Glenmark Generics; Fougera Pharms; Perrigo; Perrigo New York; Tolmar; G And W Labs

    6 of 6  
    Drug NameNasonex
    Drug LabelMometasone furoate monohydrate, the active component of NASONEX Nasal Spray, 50 mcg, is an anti-inflammatory corticosteroid having the chemical name, 9,21-Dichloro-11,17-dihydroxy-16-methylpregna-1,4-diene-3,20-dione17-(2 furoate) monohydrate, an...
    Active IngredientMometasone furoate monohydrate
    Dosage FormSpray, metered
    RouteNasal
    Strengtheq 0.05mg base/spray
    Market StatusPrescription
    CompanyMerck Sharp Dohme

    4.2 Drug Indication

    There are 3 formulations of mometasone furoate with various indications. The inhaler is indicated for prophylaxis of asthma in patients 4 years. The nasal spray is indicated for treating nasal symptoms of allergic rhinitis in patients 2 years, treating symptoms of nasal congestion from seasonal allergic rhinitis in patients 2 years, treating nasal polyps in patients 18 years, and prophylaxis of seasonal allergic rhinitis in patients 12 years. The ointment is indicated for symptomatic treatment of dermatitis and pruritis in patients 2 years.

    FDA Label

    Seasonal and perennial allergic rhinitis

    5 Pharmacology and Biochemistry
    5.1 Pharmacology

    Mometasone is a synthetic corticosteroid with an affinity for glucocorticoid receptors 22 times higher than that of [dexamethasone]. Mometasone furoate also has a lower affinity to mineralocorticoid receptors than natural corticosteroids, making it more selective in its action. Mometasone furoate diffuses across cell membranes to activate pathways responsible for reducing inflammation.

    5.2 MeSH Pharmacological Classification

    Anti-Inflammatory Agents

    Substances that reduce or suppress INFLAMMATION. (See all compounds classified as Anti-Inflammatory Agents.)

    Dermatologic Agents

    Drugs used to treat or prevent skin disorders or for the routine care of skin. (See all compounds classified as Dermatologic Agents.)

    Anti-Allergic Agents

    Agents that are used to treat allergic reactions. Most of these drugs act by preventing the release of inflammatory mediators or inhibiting the actions of released mediators on their target cells. (From AMA Drug Evaluations Annual, 1994, p475) (See all compounds classified as Anti-Allergic Agents.)

    5.3 FDA Pharmacological Classification
    5.3.1 Pharmacological Classes
    Corticosteroid Hormone Receptor Agonists [MoA]; Corticosteroid [EPC]; Corticosteroid Hormone Receptor Agonists [MoA]
    5.4 Absorption, Distribution and Excretion

    Absorption

    The mean time to peak concentration is 1.0 to 2.5 hours. Bioavailability has been reported as <1% but studies of repeat doses of inhaled corticosteroids suggest a bioavailability of 11%. The 0.1% ointment may have a bioavailability of 0.7%.

    Route of Elimination

    For an inhaled dose, approximately 74% is excreted in the feces and 8% is excreted in the urine.

    Volume of Distribution

    Steady state volume of distribution of 152L.

    Clearance

    The clearance rate of mometasone furoate is not readily available, though it may be close to 90L/h.

    5.5 Metabolism/Metabolites

    Metabolism of mometasone furoate is largely performed hepatically by cytochrome P450 3A4 producing a number of metabolites. Some of these metabolites include free mometasone and 6-beta-hydroxy-mometasone furoate.

    5.6 Biological Half-Life

    The terminal half life of an inhaled dose is approximately 5 hours though it has been reported as 5.8 hours by other sources.

    5.7 Mechanism of Action

    In asthma, mometasone is believed to inhibit mast cells, eosinophils, basophils, and lymphocytes. There is also evidence of inhibition of histamine, leukotrienes, and cytokines. Corticosteroids diffuse across cell membranes into the cytosol of cells where they bind to glucocorticoid receptors to produce their activity. Mometasone furoate has a particularly high receptor affinity compare to other corticosteroids, 22 times higher than that of [dexamethasone]. Mometasone furoate binding to a glucocorticoid receptor causes conformational changes in the receptor, separation from chaperones, and the receptor moves to the nucleus. Once at the nucleus, receptors dimerize and bind to a DNA sequence known as the glucocorticoid response element which either increases expression of anti-inflammatory molecules or inhibits expression of pro-inflammatory molecules (such as interleukins 4 and 5). Mometasone furoate also reduces inflammation by blocking transcription factors such as activator-protein-1 and nuclear factor kappa B (NF-kappaB).

    API Reference Price

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ORGANON INTERNATIONAL SERVICES GMBH","supplierCountry":"SINGAPORE","foreign_port":"SINGAPORE","customer":"TORRENT PHARMACEUTICALS LIMITED","customerCountry":"INDIA","quantity":"5.00","actualQuantity":"5","unit":"KGS","unitRateFc":"56000","totalValueFC":"286093.8","currency":"USD","unitRateINR":"4751600","date":"30-Aug-2024","totalValueINR":"23758000","totalValueInUsd":"286093.8","indian_port":"Bombay Air","hs_no":"29372200","bill_no":"5336467","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"SINGAPORE","selfForZScoreResived":"Pharma Grade","supplierPort":"SINGAPORE","supplierAddress":"WEYSTRASSE 20 CH-6006 LUCERNE-6006SDNFSDNF SWITZERLAND","customerAddress":"TORRENT HOUSE,"}]
    05-Jan-2021
    31-Aug-2024
    KGS
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    Average Price (USD/KGS)

    Number of Transactions

    Total Quantity (KGS)

    Total Value (USD)

    Quantity (KGS) & Unit rate (USD/KGS) over time

    API Imports and Exports

    Importing Country Total Quantity
    (KGS)    		 Average Price
    (USD/KGS)    		 Number of Transactions

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    DRUG PRODUCT COMPOSITIONS

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    DOSAGE - OINTMENT;TOPICAL - 0.1%

    USFDA APPLICATION NUMBER - 19543

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    DOSAGE - CREAM;TOPICAL - 0.1% **Federal Regis...DOSAGE - CREAM;TOPICAL - 0.1% **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

    USFDA APPLICATION NUMBER - 19625

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    DOSAGE - LOTION;TOPICAL - 0.1% **Federal Regi...DOSAGE - LOTION;TOPICAL - 0.1% **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

    USFDA APPLICATION NUMBER - 19796

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    DOSAGE - AEROSOL, METERED;INHALATION - 0.05MG...DOSAGE - AEROSOL, METERED;INHALATION - 0.05MG/INH

    USFDA APPLICATION NUMBER - 205641

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    DOSAGE - AEROSOL, METERED;INHALATION - 0.10MG...DOSAGE - AEROSOL, METERED;INHALATION - 0.10MG/INH

    USFDA APPLICATION NUMBER - 205641

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    DOSAGE - AEROSOL, METERED;INHALATION - 0.20MG...DOSAGE - AEROSOL, METERED;INHALATION - 0.20MG/INH

    USFDA APPLICATION NUMBER - 205641

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    DOSAGE - SPRAY, METERED;NASAL - 0.05MG/SPRAY ...DOSAGE - SPRAY, METERED;NASAL - 0.05MG/SPRAY **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

    USFDA APPLICATION NUMBER - 20762

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    DOSAGE - POWDER;INHALATION - 0.11MG/INH

    USFDA APPLICATION NUMBER - 21067

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    DOSAGE - POWDER;INHALATION - 0.22MG/INH

    USFDA APPLICATION NUMBER - 21067

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    DOSAGE - AEROSOL, METERED;INHALATION - 0.005M...DOSAGE - AEROSOL, METERED;INHALATION - 0.005MG/INH;0.05MG/INH

    USFDA APPLICATION NUMBER - 22518

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    DOSAGE - AEROSOL, METERED;INHALATION - 0.005M...DOSAGE - AEROSOL, METERED;INHALATION - 0.005MG/INH;0.1MG/INH

    USFDA APPLICATION NUMBER - 22518

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    DOSAGE - AEROSOL, METERED;INHALATION - 0.005M...DOSAGE - AEROSOL, METERED;INHALATION - 0.005MG/INH;0.2MG/INH

    USFDA APPLICATION NUMBER - 22518

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