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2 Drugs in Development

2 Drugs in Development

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Also known as: 1802518-92-8, Minzasolmin [inn], 3n0435tg2d, Unii-3n0435tg2d, (r)-n-(1-(1h-indol-3-yl)hexan-2-yl)-2-(4-methylpiperazin-1-yl)thiazole-5-carboxamide, 5-thiazolecarboxamide, n-((1r)-1-(1h-indol-3-ylmethyl)pentyl)-2-(4-methyl-1-piperazinyl)-

Molecular Formula

C₂₃H₃₁N₅OS

Molecular Weight

425.6 g/mol

InChI Key

GDFWCSZNQVAQGR-GOSISDBHSA-N

FDA UNII

3N0435TG2D

Minzasolmin is under investigation in clinical trial NCT05543252 (An Extension Study to Evaluate the Long-term Efficacy, Safety and Tolerability of Minzasolmin (UCB0599) in Study Participants With Parkinson's Disease).

1 2D Structure

Minzasolmin

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

N-[(2R)-1-(1H-indol-3-yl)hexan-2-yl]-2-(4-methylpiperazin-1-yl)-1,3-thiazole-5-carboxamide

2.1.2 InChI

InChI=1S/C23H31N5OS/c1-3-4-7-18(14-17-15-24-20-9-6-5-8-19(17)20)26-22(29)21-16-25-23(30-21)28-12-10-27(2)11-13-28/h5-6,8-9,15-16,18,24H,3-4,7,10-14H2,1-2H3,(H,26,29)/t18-/m1/s1

2.1.3 InChI Key

GDFWCSZNQVAQGR-GOSISDBHSA-N

2.2 Other Identifiers

2.2.1 UNII

3N0435TG2D

2.3 Synonyms

2.3.1 Depositor-Supplied Synonyms

1. 1802518-92-8

2. Minzasolmin [inn]

3. 3n0435tg2d

4. Unii-3n0435tg2d

5. (r)-n-(1-(1h-indol-3-yl)hexan-2-yl)-2-(4-methylpiperazin-1-yl)thiazole-5-carboxamide

6. 5-thiazolecarboxamide, N-((1r)-1-(1h-indol-3-ylmethyl)pentyl)-2-(4-methyl-1-piperazinyl)-

7. 5-thiazolecarboxamide, N-[(1r)-1-(1h-indol-3-ylmethyl)pentyl]-2-(4-methyl-1-piperazinyl)-

8. N-((1r)-1-(1h-indol-3-ylmethyl)pentyl)-2-(4-methylpiperazin-1-yl)thiazole-5-carboxamide

9. N-[(2r)-1-(1h-indol-3-yl)hexan-2-yl]-2-(4-methylpiperazin-1-yl)-1,3-thiazole-5-carboxamide

10. Minzasolmina

11. Minzasolmine

12. (r)-n-[1-(1h-indol-3-yl)hexan-2-yl]-2-(4-methylpiperazin-1-yl)thiazole-5-carboxamide

13. N-[(1r)-1-(1h-indol-3-ylmethyl)pentyl]-2-(4-methylpiperazin-1-yl)thiazole-5-carboxamide

14. Minzasolmin (usan/inn)

15. Minzasolmin [usan]

16. Dlx313

17. Chembl5095072

18. Schembl16973853

19. Dlx-313

20. Bdbm510823

21. Glxc-26948

22. Ex-a6318

23. Ucb-0599

24. Da-65474

25. Hy-145580

26. Us11078196, Ex. 28

27. Cs-0376408

28. D12796

29. (r)-n-(1-(1h-indol-3-yl)hexan- 2-yl)-2-(4-methylpiperazin-1- Yl)thiazole-5-carboxamide

30. N-[(1r)-1-(1h-indol-3-ylmethyl)pentyl]-2-(4-methyl-1-piperazinyl)-5-thiazolecarboxamide

2.4 Create Date

2016-02-23

3 Chemical and Physical Properties

Molecular Formula	C₂₃H₃₁N₅OS
Molecular Weight	425.6 g/mol
XLogP3	4.8
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	8
Exact Mass	Da
Monoisotopic Mass	Da
Topological Polar Surface Area	92.5
Heavy Atom Count	30
Formal Charge	0
Complexity	556
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1