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Chemistry

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Also known as: Lysine vasopressin, Lysipressin, Syntopressin, 50-57-7, Postacton, Diapid
Molecular Formula
C46H65N13O12S2
Molecular Weight
1056.2  g/mol
InChI Key
BJFIDCADFRDPIO-DZCXQCEKSA-N

Lypressin
The porcine antidiuretic hormone (VASOPRESSINS). It is a cyclic nonapeptide that differs from ARG-VASOPRESSIN by one amino acid, containing a LYSINE at residue 8 instead of an ARGININE. Lys-vasopressin is used to treat DIABETES INSIPIDUS or to improve vasomotor tone and BLOOD PRESSURE.
1 2D Structure

Lypressin

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(2S)-N-[(2S)-6-amino-1-[(2-amino-2-oxoethyl)amino]-1-oxohexan-2-yl]-1-[(4R,7S,10S,13S,16S,19R)-19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-benzyl-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]pyrrolidine-2-carboxamide
2.1.2 InChI
InChI=1S/C46H65N13O12S2/c47-17-5-4-9-29(40(65)52-22-38(51)63)54-45(70)35-10-6-18-59(35)46(71)34-24-73-72-23-28(48)39(64)55-31(20-26-11-13-27(60)14-12-26)43(68)56-32(19-25-7-2-1-3-8-25)42(67)53-30(15-16-36(49)61)41(66)57-33(21-37(50)62)44(69)58-34/h1-3,7-8,11-14,28-35,60H,4-6,9-10,15-24,47-48H2,(H2,49,61)(H2,50,62)(H2,51,63)(H,52,65)(H,53,67)(H,54,70)(H,55,64)(H,56,68)(H,57,66)(H,58,69)/t28-,29-,30-,31-,32-,33-,34-,35-/m0/s1
2.1.3 InChI Key
BJFIDCADFRDPIO-DZCXQCEKSA-N
2.1.4 Canonical SMILES
C1CC(N(C1)C(=O)C2CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N2)CC(=O)N)CCC(=O)N)CC3=CC=CC=C3)CC4=CC=C(C=C4)O)N)C(=O)NC(CCCCN)C(=O)NCC(=O)N
2.1.5 Isomeric SMILES
C1C[C@H](N(C1)C(=O)[C@@H]2CSSC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N2)CC(=O)N)CCC(=O)N)CC3=CC=CC=C3)CC4=CC=C(C=C4)O)N)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N
2.2 Synonyms
2.2.1 MeSH Synonyms

1. 8 Lysine Vasopressin

2. 8-lysine Vasopressin

3. Diapid

4. Lys Vasopressin

5. Lys-vasopressin

6. Lysine Vasopressin

7. Lysyl Vasopressin

8. Postacton

9. Vasopressin, 8-lysine

10. Vasopressin, Lysine

11. Vasopressin, Lysyl

2.2.2 Depositor-Supplied Synonyms

1. Lysine Vasopressin

2. Lysipressin

3. Syntopressin

4. 50-57-7

5. Postacton

6. Diapid

7. Lysine Pitressin

8. 8-l-lysinevasopressin

9. L-lysine Vasopressin

10. Vasopressin-8-lysine

11. Vasopressin Pig

12. Vasopressin, 8-l-lysine-

13. (8-lysine)vasopressin

14. Vasopressin, 8-l-lysine

15. Vasopressin (lysine Form)

16. [lys8]-vasopressin

17. 8-l-lysine Vasopressin

18. 50-57-7 (free Base)

19. [8-lysine]vasopressin

20. Lysine-vasopressin

21. Dsstox_cid_28501

22. Dsstox_rid_82773

23. Dsstox_gsid_48575

24. L-cysteinyl-l-tyrosyl-l-phenylalanyl-l-glutaminyl-l-asparaginyl-l-cysteinyl-l-prolyl-l-lysylglycinamide Cyclic (1->6)-disulfide

25. Lipressina

26. Lypressine

27. Lypressinum

28. Lysopressin

29. Lipresina

30. Lysylvasopressin

31. (lys8)-vasopressin

32. Cas-50-57-7

33. (s)-n-((s)-6-amino-1-((2-amino-2-oxoethyl)amino)-1-oxohexan-2-yl)-1-((4r,7s,10s,13s,16s,19r)-19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-benzyl-16-(4-hydroxybenzyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosane-4-carbonyl)pyrrolidine-2-carboxamide

34. L-8

35. Lipressina [dcit]

36. Lipresina [inn-spanish]

37. Lypressine [inn-french]

38. Lypressinum [inn-latin]

39. Unii-7czf3l922y

40. 3-(phenylalanine)-8-lysine Oxytocin

41. L-lysinamide,

42. Lysine-adh

43. Lypressin [usan:usp:inn:ban]

44. Ncgc00181743-01

45. Ncgc00181743-02

46. Lvp

47. Einecs 200-050-5

48. Brn 4648365

49. [lys8]avp

50. Schembl33287

51. 7czf3l922y

52. Gtpl2172

53. Chembl1200690

54. Dtxsid8048575

55. Chebi:94802

56. Cys-tyr-phe-gln-asn-cys-pro-lys-gly-nh2, Cyclic 1-6 Disulfide

57. Hy-p0004

58. Tox21_112902

59. Tox21_113427

60. [lys8]-vasopressinlysine Vasopressin

61. Mfcd00076754

62. Ccg-270620

63. Cs-5838

64. Db14642

65. (2s)-n-[(2s)-6-amino-1-[(2-amino-2-oxoethyl)amino]-1-oxohexan-2-yl]-1-[(4r,7s,10s,13s,16s,19r)-19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-benzyl-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]pyrrolidine-2-carboxamide

66. Oxytocin, 3-(l-phenylalanine)-8-l-lysine-

67. Vasopressin, 8-l-lysine- (7ci,8ci,9ci)

68. C75370

69. L]carbonyl]-l-prolyl-n-(2-amino-2-oxoethyl)-

70. 076l754

71. Brd-k93331255-001-01-2

72. Q27082434

73. 1,2-dithia-5,8,11,14,17-pentaazacycloeicosane-10-propionamide

74. Cys-tyr-phe-gln-asn-cys-pro-lys-gly-nh2[disulfide Bridge: 1-6]

75. (2s)-n-[(2s)-6-amino-1-[(2-amino-2-oxoethyl)amino]-1-oxohexan-2-yl]-1-[(4r,7s,10s,13s,16s,19r)-19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-13-(phenylmethyl)1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]pyrrolidine-2-carboxamide

76. (2s)-n-[(2s)-6-amino-1-[(2-amino-2-oxoethyl)amino]-1-oxohexan-2-yl]-1-[[(4r,7s,10s,13s,16s,19r)-19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-13-(phenylmethyl)-1,2-dithia-5,8,11,14,17-pentazacycloeicos-4-yl]-oxomethyl]-2-pyrrolidinecarboxamide

77. 1-[[(4r,7s,10s,13s,16s,19r)-19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-13-(phenylmethyl)-1,2-dithia-5,8,11,14,17-pentaazacycloeicos-4-y

78. 1-{[(4r,7s,10s,13s,16s,19r)-19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-benzyl-16-(4-hydroxybenzyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl]carbonyl}-l-p Rolyl-l-lysylglycinamide

79. 19-amino-4-[2-[[5-amino-1-[(carbamoylmethyl)carbamoyl]pentyl]carbamoyl]-1-pyrrolidinylcarbonyl]-13-benzyl-7-(carbamoylmethyl)-16-p-hydroxybenzyl-6,9,12,15,18-pentaoxo- (6ci)

80. Glycinamide, L-cysteinyl-l-tyrosyl-l-phenylalanyl-l-glutaminyl-l-asparaginyl-l-cysteinyl-l-prolyl-l-lysyl-, Cyclic (1>6)-disulfide

81. L 8

82. L-cysteinyl-l-tyrosyl-l-phenylalanyl-l-glutaminyl-l-asparaginyl-l-cysteinyl-l-prolyl-l-lysylglycinamide Cyclic (1-6)-disulfide

2.3 Create Date
2005-06-01
3 Chemical and Physical Properties
Molecular Weight 1056.2 g/mol
Molecular Formula C46H65N13O12S2
XLogP3-3.9
Hydrogen Bond Donor Count13
Hydrogen Bond Acceptor Count16
Rotatable Bond Count19
Exact Mass1055.43170691 g/mol
Monoisotopic Mass1055.43170691 g/mol
Topological Polar Surface Area476 Ų
Heavy Atom Count73
Formal Charge0
Complexity1960
Isotope Atom Count0
Defined Atom Stereocenter Count8
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Antidiuretic Agents

Agents that reduce the excretion of URINE, most notably the octapeptide VASOPRESSINS. (See all compounds classified as Antidiuretic Agents.)


Hemostatics

Agents acting to arrest the flow of blood. Absorbable hemostatics arrest bleeding either by the formation of an artificial clot or by providing a mechanical matrix that facilitates clotting when applied directly to the bleeding surface. These agents function more at the capillary level and are not effective at stemming arterial or venous bleeding under any significant intravascular pressure. (See all compounds classified as Hemostatics.)


Vasoconstrictor Agents

Drugs used to cause constriction of the blood vessels. (See all compounds classified as Vasoconstrictor Agents.)


4.2 ATC Code

H - Systemic hormonal preparations, excl. sex hormones and insulins

H01 - Pituitary and hypothalamic hormones and analogues

H01B - Posterior pituitary lobe hormones

H01BA - Vasopressin and analogues

H01BA03 - Lypressin


API SUPPLIERS

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Shenzhen JYMed Technology

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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Shenzhen JYMed Technology

China

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Jin Dun Medical

China

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Jin Dun Medical

China

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BCN Peptides

Spain

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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BCN Peptides

Spain

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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BCN Peptides

Spain
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BCN Peptides

Spain
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Lypressin

About the Company : BCN Peptides is a privately own company completely focused on the cGMP manufacture of Bioactive Peptides for Pharmaceutical and Veterinary applications. We are a customer oriented...

BCN Peptides is a privately own company completely focused on the cGMP manufacture of Bioactive Peptides for Pharmaceutical and Veterinary applications. We are a customer oriented organization focused on fulfilling the client’s needs at each stage of the their peptide drug development and lifecycle management. It also includes a team of dedicated and passionate scientists which help us to provide to our customer a scientific excellence in terms of synthetic peptide chemistry and analytical expertise. BCN Peptides has an excellent track record of successful inspections by Global Health Agencies (US FDA, EDQM, KFDA,…)
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Battery Seminar
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Lypressin

About the Company : JIN DUN Medical Research Institute is affiliated to Shanghai JIN DUN Industrial Co., Ltd., headquartered in Shanghai, adjacent to Hongqiao High-speed Railway Station and Hongqiao I...

JIN DUN Medical Research Institute is affiliated to Shanghai JIN DUN Industrial Co., Ltd., headquartered in Shanghai, adjacent to Hongqiao High-speed Railway Station and Hongqiao International airport. JIN DUN Medical Research Institute is committed to providing pharmaceutical intermediates and raw materials with the purpose of innovative drug research. Customized R&D and customized production services.
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Battery Seminar
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Lypressin

About the Company : Shenzhen JYMed Technology Co.,Ltd is a high-tech enterprise engaged in research and development, manufacturing and commercialization of peptides based products, including active ph...

Shenzhen JYMed Technology Co.,Ltd is a high-tech enterprise engaged in research and development, manufacturing and commercialization of peptides based products, including active pharmaceutical ingredient peptides, cosmetic peptides, and custom peptides as well other new drug development. We strive for continuing innovations in new peptide synthesis technology and process optimization, and our technical team have over decade of experience in peptide synthesis. Our peptide plant is located in Nanjing, Jiangsu province and it has set up a facility of 30,000 square meters in compliance with cGMP guideline.
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LYPRESSIN

Brand Name : DIAPID

Dosage Form : SOLUTION;NASAL

Dosage Strength : 0.185MG/ML

Packaging :

Approval Date : 1982-01-01

Application Number : 16755

Regulatory Info : DISCN

Registration Country : USA

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NOVARTIS

Switzerland
Mental Health
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NOVARTIS

Switzerland
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LYPRESSIN

Brand Name : DIAPID

Dosage Form : SOLUTION;NASAL

Dosage Strength : 0.185MG/ML

Approval Date : 1982-01-01

Application Number : 16755

RX/OTC/DISCN : DISCN

RLD : No

TE Code :

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REF. STANDARDS & IMPURITIES

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Looking for 50-57-7 / Lypressin API manufacturers, exporters & distributors?

Lypressin manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Lypressin API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Lypressin manufacturer or Lypressin supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Lypressin manufacturer or Lypressin supplier.

PharmaCompass also assists you with knowing the Lypressin API Price utilized in the formulation of products. Lypressin API Price is not always fixed or binding as the Lypressin Price is obtained through a variety of data sources. The Lypressin Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Lypressin

Synonyms

Lysine vasopressin, Lysipressin, Syntopressin, 50-57-7, Postacton, Diapid

Cas Number

50-57-7

About Lypressin

The porcine antidiuretic hormone (VASOPRESSINS). It is a cyclic nonapeptide that differs from ARG-VASOPRESSIN by one amino acid, containing a LYSINE at residue 8 instead of an ARGININE. Lys-vasopressin is used to treat DIABETES INSIPIDUS or to improve vasomotor tone and BLOOD PRESSURE.

Lypressin Manufacturers

A Lypressin manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Lypressin, including repackagers and relabelers. The FDA regulates Lypressin manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Lypressin API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Lypressin manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Lypressin Suppliers

A Lypressin supplier is an individual or a company that provides Lypressin active pharmaceutical ingredient (API) or Lypressin finished formulations upon request. The Lypressin suppliers may include Lypressin API manufacturers, exporters, distributors and traders.

click here to find a list of Lypressin suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Lypressin GMP

Lypressin Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Lypressin GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Lypressin GMP manufacturer or Lypressin GMP API supplier for your needs.

Lypressin CoA

A Lypressin CoA (Certificate of Analysis) is a formal document that attests to Lypressin's compliance with Lypressin specifications and serves as a tool for batch-level quality control.

Lypressin CoA mostly includes findings from lab analyses of a specific batch. For each Lypressin CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Lypressin may be tested according to a variety of international standards, such as European Pharmacopoeia (Lypressin EP), Lypressin JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Lypressin USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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