Levoleucovorin

Synopsis, Chemistry

APIs // Active Pharmaceutical Ingredients

2 API Suppliers, 1 USDMF, 2 NDC API, 2 Listed Suppliers

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3 Drug(s) in Development

3 Drug(s) in Development

PRICE INFORMATION

API Reference Price, API Imports

DOSSIERs // Finished Dosage Formulations

8 Dossiers, 2 FDA Orange Book, 6 Europe

DRUG PRODUCT COMPOSITION

POWDER;INTRAVENOUS - 175MG/VIAL, POWDER;INTRAVENOUS - 300MG/VIAL

POWDER;INTRAVENOUS - 175MG/VIAL
POWDER;INTRAVENOUS - 300MG/VIAL

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Suppliers, 2 Actylis

GLOBAL SALES INFORMATION

6 Finished Drug Prices

6 Finished Drug Prices

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2 US Patents

2 US Patents

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6 News

6 News

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API Suppliers

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JDMFs Filed

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3,410

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INTERMEDIATES

DOSSIERS // FDF

USA (Orange Book)

Europe

Canada

Australia

South Africa

Uploaded Dossiers

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U.S. Medicaid

Annual Reports

FDF Market Place

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USFDA Orange Book Patents

USFDA Exclusivities

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Blog #PharmaFlow

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EDQM

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Also known as:

Molecular Formula

C₂₀H₂₃N₇O₇

Molecular Weight

473.4 g/mol

InChI Key

VVIAGPKUTFNRDU-STQMWFEESA-N

1 2D Structure

Levoleucovorin

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

(2S)-2-[[4-[[(6S)-2-amino-5-formyl-4-oxo-1,6,7,8-tetrahydropteridin-6-yl]methylamino]benzoyl]amino]pentanedioic acid

2.1.2 InChI

InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32)/t12-,13-/m0/s1

2.1.3 InChI Key

VVIAGPKUTFNRDU-STQMWFEESA-N

2.1.4 Canonical SMILES

C1C(N(C2=C(N1)NC(=NC2=O)N)C=O)CNC3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O

2.1.5 Isomeric SMILES

C1[C@@H](N(C2=C(N1)NC(=NC2=O)N)C=O)CNC3=CC=C(C=C3)C(=O)N[C@@H](CCC(=O)O)C(=O)O

2.2 Create Date

2004-09-16

3 Chemical and Physical Properties

Molecular Formula	C₂₀H₂₃N₇O₇
Molecular Weight	473.4 g/mol
XLogP3	-1.2
Hydrogen Bond Donor Count	7
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	9
Exact Mass	473.16589610 g/mol
Monoisotopic Mass	473.16589610 g/mol
Topological Polar Surface Area	216 A^2
Heavy Atom Count	34
Formal Charge	0
Complexity	911
Isotope Atom Count	0
Defined Atom Stereocenter Count	2
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1