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Copper Sulphate Pentahydrate
Also known as: Copper(ii) sulfate pentahydrate, 7758-99-8, Cupric sulfate pentahydrate, Blue vitriol, Copper(2+) sulfate pentahydrate, Copper (ii) sulfate pentahydrate
Molecular Formula
CuH10O9S
Molecular Weight
249.69  g/mol
InChI Key
JZCCFEFSEZPSOG-UHFFFAOYSA-L
FDA UNII
LRX7AJ16DT

A sulfate salt of copper. It is a potent emetic and is used as an antidote for poisoning by phosphorus. It also can be used to prevent the growth of algae.
1 2D Structure

Copper Sulphate Pentahydrate

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
copper;sulfate;pentahydrate
2.1.2 InChI
InChI=1S/Cu.H2O4S.5H2O/c;1-5(2,3)4;;;;;/h;(H2,1,2,3,4);5*1H2/q+2;;;;;;/p-2
2.1.3 InChI Key
JZCCFEFSEZPSOG-UHFFFAOYSA-L
2.1.4 Canonical SMILES
O.O.O.O.O.[O-]S(=O)(=O)[O-].[Cu+2]
2.2 Other Identifiers
2.2.1 UNII
LRX7AJ16DT
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Blue Vitriol

2. Copper Sulfate

3. Cupric Sulfate

4. Sulfate, Copper

5. Sulfate, Cupric

6. Vitriol, Blue

2.3.2 Depositor-Supplied Synonyms

1. Copper(ii) Sulfate Pentahydrate

2. 7758-99-8

3. Cupric Sulfate Pentahydrate

4. Blue Vitriol

5. Copper(2+) Sulfate Pentahydrate

6. Copper (ii) Sulfate Pentahydrate

7. Copper(ii) Sulfate, Pentahydrate

8. Copper;sulfate;pentahydrate

9. Copper Sulphate Pentahydrate

10. Cupric Sulfate [usp]

11. Copper(2+) Sulfate (1:1) Pentahydrate

12. Copper Sulfate, Pentahydrate

13. Mfcd00149681

14. Lrx7aj16dt

15. Calcanthite

16. Copper(ii) Sulphate Pentahydrate

17. Vitriol, Blue

18. Sulfuric Acid Copper(2+) Salt (1:1), Pentahydrate

19. Cupric Sulfate (usp)

20. Bluestone

21. Triangle

22. Vencedor

23. Blue Copperas

24. Blue Vicking

25. Salzburg Vitriol

26. Blue Copper As

27. Caswell No. 256

28. Kupfervitriol

29. Kupfervitriol [german]

30. Ccris 5556

31. Hsdb 2968

32. Kupfersulfat-pentahydrat [german]

33. Kupfersulfat-pentahydrat

34. Copper Sulfate (cuso4) Pentahydrate

35. Unii-lrx7aj16dt

36. Cuso4.5h2o

37. Epa Pesticide Chemical Code 024401

38. Sentry Aq Mardel Coppersafe

39. Cuso4(h2o)5

40. Cupric Sulfate (pentahydrate)

41. Sulfuric Acid, Copper(2+) Salt, Pentahydrate

42. Cuprum Sulphuricum

43. Sulfuric Acid, Copper(2+) Salt (1:1), Pentahydrate

44. Liquid Copper Sulfate

45. Cupric Sulfate (tn)

46. Copper Sulfate, Crystal

47. Copper Sulphate(5.h2o)

48. Cupric Sulphate Pentahydrate

49. Copper (as Cupric Sulfate)

50. Copper Sulfate-penta Hydrate

51. Copper Sulfate Fine Crystal

52. Cupric Sulfate [ii]

53. Copper(ii)sulfatepentahydrate

54. Copper(ii)sulfate Pentahydrate

55. Copper Sulfate [vandf]

56. Copper(ii)sulphate Pentahydrate

57. Copper(ii)sulphate-pentahydrate

58. Cupric Sulfate [vandf]

59. Copper(11) Sulfate Pentahydrate

60. Dtxsid9031066

61. Chebi:31440

62. Cuprum Sulphuricum [hpus]

63. Copper (2+) Sulfate Pentahydrate

64. Copper (ii) Sulphate Pentahydrate

65. Copper(2+) Sulfate, Pentahydrate

66. Copper(2+) Sulfate--water (1/5)

67. Cupric Sulfate [orange Book]

68. Copper Sulfate [ep Monograph]

69. Akos025243248

70. Cupric Sulfate [usp Monograph]

71. Cupric Sulfate Pentahydrate [mi]

72. Copper(2+) Sulphate Pentahydrate

73. Copper (as Cupric Sulfate) [vandf]

74. Copper Sulfate Pentahydrate [who-dd]

75. Ft-0624051

76. Copper(ii) Sulfate Pentahydrate, Acs Reagent

77. D03613

78. Copper(2+) Sulphate (1:1) Pentahydrate

79. Copper Sulfate Pentahydrate [ep Monograph]

80. Q6135414

81. Copper(ii) Sulfate Pentahydrate (99.999%-cu) Puratrem

82. Copper(ii) Sulfate Pentahydrate, Trace Metals Grade, 99.995%

83. Sulfuric Acid Copper(2+) Salt (1:1), Hydrate (1:5)

2.4 Create Date
2004-09-16
3 Chemical and Physical Properties
Molecular Weight 249.69 g/mol
Molecular Formula CuH10O9S
Hydrogen Bond Donor Count5
Hydrogen Bond Acceptor Count9
Rotatable Bond Count0
Exact Mass248.934150 g/mol
Monoisotopic Mass248.934150 g/mol
Topological Polar Surface Area93.6 Ų
Heavy Atom Count11
Formal Charge0
Complexity62.2
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count7
4 Drug and Medication Information
4.1 Therapeutic Uses

MEDICATION (VET): AS PROPHYLACTIC &/OR THERAPEUTIC FOOT BATH IN FOOT ROT OF CATTLE AND SHEEP; AS FUNGICIDAL AGENT IN THE THERAPY OF RINGWORM & FUNGAL SYNDROMES OF SKIN; AS CAUSTIC IN DESTROYING FISTULOUS TRACTS, NECROTIC INTERDIGITAL MASSES IN FOOT ROT, PROUD FLESH, AND ULCERATIVE STOMATITIS; /HAS BEEN USED/ AS AN EMETIC IN CATS, DOGS, AND PIGS OR TO PPT POISONOUS PHORPHORUS CMPD SUCH AS ZINC PHOSPHIDE; AS HEMATINIC WITH IRON CMPD; AS ASTRINGENT IN ANTIDIARRHEALS PARTICULARLY FOR CALVES OR FEEDLOT CATTLE, TO CONTROL INTESTINAL MONILIASIS & INHIBIT ASCARID GROWTH IN POULTRY; CONTROL TRICHOMONIASIS & HEXAMITIASIS IN TURKEYS; & REFLEXLY CLOSE THE ESOPHAGEAL GROOVE IN SHEEP.

Rossoff, I.S. Handbook of Veterinary Drugs. New York: Springer Publishing Company, 1974., p. 136


IT MAY RARELY BE USED AS HEMATINIC IN CERTAIN FORMS OF NUTRITIONAL ANEMIAS, ESP IN CHILDREN.

Osol, A. (ed.). Remington's Pharmaceutical Sciences. 16th ed. Easton, Pennsylvania: Mack Publishing Co., 1980., p. 748


MEDICATION (VET): NUTRITIONAL FACTOR; IN COPPER DEFICIENCY OF RUMINANTS.

The Merck Index. 10th ed. Rahway, New Jersey: Merck Co., Inc., 1983., p. 379


IN UNITED KINGDOM ITS ANTIBACTERIAL EFFECT IS UTILIZED AS APPROVED FEED ADDITIVE FOR IMPROVING RATE OF GAIN & FEED EFFICIENCY OF SWINE (NOT APPROVED IN UNITED STATES BECAUSE OF ENVIRONMENTAL CONCERNS REGARDING BIOCONCENTRATION IN SOIL & SURFACE WATER).

Jones, L.M., et al. Veterinary Pharmacology & Therapeutics. 4th ed. Ames: Iowa State University Press, 1977., p. 885


MEDICATION (VET): IT IS ALSO USED IN TREATMENT OF PARASITIC GASTRITIS IN SHEEP.

Clarke, M. L., D. G. Harvey and D. J. Humphreys. Veterinary Toxicology. 2nd ed. London: Bailliere Tindall, 1981., p. 44


4.2 Drug Warning

... Its routine use as an emetic is not recommended, because of the potential toxicity of improperly prepared soln and the hazards attending the use of large, corrosive doses.

Osol, A. (ed.). Remington's Pharmaceutical Sciences. 16th ed. Easton, Pennsylvania: Mack Publishing Co., 1980., p. 748


MAY CAUSE DRAMATIC INCR IN MORTALITY OF TURKEYS GIVEN BLACKHEAD CONTROL DRUGS CONTAINING ARSENIC & EXPOSED TO BLACKHEAD.

Rossoff, I.S. Handbook of Veterinary Drugs. New York: Springer Publishing Company, 1974., p. 136


CUPRIC ... SULFATE /AS EMETIC/ OFTEN IS EFFECTIVE, BUT POTENTIAL HEMOLYTIC & RENAL TOXICITY IS TOO GREAT TO RECOMMEND USE. ...

American Medical Association, AMA Department of Drugs. AMA Drug Evaluations. 4th ed. Chicago: American Medical Association, 1980., p. 1436


5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Antidotes

Agents counteracting or neutralizing the action of POISONS. (See all compounds classified as Antidotes.)


Emetics

Agents that cause vomiting. They may act directly on the gastrointestinal tract, bringing about emesis through local irritant effects, or indirectly, through their effects on the chemoreceptor trigger zone in the postremal area near the medulla. (See all compounds classified as Emetics.)


5.2 Absorption, Distribution and Excretion

AFTER ADMIN COPPER(II) SULFATE, PENTAHYDRATE FOR 7 DAYS IP, COPPER ACCUMULATED IN MITOCHONDRIAL & LYSOSOMAL FRACTIONS OF RAT LIVER, MAINLY IN LYSOSOMES.

FELDMAN G ET AL; BIOL GASTRO-ENTEROL 5 (1): 37 (1972)


5.3 Mechanism of Action

HUMAN RBC INCUBATED WITH COPPER SULFATE WERE TESTED FOR OSMOTIC FRAGILITY, DEFORMABILITY, & ELECTROPHORETIC PROPERTIES OF MEMBRANE PROTEINS. COPPER TREATMENT OXIDIZED THE -SH OF THE MEMBRANE PROTEINS TO FORM INTERMOLECULAR DISULFIDE BONDS, CAUSING A REDUCTION IN MEMBRANE FLEXIBILITY. /COPPER SULFATE/

NAKASHIMA K ET AL; BIOMED RES 1 (6): 548-551 (1981)


COPPER SULFATE INJECTED IP AT 2 MG COPPER/KG INTO VITAMIN E & SELENIUM DEFICIENT RATS CAUSED A 6 FOLD INCREASE IN THE FORMATION OF THE LIPID PEROXIDATION PRODUCT ETHANE, & CAUSED ACUTE MORTALITY IN 4/5 RATS. SELENIUM SUPPLEMENTATION OF THE DIET AT 0.5 PPM SELENIUM PREVENTED THE INCREASE IN ETHANE PRODUCTION CAUSED BY COPPER INJECTION & REDUCED MORTALITY TO 1/5 RATS. THE CORRELATION OF INCREASED PRODUCTION OF ETHANE WITH INCREASED MORTALITY SUGGESTED THAT LIPID PEROXIDATION MAY BE IMPORTANT IN THE INCREASED TOXICITY OF COPPER IN VITAMIN E & SELENIUM DEFICIENT RATS. /COPPER SULFATE/

PMID:7063501 DOUGHERTY JJ, HOEKSTRA WG; PROC SOC EXP BIOL MED 169 (2): 201-8 (1982)


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