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Chemistry

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Also known as: 1015474-32-4, Cc-122, 3-(5-amino-2-methyl-4-oxoquinazolin-3(4h)-yl)piperidine-2,6-dione, Cc122, Cc 122, Avadomide [usan]
Molecular Formula
C14H14N4O3
Molecular Weight
286.29  g/mol
InChI Key
RSNPAKAFCAAMBH-UHFFFAOYSA-N
FDA UNII
28DZS29F59

Avadomide
Avadomide is a novel, small molecule cereblon-modulating agent with potential antineoplastic, antiangiogenic and immunomodulatory activities. Upon oral administration, avadomide binds to and modulates cereblon to promote recruitment of the hematopoietic transcription factors Aiolos and Ikaros to the Cullin-4 RING E3 ubiquitin ligase complex. This binding results in the ubiquitination and rapid proteasomal degradation of Aiolos and Ikaros and the derepression of interferon (IFN)-stimulated genes, including DDX58 and IRF7, leading to apoptosis of certain tumor cells. Additionally, Aiolos degredation leads to derepression of the IL2 gene, thereby enhancing interleukin-2 production, costimulation of T-lymphocytes and IL-2-induced T-cell proliferation. Avadomide may also promote the activation of natural killer (NK) cells, potentially enhancing tumor cell killing. Aiolos and Ikaros are transcriptional repressors known to play an important role in normal B- and T-cell function.
1 2D Structure

Avadomide

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
3-(5-amino-2-methyl-4-oxoquinazolin-3-yl)piperidine-2,6-dione
2.1.2 InChI
InChI=1S/C14H14N4O3/c1-7-16-9-4-2-3-8(15)12(9)14(21)18(7)10-5-6-11(19)17-13(10)20/h2-4,10H,5-6,15H2,1H3,(H,17,19,20)
2.1.3 InChI Key
RSNPAKAFCAAMBH-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC1=NC2=CC=CC(=C2C(=O)N1C3CCC(=O)NC3=O)N
2.2 Other Identifiers
2.2.1 UNII
28DZS29F59
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 3-(5-amino-2-methyl-4-oxoquinazolin-3(4h)-yl)piperidine-2,6-dione

2. Cc-122

2.3.2 Depositor-Supplied Synonyms

1. 1015474-32-4

2. Cc-122

3. 3-(5-amino-2-methyl-4-oxoquinazolin-3(4h)-yl)piperidine-2,6-dione

4. Cc122

5. Cc 122

6. Avadomide [usan]

7. Avadomide(cc-122)

8. 28dzs29f59

9. 3-(5-amino-2-methyl-4-oxoquinazolin-3-yl)piperidine-2,6-dione

10. 3-(5-amino-2-methyl-4-oxo-4h-quinazolin-3-yl)-piperidine-2,6-dione

11. 3-(5-amino-2-methyl-4-oxo-4h-quinazolin-3-yl)piperidine-2,6-dione

12. 2,6-piperidinedione, 3-(5-amino-2-methyl-4-oxo-3(4h)-quinazolinyl)-

13. 2,6-piperidinedione, 3-(5-amino-2-methyl-4-oxo-3(4h)-quinazolinyl)-;2,6-piperidinedione, 3-(5-amino-2-methyl-4-oxo-3(4h)-quinazolinyl)-

14. Cc-122avadomide

15. Avadomide [inn]

16. Avadomide (usan/inn)

17. Avadomide [who-dd]

18. Cc-112

19. Schembl282749

20. Unii-28dzs29f59

21. Us9694015, Compound A

22. Cc-122;cc 122;avadomide

23. Chembl3989934

24. Bdbm76986

25. Gtpl10522

26. Amy16366

27. Bcp15938

28. Ex-a1191

29. S7892

30. Ccg-267340

31. Cs-5995

32. Db14857

33. Sb18829

34. Compound A [wo2014039960a1]

35. Ac-33084

36. As-55858

37. Bp-27973

38. Db-112299

39. Hy-100507

40. C71075

41. D11132

42. A921203

43. 3-(5-amino-2-methy-4-oxo-4h-quinazolin-3-yl)-piperidine-2,6-dione

44. 3-(5-amino-2-methyl-4-oxoquinazolin-3 (4h)-yl)piperidine-2,6-dione

45. Rac-(3r)-3-(5-amino-2-methyl-4-oxoquinazolin-3(4h)-yl)piperidine-2,6-dione

2.4 Create Date
2008-10-20
3 Chemical and Physical Properties
Molecular Weight 286.29 g/mol
Molecular Formula C14H14N4O3
XLogP30
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count1
Exact Mass286.10659032 g/mol
Monoisotopic Mass286.10659032 g/mol
Topological Polar Surface Area105 Ų
Heavy Atom Count21
Formal Charge0
Complexity530
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

Treatment of mature B-cell neoplasms


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Looking for 1015474-32-4 / Avadomide API manufacturers, exporters & distributors?

Avadomide manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Avadomide API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Avadomide manufacturer or Avadomide supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Avadomide manufacturer or Avadomide supplier.

PharmaCompass also assists you with knowing the Avadomide API Price utilized in the formulation of products. Avadomide API Price is not always fixed or binding as the Avadomide Price is obtained through a variety of data sources. The Avadomide Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Avadomide

Synonyms

1015474-32-4, Cc-122, 3-(5-amino-2-methyl-4-oxoquinazolin-3(4h)-yl)piperidine-2,6-dione, Cc122, Cc 122, Avadomide [usan]

Cas Number

1015474-32-4

Unique Ingredient Identifier (UNII)

28DZS29F59

About Avadomide

Avadomide is a novel, small molecule cereblon-modulating agent with potential antineoplastic, antiangiogenic and immunomodulatory activities. Upon oral administration, avadomide binds to and modulates cereblon to promote recruitment of the hematopoietic transcription factors Aiolos and Ikaros to the Cullin-4 RING E3 ubiquitin ligase complex. This binding results in the ubiquitination and rapid proteasomal degradation of Aiolos and Ikaros and the derepression of interferon (IFN)-stimulated genes, including DDX58 and IRF7, leading to apoptosis of certain tumor cells. Additionally, Aiolos degredation leads to derepression of the IL2 gene, thereby enhancing interleukin-2 production, costimulation of T-lymphocytes and IL-2-induced T-cell proliferation. Avadomide may also promote the activation of natural killer (NK) cells, potentially enhancing tumor cell killing. Aiolos and Ikaros are transcriptional repressors known to play an important role in normal B- and T-cell function.

CC-122;CC 122;Avadomide Manufacturers

A CC-122;CC 122;Avadomide manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of CC-122;CC 122;Avadomide, including repackagers and relabelers. The FDA regulates CC-122;CC 122;Avadomide manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. CC-122;CC 122;Avadomide API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

CC-122;CC 122;Avadomide Suppliers

A CC-122;CC 122;Avadomide supplier is an individual or a company that provides CC-122;CC 122;Avadomide active pharmaceutical ingredient (API) or CC-122;CC 122;Avadomide finished formulations upon request. The CC-122;CC 122;Avadomide suppliers may include CC-122;CC 122;Avadomide API manufacturers, exporters, distributors and traders.

CC-122;CC 122;Avadomide GMP

CC-122;CC 122;Avadomide Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of CC-122;CC 122;Avadomide GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right CC-122;CC 122;Avadomide GMP manufacturer or CC-122;CC 122;Avadomide GMP API supplier for your needs.

CC-122;CC 122;Avadomide CoA

A CC-122;CC 122;Avadomide CoA (Certificate of Analysis) is a formal document that attests to CC-122;CC 122;Avadomide's compliance with CC-122;CC 122;Avadomide specifications and serves as a tool for batch-level quality control.

CC-122;CC 122;Avadomide CoA mostly includes findings from lab analyses of a specific batch. For each CC-122;CC 122;Avadomide CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

CC-122;CC 122;Avadomide may be tested according to a variety of international standards, such as European Pharmacopoeia (CC-122;CC 122;Avadomide EP), CC-122;CC 122;Avadomide JP (Japanese Pharmacopeia) and the US Pharmacopoeia (CC-122;CC 122;Avadomide USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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