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1. Jevtana
2. Kabazitaxel
1. 183133-96-2
2. Jevtana
3. Taxoid Xrp6258
4. Txd 258
5. Xrp-6258
6. Cabazitaxelum
7. Xrp6258
8. Xrp 6258
9. Jevtana (tn)
10. Nsc-761432
11. Chebi:63584
12. Txd-258
13. 51f690397j
14. Kabazitaxel
15. Jevtana Kit
16. Cabazitaxel (jevtana)
17. (2ar,4s,4as,6r,9s,11s,12s,12ar,12bs)-12b-acetoxy-9-(((2r,3s)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-3-phenylpropanoyl)oxy)-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1h-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl Benzoate.
18. Cabazitaxel Acetonate
19. Cabazitaxel Acetonate [jan]
20. Cabazitaxel Injection
21. Cabazitaxel [usan:inn]
22. Jevanta
23. Txd258
24. Unii-51f690397j
25. Rpr 116258a
26. Rpr-116258a
27. Cabazitaxel [mi]
28. Cabazitaxel [inn]
29. Cabazitaxel (usan/inn)
30. Cabazitaxel [usan]
31. Cabazitaxel [vandf]
32. Cabazitaxel [mart.]
33. Cabazitaxel [who-dd]
34. Schembl179674
35. Cabazitaxel [ema Epar]
36. Gtpl6798
37. Chembl1201748
38. Amy4317
39. Cabazitaxel [orange Book]
40. Dtxsid40171389
41. Ex-a838
42. Mfcd18827611
43. Nsc761432
44. Nsc794609
45. S3022
46. Zinc85536932
47. Akos032947285
48. Ccg-270519
49. Cs-0972
50. Db06772
51. Nsc 761432
52. Nsc-794609
53. Ncgc00346704-01
54. Ncgc00346704-03
55. As-75355
56. Hy-15459
57. A25044
58. D09755
59. Ab01273971-01
60. Ab01273971_02
61. Q412963
62. Sr-01000941585
63. J-011721
64. J-519981
65. Sr-01000941585-1
66. (((tertbutoxy)carbonyl)amino)-2-hydroxy-3-phenylpropanoate1-hydroxy-7beta,10beta-dimethoxy-9-oxo-5beta,20-epoxytax-11-ene-2alpha,4,13alpha-triyl 4-acetate 2-benzoate 13-((2r,3s)-3-
67. (1s)-5beta,20-epoxy-9-oxo-7beta,10beta-dimethoxytaxa-11-ene-1,2alpha,4alpha,13alpha-tetraol 2-benzoate 4-acetate 13-[(2r,3s)-2-hydroxy-3-(tert-butoxycarbonylamino)-3-phenylpropionate]
68. (1s,2s,3r,4s,7r,9s,10s,12r,15s)-4-(acetyloxy)-15-{[(2r,3s)-3-{[(tert-butoxy)carbonyl]amino}-2-hydroxy-3-phenylpropanoyl]oxy}-1-hydroxy-9,12-dimethoxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.0(3),(1)?.0?,?]heptadec-13-en-2-yl Benzoate
69. (1s,2s,3r,4s,7r,9s,10s,12r,15s)-4-(acetyloxy)-15-{[(2r,3s)-3-{[(tert-butoxy)carbonyl]amino}-2-hydroxy-3-phenylpropanoyl]oxy}-1-hydroxy-9,12-dimethoxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.0^{3,10}.0^{4,7}]heptadec-13-en-2-yl Benzoate
70. (2alpha,5beta,7beta,10beta,13alpha)-4-acetoxy-13-({(2r,3s)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoyl}oxy)-1-hydroxy-7,10-dimethoxy-9-oxo-5,20-epoxytax-11-en-2-yl Benzoate
71. (2ar,4s,4as,6r,9s,11s,12s,12ar,12bs)-12b-acetoxy-9-(((2r,3s)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-3-phenylpropanoyl)oxy)-11-hydroxy-4,6-dimethoxy-4a,8,13,1
72. (2ar,4s,4as,6r,9s,11s,12s,12ar,12bs)-12b-acetoxy-9-(((2r,3s)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-3-phenylpropanoyl)oxy)-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1h-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl Benzoate
73. [(1s,2s,3r,4s,7r,9s,10s,12r,15s)-4-acetyloxy-1-hydroxy-15-[(2r,3s)-2-hydroxy-3-[(2-methylpropan-2-yl)oxycarbonylamino]-3-phenylpropanoyl]oxy-9,12-dimethoxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-2-yl] Benzoate
74. 1-hydroxy-7,10-dimethoxy-9-oxo-5,20-epoxytax-11-ene-2,4,13-triyl 4-acetate 2-benzoate 13-((2r,3s)-3-(((tertbutoxy)carbonyl)amino)-2-hydroxy-3-phenylpropanoate)
75. 1-hydroxy-7.beta.,10.beta.-dimethoxy-9-oxo-5.beta.,20-epoxytax-11-ene-2.alpha.,4,13.alpha.-triyl 4-acetate 2-benzoate 13-((2r,3s)-3-(((tert-butoxy)carbonyl)amino)-2-hydroxy-3-phenylpropanoate)
76. Benzenepropanoic Acid, Beta-[[(1,1-dimethylethoxy)carbonyl]amino]-alpha-hydroxy-, (2ar,4s,4as,6r,9s,11s,12s,12ar,12bs)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1h-cyclodeca[3,4]benz[1,2-b]oxet-9-yl Ester, (alphar,betas)-
Molecular Weight | 835.9 g/mol |
---|---|
Molecular Formula | C45H57NO14 |
XLogP3 | 2.7 |
Hydrogen Bond Donor Count | 3 |
Hydrogen Bond Acceptor Count | 14 |
Rotatable Bond Count | 15 |
Exact Mass | 835.37790549 g/mol |
Monoisotopic Mass | 835.37790549 g/mol |
Topological Polar Surface Area | 202 Ų |
Heavy Atom Count | 60 |
Formal Charge | 0 |
Complexity | 1690 |
Isotope Atom Count | 0 |
Defined Atom Stereocenter Count | 11 |
Undefined Atom Stereocenter Count | 0 |
Defined Bond Stereocenter Count | 0 |
Undefined Bond Stereocenter Count | 0 |
Covalently Bonded Unit Count | 1 |
1 of 2 | |
---|---|
Drug Name | Jevtana kit |
Active Ingredient | Cabazitaxel |
Dosage Form | Solution |
Route | Iv (infusion) |
Strength | 60mg/1.5ml (40mg/ml) |
Market Status | Prescription |
Company | Sanofi Aventis Us |
2 of 2 | |
---|---|
Drug Name | Jevtana kit |
Active Ingredient | Cabazitaxel |
Dosage Form | Solution |
Route | Iv (infusion) |
Strength | 60mg/1.5ml (40mg/ml) |
Market Status | Prescription |
Company | Sanofi Aventis Us |
For treatment of patients with hormone-refractory metastatic prostate cancer previously treated with a docetaxel-containing treatment regimen.
FDA Label
Jevtana in combination with prednisone or prednisolone is indicated for the treatment of patients with hormone-refractory metastatic prostate cancer previously treated with a docetaxel-containing regimen.
Treatment of prostate cancer
Treatment of patients with hormone refractory metastatic prostate cancer previously treated with a docetaxel-containing regimen.
Cabaitaxel has anti-tumour properties and is effective against docetaxel-sensitive and -insensitive tumours.
L01CD
L01CD04
L01CD04
L - Antineoplastic and immunomodulating agents
L01 - Antineoplastic agents
L01C - Plant alkaloids and other natural products
L01CD - Taxanes
L01CD04 - Cabazitaxel
Absorption
After an intravenous dose of cabazitaxel 25 mg/m2 every three weeks to a population of 170 patients with solid tumors, the mean Cmax in patients with metastatic prostate cancer was 226 ng/mL (CV 107%) and was reached at the end of the one-hour infusion (Tmax). The mean AUC in patients with metastatic prostate cancer was 991 ng.h/mL (CV 34%). Administration with prednisone or prednisolone do not effect the pharmacokinetic profile of cabazitaxel.
Route of Elimination
After a one-hour intravenous infusion [14C]-cabazitaxel 25 mg/m2, approximately 80% of the administered dose was eliminated within 2 weeks. Cabazitaxel is mainly excreted in the feces as numerous metabolites (76% of the dose); while renal excretion of cabazitaxel and metabolites account for 3.7% of the dose (2.3% as unchanged drug in urine).
Volume of Distribution
The volume of distribution (Vss) was 4,864 L (2,643 L/m2 for a patient with a median BSA of 1.84 m2) at steady state. Compared to other taxanes, penetrates the CNS to a greater extent.
Clearance
Cabazitaxel has a plasma clearance of 48.5 L/h (CV 39%; 26.4 L/h/m2 for a patient with a median BSA of 1.84 m2) in patients with metastatic prostate cancer.
Cabazitaxel is extensively metabolized in the liver (>95%), mainly by the CYP3A4/5 isoenzyme (80% to 90%), and to a lesser extent by CYP2C8 which results in 20 different metabolites. Two of these metabolites are active demethylated derivatives of cabaxitaxel and referred to as RPR112698 and RPR123142 respectively. Docetaxel is another metabolite of cabazitaxel. Cabazitaxel is the main circulating moiety in human plasma.
Following a one-hour intravenous infusion, plasma concentrations of cabazitaxel can be described by a three-compartment pharmacokinetic model with -, -, and - half-lives of 4 minutes, 2 hours, and 95 hours, respectively.
Cabazitaxel is a microtubule inhibitor. Cabazitaxel binds to tubulin and promotes its assembly into microtubules while simultaneously inhibiting disassembly. This leads to the stabilization of microtubules, which results in the interference of mitotic and interphase cellular functions. The cell is then unable to progress further into the cell cycle, being stalled at metaphase, thus triggering apoptosis of the cancer cell.
Sanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.
GDUFA
DMF Review : N/A
Rev. Date :
Pay. Date :
DMF Number : 23496
Submission : 2010-01-29
Status : Active
Type : II
DRL offers a portfolio of products & services, including APIs, CMO services, generics, biosimilars & differentiated formulations.
GDUFA
DMF Review : Complete
Rev. Date : 2014-06-17
Pay. Date : 2014-03-20
DMF Number : 27895
Submission : 2014-02-18
Status : Active
Type : II
TAPI, a leading global supplier of APIs, provides over 350 products and customized CDMO solutions for every stage of development.
GDUFA
DMF Review : Complete
Rev. Date : 2014-06-02
Pay. Date : 2014-03-19
DMF Number : 28101
Submission : 2014-04-01
Status : Active
Type : II
GDUFA
DMF Review : Complete
Rev. Date : 2014-07-15
Pay. Date : 2014-04-16
DMF Number : 28159
Submission : 2014-04-21
Status : Active
Type : II
GDUFA
DMF Review : Complete
Rev. Date : 2014-03-28
Pay. Date : 2014-02-19
DMF Number : 27978
Submission : 2014-02-20
Status : Active
Type : II
GDUFA
DMF Review : Complete
Rev. Date : 2014-09-04
Pay. Date : 2014-05-20
DMF Number : 28293
Submission : 2014-06-12
Status : Active
Type : II
GDUFA
DMF Review : Complete
Rev. Date : 2014-03-28
Pay. Date : 2014-03-04
DMF Number : 27831
Submission : 2014-03-03
Status : Active
Type : II
GDUFA
DMF Review : N/A
Rev. Date :
Pay. Date :
DMF Number : 25769
Submission : 2012-02-07
Status : Inactive
Type : II
GDUFA
DMF Review : N/A
Rev. Date :
Pay. Date :
DMF Number : 27339
Submission : 2013-07-18
Status : Inactive
Type : II
GDUFA
DMF Review : Complete
Rev. Date : 2014-02-08
Pay. Date : 2013-09-06
DMF Number : 27441
Submission : 2013-09-26
Status : Active
Type : II
LGM Pharma accelerates & optimizes the new product pathway from early development through commercialization.
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TAPI, a leading global supplier of APIs, provides over 350 products and customized CDMO solutions for every stage of development.
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Details:
Cabazitaxel intravenous powder of strength 60mg/1.5ml (40mg/ml), is an antineoplastic agent and a microtubule inhibitor used in the treatment of prostate cancer.
Lead Product(s): Cabazitaxel
Therapeutic Area: Oncology Brand Name: Cabazitaxel-Generic
Study Phase: Approved FDFProduct Type: Cytotoxic Drug
Sponsor: Natco Pharma
Deal Size: Inapplicable Upfront Cash: Inapplicable
Deal Type: Inapplicable July 25, 2022
Lead Product(s) : Cabazitaxel
Therapeutic Area : Oncology
Highest Development Status : Approved FDF
Partner/Sponsor/Collaborator : Natco Pharma
Deal Size : Inapplicable
Deal Type : Inapplicable
Natco Pharma's Partner Breckenridge Gets FDA Nod for Prostate Cancer Drug
Details : Cabazitaxel intravenous powder of strength 60mg/1.5ml (40mg/ml), is an antineoplastic agent and a microtubule inhibitor used in the treatment of prostate cancer.
Product Name : Cabazitaxel-Generic
Product Type : Cytotoxic Drug
Upfront Cash : Inapplicable
July 25, 2022
Details:
Cabazitaxel Intravenous Powder (generic for Jevtana Kit®), is a Microtubule inhibitor, available in the 60mg/1.5mL (40mg/mL) strength used fo the treatment of Prostate cancer.
Lead Product(s): Cabazitaxel
Therapeutic Area: Oncology Brand Name: Cabazitaxel-Generic
Study Phase: Approved FDFProduct Type: Cytotoxic Drug
Sponsor: Natco Pharma
Deal Size: Inapplicable Upfront Cash: Inapplicable
Deal Type: Inapplicable January 08, 2022
Lead Product(s) : Cabazitaxel
Therapeutic Area : Oncology
Highest Development Status : Approved FDF
Partner/Sponsor/Collaborator : Natco Pharma
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : Cabazitaxel Intravenous Powder (generic for Jevtana Kit®), is a Microtubule inhibitor, available in the 60mg/1.5mL (40mg/mL) strength used fo the treatment of Prostate cancer.
Product Name : Cabazitaxel-Generic
Product Type : Cytotoxic Drug
Upfront Cash : Inapplicable
January 08, 2022
Details:
Cabazitaxel EVER Pharma in combination with prednisone or prednisolone is indicated for the treatment of patients with metastatic castration resistant prostate cancer.
Lead Product(s): Cabazitaxel,Prednisone
Therapeutic Area: Oncology Brand Name: Cabazitaxel EVER Pharma
Study Phase: Approved FDFProduct Type: Cytotoxic Drug
Sponsor: Inapplicable
Deal Size: Inapplicable Upfront Cash: Inapplicable
Deal Type: Inapplicable October 21, 2020
Lead Product(s) : Cabazitaxel,Prednisone
Therapeutic Area : Oncology
Highest Development Status : Approved FDF
Partner/Sponsor/Collaborator : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
EVER Pharma gains EU marketing authorization for value-added Cabazitaxel
Details : Cabazitaxel EVER Pharma in combination with prednisone or prednisolone is indicated for the treatment of patients with metastatic castration resistant prostate cancer.
Product Name : Cabazitaxel EVER Pharma
Product Type : Cytotoxic Drug
Upfront Cash : Inapplicable
October 21, 2020
Details:
The net proceeds will be used to fund the development of XmAb20717 (vudalimab), a bispecific antibody. It is being evaluated for the treatment of Metastatic Castration-resistant Prostate Cancer.
Lead Product(s): Vudalimab,Cabazitaxel,Carboplatin
Therapeutic Area: Oncology Brand Name: XmAb20717
Study Phase: Phase IIProduct Type: Antibody
Sponsor: Leerink Partners
Deal Size: $201.3 million Upfront Cash: Undisclosed
Deal Type: Public Offering December 09, 2024
Lead Product(s) : Vudalimab,Cabazitaxel,Carboplatin
Therapeutic Area : Oncology
Highest Development Status : Phase II
Partner/Sponsor/Collaborator : Leerink Partners
Deal Size : $201.3 million
Deal Type : Public Offering
Xencor Closes Public Offering with Full Exercise of Underwriters' Option
Details : The net proceeds will be used to fund the development of XmAb20717 (vudalimab), a bispecific antibody. It is being evaluated for the treatment of Metastatic Castration-resistant Prostate Cancer.
Product Name : XmAb20717
Product Type : Antibody
Upfront Cash : Undisclosed
December 09, 2024
Details:
The net proceeds will be used to fund the development of XmAb20717 (vudalimab), a bispecific antibody. It is being evaluated for the treatment of Metastatic Castration-resistant Prostate Cancer.
Lead Product(s): Vudalimab,Cabazitaxel,Carboplatin
Therapeutic Area: Oncology Brand Name: XmAb20717
Study Phase: Phase IIProduct Type: Antibody
Sponsor: Leerink Partners
Deal Size: $175.0 million Upfront Cash: Undisclosed
Deal Type: Public Offering November 09, 2024
Lead Product(s) : Vudalimab,Cabazitaxel,Carboplatin
Therapeutic Area : Oncology
Highest Development Status : Phase II
Partner/Sponsor/Collaborator : Leerink Partners
Deal Size : $175.0 million
Deal Type : Public Offering
Xencor Announces Pricing of $175 Million Public Offering of Common Stock
Details : The net proceeds will be used to fund the development of XmAb20717 (vudalimab), a bispecific antibody. It is being evaluated for the treatment of Metastatic Castration-resistant Prostate Cancer.
Product Name : XmAb20717
Product Type : Antibody
Upfront Cash : Undisclosed
November 09, 2024
Details:
The net proceeds will be used to fund the development of XmAb20717 (vudalimab), a bispecific antibody. It is being evaluated for the treatment of Metastatic Castration-resistant Prostate Cancer.
Lead Product(s): Vudalimab,Cabazitaxel,Carboplatin
Therapeutic Area: Oncology Brand Name: XmAb20717
Study Phase: Phase IIProduct Type: Antibody
Sponsor: Leerink Partners
Deal Size: Undisclosed Upfront Cash: Undisclosed
Deal Type: Public Offering October 09, 2024
Lead Product(s) : Vudalimab,Cabazitaxel,Carboplatin
Therapeutic Area : Oncology
Highest Development Status : Phase II
Partner/Sponsor/Collaborator : Leerink Partners
Deal Size : Undisclosed
Deal Type : Public Offering
Xencor Announces Proposed Public Offering of Common Stock
Details : The net proceeds will be used to fund the development of XmAb20717 (vudalimab), a bispecific antibody. It is being evaluated for the treatment of Metastatic Castration-resistant Prostate Cancer.
Product Name : XmAb20717
Product Type : Antibody
Upfront Cash : Undisclosed
October 09, 2024
Details:
The positive interim results are particularly significant given all patients in this cohort had late-stage prostate cancer and had failed multiple anti-cancer treatments (including taxanes), in addition to surgeries and radiation, prior to entering the DEP® cabazitaxel trial.
Lead Product(s): Cabazitaxel
Therapeutic Area: Oncology Brand Name: DEP Cabazitaxel
Study Phase: Phase IIProduct Type: Cytotoxic Drug
Sponsor: Inapplicable
Deal Size: Inapplicable Upfront Cash: Inapplicable
Deal Type: Inapplicable November 27, 2021
Lead Product(s) : Cabazitaxel
Therapeutic Area : Oncology
Highest Development Status : Phase II
Partner/Sponsor/Collaborator : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Starpharma Releases Positive DEP® phase 2 Interim Results in Prostate Cancer
Details : The positive interim results are particularly significant given all patients in this cohort had late-stage prostate cancer and had failed multiple anti-cancer treatments (including taxanes), in addition to surgeries and radiation, prior to entering the D...
Product Name : DEP Cabazitaxel
Product Type : Cytotoxic Drug
Upfront Cash : Inapplicable
November 27, 2021
Details:
The composition of matter patent covers a DEP® dendrimer conjugated to multiple cabazitaxel drug molecules via a particular releasable linker. DEP® cabazitaxel is a proprietary nanoparticle version of leading prostate cancer drug cabazitaxel (Jevtana®).
Lead Product(s): Cabazitaxel
Therapeutic Area: Oncology Brand Name: DEP Cabazitaxel
Study Phase: Phase I/ Phase IIProduct Type: Cytotoxic Drug
Sponsor: Inapplicable
Deal Size: Inapplicable Upfront Cash: Inapplicable
Deal Type: Inapplicable September 15, 2021
Lead Product(s) : Cabazitaxel
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Partner/Sponsor/Collaborator : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
US Patent Issued For DEP® Cabazitaxel Nanoparticle
Details : The composition of matter patent covers a DEP® dendrimer conjugated to multiple cabazitaxel drug molecules via a particular releasable linker. DEP® cabazitaxel is a proprietary nanoparticle version of leading prostate cancer drug cabazitaxel (Jevtana®...
Product Name : DEP Cabazitaxel
Product Type : Cytotoxic Drug
Upfront Cash : Inapplicable
September 15, 2021
Sanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.
RLD : Yes
TE Code : AP
Brand Name : JEVTANA KIT
Dosage Form : SOLUTION;INTRAVENOUS
Dosage Strength : 60MG/1.5ML (40MG/ML)
Approval Date : 2010-06-17
Application Number : 201023
RX/OTC/DISCN : RX
RLD : Yes
TE Code : AP
DRL offers a portfolio of products & services, including APIs, CMO services, generics, biosimilars & differentiated formulations.
RLD : No
TE Code : AP
Brand Name : CABAZITAXEL
Dosage Form : SOLUTION;INTRAVENOUS
Dosage Strength : 60MG/1.5ML (40MG/ML)
Approval Date : 2023-02-10
Application Number : 207718
RX/OTC/DISCN : RX
RLD : No
TE Code : AP
RLD : No
TE Code :
Brand Name : CABAZITAXEL
Dosage Form : SOLUTION;INTRAVENOUS
Dosage Strength : 60MG/1.5ML (40MG/ML)
Approval Date : 2022-06-23
Application Number : 207619
RX/OTC/DISCN : DISCN
RLD : No
TE Code :
RLD : No
TE Code : AP
Brand Name : CABAZITAXEL
Dosage Form : SOLUTION;INTRAVENOUS
Dosage Strength : 60MG/1.5ML (40MG/ML)
Approval Date : 2022-10-26
Application Number : 207693
RX/OTC/DISCN : RX
RLD : No
TE Code : AP
RLD : Yes
TE Code :
Brand Name : CABAZITAXEL
Dosage Form : SOLUTION;INTRAVENOUS
Dosage Strength : 60MG/3ML (20MG/ML)
Approval Date : 2021-12-29
Application Number : 207949
RX/OTC/DISCN : DISCN
RLD : Yes
TE Code :
RLD : Yes
TE Code :
Brand Name : CABAZITAXEL
Dosage Form : SOLUTION;INTRAVENOUS
Dosage Strength : 60MG/6ML (10MG/ML)
Approval Date : 2024-03-14
Application Number : 207970
RX/OTC/DISCN : DISCN
RLD : Yes
TE Code :
RLD : No
TE Code :
Brand Name : CABAZITAXEL
Dosage Form : SOLUTION;INTRAVENOUS
Dosage Strength : 60MG/1.5ML (40MG/ML)
Approval Date : 2023-02-10
Application Number : 207736
RX/OTC/DISCN : DISCN
RLD : No
TE Code :
RLD :
TE Code :
Brand Name : CABAZITAXEL
Dosage Form : UNKNOWN
Dosage Strength : UNKNOWN
Approval Date :
Application Number : 207735
RX/OTC/DISCN :
RLD :
TE Code :
RLD :
TE Code :
Brand Name : CABAZITAXEL
Dosage Form : SOLUTION;INTRAVENOUS
Dosage Strength : 45MG/4.5ML (10MG/ML)
Approval Date :
Application Number : 208715
RX/OTC/DISCN :
RLD :
TE Code :
RLD :
TE Code :
Brand Name : CABAZITAXEL
Dosage Form : SOLUTION;INTRAVENOUS
Dosage Strength : 60MG/6ML (10MG/ML)
Approval Date :
Application Number : 208715
RX/OTC/DISCN :
RLD :
TE Code :
Sanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.
Regulatory Info :
Registration Country : Sweden
Brand Name : JEVTANA
Dosage Form : CONCENTRATE AND SOLVENT FOR
Dosage Strength : 60 MG
Packaging :
Approval Date :
Application Number :
Regulatory Info :
Registration Country : Sweden
Sanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.
Regulatory Info :
Registration Country : Italy
Brand Name : Jevtana
Dosage Form : Cabazitaxel 60Mg 1 Unit Parenteral Use
Dosage Strength : 1 vial EV 60 mg 1.5 ml + 1 vial solv 4.5 ml
Packaging :
Approval Date :
Application Number :
Regulatory Info :
Registration Country : Italy
Sanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.
Regulatory Info :
Registration Country : Norway
Brand Name : Jevtana
Dosage Form : Concentrate and liquid to the infusion fluid, resolution
Dosage Strength : 60 mg
Packaging : Hood glass
Approval Date :
Application Number :
Regulatory Info :
Registration Country : Norway
Sanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.
Regulatory Info :
Registration Country : Switzerland
Brand Name : Jevtana
Dosage Form : Inf Konz
Dosage Strength : 60mg
Packaging :
Approval Date :
Application Number :
Regulatory Info :
Registration Country : Switzerland
Regulatory Info :
Registration Country : Switzerland
Brand Name : Cabazitaxel Accord
Dosage Form : Inf Conc
Dosage Strength : 60mg/3ml
Packaging :
Approval Date :
Application Number :
Regulatory Info :
Registration Country : Switzerland
Regulatory Info :
Registration Country : Switzerland
Brand Name : Cabazitaxel Labatec
Dosage Form : Inf Conc
Dosage Strength : 60mg/6ml
Packaging :
Approval Date :
Application Number :
Regulatory Info :
Registration Country : Switzerland
Regulatory Info :
Registration Country : Norway
Brand Name : Jevtana
Dosage Form : Concentrate and liquid to the infusion fluid, resolution
Dosage Strength : 60 mg
Packaging : Hood glass
Approval Date :
Application Number :
Regulatory Info :
Registration Country : Norway
Regulatory Info :
Registration Country : Norway
Brand Name : Cabazitaxel Sandoz
Dosage Form : Concentrate for infusion solution, solution
Dosage Strength : 10 mg/ml
Packaging : Vials 5 6ml
Approval Date :
Application Number :
Regulatory Info :
Registration Country : Norway
Regulatory Info :
Registration Country : Switzerland
Brand Name : Cabazitaxel Sandoz
Dosage Form : Inf L?s
Dosage Strength : 60mg/6ml
Packaging :
Approval Date :
Application Number :
Regulatory Info :
Registration Country : Switzerland
Regulatory Info : Generic
Registration Country : United Kingdom
Brand Name :
Dosage Form : SOLUTION
Dosage Strength : 100MG/45ML
Packaging : Vial
Approval Date :
Application Number :
Regulatory Info : Generic
Registration Country : United Kingdom
DRL offers a portfolio of products & services, including APIs, CMO services, generics, biosimilars & differentiated formulations.
Regulatory Info : Lead Market Dossiers- Filed
Registration Country : India
Brand Name :
Dosage Form : Injection
Dosage Strength : 40MG/ML
Packaging :
Approval Date :
Application Number :
Regulatory Info : Lead Market Dossiers- Filed
Registration Country : India
DRL offers a portfolio of products & services, including APIs, CMO services, generics, biosimilars & differentiated formulations.
Packaging :
Regulatory Info : Lead Market Dossiers- Filed
Dosage : Injection
Dosage Strength : 40MG/ML
Brand Name :
Approval Date :
Application Number :
Registration Country : India
DRL offers a portfolio of products & services, including APIs, CMO services, generics, biosimilars & differentiated formulations.
Regulatory Info : Lead Market Dossiers- Approved...
Registration Country : India
Brand Name :
Dosage Form : Injection
Dosage Strength : 60MG/1.5ML
Packaging :
Approval Date :
Application Number :
Regulatory Info : Lead Market Dossiers- Approved...
Registration Country : India
DRL offers a portfolio of products & services, including APIs, CMO services, generics, biosimilars & differentiated formulations.
Packaging :
Regulatory Info : Lead Market Dossiers- Approved...
Dosage : Injection
Dosage Strength : 60MG/1.5ML
Brand Name :
Approval Date :
Application Number :
Registration Country : India
Regulatory Info :
Registration Country : Iran
Brand Name : Cabotax
Dosage Form : Vial
Dosage Strength : 60MG/1.5ML
Packaging :
Approval Date :
Application Number :
Regulatory Info :
Registration Country : Iran
Packaging :
Regulatory Info :
Dosage : Vial
Dosage Strength : 60MG/1.5ML
Brand Name : Cabotax
Approval Date :
Application Number :
Registration Country : Iran
Ever Pharma, highly specialized CDMO in producing complex injectables including high potency & controlled substances, suspensions, etc.
Regulatory Info :
Registration Country : Austria
Brand Name :
Dosage Form : Concentrate for Soluti...
Dosage Strength : 10MG/1ML
Packaging :
Approval Date :
Application Number :
Regulatory Info :
Registration Country : Austria
Ever Pharma, highly specialized CDMO in producing complex injectables including high potency & controlled substances, suspensions, etc.
Packaging :
Regulatory Info :
Dosage : Concentrate for Soluti...
Dosage Strength : 10MG/1ML
Brand Name :
Approval Date :
Application Number :
Registration Country : Austria
Regulatory Info :
Registration Country : Iran
Brand Name : Cabotax
Dosage Form : Injectable
Dosage Strength : 60MG/1.5ML
Packaging : Vial
Approval Date :
Application Number :
Regulatory Info :
Registration Country : Iran
Packaging : Vial
Regulatory Info :
Dosage : Injectable
Dosage Strength : 60MG/1.5ML
Brand Name : Cabotax
Approval Date :
Application Number :
Registration Country : Iran
Regulatory Info : Generic
Registration Country : India
Brand Name :
Dosage Form : Injection
Dosage Strength : 60MG/1.5ML
Packaging :
Approval Date :
Application Number :
Regulatory Info : Generic
Registration Country : India
Packaging :
Regulatory Info : Generic
Dosage : Injection
Dosage Strength : 60MG/1.5ML
Brand Name :
Approval Date :
Application Number :
Registration Country : India
Regulatory Info :
Registration Country : India
Brand Name :
Dosage Form : Injection
Dosage Strength : 60MG
Packaging :
Approval Date :
Application Number :
Regulatory Info :
Registration Country : India
Packaging :
Regulatory Info :
Dosage : Injection
Dosage Strength : 60MG
Brand Name :
Approval Date :
Application Number :
Registration Country : India
Regulatory Info :
Registration Country : India
Brand Name :
Dosage Form : Injection
Dosage Strength : 60MG
Packaging :
Approval Date :
Application Number :
Regulatory Info :
Registration Country : India
Packaging :
Regulatory Info :
Dosage : Injection
Dosage Strength : 60MG
Brand Name :
Approval Date :
Application Number :
Registration Country : India
Regulatory Info : Generic
Registration Country : China
Brand Name :
Dosage Form : INJECTION
Dosage Strength : 60MG
Packaging :
Approval Date :
Application Number :
Regulatory Info : Generic
Registration Country : China
Packaging :
Regulatory Info : Generic
Dosage : INJECTION
Dosage Strength : 60MG
Brand Name :
Approval Date :
Application Number :
Registration Country : China
Regulatory Info :
Registration Country : India
Brand Name : CABAZITHER
Dosage Form : Injection
Dosage Strength : 60mg/6ml
Packaging :
Approval Date :
Application Number :
Regulatory Info :
Registration Country : India
Packaging :
Regulatory Info :
Dosage : Injection
Dosage Strength : 60mg/6ml
Brand Name : CABAZITHER
Approval Date :
Application Number :
Registration Country : India
Global Sales Information
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13 Nov 2019
Patents & EXCLUSIVITIES
Patent Expiration Date : 2030-10-27
US Patent Number : 10716777
Drug Substance Claim :
Drug Product Claim :
Application Number : 201023
Patent Use Code : U-2856
Delist Requested :
Patent Use Description :
Patent Expiration Date : 2030-10-27
Patent Expiration Date : 2030-10-27
US Patent Number : 8927592
Drug Substance Claim :
Drug Product Claim :
Application Number : 201023
Patent Use Code : U-3200
Delist Requested :
Patent Use Description :
Patent Expiration Date : 2030-10-27
Patent Expiration Date : 2025-12-10
US Patent Number : 7241907
Drug Substance Claim : Y
Drug Product Claim :
Application Number : 201023
Patent Use Code :
Delist Requested :
Patent Use Description :
Patent Expiration Date : 2025-12-10
Patent Expiration Date : 2031-04-27
US Patent Number : 8927592*PED
Drug Substance Claim :
Drug Product Claim :
Application Number : 201023
Patent Use Code :
Delist Requested :
Patent Use Description :
Patent Expiration Date : 2031-04-27
Patent Expiration Date : 2026-06-10
US Patent Number : 7241907*PED
Drug Substance Claim :
Drug Product Claim :
Application Number : 201023
Patent Use Code :
Delist Requested :
Patent Use Description :
Patent Expiration Date : 2026-06-10
Patent Expiration Date : 2030-10-27
US Patent Number : 10583110
Drug Substance Claim :
Drug Product Claim :
Application Number : 201023
Patent Use Code : U-2753
Delist Requested :
Patent Use Description :
Patent Expiration Date : 2030-10-27
Patent Expiration Date : 2016-03-25
Date Granted : 2004-02-17
Brand Name : JEVTANA
Patent Number : 2214319
Filing Date : 1996-03-25
Strength per Unit : 40 mg / mL
Dosage Form : Solution
Human Or VET : Human
Route of Administration : Intravenous
Patent Expiration Date : 2016-03-25
Date Granted : 2004-02-17
REF. STANDARDS & IMPURITIES
CAS Number : 145514-62-1
Quantity Per Vial :
Sale Unit :
Price :
Details : In stock
Monograph :
Storage :
Code/Batch No : C0065.24
ABOUT THIS PAGE
15
PharmaCompass offers a list of Cabazitaxel API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Cabazitaxel manufacturer or Cabazitaxel supplier for your needs.
Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Cabazitaxel manufacturer or Cabazitaxel supplier.
PharmaCompass also assists you with knowing the Cabazitaxel API Price utilized in the formulation of products. Cabazitaxel API Price is not always fixed or binding as the Cabazitaxel Price is obtained through a variety of data sources. The Cabazitaxel Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.
A Cabazitaxel manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Cabazitaxel, including repackagers and relabelers. The FDA regulates Cabazitaxel manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Cabazitaxel API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.
click here to find a list of Cabazitaxel manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.
A Cabazitaxel supplier is an individual or a company that provides Cabazitaxel active pharmaceutical ingredient (API) or Cabazitaxel finished formulations upon request. The Cabazitaxel suppliers may include Cabazitaxel API manufacturers, exporters, distributors and traders.
click here to find a list of Cabazitaxel suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.
A Cabazitaxel DMF (Drug Master File) is a document detailing the whole manufacturing process of Cabazitaxel active pharmaceutical ingredient (API) in detail. Different forms of Cabazitaxel DMFs exist exist since differing nations have different regulations, such as Cabazitaxel USDMF, ASMF (EDMF), JDMF, CDMF, etc.
A Cabazitaxel DMF submitted to regulatory agencies in the US is known as a USDMF. Cabazitaxel USDMF includes data on Cabazitaxel's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Cabazitaxel USDMF is kept confidential to protect the manufacturer’s intellectual property.
click here to find a list of Cabazitaxel suppliers with USDMF on PharmaCompass.
A Cabazitaxel written confirmation (Cabazitaxel WC) is an official document issued by a regulatory agency to a Cabazitaxel manufacturer, verifying that the manufacturing facility of a Cabazitaxel active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Cabazitaxel APIs or Cabazitaxel finished pharmaceutical products to another nation, regulatory agencies frequently require a Cabazitaxel WC (written confirmation) as part of the regulatory process.
click here to find a list of Cabazitaxel suppliers with Written Confirmation (WC) on PharmaCompass.
National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Cabazitaxel as an active pharmaceutical ingredient (API).
The FDA updates the NDC directory daily. The NDC numbers for Cabazitaxel API and other APIs are published in this directory by the FDA.
The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.
Pharmaceutical companies that manufacture Cabazitaxel as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.
The NDC directory also contains data on finished compounded human drug products that contain Cabazitaxel and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Cabazitaxel NDC to their finished compounded human drug products, they may choose to do so.
click here to find a list of Cabazitaxel suppliers with NDC on PharmaCompass.
Cabazitaxel Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.
GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).
PharmaCompass offers a list of Cabazitaxel GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Cabazitaxel GMP manufacturer or Cabazitaxel GMP API supplier for your needs.
A Cabazitaxel CoA (Certificate of Analysis) is a formal document that attests to Cabazitaxel's compliance with Cabazitaxel specifications and serves as a tool for batch-level quality control.
Cabazitaxel CoA mostly includes findings from lab analyses of a specific batch. For each Cabazitaxel CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.
Cabazitaxel may be tested according to a variety of international standards, such as European Pharmacopoeia (Cabazitaxel EP), Cabazitaxel JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Cabazitaxel USP).