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Amifampridine Phosphate
Also known as: Zenas, 3,4-diaminopyridine phosphate, 446254-47-3, Firdapse (tn), Amifampridine phosphate [mi], 3,4-pyridinediamine, phosphate (1:1)
Molecular Formula
C5H10N3O4P
Molecular Weight
207.12  g/mol
InChI Key
KAICRBBQCRKMPO-UHFFFAOYSA-N
FDA UNII
8HF8FIN815

4-Aminopyridine derivative that acts as a POTASSIUM CHANNEL blocker to increase release of ACETYLCHOLINE from nerve terminals. It is used in the treatment of CONGENITAL MYASTHENIC SYNDROMES.
1 2D Structure

Amifampridine Phosphate

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
phosphoric acid;pyridine-3,4-diamine
2.1.2 InChI
InChI=1S/C5H7N3.H3O4P/c6-4-1-2-8-3-5(4)7;1-5(2,3)4/h1-3H,7H2,(H2,6,8);(H3,1,2,3,4)
2.1.3 InChI Key
KAICRBBQCRKMPO-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C1=CN=CC(=C1N)N.OP(=O)(O)O
2.2 Other Identifiers
2.2.1 UNII
8HF8FIN815
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 3,4 Diaminopyridine

2. 3,4-diaminopyridine

3. Amifampridine

4. Firdapse

5. Ruzurgi

2.3.2 Depositor-Supplied Synonyms

1. Zenas

2. 3,4-diaminopyridine Phosphate

3. 446254-47-3

4. Firdapse (tn)

5. Amifampridine Phosphate [mi]

6. 3,4-pyridinediamine, Phosphate (1:1)

7. Amifampridine Phosphate [usan]

8. Amifampridine Phosphate [mart.]

9. Amifampridine Phosphate [who-dd]

10. 446254-47-3 (phosphate)

11. Amifampridine (phosphate)

12. Amifampridine Phosphate [ema Epar]

13. 3,4-dapp

14. 8hf8fin815

15. Pyridine-3,4-diamine Phosphate

16. Amifampridine Phosphate (usan)

17. Unii-8hf8fin815

18. Phosphoric Acid;pyridine-3,4-diamine

19. Starbld0005260

20. Schembl3958357

21. Chembl3301611

22. Dtxsid40196254

23. Hy-14946a

24. Amifampridine Phosphate [orange Book]

25. Cs-0009524

26. 3,4-diaminopyridin-1-ium Dihydrogen Phosphate

27. D10689

28. Q27270515

2.4 Create Date
2006-10-25
3 Chemical and Physical Properties
Molecular Weight 207.12 g/mol
Molecular Formula C5H10N3O4P
Hydrogen Bond Donor Count5
Hydrogen Bond Acceptor Count7
Rotatable Bond Count0
Exact Mass207.04089281 g/mol
Monoisotopic Mass207.04089281 g/mol
Topological Polar Surface Area143 Ų
Heavy Atom Count13
Formal Charge0
Complexity124
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Neuromuscular Agents

Drugs used for their actions on skeletal muscle. Included are agents that act directly on skeletal muscle, those that alter neuromuscular transmission (NEUROMUSCULAR BLOCKING AGENTS), and drugs that act centrally as skeletal muscle relaxants (MUSCLE RELAXANTS, CENTRAL). Drugs used in the treatment of movement disorders are ANTI-DYSKINESIA AGENTS. (See all compounds classified as Neuromuscular Agents.)


Potassium Channel Blockers

A class of drugs that act by inhibition of potassium efflux through cell membranes. Blockade of potassium channels prolongs the duration of ACTION POTENTIALS. They are used as ANTI-ARRHYTHMIA AGENTS and VASODILATOR AGENTS. (See all compounds classified as Potassium Channel Blockers.)


4.2 FDA Pharmacological Classification
4.2.1 Pharmacological Classes
Potassium Channel Blocker [EPC]; Potassium Channel Antagonists [MoA]
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