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Also known as: (s)-(+)-ketoprofen, 22161-81-5, (s)-ketoprofen, (+)-ketoprofen, (s)-2-(3-benzoylphenyl)propanoic acid, (2s)-2-(3-benzoylphenyl)propanoic acid
Molecular Formula
C16H14O3
Molecular Weight
254.28  g/mol
InChI Key
DKYWVDODHFEZIM-NSHDSACASA-N
FDA UNII
6KD9E78X68

Dexketoprofen Trometamol
Dexketoprofen is a non-steroidal anti-inflammatory drug. It is available in the various countries in Europe, Asia and Latin America. It has analgesic, antipyretic and anti-inflammatory properties.
1 2D Structure

Dexketoprofen Trometamol

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(2S)-2-(3-benzoylphenyl)propanoic acid
2.1.2 InChI
InChI=1S/C16H14O3/c1-11(16(18)19)13-8-5-9-14(10-13)15(17)12-6-3-2-4-7-12/h2-11H,1H3,(H,18,19)/t11-/m0/s1
2.1.3 InChI Key
DKYWVDODHFEZIM-NSHDSACASA-N
2.1.4 Canonical SMILES
CC(C1=CC(=CC=C1)C(=O)C2=CC=CC=C2)C(=O)O
2.1.5 Isomeric SMILES
C[C@@H](C1=CC(=CC=C1)C(=O)C2=CC=CC=C2)C(=O)O
2.2 Other Identifiers
2.2.1 UNII
6KD9E78X68
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Adolquir

2. Badyket

3. Dexketoprofen Trometamol

4. Enangel

5. Enantyum

6. Keral

7. Ketesse

8. Quiralam

9. Quirgel

10. Sympal

2.3.2 Depositor-Supplied Synonyms

1. (s)-(+)-ketoprofen

2. 22161-81-5

3. (s)-ketoprofen

4. (+)-ketoprofen

5. (s)-2-(3-benzoylphenyl)propanoic Acid

6. (2s)-2-(3-benzoylphenyl)propanoic Acid

7. S-(+)-ketoprofen

8. Dexketoprofen [inn]

9. Arveles

10. (+)-3-benzoylhydratropic Acid

11. (+)-(s)-m-benzoylhydratropic Acid

12. Hydratropic Acid, M-benzoyl-, (+)-

13. Ketoprofen, (s)-

14. (s)-3-benzoyl-alpha-methylbenzeneacetic Acid

15. Chembl75435

16. (s)-(+)-2-(3-benzoylphenyl)propionic Acid

17. Chebi:76128

18. 6kd9e78x68

19. Dexketoprofen (inn)

20. (2s)-2-[3-(benzenecarbonyl)phenyl]propanoic Acid

21. Smr000857177

22. Dexketoprofen [inn:ban]

23. Unii-6kd9e78x68

24. 9kl

25. Mfcd00673316

26. Biomolki_000007

27. Biomolki2_000017

28. Schembl66987

29. Bmk1-b7

30. Mls001333189

31. Mls001333190

32. Benzeneacetic Acid, 3-benzoyl-alpha-methyl-, (s)-

33. Dexketoprofen [who-dd]

34. Zinc5560

35. (s)-(+)-ketoprofen, 99%

36. Dtxsid40905141

37. Hms2090m22

38. Hms2234m14

39. Bcp13810

40. Hy-b2137

41. Bdbm50088570

42. S5192

43. 2-(3-benzoyl-phenyl)-propionic Acid

44. Akos015913672

45. Ac-8103

46. Ccg-100611

47. Cs-8173

48. Db09214

49. Ncgc00142585-01

50. Ncgc00142585-02

51. As-17683

52. Bk166230

53. (s)-2-(3-benzoyl-phenyl)-propionic Acid

54. (+)-2-(3-benzoylphenyl)propionic Acid

55. (s)-(+)-2-(3-benzoylphenyl) Propionic Acid

56. (s)-(+)-3-benzoyl-?-methylbenzeneacetic Acid

57. D07269

58. D94685

59. (2s)-2-(3-benzoylphenyl)propionic Acid

60. Ab00918363-05

61. (s)-(+)-3-benzoyl-alpha-methylbenzeneacetic Acid

62. 161k815

63. A878675

64. Q425440

65. S-(+)-ketoprofen; (s)-ketoprofen; Dexketoprofen

66. W-201922

67. (.alpha.s)-3-benzoyl-.alpha.-methylbenzeneacetic Acid

68. Benzeneacetic Acid, 3-benzoyl-.alpha.-methyl-, (.alpha.s)-

69. Benzeneacetic Acid, 3-benzoyl-.alpha.-methyl-, (s)-

70. Benzeneacetic Acid, 3-benzoyl-?-methyl-, (s)-hydratropic Acid, M-benzoyl-, (+)-

2.4 Create Date
2005-07-07
3 Chemical and Physical Properties
Molecular Weight 254.28 g/mol
Molecular Formula C16H14O3
XLogP33.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Exact Mass254.094294304 g/mol
Monoisotopic Mass254.094294304 g/mol
Topological Polar Surface Area54.4 Ų
Heavy Atom Count19
Formal Charge0
Complexity331
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

For short-term treatment of mild to moderate pain, including dysmenorrhoea, musculoskeletal pain and toothache.


5 Pharmacology and Biochemistry
5.1 Pharmacology

This drug is an isomer of ketoprofen. Dexketoprofen a propionic acid derivative with analgesic, anti-inflammatory, and antipyretic properties.


5.2 MeSH Pharmacological Classification

Anti-Inflammatory Agents, Non-Steroidal

Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. (See all compounds classified as Anti-Inflammatory Agents, Non-Steroidal.)


5.3 ATC Code

M - Musculo-skeletal system

M01 - Antiinflammatory and antirheumatic products

M01A - Antiinflammatory and antirheumatic products, non-steroids

M01AE - Propionic acid derivatives

M01AE17 - Dexketoprofen


M - Musculo-skeletal system

M02 - Topical products for joint and muscular pain

M02A - Topical products for joint and muscular pain

M02AA - Antiinflammatory preparations, non-steroids for topical use

M02AA27 - Dexketoprofen


5.4 Absorption, Distribution and Excretion

Absorption

After oral ingestion, the Dexketoprofen onset of action is within 30 minutes. The plasma half-life of Dexketoprofen is about 4-6 hours. The Cmax is about 30 minutes


Route of Elimination

Approximately 70 to 80% of the ingested dose is recovered in the urine during the first 12 hours post-ingestion, mainly as the acyl-conjugated form of the drug.


Volume of Distribution

<0.25 L/kg


Clearance

Mainly cleared via glucuronide conjugation and followed by renal excretion, mainly unchanged.


5.5 Metabolism/Metabolites

Dexketoprofen is highly lipophilic, and is metabolized in the liver by glucuronidation. In one study, after oral administration of 25 mg of dexketoprofen to young healthy adults, Tmax was approximately 30 min for a Cmax of 3.7 0.72 mg/l. Dexketoprofen trometamol is metabolized by the hepatic cytochrome P450 enzymes (CYP2C8 and CYP2C9). Dexketoprofen trometamol has a number of metabolites, with hydroxyl derivatives making up the greatest volume. In humans, hydroxylation plays a minor role. Dexketoprofen is primarily conjugated to an acyl-glucuronide


5.6 Biological Half-Life

1.65 h


5.7 Mechanism of Action

It is a non-steroidal anti-inflammatory drug (NSAID) that reduces prostaglandin synthesis via inhibition of cyclooxygenase pathway (both COX-1 and COX-2) activity.


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03-Jan-2022
27-Apr-2025
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Dexketoprofen Trometamol manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Dexketoprofen Trometamol API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Dexketoprofen Trometamol manufacturer or Dexketoprofen Trometamol supplier for your needs.

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PharmaCompass also assists you with knowing the Dexketoprofen Trometamol API Price utilized in the formulation of products. Dexketoprofen Trometamol API Price is not always fixed or binding as the Dexketoprofen Trometamol Price is obtained through a variety of data sources. The Dexketoprofen Trometamol Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Dexketoprofen Trometamol

Synonyms

(s)-(+)-ketoprofen, 22161-81-5, (s)-ketoprofen, (+)-ketoprofen, (s)-2-(3-benzoylphenyl)propanoic acid, (2s)-2-(3-benzoylphenyl)propanoic acid

Cas Number

22161-81-5

Unique Ingredient Identifier (UNII)

6KD9E78X68

About Dexketoprofen Trometamol

Dexketoprofen is a non-steroidal anti-inflammatory drug. It is available in the various countries in Europe, Asia and Latin America. It has analgesic, antipyretic and anti-inflammatory properties.

Adolquir Manufacturers

A Adolquir manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Adolquir, including repackagers and relabelers. The FDA regulates Adolquir manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Adolquir API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Adolquir manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Adolquir Suppliers

A Adolquir supplier is an individual or a company that provides Adolquir active pharmaceutical ingredient (API) or Adolquir finished formulations upon request. The Adolquir suppliers may include Adolquir API manufacturers, exporters, distributors and traders.

click here to find a list of Adolquir suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Adolquir USDMF

A Adolquir DMF (Drug Master File) is a document detailing the whole manufacturing process of Adolquir active pharmaceutical ingredient (API) in detail. Different forms of Adolquir DMFs exist exist since differing nations have different regulations, such as Adolquir USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Adolquir DMF submitted to regulatory agencies in the US is known as a USDMF. Adolquir USDMF includes data on Adolquir's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Adolquir USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Adolquir suppliers with USDMF on PharmaCompass.

Adolquir KDMF

In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.

Pharmaceutical companies submit a Adolquir Drug Master File in Korea (Adolquir KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of Adolquir. The MFDS reviews the Adolquir KDMF as part of the drug registration process and uses the information provided in the Adolquir KDMF to evaluate the safety and efficacy of the drug.

After submitting a Adolquir KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their Adolquir API can apply through the Korea Drug Master File (KDMF).

click here to find a list of Adolquir suppliers with KDMF on PharmaCompass.

Adolquir WC

A Adolquir written confirmation (Adolquir WC) is an official document issued by a regulatory agency to a Adolquir manufacturer, verifying that the manufacturing facility of a Adolquir active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Adolquir APIs or Adolquir finished pharmaceutical products to another nation, regulatory agencies frequently require a Adolquir WC (written confirmation) as part of the regulatory process.

click here to find a list of Adolquir suppliers with Written Confirmation (WC) on PharmaCompass.

Adolquir NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Adolquir as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for Adolquir API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture Adolquir as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain Adolquir and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Adolquir NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of Adolquir suppliers with NDC on PharmaCompass.

Adolquir GMP

Adolquir Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Adolquir GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Adolquir GMP manufacturer or Adolquir GMP API supplier for your needs.

Adolquir CoA

A Adolquir CoA (Certificate of Analysis) is a formal document that attests to Adolquir's compliance with Adolquir specifications and serves as a tool for batch-level quality control.

Adolquir CoA mostly includes findings from lab analyses of a specific batch. For each Adolquir CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Adolquir may be tested according to a variety of international standards, such as European Pharmacopoeia (Adolquir EP), Adolquir JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Adolquir USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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