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Also known as: Ws-12, Ws 12, (1r,2s,5r)-n-(4-methoxyphenyl)-5-methyl-2-(propan-2-yl)cyclohexane-1-carboxamide, Fema no. 4681, N-(4-methoxyphenyl)-p-menthanecarboxamide, Cyclohexanecarboxamide, n-(4-methoxyphenyl)-5-methyl-2-(1-methylethyl)-, (1r,2s,5r)-

Molecular Formula

C₁₈H₂₇NO₂

Molecular Weight

289.4 g/mol

InChI Key

HNSGVPAAXJJOPQ-XOKHGSTOSA-N

FDA UNII

1L7BVT4Z4Z

Acoltremon is under investigation in clinical trial NCT05493111 (A Long-term Safety Study Evaluating the Safety and Systemic Exposure of AR-15512).

1 2D Structure

Acoltremon

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

(1R,2S,5R)-N-(4-methoxyphenyl)-5-methyl-2-propan-2-ylcyclohexane-1-carboxamide

2.1.2 InChI

InChI=1S/C18H27NO2/c1-12(2)16-10-5-13(3)11-17(16)18(20)19-14-6-8-15(21-4)9-7-14/h6-9,12-13,16-17H,5,10-11H2,1-4H3,(H,19,20)/t13-,16+,17-/m1/s1

2.1.3 InChI Key

HNSGVPAAXJJOPQ-XOKHGSTOSA-N

2.2 Other Identifiers

2.2.1 UNII

1L7BVT4Z4Z

2.3 Synonyms

2.3.1 MeSH Synonyms

1. N-(4-methoxyphenyl)-4-menthone-3-carboxamide

2. N-(4-methoxyphenyl)-p-menthone-3-carboxamide

3. Ws 12 Compound

4. Ws-12

5. Ws-12 Compound

6. Ws12 Compound

2.3.2 Depositor-Supplied Synonyms

1. Ws-12

2. Ws 12

3. (1r,2s,5r)-n-(4-methoxyphenyl)-5-methyl-2-(propan-2-yl)cyclohexane-1-carboxamide

4. Fema No. 4681

5. N-(4-methoxyphenyl)-p-menthanecarboxamide

6. Cyclohexanecarboxamide, N-(4-methoxyphenyl)-5-methyl-2-(1-methylethyl)-, (1r,2s,5r)-

7. (1r,2s,5r)-n-(4-methoxyphenyl)-5-methyl-2-(1-methylethyl)cyclohexanecarboxamide

8. N-(4-methoxyphenyl)-p-menthane-carboxamide

9. (1r,2s,5r)-methoxyphenyl)-5-methyl-2-propan-n-(4-2-ylcyclohexane-1-carboxamide

10. N-(4-methoxyphenyl)-5-methyl-2-(1-methylethyl)cyclohexanecarboxamide, (1r,2s,5r)-

11. 68489-09-8

12. Acoltremon

13. Cyclohexanecarboxamide,n-(4-methoxyphenyl)-5-methyl-2-(1-methylethyl)-, (1r,2s,5r)-

14. 1l7bvt4z4z

15. (1r,2s,5r)-n-(4-methoxyphenyl)-5-methyl-2-propan-2-ylcyclohexane-1-carboxamide

16. (1r,2s,5r)-2-isopropyl-n-(4-methoxyphenyl)-5-methylcyclohexane-1-carboxamide

17. Chembl2441929

18. Avx-012

19. [1r,2s,5r]-n-(4-methoxyphenyl)-p-menthanecarboxamide

20. Ws12

21. Hnsgvpaaxjjopq-xokhgstosa-n

22. Acoltremon [inn]

23. Unii-1l7bvt4z4z

24. Gtpl4343

25. Schembl2575067

26. Dtxsid10460636

27. Glxc-22261

28. Tca48909

29. Bdbm50442649

30. Akos024457397

31. Ws 12 Is Known As A Trpm8 Agonist.

32. Da-59157

33. Kxs

34. Hy-108449

35. Cs-0028711

36. E77039

37. Q27089230

38. N-(4-methoxyphenyl)-5-methyl-2- (1-methylethyl)cyclohexanecarboxamide, (1r,2s,5r)-

39. 847565-93-9

40. Cyclohexanecarboxamide, N-(4-methoxyphenyl)-5-methyl-2-(1-methylethyl)-, [1r-(1alpha,2beta,5alpha)]-

2.4 Create Date

2006-10-26

3 Chemical and Physical Properties

Molecular Formula	C₁₈H₂₇NO₂
Molecular Weight	289.4 g/mol
XLogP3	4.6
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	4
Exact Mass	Da
Monoisotopic Mass	Da
Topological Polar Surface Area	38.3
Heavy Atom Count	21
Formal Charge	0
Complexity	334
Isotope Atom Count	0
Defined Atom Stereocenter Count	3
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1