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    Acoltremon

    DEVELOPMENTS

    DIGITAL CONTENT

    PharmaCompass
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    2D Structure
    Also known as: Ws-12, Ws 12, (1r,2s,5r)-n-(4-methoxyphenyl)-5-methyl-2-(propan-2-yl)cyclohexane-1-carboxamide, Fema no. 4681, N-(4-methoxyphenyl)-p-menthanecarboxamide, Cyclohexanecarboxamide, n-(4-methoxyphenyl)-5-methyl-2-(1-methylethyl)-, (1r,2s,5r)-
    Molecular Formula
    C18H27NO2
    Molecular Weight
    289.4  g/mol
    InChI Key
    HNSGVPAAXJJOPQ-XOKHGSTOSA-N
    FDA UNII
    1L7BVT4Z4Z
    Acoltremon is under investigation in clinical trial NCT05493111 (A Long-term Safety Study Evaluating the Safety and Systemic Exposure of AR-15512).
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    (1R,2S,5R)-N-(4-methoxyphenyl)-5-methyl-2-propan-2-ylcyclohexane-1-carboxamide
    2.1.2 InChI
    InChI=1S/C18H27NO2/c1-12(2)16-10-5-13(3)11-17(16)18(20)19-14-6-8-15(21-4)9-7-14/h6-9,12-13,16-17H,5,10-11H2,1-4H3,(H,19,20)/t13-,16+,17-/m1/s1
    2.1.3 InChI Key
    HNSGVPAAXJJOPQ-XOKHGSTOSA-N
    2.2 Other Identifiers
    2.2.1 UNII
    1L7BVT4Z4Z
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. N-(4-methoxyphenyl)-4-menthone-3-carboxamide

    2. N-(4-methoxyphenyl)-p-menthone-3-carboxamide

    3. Ws 12 Compound

    4. Ws-12

    5. Ws-12 Compound

    6. Ws12 Compound

    2.3.2 Depositor-Supplied Synonyms

    1. Ws-12

    2. Ws 12

    3. (1r,2s,5r)-n-(4-methoxyphenyl)-5-methyl-2-(propan-2-yl)cyclohexane-1-carboxamide

    4. Fema No. 4681

    5. N-(4-methoxyphenyl)-p-menthanecarboxamide

    6. Cyclohexanecarboxamide, N-(4-methoxyphenyl)-5-methyl-2-(1-methylethyl)-, (1r,2s,5r)-

    7. (1r,2s,5r)-n-(4-methoxyphenyl)-5-methyl-2-(1-methylethyl)cyclohexanecarboxamide

    8. N-(4-methoxyphenyl)-p-menthane-carboxamide

    9. (1r,2s,5r)-methoxyphenyl)-5-methyl-2-propan-n-(4-2-ylcyclohexane-1-carboxamide

    10. N-(4-methoxyphenyl)-5-methyl-2-(1-methylethyl)cyclohexanecarboxamide, (1r,2s,5r)-

    11. 68489-09-8

    12. Acoltremon

    13. Cyclohexanecarboxamide,n-(4-methoxyphenyl)-5-methyl-2-(1-methylethyl)-, (1r,2s,5r)-

    14. 1l7bvt4z4z

    15. (1r,2s,5r)-n-(4-methoxyphenyl)-5-methyl-2-propan-2-ylcyclohexane-1-carboxamide

    16. (1r,2s,5r)-2-isopropyl-n-(4-methoxyphenyl)-5-methylcyclohexane-1-carboxamide

    17. Chembl2441929

    18. Avx-012

    19. [1r,2s,5r]-n-(4-methoxyphenyl)-p-menthanecarboxamide

    20. Ws12

    21. Hnsgvpaaxjjopq-xokhgstosa-n

    22. Acoltremon [inn]

    23. Unii-1l7bvt4z4z

    24. Gtpl4343

    25. Schembl2575067

    26. Dtxsid10460636

    27. Glxc-22261

    28. Tca48909

    29. Bdbm50442649

    30. Akos024457397

    31. Ws 12 Is Known As A Trpm8 Agonist.

    32. Da-59157

    33. Kxs

    34. Hy-108449

    35. Cs-0028711

    36. E77039

    37. Q27089230

    38. N-(4-methoxyphenyl)-5-methyl-2- (1-methylethyl)cyclohexanecarboxamide, (1r,2s,5r)-

    39. 847565-93-9

    40. Cyclohexanecarboxamide, N-(4-methoxyphenyl)-5-methyl-2-(1-methylethyl)-, [1r-(1alpha,2beta,5alpha)]-

    2.4 Create Date
    2006-10-26
    3 Chemical and Physical Properties
    Molecular Weight 289.4 g/mol
    Molecular Formula C18H27NO2
    XLogP34.6
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count2
    Rotatable Bond Count4
    Exact Mass Da
    Monoisotopic Mass Da
    Topological Polar Surface Area38.3
    Heavy Atom Count21
    Formal Charge0
    Complexity334
    Isotope Atom Count0
    Defined Atom Stereocenter Count3
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1