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1. Cilazapril Anhydrous
2. Cilazapril Hydrate
3. Cilazapril Monohydrate
4. Cilazapril Monohydrobromide
5. Cilazapril, (s*)-isomer
6. Cilazapril, Anhydrous
7. Inhibace
8. Ro 31 2848
9. Ro 31-2848
10. Ro 312848
11. Ro-31-2848
12. Ro312848
1. 88768-40-5
2. Cilazapril Anhydrous
3. Inhibace
4. Cilazaprilum
5. Vascace
6. Cilazapril (anhydrous)
7. Dynorm
8. Cilazapril Hydrate
9. Cilazapril [inn]
10. Ro 34-2848
11. Anhydrous Cilazapril
12. Cilazapril (inn)
13. Inhibace (tn)
14. 6h-pyridazino(1,2-a)(1,2)diazepine-1-carboxylic Acid, 9-(((1s)-1-(ethoxycarbonyl)-3-phenylpropyl)amino)octahydro-10-oxo-, (1s,9s)-
15. Initiss
16. (4s,7s)-7-[[(2s)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]-6-oxo-1,2,3,4,7,8,9,10-octahydropyridazino[1,2-a]diazepine-4-carboxylic Acid
17. Ncgc00182039-01
18. Cilazaprilum [latin]
19. Ro-312848006
20. 8q9454114q
21. Cilazil
22. Inibace
23. Vascase
24. Unii-8q9454114q
25. Ro-312848
26. Cilazapril [mi]
27. Cilazapril [vandf]
28. Cilazapril [who-dd]
29. Dsstox_cid_28555
30. Dsstox_rid_82827
31. Dsstox_gsid_48629
32. Schembl24962
33. Chebi:3698
34. Chembl515606
35. Gtpl6459
36. Dtxsid1048629
37. Hy-a0043
38. Zinc3781951
39. Tox21_112971
40. Ac-269
41. Akos015951168
42. Db01340
43. Ro34-2848
44. Ncgc00182039-02
45. Ro-34-2848
46. (1s,9s)-9-{[(2s)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}-10-oxooctahydro-6h-pyridazino[1,2-a][1,2]diazepine-1-carboxylic Acid
47. 6h-pyridazino(1,2-a)(1,2)diazepine-1-carboxylic Acid, 9-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)octahydro-10-oxo-, (1s-(1alpha,9alpha(r*)))-
48. 6h-pyridazino[1,2-a][1,2]diazepine-1-carboxylicacid, 9-[[(1s)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]octahydro-10-oxo-,(1s,9s)-
49. Cas-88768-40-5
50. Ro 31-2848006
51. D07699
52. Ab01565812_02
53. 768c405
54. A916338
55. Q867350
56. Ro-31-2848/006
57. Brd-k96177243-002-01-9
58. (1s,9s)-9-(((s)-1-carboxy-3-phenylpropyl)amino)octahydro-10-oxo-6h-pyridazino(1,2-a)(1,2)diazepine-1-carboxylic Acid 9-ethyl Ester
59. (1s,9s)-9-(((s)-1-ethoxy-1-oxo-4-phenylbutan-2-yl)amino)-10-oxooctahydro-6h-pyridazino[1,2-a][1,2]diazepine-1-carboxylic Acid
60. (1s,9s)-9-[[(1s)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]octahydro-10-oxo-6h-pyridazino[1,2-a][1,2]diazepine-1-carboxylic Acid
61. (1s,9s)-9-[[(2s)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]-10-oxo-1,2,3,4,6,7,8,9-octahydropyridazino[1,2-a]diazepine-1-carboxylic Acid
62. (1s,9s)-9-{[(2s)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}-10-oxo-octahydro-1h-pyridazino[1,2-a][1,2]diazepine-1-carboxylic Acid
63. (5s,8s)-5-{[(1s)-1-ethoxycarbonyl-3-phenyl-propyl]-amino}-6-oxo-1,7-diazabicyclo[5.4.0]undecane-8-carboxylic Acid
64. 6h-pyridazino(1,2-a)(1,2)diazepine-1-carboxylic Acid, 9-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)octahydro-10-oxo-, Monohydrate, (1s-(1.alpha.,9.alpha.(r*)))
| Molecular Weight | 417.5 g/mol |
|---|---|
| Molecular Formula | C22H31N3O5 |
| XLogP3 | 0.6 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 7 |
| Rotatable Bond Count | 9 |
| Exact Mass | 417.22637110 g/mol |
| Monoisotopic Mass | 417.22637110 g/mol |
| Topological Polar Surface Area | 99.2 Ų |
| Heavy Atom Count | 30 |
| Formal Charge | 0 |
| Complexity | 608 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 3 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
Cilazapril is an ACE inhibtor class drug used in the treatment of hypertension and heart failure.
FDA Label
Cilazapril inhibits the production angiotensin II. By doing so, it decreases sodium and water reabsorption (via aldosterone) and it decreases vasoconstriction. The combined effect of this is a decrease in vascular resistance, and therefore, blood pressure. The absolute bioavailability of cilazaprilat after oral administration of cilazapril is 57% based on urinary recovery data. (The absolute bioavailability of cilazaprilat after oral administration of cilazaprilat is 19%.) Ingestion of food immediately before the administration of cilazapril reduces the average peak plasma concentration of cilazaprilat by 29%, delays the peak by one hour and reduces the bioavailability of cilazaprilat by 14%. These pharmacokinetic changes have little influence on plasma ACE inhibition.
Angiotensin-Converting Enzyme Inhibitors
A class of drugs whose main indications are the treatment of hypertension and heart failure. They exert their hemodynamic effect mainly by inhibiting the renin-angiotensin system. They also modulate sympathetic nervous system activity and increase prostaglandin synthesis. They cause mainly vasodilation and mild natriuresis without affecting heart rate and contractility. (See all compounds classified as Angiotensin-Converting Enzyme Inhibitors.)
Antihypertensive Agents
Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)
C09AA08
S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355
C - Cardiovascular system
C09 - Agents acting on the renin-angiotensin system
C09A - Ace inhibitors, plain
C09AA - Ace inhibitors, plain
C09AA08 - Cilazapril
Absorption
Maximum plasma concentrations of cilazaprilat are reached within two hours after administration of cilazapril.
Route of Elimination
Cilazaprilat is eliminated unchanged by the kidneys. The total urinary recovery of cilazaprilat after intravenous administration of 2.5 mg is 91%.
Clearance
Total clearance is 12.3 L/h and renal clearance is 10.8 L/h. The total urinary recovery of cilazaprilat following the oral administration of 2.5 mg cilazapril is 52.6%.
Half-lives for the periods 1 to 4 hours and 1 to 7 days after the intravenous administration of 2.5 mg cilazaprilat are 0.90 and 46.2 hours respectively.
Cilazapril is a pyridazine ACE inhibitor. It competes with angiotensin I for binding at the angiotensin-converting enzyme, blocking the conversion of angiotensin I to angiotensin II. As angiotensin II is a vasoconstrictor and a negative feedback mediator for renin activity, lower angiotensin II levels results in a decrease in blood pressure, an increase in renin activity, and stimulation of baroreceptor reflex mechanisms. Kininase II, an enzyme which degrades the vasodilator bradykinin, is identical to ACE and may also be inhibited.
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PharmaCompass offers a list of Cilazapril API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Cilazapril manufacturer or Cilazapril supplier for your needs.
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PharmaCompass also assists you with knowing the Cilazapril API Price utilized in the formulation of products. Cilazapril API Price is not always fixed or binding as the Cilazapril Price is obtained through a variety of data sources. The Cilazapril Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.
A AC-269 manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of AC-269, including repackagers and relabelers. The FDA regulates AC-269 manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. AC-269 API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.
click here to find a list of AC-269 manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.
A AC-269 supplier is an individual or a company that provides AC-269 active pharmaceutical ingredient (API) or AC-269 finished formulations upon request. The AC-269 suppliers may include AC-269 API manufacturers, exporters, distributors and traders.
click here to find a list of AC-269 suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.
The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.
The AC-269 Drug Master File in Japan (AC-269 JDMF) empowers AC-269 API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).
PMDA reviews the AC-269 JDMF during the approval evaluation for pharmaceutical products. At the time of AC-269 JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.
click here to find a list of AC-269 suppliers with JDMF on PharmaCompass.
In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.
Pharmaceutical companies submit a AC-269 Drug Master File in Korea (AC-269 KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of AC-269. The MFDS reviews the AC-269 KDMF as part of the drug registration process and uses the information provided in the AC-269 KDMF to evaluate the safety and efficacy of the drug.
After submitting a AC-269 KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their AC-269 API can apply through the Korea Drug Master File (KDMF).
click here to find a list of AC-269 suppliers with KDMF on PharmaCompass.
A AC-269 CEP of the European Pharmacopoeia monograph is often referred to as a AC-269 Certificate of Suitability (COS). The purpose of a AC-269 CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of AC-269 EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of AC-269 to their clients by showing that a AC-269 CEP has been issued for it. The manufacturer submits a AC-269 CEP (COS) as part of the market authorization procedure, and it takes on the role of a AC-269 CEP holder for the record. Additionally, the data presented in the AC-269 CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the AC-269 DMF.
A AC-269 CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. AC-269 CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.
click here to find a list of AC-269 suppliers with CEP (COS) on PharmaCompass.
A AC-269 written confirmation (AC-269 WC) is an official document issued by a regulatory agency to a AC-269 manufacturer, verifying that the manufacturing facility of a AC-269 active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting AC-269 APIs or AC-269 finished pharmaceutical products to another nation, regulatory agencies frequently require a AC-269 WC (written confirmation) as part of the regulatory process.
click here to find a list of AC-269 suppliers with Written Confirmation (WC) on PharmaCompass.
AC-269 Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.
GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).
PharmaCompass offers a list of AC-269 GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right AC-269 GMP manufacturer or AC-269 GMP API supplier for your needs.
A AC-269 CoA (Certificate of Analysis) is a formal document that attests to AC-269's compliance with AC-269 specifications and serves as a tool for batch-level quality control.
AC-269 CoA mostly includes findings from lab analyses of a specific batch. For each AC-269 CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.
AC-269 may be tested according to a variety of international standards, such as European Pharmacopoeia (AC-269 EP), AC-269 JP (Japanese Pharmacopeia) and the US Pharmacopoeia (AC-269 USP).
