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    Vericiguat

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    01 1M/s Maithri Drugs Private Limited

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    Maithri Drugs

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    Vericiguat IH

    Date of Issue : 2024-02-12

    Valid Till : 2027-02-11

    Written Confirmation Number : WC-0407

    Address of the Firm : Sy. No. 205, 222 to 226, IDA Bonthapally, Bonthapally (Village), Gummadidala (Ma...

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    Looking for 1350653-20-1 / Vericiguat API manufacturers, exporters & distributors?

    Vericiguat manufacturers, exporters & distributors 1

    77

    PharmaCompass offers a list of Vericiguat API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, and more, enabling you to easily find the right Vericiguat manufacturer or Vericiguat supplier for your needs.

    Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Vericiguat manufacturer or Vericiguat supplier.

    API | Excipient name

    Vericiguat

    Synonyms

    1350653-20-1, Verquvo, Methyl (4,6-diamino-2-(5-fluoro-1-(2-fluorobenzyl)-1h-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-5-yl)carbamate, Mk-1242, Vericiguat [inn], Bay-1021189

    Cas Number

    1350653-20-1

    Unique Ingredient Identifier (UNII)

    LV66ADM269

    About Vericiguat

    Vericiguat is a direct stimulator of soluble guanylate cyclase (sGC) used in the management of systolic heart failure to reduce mortality and hospitalizations. A key component of the NO-sGC-cGMP signaling pathway that helps to regulate the cardiovascular system, sGC enzymes are intracellular enzymes found in vascular smooth muscle cells (amongst other cell types) that catalyze the synthesis of cyclic guanosine monophosphate (cGMP) in response to activation by nitric oxide (NO). Cyclic GMP acts as a second messenger, activating a number of downstream signaling cascades that elicit a broad variety of effects, and these diverse cellular effects have implicated deficiencies in its production (primarily due to insufficient NO bioavailability) in the pathogenesis of various cardiovascular diseases. As a direct stimulator of sGC, vericiguat mitigates the need for a functional NO-sGC-cGMP axis and thereby helps to prevent the myocardial and vascular dysfunction associated with decreased sGC activity in heart failure. Vericiguat was approved by the FDA in January 2021 - developed by Merck under the brand name Verquvo - for use in certain patients with systolic heart failure. Although not the first sGC stimulator to be granted FDA approval ([riociguat] was approved in 2013 for use in pulmonary hypertension), vericiguat is unique amongst its peers in that modifications to its structure have dramatically decreased its susceptibility to oxidative metabolism, resulting in a relatively long half-life and allowing for once-daily dosing.

    Vericiguat Manufacturers

    A Vericiguat manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Vericiguat, including repackagers and relabelers. The FDA regulates Vericiguat manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Vericiguat API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of Vericiguat manufacturers with USDMF, JDMF, KDMF, CEP, GMP, and COA related information on PhamaCompass.

    Vericiguat Suppliers

    A Vericiguat supplier is an individual or a company that provides Vericiguat active pharmaceutical ingredient (API) or Vericiguat finished formulations upon request. The Vericiguat suppliers may include Vericiguat API manufacturers, exporters, distributors and traders.

    click here to find a list of Vericiguat suppliers with USDMF, JDMF, KDMF, CEP, GMP, and COA related information on PharmaCompass.

    Vericiguat WC

    A Vericiguat written confirmation (Vericiguat WC) is an official document issued by a regulatory agency to a Vericiguat manufacturer, verifying that the manufacturing facility of a Vericiguat active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Vericiguat APIs or Vericiguat finished pharmaceutical products to another nation, regulatory agencies frequently require a Vericiguat WC (written confirmation) as part of the regulatory process.

    click here to find a list of Vericiguat suppliers with Written Confirmation (WC) on PharmaCompass.

    Vericiguat Manufacturers | Traders | Suppliers

    Vericiguat Manufacturers, Traders, Suppliers 1
    17

    We have 1 companies offering Vericiguat

    Get in contact with the supplier of your choice:

    1. Maithri Drugs
    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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