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Inc","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Nutrition & Weight Loss","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"ZyVersa Therapeutics, Inc \/ Undisclosed","highestDevelopmentStatusID":"4","companyTruncated":"ZyVersa Therapeutics, Inc \/ Undisclosed"}]

    Find Clinical Drug Pipeline Developments & Deals by ZyVersa Therapeutics, Inc

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                            01

                            ZyVersa Therapeutics, Inc

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                            Lead Product(s) : Hydroxypropyl-Beta Cyclodextrin

                            Therapeutic Area : Genetic Disease

                            Study Phase : Approved FDF

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            FDA Allows Compassionate Use Of ZyVersa’s VAR 200 In ApoCII Amyloidosis

                            Details : Cholesterol Efflux Mediator™ VAR 200 (2-hydroxypropyl-beta-cyclodextrin, 2HPβCD) is an injectable drug got emergency compassionate use in a patient with ApoCII amyloidosis.

                            Product Name : VAR 200

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            July 08, 2025

                            Lead Product(s) : Hydroxypropyl-Beta Cyclodextrin

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Approved FDF

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            02

                            ZyVersa Therapeutics, Inc

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                            ZyVersa Therapeutics, Inc

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                            Lead Product(s) : Hydroxypropyl-Beta Cyclodextrin

                            Therapeutic Area : Nephrology

                            Study Phase : Phase II

                            Sponsor : Williamsburg Venture Holdings

                            Deal Size : $10.0 million

                            Deal Type : Agreement

                            DEALS_DEV arrow-down

                            ZyVersa Announces Share Purchase Agreement Partnership with Williamsburg Venture

                            Details : The proceeds will be used to advance clinical development of VAR 200 in development for treatment of chronic kidney diseases.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Undisclosed

                            June 25, 2025

                            Lead Product(s) : Hydroxypropyl-Beta Cyclodextrin

                            Therapeutic Area : Nephrology

                            Highest Development Status : Phase II

                            Sponsor : Williamsburg Venture Holdings

                            Deal Size : $10.0 million

                            Deal Type : Agreement

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                            03

                            ZyVersa Therapeutics, Inc

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                            Lead Product(s) : IC-100-08

                            Therapeutic Area : Nutrition and Weight Loss

                            Study Phase : Preclinical

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            ZyVersa Shows Promise Using Inflammasome & GLP-1 Combo for Obesity Needs

                            Details : IC 100 is an inflammasome ASC Inhibitor, which is currently under development for the treatment of obesity.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            May 07, 2025

                            Lead Product(s) : IC-100-08

                            Therapeutic Area : Nutrition and Weight Loss

                            Highest Development Status : Preclinical

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            04

                            ZyVersa Therapeutics, Inc

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                            ZyVersa Therapeutics, Inc

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                            Lead Product(s) : IC 100

                            Therapeutic Area : Neurology

                            Study Phase : Preclinical

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            ZyVersa Data Shows Inflammasome Inhibition Lowers Neuroinflammation in Alzheimer’s

                            Details : IC 100 is a NLRP3-inflammasome inhibitor, small molecule drug candidate, which is currently being evaluated for the treatment of alzheimer’s disease.

                            Product Name : Undisclosed

                            Product Type : Antibody, Unconjugated

                            Upfront Cash : Inapplicable

                            March 12, 2025

                            Lead Product(s) : IC 100

                            Therapeutic Area : Neurology

                            Highest Development Status : Preclinical

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            05

                            ZyVersa Therapeutics, Inc

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                            ZyVersa Therapeutics, Inc

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                            Lead Product(s) : IC 100

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Study Phase : Preclinical

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            ZyVersa's NLRP3 Inhibitor Shows Heart, Glucose Benefits in Obese Models

                            Details : MCC950 is a NLRP3-inflammasome inhibitor, small molecule drug candidate, which is currently being evaluated for the treatment of heart failure (HFpEF) and type 2 diabetes.

                            Product Name : Undisclosed

                            Product Type : Antibody, Unconjugated

                            Upfront Cash : Inapplicable

                            March 05, 2025

                            Lead Product(s) : IC 100

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Highest Development Status : Preclinical

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            06

                            ZyVersa Therapeutics, Inc

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                            ZyVersa Therapeutics, Inc

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                            Lead Product(s) : 2-hydroxylpropyl-beta-cyclodextrin

                            Therapeutic Area : Nephrology

                            Study Phase : Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            P2a Open Label Study to Evaluate 2-HPβCD in Subjects With Diabetic Kidney Disease

                            Details : 2-hydroxylpropyl-beta-cyclodextrin is a Other Small Molecule drug candidate, which is currently being evaluated in phase II clinical studies for the treatment of Diabetic Nephropathies.

                            Product Name : Undisclosed

                            Product Type : Carbohydrate

                            Upfront Cash : Inapplicable

                            July 05, 2024

                            Lead Product(s) : 2-hydroxylpropyl-beta-cyclodextrin

                            Therapeutic Area : Nephrology

                            Highest Development Status : Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            07

                            ZyVersa Therapeutics, Inc

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                            ZyVersa Therapeutics, Inc

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                            PREP
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                            Lead Product(s) : Hydroxypropyl-Beta Cyclodextrin

                            Therapeutic Area : Nephrology

                            Study Phase : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            ZyVersa Gets IRB Approval for Phase 2a Trial Of VAR 200 in Diabetic Kidney Disease

                            Details : VAR 200 (2-hydroxypropyl-beta-cyclodextrin) is being developed to mediate removal of excess cholesterol that damages the kidneys’ filtration system in patients with Diabetic Kidney Disease.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            March 18, 2024

                            Lead Product(s) : Hydroxypropyl-Beta Cyclodextrin

                            Therapeutic Area : Nephrology

                            Highest Development Status : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            08

                            ZyVersa Therapeutics, Inc

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                            ZyVersa Therapeutics, Inc

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                            Lead Product(s) : IC-100-08

                            Therapeutic Area : Nutrition and Weight Loss

                            Study Phase : Preclinical

                            Sponsor : Undisclosed

                            Deal Size : $2.7 million

                            Deal Type : Private Placement

                            DEALS_DEV arrow-down

                            ZyVersa Raises $2.7M as Inflammasome Inhibitors Show Promise for Obesity Treatment

                            Details : The net proceeds will be used to focus on the clinical development of IC 100-08, a novel humanized IgG4 monoclonal antibody. Currently, it is being evaluated in the preclinical studies for obesity.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Undisclosed

                            February 29, 2024

                            Lead Product(s) : IC-100-08

                            Therapeutic Area : Nutrition and Weight Loss

                            Highest Development Status : Preclinical

                            Sponsor : Undisclosed

                            Deal Size : $2.7 million

                            Deal Type : Private Placement

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                            09

                            ZyVersa Therapeutics, Inc

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                            ZyVersa Therapeutics, Inc

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                            Lead Product(s) : Hydroxypropyl-Beta Cyclodextrin

                            Therapeutic Area : Nephrology

                            Study Phase : Phase I

                            Sponsor : George Clinical

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            ZyVersa Therapeutics Engages CRO, George Clinical, for Phase 2a Clinical Trial for Cholesterol Efflux Mediator...

                            Details : VAR 200 (2-hydroxypropyl-beta-cyclodextrin, 2HPβCD) is a phase 2a-ready drug in development which has potential to treat multiple kidney diseases, including diabetic kidney disease, rare kidney diseases, FSGS (focal segmental glomerulosclerosis) and Alp...

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            December 14, 2023

                            Lead Product(s) : Hydroxypropyl-Beta Cyclodextrin

                            Therapeutic Area : Nephrology

                            Highest Development Status : Phase I

                            Sponsor : George Clinical

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            10

                            ZyVersa Therapeutics, Inc

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                            Lead Product(s) : Hydroxypropyl-Beta Cyclodextrin

                            Therapeutic Area : Nephrology

                            Study Phase : Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            ZyVersa Therapeutics Adds Two Esteemed Leaders in Nephrology to Its Renal Scientific Advisory Board to Support...

                            Details : VAR 200 (2HPβCD) is a cholesterol efflux mediator in development to ameliorate renal lipid accumulation that damages the kidneys' filtration system. VAR 200 passively and actively removes excess lipids from the kidney and has potential to treat other gl...

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            January 03, 2023

                            Lead Product(s) : Hydroxypropyl-Beta Cyclodextrin

                            Therapeutic Area : Nephrology

                            Highest Development Status : Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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