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Pharmaceutical"},{"orgOrder":0,"company":"Kaiser Permanente","sponsor":"Esperion Therapeutics","pharmaFlowCategory":"DU","therapeuticArea":"Cardiology\/Vascular Diseases","country":"","productType":"Other Small Molecule","year":"2022","type":"Inapplicable","leadProduct":"Bempedoic Acid","moa":"||ATP-citrate synthase","graph1":"Cardiology\/Vascular Diseases","graph2":"Phase IV","graph3":"Kaiser Permanente","amount2":0,"highestDevelopmentShortName":"Ph IV","therapeuticAreaShortName":"Cardiovascular Diseases","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Kaiser Permanente \/ Esperion Therapeutics","highestDevelopmentStatusID":"11","companyTruncated":"Kaiser Permanente \/ Esperion Therapeutics"},{"orgOrder":0,"company":"Seung-Whan Lee, M.D., Ph.D.","sponsor":"Yuhan Corporation","pharmaFlowCategory":"DU","therapeuticArea":"Cardiology\/Vascular Diseases","country":"","productType":"Other Small Molecule","year":"2022","type":"Inapplicable","leadProduct":"Ezetimibe","moa":"||HMG-CoA reductase (HMGCR)","graph1":"Cardiology\/Vascular Diseases","graph2":"Phase IV","graph3":"Seung-Whan Lee, M.D., Ph.D.","amount2":0,"highestDevelopmentShortName":"Ph IV","therapeuticAreaShortName":"Cardiovascular Diseases","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Seung-Whan Lee, M.D., Ph.D. \/ Yuhan Corporation","highestDevelopmentStatusID":"11","companyTruncated":"Seung-Whan Lee, M.D., Ph.D. \/ Yuhan Corporation"},{"orgOrder":0,"company":"Korea University Anam Hospital","sponsor":"Daewon Pharm. Co., Ltd | Samjin Pharmaceutical","pharmaFlowCategory":"DU","therapeuticArea":"Cardiology\/Vascular Diseases","country":"","productType":"Other Small Molecule","year":"2025","type":"Inapplicable","leadProduct":"Pitavastatin","moa":"||HMG-CoA reductase","graph1":"Cardiology\/Vascular Diseases","graph2":"Phase IV","graph3":"Korea University Anam Hospital","amount2":0,"highestDevelopmentShortName":"Ph IV","therapeuticAreaShortName":"Cardiovascular Diseases","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Korea University Anam Hospital \/ Daewon Pharm. Co., Ltd | Samjin Pharmaceutical","highestDevelopmentStatusID":"11","companyTruncated":"Korea University Anam Hospital \/ Daewon Pharm. Co., Ltd | Samjin Pharmaceutical"},{"orgOrder":0,"company":"Md. Alimur Reza","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Cardiology\/Vascular Diseases","country":"","productType":"Other Small Molecule","year":"2025","type":"Inapplicable","leadProduct":"Atorvastatin","moa":"||HMG-CoA reductase","graph1":"Cardiology\/Vascular Diseases","graph2":"Phase IV","graph3":"Md. Alimur Reza","amount2":0,"highestDevelopmentShortName":"Ph IV","therapeuticAreaShortName":"Cardiovascular Diseases","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Md. Alimur Reza \/ Inapplicable","highestDevelopmentStatusID":"11","companyTruncated":"Md. Alimur Reza \/ Inapplicable"},{"orgOrder":0,"company":"Beijing Anzhen Hospital","sponsor":"Beijing Municipal Health Commission","pharmaFlowCategory":"DU","therapeuticArea":"Cardiology\/Vascular Diseases","country":"","productType":"Antibody","year":"2021","type":"Inapplicable","leadProduct":"Evolocumab","moa":"||Subtilisin\/kexin type 9","graph1":"Cardiology\/Vascular Diseases","graph2":"Phase III","graph3":"Beijing Anzhen Hospital","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Cardiovascular Diseases","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Beijing Anzhen Hospital \/ Beijing Municipal Health Commission","highestDevelopmentStatusID":"10","companyTruncated":"Beijing Anzhen Hospital \/ Beijing Municipal Health Commission"},{"orgOrder":0,"company":"JW Pharmaceutical","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Cardiology\/Vascular Diseases","country":"","productType":"Other Small Molecule","year":"2020","type":"Inapplicable","leadProduct":"Pitavastatin","moa":"||HMG-CoA reductase","graph1":"Cardiology\/Vascular Diseases","graph2":"Phase IV","graph3":"JW Pharmaceutical","amount2":0,"highestDevelopmentShortName":"Ph IV","therapeuticAreaShortName":"Cardiovascular Diseases","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"JW Pharmaceutical \/ Inapplicable","highestDevelopmentStatusID":"11","companyTruncated":"JW Pharmaceutical \/ Inapplicable"},{"orgOrder":0,"company":"Steno Diabetes Center Copenhagen","sponsor":"Department of Clinical Physiology, Nuclear Medicine and PET at Rigshospitalet Glostrup, Valdemar Hansens Vej 1-23, 2600 Glostrup, Denmark | Aalborg University | Capital Region Pharmacy, Denmark | Alessia Fornoni, MD PhD, Professor of Medicine, Chief, Katz","pharmaFlowCategory":"DU","therapeuticArea":"Endocrinology","country":"","productType":"Other Small Molecule","year":"2020","type":"Inapplicable","leadProduct":"Ezetimibe","moa":"||Niemann-Pick C1-like protein 1","graph1":"Endocrinology","graph2":"Phase III","graph3":"Steno Diabetes Center Copenhagen","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Endocrinology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Steno Diabetes Center Copenhagen \/ Department of Clinical Physiology, Nuclear Medicine and PET at Rigshospitalet Glostrup, Valdemar Hansens Vej 1-23, 2600 Glostrup, Denmark | Aalborg University | Capital Region Pharmacy, Denmark | Alessia Fornoni, MD PhD, Professor of Medicine, Chief, Katz","highestDevelopmentStatusID":"10","companyTruncated":"Steno Diabetes Center Copenhagen \/ Department of Clinical Physiology, Nuclear Medicine and PET at Rigshospitalet Glostrup, Valdemar Hansens Vej 1-23, 2600 Glostrup, Denmark | Aalborg University | Capital Region Pharmacy, Denmark | Alessia Fornoni, MD PhD, Professor of Medicine, Chief, Katz"},{"orgOrder":0,"company":"Hanlim Pharmaceuticals Inc","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Cardiology\/Vascular Diseases","country":"","productType":"Other Small Molecule","year":"2020","type":"Inapplicable","leadProduct":"Ezetimibe","moa":"||Niemann-Pick C1-like protein 1","graph1":"Cardiology\/Vascular Diseases","graph2":"Phase III","graph3":"Hanlim Pharmaceuticals Inc","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Cardiovascular Diseases","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Hanlim Pharmaceuticals Inc \/ Inapplicable","highestDevelopmentStatusID":"10","companyTruncated":"Hanlim Pharmaceuticals Inc \/ Inapplicable"},{"orgOrder":0,"company":"Daewon Pharm. Co., Ltd","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Cardiology\/Vascular Diseases","country":"SOUTH KOREA","productType":"Other Small Molecule","year":"2023","type":"Inapplicable","leadProduct":"Ezetimibe","moa":"||Niemann-Pick C1-like protein 1","graph1":"Cardiology\/Vascular Diseases","graph2":"Phase III","graph3":"Daewon Pharm. Co., Ltd","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Cardiovascular Diseases","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Daewon Pharm. Co., Ltd \/ Inapplicable","highestDevelopmentStatusID":"10","companyTruncated":"Daewon Pharm. 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Find Clinical Drug Pipeline Developments & Deals for Zetia , Ezetrol, Ezetimibe

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                          Therapeutic Area by Lead Product

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                          Top Deals by Deal Size (USD bn)

                          01

                          Lead Product(s) : Rosuvastatin Calcium,Ezetimibe

                          Therapeutic Area : Cardiology/Vascular Diseases

                          Study Phase : Phase III

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Details : Undisclosed

                          Product Name : Undisclosed

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          December 16, 2020

                          Lead Product(s) : Rosuvastatin Calcium,Ezetimibe

                          Therapeutic Area : Cardiology/Vascular Diseases

                          Highest Development Status : Phase III

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Sanofi Company Banner

                          08

                          Details : Undisclosed

                          Product Name : Undisclosed

                          Product Type : Antibody

                          Upfront Cash : Inapplicable

                          December 30, 2013

                          Lead Product(s) : Alirocumab,Ezetimibe,Fenofibrate

                          Therapeutic Area : Cardiology/Vascular Diseases

                          Highest Development Status : Phase III

                          Sponsor : Regeneron Pharmaceuticals

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Sanofi Company Banner

                          09

                          EPSC
                          Not Confirmed
                          EPSC
                          Not Confirmed

                          Details : HLS Therapeutics for the exclusive rights to commercialize Nexletol and Nexlizet in Canada for cardiovascular disease.

                          Product Name : Nexlizet

                          Product Type : Other Small Molecule

                          Upfront Cash : Undisclosed

                          May 08, 2025

                          Lead Product(s) : Bempedoic Acid,Ezetimibe

                          Therapeutic Area : Cardiology/Vascular Diseases

                          Highest Development Status : Approved FDF

                          Sponsor : HLS Therapeutics

                          Deal Size : $5.0 million

                          Deal Type : Licensing Agreement

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                          10

                          EPSC
                          Not Confirmed
                          EPSC
                          Not Confirmed

                          Details : Nexlizet (bempedoic acid and ezetimibe) is in clinical development for Pediatric Heterozygous and Homozygous Familial Hypercholesterolemia.

                          Product Name : Nexlizet

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          March 20, 2025

                          Lead Product(s) : Bempedoic Acid,Ezetimibe

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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