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    [{"orgOrder":0,"company":"Xilio Therapeutics","sponsor":"Leerink Partners","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Antibody, Unconjugated","year":"2025","type":"Public Offering","leadProduct":"Atezolizumab","moa":"||CTLA4","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"Xilio Therapeutics","amount2":0.050000000000000003,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":0.050000000000000003,"dosageForm":"Infusion","sponsorNew":"Xilio Therapeutics \/ Leerink Partners","highestDevelopmentStatusID":"7","companyTruncated":"Xilio Therapeutics \/ Leerink Partners"},{"orgOrder":0,"company":"Xilio Therapeutics","sponsor":"Leerink Partners","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Antibody, Unconjugated","year":"2025","type":"Public Offering","leadProduct":"Atezolizumab","moa":"||CTLA4","graph1":"Oncology","graph2":"Phase I\/ Phase 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Therapeutics","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Antibody, Unconjugated","year":"2021","type":"Inapplicable","leadProduct":"Vilastobart","moa":"CTLA4","graph1":"Oncology","graph2":"Preclinical","graph3":"Xilio Therapeutics","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Xilio Therapeutics \/ Undisclosed","highestDevelopmentStatusID":"4","companyTruncated":"Xilio Therapeutics \/ Undisclosed"},{"orgOrder":0,"company":"Xilio Therapeutics","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Antibody, Unconjugated","year":"2023","type":"Inapplicable","leadProduct":"Pembrolizumab","moa":"||CTLA4","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"Xilio Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph 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Therapeutics","amount2":2.1499999999999999,"highestDevelopmentShortName":"Discovery Platform","therapeuticAreaShortName":"Oncology","amount2New":2.1499999999999999,"dosageForm":"Undisclosed","sponsorNew":"Xilio Therapeutics \/ AbbVie Inc","highestDevelopmentStatusID":"3","companyTruncated":"Xilio Therapeutics \/ AbbVie Inc"}]

    Find Clinical Drug Pipeline Developments & Deals by Xilio Therapeutics

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                            01

                            Xilio Therapeutics

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                            AIChE Annual Meeting
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                            Xilio Therapeutics

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                            Lead Product(s) : Efarindodekin Alfa

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Gilead Sciences

                            Deal Size : $647.5 million

                            Deal Type : Licensing Agreement

                            DEALS_DEV arrow-down

                            Xilio Therapeutics Announces Initiation of Phase 2 Trial for Efarindodekin Alfa (XTX301)

                            Details : Gilead has an exclusive global license to develop and commercialize XTX301 (efarindodekin alfa), Xilio’s tumor-activated IL-12, currently in Phase I trials for neoplasms treatment.

                            Product Name : Undisclosed

                            Product Type : Protein

                            Upfront Cash : $43.5 million

                            September 09, 2025

                            Lead Product(s) : Efarindodekin Alfa

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Gilead Sciences

                            Deal Size : $647.5 million

                            Deal Type : Licensing Agreement

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                            02

                            Xilio Therapeutics

                            U.S.A arrow
                            AIChE Annual Meeting
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                            Xilio Therapeutics

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                            AIChE Annual Meeting
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                            Lead Product(s) : Vilastobart,Atezolizumab

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Leerink Partners

                            Deal Size : $50.0 million

                            Deal Type : Public Offering

                            DEALS_DEV arrow-down

                            Xilio Therapeutics Announces Closing of $50.0 Million Public Offering

                            Details : The net proceeds from the offering will be used to advance the clinical development of XTX10 (vilastobart), which is being evaluated for the treatment of mss colorectal cancer.

                            Product Name : Undisclosed

                            Product Type : Antibody, Unconjugated

                            Upfront Cash : Undisclosed

                            June 05, 2025

                            Lead Product(s) : Vilastobart,Atezolizumab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Leerink Partners

                            Deal Size : $50.0 million

                            Deal Type : Public Offering

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                            03

                            Xilio Therapeutics

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                            AIChE Annual Meeting
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                            Xilio Therapeutics

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                            AIChE Annual Meeting
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                            Lead Product(s) : Vilastobart,Atezolizumab

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Leerink Partners

                            Deal Size : $50.0 million

                            Deal Type : Public Offering

                            DEALS_DEV arrow-down

                            Xilio Therapeutics Announces Pricing of $50.0 Million Public Offering

                            Details : The net proceeds from the offering will be used to advance the clinical development of XTX10 (vilastobart), which is being evaluated for the treatment of mss colorectal cancer.

                            Product Name : Undisclosed

                            Product Type : Antibody, Unconjugated

                            Upfront Cash : Undisclosed

                            June 02, 2025

                            Lead Product(s) : Vilastobart,Atezolizumab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Leerink Partners

                            Deal Size : $50.0 million

                            Deal Type : Public Offering

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                            04

                            Xilio Therapeutics

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                            AIChE Annual Meeting
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                            Xilio Therapeutics

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                            AIChE Annual Meeting
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                            Lead Product(s) : Vilastobart,Atezolizumab

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Leerink Partners

                            Deal Size : Undisclosed

                            Deal Type : Public Offering

                            DEALS_DEV arrow-down

                            Xilio Therapeutics Announces Proposed Public Offering

                            Details : The net proceeds from the offering will be used to advance the clinical development of XTX10 (vilastobart), which is being evaluated for the treatment of mss colorectal cancer.

                            Product Name : Undisclosed

                            Product Type : Antibody, Unconjugated

                            Upfront Cash : Undisclosed

                            June 02, 2025

                            Lead Product(s) : Vilastobart,Atezolizumab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Leerink Partners

                            Deal Size : Undisclosed

                            Deal Type : Public Offering

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                            05

                            Xilio Therapeutics

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                            AIChE Annual Meeting
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                            Xilio Therapeutics

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                            AIChE Annual Meeting
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                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Oncology

                            Study Phase : Discovery Platform

                            Sponsor : AbbVie Inc

                            Deal Size : $2,152.0 million

                            Deal Type : Collaboration

                            DEALS_DEV arrow-down

                            AbbVie, Xilio Partner to Develop Tumor-Activated Immunotherapies

                            Details : The collaboration will combine AbbVie's oncology expertise and Xilio's proprietary tumor-activation technology to develop novel immunotherapies, including masked T-cell engagers.

                            Product Name : Undisclosed

                            Product Type : Undisclosed

                            Upfront Cash : $52.0 million

                            February 12, 2025

                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Oncology

                            Highest Development Status : Discovery Platform

                            Sponsor : AbbVie Inc

                            Deal Size : $2,152.0 million

                            Deal Type : Collaboration

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                            06

                            Xilio Therapeutics

                            U.S.A arrow
                            AIChE Annual Meeting
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                            Xilio Therapeutics

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                            AIChE Annual Meeting
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                            Lead Product(s) : Vilastobart,Atezolizumab

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Xilio Therapeutics Announces Phase 2 Data for Vilastobart in Colorectal Cancer

                            Details : XTX101 (vilastobart) is an antibody infusion therapy inhibiting CTLA-4, is being investigated for the treatment of microsatellite stable colorectal cancer in combination with Atezolizumab.

                            Product Name : Undisclosed

                            Product Type : Antibody, Unconjugated

                            Upfront Cash : Inapplicable

                            January 21, 2025

                            Lead Product(s) : Vilastobart,Atezolizumab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            07

                            Xilio Therapeutics

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                            AIChE Annual Meeting
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                            Xilio Therapeutics

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                            AIChE Annual Meeting
                            Not Confirmed
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                            Lead Product(s) : Vilastobart,Atezolizumab

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Xilio Therapeutics Announces Vilastobart Data in Advanced Solid Tumors

                            Details : XTX101 is an antibody infusion therapy inhibiting CTLA-4, is being investigated for the treatment of microsatellite stable colorectal cancer in combination with Atezolizumab.

                            Product Name : Undisclosed

                            Product Type : Antibody, Unconjugated

                            Upfront Cash : Inapplicable

                            November 07, 2024

                            Lead Product(s) : Vilastobart,Atezolizumab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            08

                            Xilio Therapeutics

                            U.S.A arrow
                            AIChE Annual Meeting
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                            Xilio Therapeutics

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                            AIChE Annual Meeting
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                            Lead Product(s) : XTX301

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Gilead Sciences

                            Deal Size : $647.5 million

                            Deal Type : Licensing Agreement

                            DEALS_DEV arrow-down

                            Gilead and Xilio Announce Exclusive License Agreement for Tumor-Activated IL-12 Program

                            Details : Gilead has an exclusive global license to develop and commercialize XTX301, Xilio’s tumor-activated IL-12, currently in Phase I trials for neoplasms treatment.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : $43.5 million

                            March 28, 2024

                            Lead Product(s) : XTX301

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Gilead Sciences

                            Deal Size : $647.5 million

                            Deal Type : Licensing Agreement

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                            09

                            Xilio Therapeutics

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                            AIChE Annual Meeting
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                            Xilio Therapeutics

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                            AIChE Annual Meeting
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                            Lead Product(s) : XTX301

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Xilio Reports Phase 1 Safety Data for XTX301, Validating Tumor-Activated Therapies

                            Details : XTX301 is an investigational tumor-activated IL-12 designed to potently stimulate anti-tumor immunity. It is under phase 1 clinical development for the treatment of advanced solid tumor.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            January 08, 2024

                            Lead Product(s) : XTX301

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            10

                            Xilio Therapeutics

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                            AIChE Annual Meeting
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                            Xilio Therapeutics

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                            AIChE Annual Meeting
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                            Lead Product(s) : Vilastobart,Atezolizumab

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Xilio Therapeutics Announces Initiation of Enrollment for Phase 1 Combination Trial of XTX101, a Tumor-Activat...

                            Details : XTX101 is an antibody infusion therapy inhibiting CTLA-4, is being investigated for the treatment of microsatellite stable colorectal cancer in combination with Atezolizumab.

                            Product Name : Undisclosed

                            Product Type : Antibody, Unconjugated

                            Upfront Cash : Inapplicable

                            December 07, 2023

                            Lead Product(s) : Vilastobart,Atezolizumab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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