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Pharmaceuticals","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Infectious Diseases","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Vertex Pharmaceuticals \/ Kenneth Sherman","highestDevelopmentStatusID":"6","companyTruncated":"Vertex Pharmaceuticals \/ Kenneth Sherman"}]

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                            01

                            Vertex Pharmaceuticals

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                            Lead Product(s) : VX-407

                            Therapeutic Area : Genetic Disease

                            Study Phase : Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Phase 2a Study of VX-407 in Participants With ADPKD Who Have a Subset of PKD1 Gene Variants

                            Details : VX-407 is a Small Molecule drug candidate drug candidate, which is currently being evaluated in Phase II clinical studies for the treatment of Polycystic Kidney, Autosomal Dominant.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            September 08, 2025

                            Lead Product(s) : VX-407

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            02

                            Vertex Pharmaceuticals

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                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Immunology

                            Study Phase : Discovery Platform

                            Recipient : Enlaza Therapeutics

                            Deal Size : $2,045.0 million

                            Deal Type : Collaboration

                            DEALS_DEV arrow-down

                            Vertex, Enlaza Declare War on Autoimmune Disease in Potential $2B+ Pact

                            Details : The collaboration aims to utilize Enlaza’s proprietary War-Lock technology platform to develop small format drug conjugates and T-cell engagers for certain autoimmune diseases.

                            Product Name : Undisclosed

                            Product Type : Protein-drug Conjugate

                            Upfront Cash : $45.0 million

                            September 02, 2025

                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Immunology

                            Highest Development Status : Discovery Platform

                            Recipient : Enlaza Therapeutics

                            Deal Size : $2,045.0 million

                            Deal Type : Collaboration

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                            03

                            Vertex Pharmaceuticals

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                            Lead Product(s) : VX-407

                            Therapeutic Area : Genetic Disease

                            Study Phase : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Effects of VX-407 on the Pharmacokinetics of Oral Contraceptives in Healthy Participants

                            Details : VX-407 is a Other Small Molecule drug candidate, which is currently being evaluated in Phase I clinical studies for the treatment of Polycystic Kidney, Autosomal Dominant.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            July 20, 2025

                            Lead Product(s) : VX-407

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            04

                            Vertex Pharmaceuticals

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                            Lead Product(s) : Vanzacaftor,Deutivacaftor,Tezacaftor

                            Therapeutic Area : Genetic Disease

                            Study Phase : Approved FDF

                            Sponsor : NHS England

                            Deal Size : Undisclosed

                            Deal Type : Agreement

                            DEALS_DEV arrow-down

                            Vertex Announces Broad Reimbursement Agreement With NHS England for ALYFTREK

                            Details : Vertex has reached a broad reimbursement agreement with NHS England for Alyftrek (vanzacaftor, tezacaftor, and deutivacaftor). It is being indicated for the treatment of Cystic Fibrosis.

                            Product Name : Alyftrek

                            Product Type : Miscellaneous

                            Upfront Cash : Undisclosed

                            July 14, 2025

                            Lead Product(s) : Vanzacaftor,Deutivacaftor,Tezacaftor

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Approved FDF

                            Sponsor : NHS England

                            Deal Size : Undisclosed

                            Deal Type : Agreement

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                            05

                            Vertex Pharmaceuticals

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                            Lead Product(s) : VX-407

                            Therapeutic Area : Genetic Disease

                            Study Phase : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Phase I Study of Safety, Tolerability, & Pharmacokinetics of VX-407 in Healthy

                            Details : VX-407 is a Other Small Molecule drug candidate, which is currently being evaluated in Phase I clinical studies for the treatment of Polycystic Kidney, Autosomal Dominant.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            June 15, 2025

                            Lead Product(s) : VX-407

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            06

                            Vertex Pharmaceuticals

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                            Lead Product(s) : VX-670

                            Therapeutic Area : Genetic Disease

                            Study Phase : Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            A Study of Long-term Safety and Efficacy of VX-670 in Participants With Myotonic Dystrophy Type I

                            Details : VX-670 is a drug candidate, which is currently being evaluated in phase II clinical studies for the treatment of Myotonic Dystrophy.

                            Product Name : Undisclosed

                            Product Type : Undisclosed

                            Upfront Cash : Inapplicable

                            April 14, 2025

                            Lead Product(s) : VX-670

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            07

                            Vertex Pharmaceuticals

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                            ISPE Annual Meeting
                            Not Confirmed

                            Vertex Pharmaceuticals

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                            ISPE Annual Meeting
                            Not Confirmed
                            • fda
                            • EDQM
                            • WHO-GMP
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                            Lead Product(s) : Ivacaftor,Elexacaftor,Tezacaftor

                            Therapeutic Area : Genetic Disease

                            Study Phase : Approved FDF

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            EC Expands KAFTRIO Label with Ivacaftor for Cystic Fibrosis Patients

                            Details : Kaftrio (ivacaftor/tezacaftor/elexacaftor) in combination with ivacaftor is an oral medicine designed to increase the quantity and function of the CFTR protein at the cell surface.

                            Product Name : Kaftrio

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            April 07, 2025

                            Lead Product(s) : Ivacaftor,Elexacaftor,Tezacaftor

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Approved FDF

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            08

                            Vertex Pharmaceuticals

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                            ISPE Annual Meeting
                            Not Confirmed

                            Vertex Pharmaceuticals

                            U.S.A arrow
                            ISPE Annual Meeting
                            Not Confirmed
                            • fda
                            • EDQM
                            • WHO-GMP
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                            Lead Product(s) : Suzetrigine

                            Therapeutic Area : Neurology

                            Study Phase : Phase IV

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            A Single-arm Study Evaluating the Effectiveness and Safety of Suzetrigine (SUZ) for Acute Pain After Selected ...

                            Details : Suzetrigine is a Other Small Molecule drug candidate, which is currently being evaluated in phase IV clinical studies for the treatment of Acute Pain.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            March 21, 2025

                            Lead Product(s) : Suzetrigine

                            Therapeutic Area : Neurology

                            Highest Development Status : Phase IV

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            09

                            Vertex Pharmaceuticals

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                            ISPE Annual Meeting
                            Not Confirmed

                            Vertex Pharmaceuticals

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                            ISPE Annual Meeting
                            Not Confirmed
                            • fda
                            • EDQM
                            • WHO-GMP
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                            Lead Product(s) : Suzetrigine

                            Therapeutic Area : Neurology

                            Study Phase : Phase IV

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            A Single-Arm Study Evaluating the Effectiveness and Safety of Suzetrigine (SUZ) for Acute Pain After Aesthetic...

                            Details : Suzetrigine is a Other Small Molecule drug candidate, which is currently being evaluated in phase IV clinical studies for the treatment of Acute Pain.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            March 21, 2025

                            Lead Product(s) : Suzetrigine

                            Therapeutic Area : Neurology

                            Highest Development Status : Phase IV

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            10

                            Vertex Pharmaceuticals

                            U.S.A arrow
                            ISPE Annual Meeting
                            Not Confirmed

                            Vertex Pharmaceuticals

                            U.S.A arrow
                            ISPE Annual Meeting
                            Not Confirmed
                            • fda
                            • EDQM
                            • WHO-GMP
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                            Lead Product(s) : 14-C VX-993

                            Therapeutic Area : Neurology

                            Study Phase : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            A Study to Evaluate How the Body Processes 14C-VX-993 After a Single Oral Dose

                            Details : 14-C VX-993 is a Radiolabeled Compounds drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of Pain.

                            Product Name : Undisclosed

                            Product Type : Radiolabeled Compound

                            Upfront Cash : Inapplicable

                            March 20, 2025

                            Lead Product(s) : 14-C VX-993

                            Therapeutic Area : Neurology

                            Highest Development Status : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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