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            VTX002 is a peripherally-restricted, potent and selective, orally bioavailable small molecule modulator of the S1P1 receptor and being investigated for Patients with Moderate to Severe Plaque Psoriasis.

            Lead Product(s): VTX958

            Therapeutic Area: Dermatology Product Name: VTX958

            Highest Development Status: Phase II Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable November 06, 2023

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            VTX002 is a peripherally-restricted, potent and selective, orally bioavailable small molecule modulator of the S1P1 receptor and being investigated for Ulcerative Colitis.

            Lead Product(s): VTX002

            Therapeutic Area: Gastroenterology Product Name: VTX002

            Highest Development Status: Phase II Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable October 09, 2023

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            Details:

            VTX002 is a peripherally-restricted, potent and selective, orally bioavailable small molecule modulator of the S1P1 receptor and being investigated for Ulcerative Colitis. VTX958, an oral, selective, allosteric TYK2 inhibitor used for treatment of Plaque Psoriasis.

            Lead Product(s): VTX002

            Therapeutic Area: Gastroenterology Product Name: VTX002

            Highest Development Status: Phase II Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable June 07, 2023

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            The wide therapeutic window of VTX958 observed in our Phase 1 trial will allow us to explore a broad range of doses in Phase 2 trials, including doses designed to achieve biologic-like IC90 coverage of TYK2-mediated cytokines, such as IL-23.

            Lead Product(s): VTX958

            Therapeutic Area: Dermatology Product Name: VTX958

            Highest Development Status: Phase II Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable December 01, 2022

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            Details:

            Ventyx intends to use the net proceeds from the proposed private placement, to fund the clinical development of VTX958, VTX002, VTX2735 and VTX3232, the preclinical development of other programs, research activities and working capital and other general corporate purposes.

            Lead Product(s): VTX958

            Therapeutic Area: Dermatology Product Name: VTX958

            Highest Development Status: Phase I Product Type: Small molecule

            Partner/Sponsor/Collaborator: Redmile Group

            Deal Size: $176.6 million Upfront Cash: Undisclosed

            Deal Type: Private Placement September 19, 2022

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            Details:

            VTX958 is an oral, selective allosteric inhibitor of tyrosine kinase 2 (TYK2). TYK2 regulates both innate and adaptive immunity by mediating IFNα, IL-12 and IL-23 signaling.

            Lead Product(s): VTX958

            Therapeutic Area: Dermatology Product Name: VTX958

            Highest Development Status: Phase I Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable August 15, 2022

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            VTX2735 is the first of Ventyx’s two NLRP3 development candidates to enter the clinic. The second candidate, VTX3232, is an orally bioavailable, CNS-penetrant NLRP3 inhibitor and belongs to a structurally distinct chemical series than VTX2735.

            Lead Product(s): VTX2735

            Therapeutic Area: Cardiology/Vascular Diseases Product Name: VTX2735

            Highest Development Status: Phase I Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable June 29, 2022

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            Details:

            VTX002 is a peripherally-restricted, potent and selective, orally bioavailable small molecule modulator of the S1P1 receptor. It sequesters lymphocytes in the lymph nodes, resulting in fewer immune cells in the circulating blood to exacerbate inflammation.

            Lead Product(s): VTX002

            Therapeutic Area: Gastroenterology Product Name: VTX002

            Highest Development Status: Phase II Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable December 06, 2021

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            Details:

            Ventyx’s pipeline includes VTX958, a Phase 1 allosteric TYK2 inhibitor for the treatment of autoimmune diseases, VTX002, a Phase 2-ready S1P1 receptor modulator for the treatment of ulcerative colitis, and VTX2735, a Phase 1 peripheral inhibitor of the NLRP3 inflammasome.

            Lead Product(s): VTX002

            Therapeutic Area: Gastroenterology Product Name: VTX002

            Highest Development Status: IND Enabling Product Type: Small molecule

            Partner/Sponsor/Collaborator: Jefferies

            Deal Size: $151.5 million Upfront Cash: Undisclosed

            Deal Type: Public Offering October 21, 2021

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            Details:

            VTX958, an oral, selective clinical-stage tyrosine kinase type 2 inhibitor that it believes has the potential to address a broad range of immune-mediated diseases, such as psoriasis, inflammatory bowel disease, psoriatic arthritis, and lupus.

            Lead Product(s): VTX958

            Therapeutic Area: Immunology Product Name: VTX958

            Highest Development Status: Phase I Product Type: Small molecule

            Partner/Sponsor/Collaborator: Viela Bio

            Deal Size: $100.0 million Upfront Cash: Undisclosed

            Deal Type: Public Offering September 29, 2021

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