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    [{"orgOrder":0,"company":"Syntrix Pharmaceuticals","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Other Small Molecule","year":"2020","type":"Inapplicable","leadProduct":"SX-682","moa":"Interleukin-8 receptors, CXCR1\/CXCR2","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"Syntrix Pharmaceuticals","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Oral Pill","sponsorNew":"Syntrix Pharmaceuticals \/ Inapplicable","highestDevelopmentStatusID":"7","companyTruncated":"Syntrix Pharmaceuticals \/ Inapplicable"},{"orgOrder":0,"company":"Syntrix Pharmaceuticals","sponsor":"Moffitt Cancer Center | National Heart, Lung, and Blood Institute | AdventHealth | Gabrail Cancer Center Research | University of Miami | Mayo Clinic | Montefiore Medical Center | National Cancer Institute | Sidney Kimmel Comprehensive Cancer Center, 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Molecule","year":"2022","type":"Inapplicable","leadProduct":"SX-682","moa":"Interleukin-8 receptors, CXCR1\/CXCR2","graph1":"Oncology","graph2":"Phase II","graph3":"University of Washington","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"University of Washington \/ National Cancer Institute | Syntrix Pharmaceuticals","highestDevelopmentStatusID":"8","companyTruncated":"University of Washington \/ National Cancer Institute | Syntrix Pharmaceuticals"},{"orgOrder":0,"company":"Syntrix Pharmaceuticals","sponsor":"National Cancer Institute","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Other Small Molecule","year":"2024","type":"Inapplicable","leadProduct":"SX-682","moa":"Interleukin-8 receptors, CXCR1\/CXCR2","graph1":"Oncology","graph2":"Phase II","graph3":"Syntrix Pharmaceuticals","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Syntrix Pharmaceuticals \/ National Cancer Institute","highestDevelopmentStatusID":"8","companyTruncated":"Syntrix Pharmaceuticals \/ National Cancer Institute"},{"orgOrder":0,"company":"MD Anderson Cancer Center","sponsor":"Bristol Myers Squibb | Syntrix Pharmaceuticals","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"","productType":"Other Small Molecule","year":"2020","type":"Inapplicable","leadProduct":"SX-682","moa":"Interleukin-8 receptors, CXCR1\/CXCR2","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"MD Anderson Cancer Center","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"MD Anderson Cancer Center \/ Bristol Myers Squibb | Syntrix Pharmaceuticals","highestDevelopmentStatusID":"7","companyTruncated":"MD Anderson Cancer Center \/ Bristol Myers Squibb | Syntrix Pharmaceuticals"},{"orgOrder":0,"company":"Incyte Corporation","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Other Small Molecule","year":"2020","type":"Inapplicable","leadProduct":"SX-682","moa":"Bromodomain and extraterminal domain protein (BET)","graph1":"Oncology","graph2":"Phase I","graph3":"Incyte Corporation","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Incyte Corporation \/ Inapplicable","highestDevelopmentStatusID":"6","companyTruncated":"Incyte Corporation \/ Inapplicable"},{"orgOrder":0,"company":"University of Rochester","sponsor":"Syntrix Pharmaceuticals | Bristol Myers Squibb","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"","productType":"Other Small Molecule","year":"2020","type":"Inapplicable","leadProduct":"SX-682","moa":"Interleukin-8 receptors, CXCR1\/CXCR2","graph1":"Oncology","graph2":"Phase I","graph3":"University of Rochester","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"University of Rochester \/ Syntrix Pharmaceuticals | Bristol Myers Squibb","highestDevelopmentStatusID":"6","companyTruncated":"University of Rochester \/ Syntrix Pharmaceuticals | Bristol Myers Squibb"},{"orgOrder":0,"company":"Incyte Corporation","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Undisclosed","country":"U.S.A","productType":"Other Small Molecule","year":"2025","type":"Inapplicable","leadProduct":"SX-682","moa":"Bromodomain and extraterminal domain protein (BET)","graph1":"Undisclosed","graph2":"Phase I","graph3":"Incyte Corporation","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"","amount2New":0,"dosageForm":"Tablet","sponsorNew":"Incyte Corporation \/ Inapplicable","highestDevelopmentStatusID":"6","companyTruncated":"Incyte Corporation \/ Inapplicable"},{"orgOrder":0,"company":"Institute of Cancer Research, United Kingdom","sponsor":"Prostate Cancer UK | Janssen Pharmaceutica | Oncology Institute of Southern Switzerland | Syntrix Pharmaceuticals | Royal Marsden NHS Foundation Trust | Cambridge University Hospitals NHS Foundation Trust | Belfast Health and Social Care Trust | Institute","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"","productType":"Other Small Molecule","year":"2025","type":"Inapplicable","leadProduct":"SX-682","moa":"Interleukin-8 receptors, CXCR1|CXCR2","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"Institute of Cancer Research, United Kingdom","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Tablet, Film Coated","sponsorNew":"Institute of Cancer Research, United Kingdom \/ Prostate Cancer UK | Janssen Pharmaceutica | Oncology Institute of Southern Switzerland | Syntrix Pharmaceuticals | Royal Marsden NHS Foundation Trust | Cambridge University Hospitals NHS Foundation Trust | Belfast Health and Social Care Trust | Institute","highestDevelopmentStatusID":"7","companyTruncated":"Institute of Cancer Research, United Kingdom \/ Prostate Cancer UK | Janssen Pharmaceutica | Oncology Institute of Southern Switzerland | Syntrix Pharmaceuticals | Royal Marsden NHS Foundation Trust | Cambridge University Hospitals NHS Foundation Trust | Belfast Health and Social Care Trust | Institute"}]

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                            01

                            Institute of Cancer Research, United Kingdom

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                            Institute of Cancer Research, United Kingdom

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                            Lead Product(s) : SX-682

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Prostate Cancer UK | Janssen Pharmaceutica | Oncology Institute of Southern Switzerland | Syntrix Pharmaceuticals | Royal Marsden NHS Foundation Trust | Cambridge University Hospitals NHS Foundation Trust | Belfast Health and Social Care Trust | Institute

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            SX-682 with Apalutamide in Metastatic Castration-resistant Prostate Cancer

                            Details : SX-682 is a Other Small Molecule drug candidate, which is currently being evaluated in Phase I/ Phase II clinical studies for the treatment of Prostatic Neoplasms, Castration-Resistant.

                            Product Name : Undisclosed

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            June 03, 2025

                            Lead Product(s) : SX-682

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Prostate Cancer UK | Janssen Pharmaceutica | Oncology Institute of Southern Switzerland | Syntrix Pharmaceuticals | Royal Marsden NHS Foundation Trust | Cambridge University Hospitals NHS Foundation Trust | Belfast Health and Social Care Trust | Institute

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            02

                            Incyte Corporation

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                            Lead Product(s) : SX-682

                            Therapeutic Area : Undisclosed

                            Study Phase : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            A Study to Evaluate the Relative Bioavailability of New Formulations of INCB057643 Tablets Administered Orally...

                            Details : Undisclosed

                            Product Name : Undisclosed

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            April 23, 2025

                            Lead Product(s) : SX-682

                            Therapeutic Area : Undisclosed

                            Highest Development Status : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            03

                            Syntrix Pharmaceuticals

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                            Lead Product(s) : SX-682

                            Therapeutic Area : Oncology

                            Study Phase : Phase II

                            Sponsor : National Cancer Institute

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Study of SX-682 Plus Enzalutamide in Men With Abiraterone-Resistant Metastatic Castration Resistant Prostate C...

                            Details : Undisclosed

                            Product Name : Undisclosed

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            January 29, 2024

                            Lead Product(s) : SX-682

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase II

                            Sponsor : National Cancer Institute

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            04

                            University of Washington

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                            Lead Product(s) : SX-682

                            Therapeutic Area : Oncology

                            Study Phase : Phase II

                            Sponsor : National Cancer Institute | Syntrix Pharmaceuticals

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            SX-682 With Pembrolizumab for the Treatment of Metastatic or Recurrent Stage IIIC or IV Non-Small Cell Lung Ca...

                            Details : Undisclosed

                            Product Name : Undisclosed

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            October 07, 2022

                            Lead Product(s) : SX-682

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase II

                            Sponsor : National Cancer Institute | Syntrix Pharmaceuticals

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            05

                            Syntrix Pharmaceuticals

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                            Lead Product(s) : SX-682

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            First-in-Class Investigational SX-682 Demonstrates Single-Agent Efficacy in Patients with Hypomethylating Agen...

                            Details : SX-682 was well tolerated with no maximally tolerated dose and no patient discontinued treatment for adverse events. Treatment-emergent adverse events > grade 3 were most common in the 200 and 400 mg dose cohorts, and those related to neutrophils were co...

                            Product Name : Undisclosed

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            September 12, 2022

                            Lead Product(s) : SX-682

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            06

                            Syntrix Pharmaceuticals

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                            Lead Product(s) : SX-682

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            Syntrix Completes Initial SX-682 Dosing in Broad Phase 1/2 Cancer Trial Campaign

                            Details : Based on the promising results, additional Phase 1/2 trials are now also opening for SX-682 in pancreatic cancer, colorectal cancer, and in advanced tumors including breast and head & neck cancers at various institutes.

                            Product Name : Undisclosed

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            October 27, 2020

                            Lead Product(s) : SX-682

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

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                            07

                            MD Anderson Cancer Center

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                            Lead Product(s) : SX-682

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Bristol Myers Squibb | Syntrix Pharmaceuticals

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            SX-682 and Nivolumab for the Treatment of RAS-Mutated, MSS Unresectable or Metastatic Colorectal Cancer, the S...

                            Details : Undisclosed

                            Product Name : Undisclosed

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            October 22, 2020

                            Lead Product(s) : SX-682

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Bristol Myers Squibb | Syntrix Pharmaceuticals

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            08

                            University of Rochester

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                            Lead Product(s) : SX-682

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Syntrix Pharmaceuticals | Bristol Myers Squibb

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            A Study to Evaluate the Safety and Tolerability of SX-682 in Combination With Nivolumab as a Maintenance Thera...

                            Details : Undisclosed

                            Product Name : Undisclosed

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            July 20, 2020

                            Lead Product(s) : SX-682

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Syntrix Pharmaceuticals | Bristol Myers Squibb

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            09

                            Incyte Corporation

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                            Lead Product(s) : SX-682

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            Safety and Tolerability Study of INCB057643 in Participants With Myelofibrosis and Other Advanced Myeloid Neop...

                            Details : Undisclosed

                            Product Name : Undisclosed

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            February 21, 2020

                            Lead Product(s) : SX-682

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            10

                            Syntrix Pharmaceuticals

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                            Lead Product(s) : SX-682

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Moffitt Cancer Center | National Heart, Lung, and Blood Institute | AdventHealth | Gabrail Cancer Center Research | University of Miami | Mayo Clinic | Montefiore Medical Center | National Cancer Institute | Sidney Kimmel Comprehensive Cancer Center, John

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            Study of SX-682 Alone and in Combination with Oral or Intravenous Decitabine in Subjects with Myelodysplastic ...

                            Details : Undisclosed

                            Product Name : Undisclosed

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            January 28, 2020

                            Lead Product(s) : SX-682

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Moffitt Cancer Center | National Heart, Lung, and Blood Institute | AdventHealth | Gabrail Cancer Center Research | University of Miami | Mayo Clinic | Montefiore Medical Center | National Cancer Institute | Sidney Kimmel Comprehensive Cancer Center, John

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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