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Find Clinical Drug Pipeline Developments & Deals by SpringWorks Therapeutics

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                          Therapeutic Area by Lead Product

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                          Top Deals by Deal Size (USD bn)

                          01

                          FNCE
                          Not Confirmed
                          FNCE
                          Not Confirmed

                          Details : Nirogacestat HBr is a Small Molecule drug candidate drug candidate, which is currently being evaluated in Phase IV clinical studies for the treatment of Desmoid Tumors.

                          Product Name : Undisclosed

                          Product Type : Miscellaneous

                          Upfront Cash : Inapplicable

                          September 16, 2025

                          Lead Product(s) : Nirogacestat Hydrobromide

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase IV

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          02

                          FNCE
                          Not Confirmed
                          FNCE
                          Not Confirmed

                          Details : Nirogacestat is a Small Molecule drug candidate drug candidate, which is currently being evaluated in Phase II clinical studies for the treatment of Desmoid Tumors.

                          Product Name : Undisclosed

                          Product Type : Miscellaneous

                          Upfront Cash : Inapplicable

                          September 12, 2025

                          Lead Product(s) : Nirogacestat Hydrobromide

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          03

                          FNCE
                          Not Confirmed
                          FNCE
                          Not Confirmed

                          Details : Nirogacestat HBr is a Small Molecule drug candidate drug candidate, which is currently being evaluated in Phase I clinical studies for the treatment of undefined medical condition.

                          Product Name : Undisclosed

                          Product Type : Miscellaneous

                          Upfront Cash : Inapplicable

                          September 12, 2025

                          Lead Product(s) : Nirogacestat Hydrobromide

                          Therapeutic Area : Undisclosed

                          Highest Development Status : Phase I

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          04

                          FNCE
                          Not Confirmed
                          FNCE
                          Not Confirmed

                          Details : Through the acquisition, Merck will leverage SpringWorks’ oncology portfolio, including Ogsiveo (Nirogacestat HBr). It is being indicated for adult patients with progressing desmoid tumors.

                          Product Name : Ogsiveo

                          Product Type : Miscellaneous

                          Upfront Cash : $3,900.0 million

                          July 01, 2025

                          Lead Product(s) : Nirogacestat Hydrobromide

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved FDF

                          Sponsor : Merck Group

                          Deal Size : $3,900.0 million

                          Deal Type : Acquisition

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                          05

                          FNCE
                          Not Confirmed
                          FNCE
                          Not Confirmed

                          Details : Mirdametinib is a Other Small Molecule drug candidate, which is currently being evaluated in Phase I clinical studies for the treatment of unspecified medical condition.

                          Product Name : Undisclosed

                          Product Type : Miscellaneous

                          Upfront Cash : Inapplicable

                          May 30, 2025

                          Lead Product(s) : Mirdametinib

                          Therapeutic Area : Undisclosed

                          Highest Development Status : Phase I

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          06

                          FNCE
                          Not Confirmed
                          FNCE
                          Not Confirmed

                          Details : Through the acquisition, Merck will leverage SpringWorks’ oncology portfolio, including Ogsiveo (Nirogacestat HBr). It is being indicated for adult patients with progressing desmoid tumors.

                          Product Name : Ogsiveo

                          Product Type : Miscellaneous

                          Upfront Cash : $3900 million

                          April 28, 2025

                          Lead Product(s) : Nirogacestat Hydrobromide

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved FDF

                          Sponsor : Merck Group

                          Deal Size : $3,900.0 million

                          Deal Type : Acquisition

                          blank

                          07

                          FNCE
                          Not Confirmed
                          FNCE
                          Not Confirmed

                          Details : Mirdametinib is a Other Small Molecule drug candidate, which is currently being evaluated in phase I/ phase II clinical studies for the treatment of Liposarcoma.

                          Product Name : Undisclosed

                          Product Type : Miscellaneous

                          Upfront Cash : Inapplicable

                          February 25, 2025

                          Lead Product(s) : Mirdametinib

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Recipient : Memorial Sloan Kettering Cancer Center

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          08

                          FNCE
                          Not Confirmed
                          FNCE
                          Not Confirmed

                          Details : Gomekli (mirdametinib) is an MEK inhibitor. It is indicated in pediatric and adult patients with neurofibromatosis type 1-associated plexiform neurofibromas (NF1-PN).

                          Product Name : Gomekli

                          Product Type : Miscellaneous

                          Upfront Cash : Inapplicable

                          February 11, 2025

                          Lead Product(s) : Mirdametinib

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved FDF

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          09

                          FNCE
                          Not Confirmed
                          FNCE
                          Not Confirmed

                          Details : Under the exclusive license agreement, SpringWorks Therapeutics will be responsible for the global development and commercialization of RPT04402 for treating PP2A mutant uterine cancer.

                          Product Name : Undisclosed

                          Product Type : Miscellaneous

                          Upfront Cash : $13.0 million

                          January 13, 2025

                          Lead Product(s) : RPT04402

                          Therapeutic Area : Oncology

                          Highest Development Status : Preclinical

                          Recipient : Rappta Therapeutics

                          Deal Size : Undisclosed

                          Deal Type : Licensing Agreement

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                          10

                          FNCE
                          Not Confirmed
                          FNCE
                          Not Confirmed

                          Details : PD-0325901 (mirdametinib) is an investigational MEK inhibitor. It is being evaluated in pediatric and adult patients with neurofibromatosis type 1-associated plexiform neurofibromas (NF1-PN).

                          Product Name : Undisclosed

                          Product Type : Miscellaneous

                          Upfront Cash : Inapplicable

                          August 28, 2024

                          Lead Product(s) : Mirdametinib

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : Phase II

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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