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Scheulen \/ ClinAssess"},{"orgOrder":0,"company":"Eanm Research","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"","productType":"Miscellaneous","year":"2012","type":"Inapplicable","leadProduct":"Sorafenib","moa":"Serine\/threonine-protein kinase RAF","graph1":"Oncology","graph2":"Phase II","graph3":"Eanm Research","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Eanm Research \/ Undisclosed","highestDevelopmentStatusID":"8","companyTruncated":"Eanm Research \/ Undisclosed"},{"orgOrder":0,"company":"Hamid Sayar","sponsor":"Takeda Pharmaceutical | Bayer AG | Merck & Co","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"","productType":"Miscellaneous","year":"2012","type":"Inapplicable","leadProduct":"Sorafenib","moa":"Serine\/threonine-protein kinase RAF","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"Hamid Sayar","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Hamid Sayar \/ Takeda Pharmaceutical | Bayer AG | Merck & Co","highestDevelopmentStatusID":"7","companyTruncated":"Hamid Sayar \/ Takeda Pharmaceutical | Bayer AG | Merck & Co"},{"orgOrder":0,"company":"Singapore General Hospital","sponsor":"National Cancer Centre, Singapore | National Medical Research Council, Singapore | Singapore Clinical Research Institute | Sirtex Medical","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"SINGAPORE","productType":"Miscellaneous","year":"2010","type":"Inapplicable","leadProduct":"Sorafenib","moa":"Serine\/threonine-protein kinase RAF | Stem cell growth factor receptor | Serine\/threonine-protein kinase B-raf | Platelet-derived growth factor receptor beta | Vascular endothelial growth factor receptor | Tyrosine-protein kinase receptor FLT3 | Tyrosine-protein kinase receptor RET","graph1":"Oncology","graph2":"Phase III","graph3":"Singapore General Hospital","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Tablet","sponsorNew":"Singapore General Hospital \/ National Cancer Centre, Singapore | National Medical Research Council, Singapore | Singapore Clinical Research Institute | Sirtex Medical","highestDevelopmentStatusID":"10","companyTruncated":"Singapore General Hospital \/ National Cancer Centre, Singapore | National Medical Research Council, Singapore | Singapore Clinical Research Institute | Sirtex Medical"},{"orgOrder":0,"company":"GERCOR","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"FRANCE","productType":"Miscellaneous","year":"2010","type":"Inapplicable","leadProduct":"Sorafenib","moa":"Serine\/threonine-protein kinase RAF | Stem cell growth factor receptor | Serine\/threonine-protein kinase B-raf | Platelet-derived growth factor receptor beta | Vascular endothelial growth factor receptor | Tyrosine-protein kinase receptor FLT3 | Tyrosine-protein kinase receptor RET","graph1":"Oncology","graph2":"Phase II","graph3":"GERCOR","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"GERCOR \/ Undisclosed","highestDevelopmentStatusID":"8","companyTruncated":"GERCOR \/ Undisclosed"},{"orgOrder":0,"company":"Bayer AG","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"GERMANY","productType":"Miscellaneous","year":"2010","type":"Inapplicable","leadProduct":"Sorafenib","moa":"Serine\/threonine-protein kinase RAF | Stem cell growth factor receptor | Serine\/threonine-protein kinase B-raf | Platelet-derived growth factor receptor beta | Vascular endothelial growth factor receptor | Tyrosine-protein kinase receptor FLT3 | Tyrosine-protein kinase receptor RET","graph1":"Oncology","graph2":"Phase IV","graph3":"Bayer AG","amount2":0,"highestDevelopmentShortName":"Ph IV","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Tablet","sponsorNew":"Bayer AG \/ Undisclosed","highestDevelopmentStatusID":"11","companyTruncated":"Bayer AG \/ Undisclosed"},{"orgOrder":0,"company":"Bayer AG","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"GERMANY","productType":"Miscellaneous","year":"2014","type":"Inapplicable","leadProduct":"Sorafenib","moa":"Serine\/threonine-protein kinase RAF | Stem cell growth factor receptor | Serine\/threonine-protein kinase B-raf | Platelet-derived growth factor receptor beta | Vascular endothelial growth factor receptor | Tyrosine-protein kinase receptor FLT3 | Tyrosine-protein kinase receptor RET","graph1":"Oncology","graph2":"Phase II","graph3":"Bayer AG","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Bayer AG \/ Undisclosed","highestDevelopmentStatusID":"8","companyTruncated":"Bayer AG \/ Undisclosed"},{"orgOrder":0,"company":"Jonsson Comprehensive Cancer Center","sponsor":"Bayer AG","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Miscellaneous","year":"2012","type":"Inapplicable","leadProduct":"Sorafenib","moa":"Serine\/threonine-protein kinase RAF | Stem cell growth factor receptor | Serine\/threonine-protein kinase B-raf | Platelet-derived growth factor receptor beta | Vascular endothelial growth factor receptor | Tyrosine-protein kinase receptor FLT3 | Tyrosine-protein kinase receptor RET","graph1":"Oncology","graph2":"Phase II","graph3":"Jonsson Comprehensive Cancer Center","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Jonsson Comprehensive Cancer Center \/ Bayer AG","highestDevelopmentStatusID":"8","companyTruncated":"Jonsson Comprehensive Cancer Center \/ Bayer AG"},{"orgOrder":0,"company":"Vidac Pharma","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"UNITED KINGDOM","productType":"Miscellaneous","year":"2024","type":"Inapplicable","leadProduct":"Cisplatin","moa":"||VDAC\/HK2 interaction","graph1":"Oncology","graph2":"Preclinical","graph3":"Vidac Pharma","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Vidac Pharma \/ Undisclosed","highestDevelopmentStatusID":"4","companyTruncated":"Vidac Pharma \/ Undisclosed"}]

Find Clinical Drug Pipeline Developments & Deals for Sorafenib

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                          Top Deals by Deal Size (USD bn)

                          01

                          OTS 2025
                          Not Confirmed
                          OTS 2025
                          Not Confirmed

                          Details : VDA-1275 is a potent small molecule new chemical entity (NCE) with novel mechanism of action that selectively modulates VDAC/HK2 interaction. It is being developed for the treatment of solid tumors.

                          Product Name : Undisclosed

                          Product Type : Miscellaneous

                          Upfront Cash : Inapplicable

                          February 19, 2024

                          Lead Product(s) : VDA-1275,Cisplatin,Sorafenib

                          Therapeutic Area : Oncology

                          Highest Development Status : Preclinical

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          02

                          OTS 2025
                          Not Confirmed
                          OTS 2025
                          Not Confirmed

                          Details : Sorafenib is a Other Small Molecule drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of undefined medical condition.

                          Product Name : Undisclosed

                          Product Type : Miscellaneous

                          Upfront Cash : Inapplicable

                          August 01, 2023

                          Lead Product(s) : Sorafenib

                          Therapeutic Area : Undisclosed

                          Highest Development Status : Phase I

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          03

                          OTS 2025
                          Not Confirmed
                          OTS 2025
                          Not Confirmed

                          Details : CVM-1118 (foslinanib) is a new small molecule chemical entity and a potential anti-cancer agent in numerous human cancer cell lines with strong anti-cancer activity, high safety margin, and multiple mechanisms of actions in targeting cancer-specific fact...

                          Product Name : Undisclosed

                          Product Type : Miscellaneous

                          Upfront Cash : Undisclosed

                          September 27, 2022

                          Lead Product(s) : Foslinanib,Sorafenib

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : TaiRx

                          Deal Size : Undisclosed

                          Deal Type : Partnership

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                          04

                          OTS 2025
                          Not Confirmed
                          OTS 2025
                          Not Confirmed

                          Details : OUTREACH-2 study evaluating MTL-CEBPA specifically up-regulates CCAAT/enhancer-binding protein alpha (C/EBP-α) in combination with sorafenib, in comparison to sorafenib alone, in up to 150 patients.

                          Product Name : MTL-CEBPA

                          Product Type : Oligonucleotide

                          Upfront Cash : Inapplicable

                          January 25, 2022

                          Lead Product(s) : MTL-CEBPA,Sorafenib

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Bayer AG

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          05

                          OTS 2025
                          Not Confirmed
                          OTS 2025
                          Not Confirmed

                          Details : The median sorafenib treatment duration was only nine weeks, a much shorter treatment duration than the referenced historical controls. The median treatment duration of TTFields was 10 weeks.

                          Product Name : Nexavar

                          Product Type : Miscellaneous

                          Upfront Cash : Inapplicable

                          July 01, 2021

                          Lead Product(s) : Sorafenib

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          06

                          OTS 2025
                          Not Confirmed
                          OTS 2025
                          Not Confirmed

                          Details : Last patient has been enrolled in the HEPANOVA trial, a phase 2 pilot trial testing Tumor Treating Fields in combination with sorafenib in patients with advanced liver cancer.

                          Product Name : Nexavar

                          Product Type : Miscellaneous

                          Upfront Cash : Inapplicable

                          July 07, 2020

                          Lead Product(s) : Sorafenib

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          07

                          OTS 2025
                          Not Confirmed
                          OTS 2025
                          Not Confirmed

                          Details : Observed clinical activity, including durable and complete tumour responses, suggests that MTL-CEBPA may increase the effectiveness of sorafenib standard of care.

                          Product Name : MTL-CEBPA

                          Product Type : Oligonucleotide

                          Upfront Cash : Inapplicable

                          May 29, 2020

                          Lead Product(s) : MTL-CEBPA,Sorafenib

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          08

                          OTS 2025
                          Not Confirmed
                          OTS 2025
                          Not Confirmed

                          Details : The randomized, placebo-controlled Phase 2b study of YIV-906 is evaluating efficacy, safety, and quality of life in patients with hepatitis B-positive HCC.

                          Product Name : Undisclosed

                          Product Type : Plant Extract/Herbal

                          Upfront Cash : Inapplicable

                          April 06, 2020

                          Lead Product(s) : YIV-906,Sorafenib

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          09

                          OTS 2025
                          Not Confirmed
                          OTS 2025
                          Not Confirmed

                          Details : Sorafenib is a Other Small Molecule drug candidate, which is currently being evaluated in phase II clinical studies for the treatment of Carcinoma, Hepatocellular.

                          Product Name : Undisclosed

                          Product Type : Miscellaneous

                          Upfront Cash : Inapplicable

                          June 27, 2019

                          Lead Product(s) : Sorafenib

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          10

                          First Affiliated Hospital Xi'an Jiaotong University

                          Country arrow
                          OTS 2025
                          Not Confirmed

                          First Affiliated Hospital Xi'an Jiaotong University

                          Country arrow
                          OTS 2025
                          Not Confirmed

                          Details : Sorafenib is a Other Small Molecule drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of Carcinoma, Hepatocellular.

                          Product Name : Undisclosed

                          Product Type : Miscellaneous

                          Upfront Cash : Inapplicable

                          May 29, 2019

                          Lead Product(s) : Sorafenib

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Eureka Therapeutics

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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