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                          01

                          The MedTech Conference
                          Not Confirmed
                          The MedTech Conference
                          Not Confirmed

                          Details : Orchestra BioMed secured strategic backing from Ligand and Medtronic to advance its lead programs, AVIM Therapy for hypertension and Virtue SAB delivering sirolimus for vascular disease.

                          Product Name : Virtue SAB

                          Product Type : Antibiotic

                          Upfront Cash : Undisclosed

                          July 31, 2025

                          Lead Product(s) : Sirolimus

                          Therapeutic Area : Cardiology/Vascular Diseases

                          Highest Development Status : Undisclosed

                          Sponsor : Ligand Pharmaceuticals

                          Deal Size : $40.0 million

                          Deal Type : Financing

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                          02

                          The MedTech Conference
                          Not Confirmed
                          The MedTech Conference
                          Not Confirmed

                          Details : The funding aims to advance the clinica development of comapany's late stage product Qtorin (sirolimus), which is being evaluated for the treatment of microcystic lymphatic malformations.

                          Product Name : Qtorin

                          Product Type : Antibiotic

                          Upfront Cash : Undisclosed

                          June 09, 2025

                          Lead Product(s) : Sirolimus

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : FDA

                          Deal Size : $2.6 million

                          Deal Type : Funding

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                          03

                          The MedTech Conference
                          Not Confirmed
                          The MedTech Conference
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                          Details : The funding will be used to support registrational eRapa, a proprietary oral tablet formulation of rapamycin, phase 3 program in familial adenomatous polyposis.

                          Product Name : eRapa

                          Product Type : Antibiotic

                          Upfront Cash : Undisclosed

                          May 22, 2025

                          Lead Product(s) : Sirolimus

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : Phase III

                          Sponsor : CPRIT

                          Deal Size : $20.0 million

                          Deal Type : Funding

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                          04

                          The MedTech Conference
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                          The MedTech Conference
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                          Details : eRapa, a proprietary encapsulated form of rapamycin, also known as sirolimus, is being developed for the treatment of familial adenomatous polyposis (FAP).

                          Product Name : eRapa

                          Product Type : Antibiotic

                          Upfront Cash : Inapplicable

                          May 12, 2025

                          Lead Product(s) : Sirolimus

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : Phase II

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          05

                          The MedTech Conference
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                          The MedTech Conference
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                          Details : ERapa (Rapamycin) is a Antibiotic drug candidate, which is currently being evaluated in phase III clinical studies for the treatment of Adenomatous Polyposis Coli.

                          Product Name : eRapa

                          Product Type : Antibiotic

                          Upfront Cash : Inapplicable

                          April 30, 2025

                          Lead Product(s) : Sirolimus

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : Phase III

                          Sponsor : Biodexa Pharmaceuticals

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          06

                          CSPC ZhongQi

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                          The MedTech Conference
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                          CSPC ZhongQi

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                          The MedTech Conference
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                          Details : Sirolimus is a Antibiotic drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of Breast Neoplasms.

                          Product Name : Undisclosed

                          Product Type : Antibiotic

                          Upfront Cash : Inapplicable

                          April 23, 2025

                          Lead Product(s) : Sirolimus

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          07

                          Narrows Institute for Biomedical Research

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                          The MedTech Conference
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                          Narrows Institute for Biomedical Research

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                          The MedTech Conference
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                          Details : Sirolimus is a Antibiotic drug candidate, which is currently being evaluated in phase II clinical studies for the treatment of Acanthosis Nigricans.

                          Product Name : Undisclosed

                          Product Type : Antibiotic

                          Upfront Cash : Inapplicable

                          April 23, 2025

                          Lead Product(s) : Sirolimus

                          Therapeutic Area : Dermatology

                          Highest Development Status : Phase II

                          Sponsor : Nobelpharma

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          08

                          The MedTech Conference
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                          The MedTech Conference
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                          Details : The Magnitude® is a sirolimus-eluting bioresorbable scaffold by R3 vascular. It is a vascular implant designed for below-the-knee peripheral artery disease (PAD).

                          Product Name : Magnitude

                          Product Type : Antibiotic

                          Upfront Cash : Inapplicable

                          April 22, 2025

                          Lead Product(s) : Sirolimus

                          Therapeutic Area : Cardiology/Vascular Diseases

                          Highest Development Status : Phase III

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          09

                          CSPC ZhongQi

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                          The MedTech Conference
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                          CSPC ZhongQi

                          Country arrow
                          The MedTech Conference
                          Not Confirmed

                          Details : Sirolimus is a Antibiotic drug candidate, which is currently being evaluated in phase III clinical studies for the treatment of Breast Neoplasms.

                          Product Name : Undisclosed

                          Product Type : Antibiotic

                          Upfront Cash : Inapplicable

                          April 16, 2025

                          Lead Product(s) : Sirolimus

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          10

                          The MedTech Conference
                          Not Confirmed
                          The MedTech Conference
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                          Details : Through the divestment, Kaken assumes ownership of FYARRO (sirolimus protein-bound particles for injectable suspension) used to treat adults with malignant perivascular epithelioid cell tumor.

                          Product Name : Fyarro

                          Product Type : Antibiotic

                          Upfront Cash : $100.0 million

                          March 26, 2025

                          Lead Product(s) : Sirolimus Protein-bound Particle,Sirolimus

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved FDF

                          Sponsor : Kaken Pharmaceuticals

                          Deal Size : $100.0 million

                          Deal Type : Divestment

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